Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale最新文献_第5页

Biologics for severe uncontrolled chronic rhinosinusitis with nasal polyps: a change management approach. Consensus of the Joint Committee of Italian Society of Otorhinolaryngology on biologics in rhinology. 生物制剂治疗严重不受控制的慢性鼻窦炎伴鼻息肉:一种改变管理方法。意大利耳鼻咽喉学会联合委员会关于鼻科生物制剂的共识。

IF 2

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale Pub Date : 2022-02-01 Epub Date: 2021-07-23 DOI: 10.14639/0392-100X-N1614

Eugenio De Corso, Gianluca Bellocchi, Michele De Benedetto, Nicola Lombardo, Alberto Macchi, Luca Malvezzi, Gaetano Motta, Fabio Pagella, Claudio Vicini, Desiderio Passali

{"title":"Biologics for severe uncontrolled chronic rhinosinusitis with nasal polyps: a change management approach. Consensus of the Joint Committee of Italian Society of Otorhinolaryngology on biologics in rhinology.","authors":"Eugenio De Corso, Gianluca Bellocchi, Michele De Benedetto, Nicola Lombardo, Alberto Macchi, Luca Malvezzi, Gaetano Motta, Fabio Pagella, Claudio Vicini, Desiderio Passali","doi":"10.14639/0392-100X-N1614","DOIUrl":"https://doi.org/10.14639/0392-100X-N1614","url":null,"abstract":"SUMMARY Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition of nasal mucosa and paranasal sinuses, predominantly mediated by type 2 inflammation and often associated with comorbid asthma and/or Exacerbated Respiratory Disease (N-ERD). The standard of care involves local and systemic corticosteroids and/or sinonasal surgery, although these options may be associated with recurrences and patients may require revision surgery. Difficult-to-treat patients, in fact, have a more severe disease requiring high systemic corticosteroid use and/or multiple sinonasal surgeries. Literature data suggests that biologic agents targeting specific key effectors of type 2 inflammation may offer supplemental therapy for patients with severe and uncontrolled CRSwNP, leading to significant improvement in several outcomes. For these reasons, over the years the endotyping of the disease has become increasingly important. Herein, we provide not only an update on the existing studies about the most promising biologics in CRSwNP, but also critical discussion on controversies about the use of biologics in severe uncontrolled CRSwNP. We finally provide consensus on strategic issues gathered among experts of the Joint Committee of Italian Society of Otorhinolaryngology on biologics in order to offer the best care for difficult to treat patients.","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":" ","pages":"1-16"},"PeriodicalIF":2.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/e8/aoi-2022-01-1.PMC9058929.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39211680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

The association between dysphagia and OSA. 吞咽困难与呼吸暂停综合症之间的关系。

IF 2

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale Pub Date : 2022-02-01 Epub Date: 2022-02-07 DOI: 10.14639/0392-100X-N1578

Lorenzo Marra, Giada Cavallaro, Valentina Di Lecce, Giorgio Castellana, Carla Santomasi, Vincenzo Di Nicola, Nicola Antonio Adolfo Quaranta, Giovanna Elisiana Carpagnano, Onofrio Resta, Maria Luisa Fiorella

{"title":"The association between dysphagia and OSA.","authors":"Lorenzo Marra, Giada Cavallaro, Valentina Di Lecce, Giorgio Castellana, Carla Santomasi, Vincenzo Di Nicola, Nicola Antonio Adolfo Quaranta, Giovanna Elisiana Carpagnano, Onofrio Resta, Maria Luisa Fiorella","doi":"10.14639/0392-100X-N1578","DOIUrl":"https://doi.org/10.14639/0392-100X-N1578","url":null,"abstract":"Objective: The aim of our study was to investigate the presence of dysphagia in patients with Obstructive Sleep Apnoea (OSA) and to correlate swallowing impairment with hypnologic and anatomic parameters.Methods: The study population includes 36 patients suffering from OSA. Patients were divided into two groups using the presence of dysphagia as a distinctive parameter. Group 1 included 27 OSA patients without signs of dysphagia and Group 2 included 9 OSA patients with signs of dysphagia.Results: The age of patients in Group 2 was higher compared with the age of patients in Group 1. Analysis of Continuous Positive Airway Pressure (CPAP), obtained in the titration phase, showed that OSA patients with signs of dysphagia required a higher level of CPAP pressure than those who were not affected by swallowing abnormalities (12.6 ± 1 vs 10.5 ± 1.9 p = 0.003). No other differences in anthropometric, hypnologic, or arterial blood gas values were found between the two groups.Conclusions: In clinical practice, all OSA patients should undergo a complete ENT exam, including assessment of swallowing, before CPAP therapy is started. This may predict the need for higher CPAP pressure settings to resolve apnoea episodes in the presence of dysphagia as well as guide the choice of CPAP interfaces (orofacial vs. nasal) in these patients.","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":" ","pages":"82-88"},"PeriodicalIF":2.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/fb/aoi-2022-01-82.PMC9058934.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39599561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Occlusal splint therapy in patients with Ménière's disease and temporomandibular joint disorder. 咬合夹板治疗mims病和颞下颌关节紊乱。

