npj women's health最新文献_第3页

Circulating inflammatory biomarkers and endometriosis lesion characteristics in the WisE consortium. WisE联盟的循环炎症生物标志物和子宫内膜异位症病变特征。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-10-31 DOI: 10.1038/s44294-025-00110-x

Kathryn L Terry, Amy Shafrir, Ashley Laliberte, Allison F Vitonis, Kurtis Garbutt, Mary DePari, Christian Becker, Naoko Sasamoto, Krina T Zondervan, Stacey A Missmer

{"title":"Circulating inflammatory biomarkers and endometriosis lesion characteristics in the WisE consortium.","authors":"Kathryn L Terry, Amy Shafrir, Ashley Laliberte, Allison F Vitonis, Kurtis Garbutt, Mary DePari, Christian Becker, Naoko Sasamoto, Krina T Zondervan, Stacey A Missmer","doi":"10.1038/s44294-025-00110-x","DOIUrl":"10.1038/s44294-025-00110-x","url":null,"abstract":"Endometriosis is a chronic inflammatory condition requiring surgical or imaging visualization for definitive diagnosis. How endometriotic lesion characteristics relate to circulating inflammatory markers remains unclear. We evaluated 11 inflammatory biomarkers, including interleukin (IL)-1β, -6, -8, -10, -16, tumor necrosis factor (TNF)-α, thymus and activation regulated chemokine (TARC), monocyte chemotactic protein (MCP)-1, -4, and Interferon gamma-induced protein (IP)-10, in 566 participants with endometriosis from the Women's Health Study: From Adolescence to Adulthood (A2A), Endometriosis Oxford Care & Research (CaRe) study (ENDOX) and Endometriosis: Natural History, Diagnosis, and Outcome (ENDO) study to evaluate associations with endometriosis characteristics, including macrophenotype (superficial lesions only, versus endometrioma and/or deep lesions), lesion appearance (color, vascularity), and anatomic location. We observed nominally statistically significant variation in circulating inflammatory markers by lesion color, vascularity, and location but no significant associations between circulating inflammatory markers and rASRM stage or macrophenotype, which could be due to a small number of participants with non-superficial lesions.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"62"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of artificial intelligence in sexual and reproductive health: a comprehensive scoping review. 人工智能在性健康和生殖健康中的应用：全面范围审查。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-12-18 DOI: 10.1038/s44294-025-00118-3

Sara Mengistu, Tigest Tamrat, Ana-Pilar Betran, Sofia Pirsch, Agata Ferretti, Gitau Mburu, Melaku Birhanu Alemu, Rohit Malpani, Maria Barreix, Carl Massonneau, Yu Zhao, Rose Weeks, Ghulam Mohammad Paracha, Sarah Tanishka Nethan, Smisha Agarwal, Jennifer Dunne, Gizachew Tessema, Maribel Almonte, Shona Dalal, Kanika Kalra, Rajeshwari Singh, Shada AlSalamah, Gavin Pereira, Sameer Pujari, Lale Say

{"title":"The use of artificial intelligence in sexual and reproductive health: a comprehensive scoping review.","authors":"Sara Mengistu, Tigest Tamrat, Ana-Pilar Betran, Sofia Pirsch, Agata Ferretti, Gitau Mburu, Melaku Birhanu Alemu, Rohit Malpani, Maria Barreix, Carl Massonneau, Yu Zhao, Rose Weeks, Ghulam Mohammad Paracha, Sarah Tanishka Nethan, Smisha Agarwal, Jennifer Dunne, Gizachew Tessema, Maribel Almonte, Shona Dalal, Kanika Kalra, Rajeshwari Singh, Shada AlSalamah, Gavin Pereira, Sameer Pujari, Lale Say","doi":"10.1038/s44294-025-00118-3","DOIUrl":"10.1038/s44294-025-00118-3","url":null,"abstract":"This scoping review examines the use of artificial intelligence (AI) in sexual and reproductive health (SRH) to guide future research and policymaking. We conducted searches across four electronic databases in October 2023. We included primary research studies applying AI on any SRH topic, regardless of language and timeframe. Our search retrieved 12,823 articles, of which abstracts and full texts were independently screened by two reviewers, yielding 2666 studies for final analysis. The predominant health topics were maternal health (44.9%; n = 1198); reproductive cancers (29.2%; n = 779), mainly cervical cancer; and infertility and fertility care (12.6%; n = 337). AI tools were primarily used to facilitate screening and diagnosis (74.2%, n = 1980), support treatment and care management (8.7%, n = 233), and understand health trends (8.6%, n = 230). While substantial progress has been made in certain domains, significant gaps remain in geographic representation, methodological rigor, and deployment studies with external validity.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12714584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Untargeted metabolomics reveals key pathways in miscarriage: steroid, folate, fatty acid & glycosaminoglycan metabolism. 非靶向代谢组学揭示了流产的关键途径：类固醇、叶酸、脂肪酸和糖胺聚糖代谢。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-06-13 DOI: 10.1038/s44294-025-00085-9