IF 2

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale Pub Date : 2022-02-01 Epub Date: 2022-02-07 DOI: 10.14639/0392-100X-N1641

Daniele Monzani, Carlo Baraldi, Enrico Apa, Matteo Alicandri-Ciufelli, Carlo Bertoldi, Elisabeth Röggla, Simona Guerzoni, Daniele Marchioni, Luca Pani

{"title":"Occlusal splint therapy in patients with Ménière's disease and temporomandibular joint disorder.","authors":"Daniele Monzani, Carlo Baraldi, Enrico Apa, Matteo Alicandri-Ciufelli, Carlo Bertoldi, Elisabeth Röggla, Simona Guerzoni, Daniele Marchioni, Luca Pani","doi":"10.14639/0392-100X-N1641","DOIUrl":"https://doi.org/10.14639/0392-100X-N1641","url":null,"abstract":"Objective: This retrospective study aimed to verify the outcomes of stabilising occlusal splint therapy prescribed to 22 patients with unilateral definite Ménière's disease and comorbid temporomandibular joint disorder.Methods: The results of a battery of audiometric and vestibular tests were recorded before and after 6 months of treatment, as well as the scores of disease-specific questionnaires.Results: The average hearing threshold in the affected ear and the acoustic immittance were unchanged. No spontaneous and positional nystagmus were recorded. Caloric hypo-responsiveness and vestibular myogenic evoked responses did not vary. No changes of stabilometric body sway parameters in eyes opened condition and with optokinetic stimulation delivered to the unaffected labyrinth were observed. A significant reduction was recorded in eyes closed condition and with the optokinetic stimulation toward the affected ear. The Tinnitus Handicap Inventory, the Situational Vertigo Questionnaire and the Numeric Pain Rating Scale scores improved. The number of vertigo attacks was reduced.Conclusions: Occlusal splint therapy is a favourable option to reduce aural symptoms of Ménière's disease and comorbid temporomandibular joint disorder, even if its pathophysiological mechanism remains elusive.","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":" ","pages":"89-96"},"PeriodicalIF":2.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/e4/aoi-2022-01-89.PMC9058932.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39599562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Systematic interpretation of confocal laser endomicroscopy: larynx and pharynx confocal imaging score. 共聚焦激光内镜的系统解释:喉和咽共聚焦成像评分。

IF 2

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale Pub Date : 2022-02-01 Epub Date: 2022-02-07 DOI: 10.14639/0392-100X-N1643

Matti Sievert, Konstantinos Mantsopoulos, Sarina K Mueller, Markus Eckstein, Robin Rupp, Marc Aubreville, Florian Stelzle, Nicolai Oetter, Andreas Maier, Heinrich Iro, Miguel Goncalves

{"title":"Systematic interpretation of confocal laser endomicroscopy: larynx and pharynx confocal imaging score.","authors":"Matti Sievert, Konstantinos Mantsopoulos, Sarina K Mueller, Markus Eckstein, Robin Rupp, Marc Aubreville, Florian Stelzle, Nicolai Oetter, Andreas Maier, Heinrich Iro, Miguel Goncalves","doi":"10.14639/0392-100X-N1643","DOIUrl":"https://doi.org/10.14639/0392-100X-N1643","url":null,"abstract":"Objective: Development and validation of a confocal laser endomicroscopy (CLE) classification score for the larynx and pharynx.Methods: Thirteen patients (154 video sequences, 9240 images) with laryngeal or pharyngeal SCC were included in this prospective study between October 2020 and February 2021. Each CLE sequence was correlated with the gold standard of histopathological examination. Based on a dataset of 94 video sequences (5640 images), a scoring system was developed. In the remaining 60 sequences (3600 images), the score was validated by four CLE experts and four head and neck surgeons who were not familiar with CLE.Results: Tissue homogeneity, cell size, borders and clusters, capillary loops and the nucleus/cytoplasm ratio were defined as the scoring criteria. Using this score, the CLE experts obtained an accuracy, sensitivity, and specificity of 90.8%, 95.1%, and 86.4%, respectively, and the CLE non-experts of 86.2%, 86.4%, and 86.1%. Interobserver agreement Fleiss' kappa was 0.8 and 0.6, respectively.Conclusions: CLE can be reliably evaluated based on defined and reproducible imaging features, which demonstrate a high diagnostic value. CLE can be easily integrated into the intraoperative setting and generate real-time, in-vivo microscopic images to demarcate malignant changes.","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":" ","pages":"26-33"},"PeriodicalIF":2.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/6d/aoi-2022-01-26.PMC9058938.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39599563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

[Consensus conference on the rationale for use of anti-inflammatory agents in otorhinolaryngology]. [在耳鼻喉科使用抗炎药的基本原理的共识会议]。

IF 2

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale Pub Date : 2003-08-01

引用次数: 0