Chee Wai Ku, Yu Bin Tan, Kuan Yang Chew, Chee Onn Ku, Shi Tong Carissa Ng, Thiam Chye Tan, Yie Hou Lee

{"title":"Untargeted metabolomics reveals key pathways in miscarriage: steroid, folate, fatty acid & glycosaminoglycan metabolism.","authors":"Chee Wai Ku, Yu Bin Tan, Kuan Yang Chew, Chee Onn Ku, Shi Tong Carissa Ng, Thiam Chye Tan, Yie Hou Lee","doi":"10.1038/s44294-025-00085-9","DOIUrl":"10.1038/s44294-025-00085-9","url":null,"abstract":"Metabolites influencing miscarriage outcomes remain understudied. We hypothesized that aberrant metabolism impacts threatened miscarriage outcomes and that understanding these pathways could offer new management strategies. This case-control study analyzed serum metabolomics from 80 women between 5 and 12 weeks' gestation at KK Women's and Children's Hospital, Singapore, comparing three groups: women with threatened miscarriage who miscarried (TMMC), those with ongoing pregnancies (TMO), and women with normal pregnancies (NP). Using untargeted liquid chromatography-mass spectrometry and pathway analysis through MetaboAnalyst 5.0 and the Kyoto Encyclopedia of Genes and Genomes, 267 metabolites across 12 enriched pathways were identified. Dysregulations in steroid (AUC 0.82), folate (AUC 0.59), fatty acid (AUC 0.70), and glucosaminoglycan (AUC 0.64) pathways distinguished women who miscarried from those with ongoing pregnancies (TMMC vs TMO). We provide initial insights into the metabolic profile associated with miscarriage, highlighting disruptions in steroid hormone, fatty acid, folate, and glucosaminoglycan biosynthesis. Further validation may support biomarker development for prognostication.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking women's endocrine milieu in mice for women's health-related studies. 在小鼠中模拟女性内分泌环境，用于女性健康相关研究。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-02-22 DOI: 10.1038/s44294-025-00060-4

Céline Constantin, Daria Matvienko, Csaba László, Valentina Scabia, Laura Battista, Pierre-Alain Binz, Stephen J Bruce, Cathrin Brisken

{"title":"Mimicking women's endocrine milieu in mice for women's health-related studies.","authors":"Céline Constantin, Daria Matvienko, Csaba László, Valentina Scabia, Laura Battista, Pierre-Alain Binz, Stephen J Bruce, Cathrin Brisken","doi":"10.1038/s44294-025-00060-4","DOIUrl":"10.1038/s44294-025-00060-4","url":null,"abstract":"To improve preclinical studies and their translation, patient-derived xenografts (PDXs) are increasingly used. They have human-specific tumor characteristics and reflect intra and inter-tumor heterogeneity. However, the endocrine milieu differs between humans and host mice. In light of sex-specific cancer biology and a rise in endocrine-related cancers there is an urgent need to correctly reflect the hormonal milieu in PDX models. We show that female mice of NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ (NSG) strain widely used for PDXs has 17-β-estradiol (E2) and testosterone (T) levels comparable to C57Bl6 females but higher progesterone (P4) levels. E2 levels are comparable, T levels are lower and P4 levels higher than those observed in postmenopausal women. Ovariectomy increases T to levels observed in postmenopausal women. Subcutaneous E2 and combined E2/P4 silicon pellets provide NSG females with premenopausal ovarian hormone levels. These procedures humanize the endocrine environment of experimental animals, improving PDX relevance in women's health-related research.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring COVID-19 vaccine attitudes among pregnant women: key factors and strategies to enhance uptake. 探讨孕妇对COVID-19疫苗接种的态度：关键因素和加强接种的策略

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-11-26 DOI: 10.1038/s44294-025-00115-6

Maclaine A Parish, Sanaa Badhwar, Heang-Lee Tan, Imaima Causbhoy, Alyssa Kretz, Jeanne Sheffield, Sabra L Klein, Rosemary Morgan

{"title":"Exploring COVID-19 vaccine attitudes among pregnant women: key factors and strategies to enhance uptake.","authors":"Maclaine A Parish, Sanaa Badhwar, Heang-Lee Tan, Imaima Causbhoy, Alyssa Kretz, Jeanne Sheffield, Sabra L Klein, Rosemary Morgan","doi":"10.1038/s44294-025-00115-6","DOIUrl":"10.1038/s44294-025-00115-6","url":null,"abstract":"Pregnancy increases the risk of adverse outcomes from many infections. SARS-CoV-2 infection during pregnancy leads to higher risks of adverse pregnancy outcomes, including preterm birth, stillbirth, congenital birth defects, and intrauterine growth restriction. Preventing severe illness from SARS-CoV-2 during pregnancy is crucial for improving health outcomes and is best achieved by COVID-19 vaccination. While vaccination is recommended by the American College of Obstetricians and Gynecologists and is safe and efficacious during pregnancy, vaccine uptake among pregnant women is starkly lower than in the general population. Through semi-structured interviews, we assessed attitudes towards COVID-19 vaccination during pregnancy and identified key factors influencing decision-making across the healthcare continuum to inform public health interventions. In addition to improving vaccine accessibility and affordability, it is crucial to implement interventions that promote trust in healthcare providers. These efforts are essential to increasing vaccine uptake among this population, providing protection for pregnant women and their children.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12657226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in sleep apnea and Alzheimer's Disease: role of cerebrovascular dysfunction. 睡眠呼吸暂停和阿尔茨海默病的性别差异：脑血管功能障碍的作用。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-05-05 DOI: 10.1038/s44294-025-00076-w

Ian M Greenlund, Jill N Barnes, Sarah E Baker, Virend K Somers, Joshua M Bock

引用次数: 0

Estrogen regulation of the nucleus accumbens as a gateway to understanding menopause associated metabolic dysfunction. 雌激素调节伏隔核作为了解更年期相关代谢功能障碍的途径。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-04-23 DOI: 10.1038/s44294-025-00071-1

Cheryl S Rosenfeld, Victoria J Vieira-Potter

引用次数: 0

Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence. 通过手术、组学、健康数据和人工智能研究子宫内膜异位症表型的现实世界视角。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1038/s44294-024-00052-w

Camran R Nezhat, Tomiko T Oskotsky, Joshua F Robinson, Susan J Fisher, Angie Tsuei, Binya Liu, Juan C Irwin, Brice Gaudilliere, Marina Sirota, David K Stevenson, Linda C Giudice

引用次数: 0

Quantitative and longitudinal assessment of human placental inflammation using diffusion basis spectrum imaging. 利用扩散基谱成像对人类胎盘炎症进行定量和纵向评估。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-01-03 DOI: 10.1038/s44294-024-00049-5

Zhexian Sun, Wenjie Wu, Zezhen Xiang, Hansong Gao, Weina Ju, Cherilyn Uhm, Ian S Hagemann, Pamela K Woodard, Nanbert Zhong, Alison G Cahill, Qing Wang, Yong Wang

{"title":"Quantitative and longitudinal assessment of human placental inflammation using diffusion basis spectrum imaging.","authors":"Zhexian Sun, Wenjie Wu, Zezhen Xiang, Hansong Gao, Weina Ju, Cherilyn Uhm, Ian S Hagemann, Pamela K Woodard, Nanbert Zhong, Alison G Cahill, Qing Wang, Yong Wang","doi":"10.1038/s44294-024-00049-5","DOIUrl":"10.1038/s44294-024-00049-5","url":null,"abstract":"Besides exchanging nutrients, gases, and wastes, placenta is an intermediary between maternal and fetal immune systems. However, no method exists to safely image and monitor placental inflammation during pregnancy. We customized a Magnetic Resonance Imaging (MRI) method, diffusion basis spectrum imaging (DBSI), to measure immune cells in placenta. We validated placental DBSI in simulations and ex-vivo specimens, then applied it to 202 MRI scans from 82 patients whose placentas were classified as non-inflammation (n = 70) or inflammation (n = 12). Our method imaged the 3D distribution of immune cells, revealing significantly greater infiltration in the inflammation placentas from early (2.8% ± 0.7% vs. 4.8% ± 0.65%, p < 0.01) to late pregnancy (4.75% ± 0.9% vs. 7.25% ± 2.13%, p < 0.01). DBSI detects elevated immune cell infiltration associated with placental inflammation and enables non-invasive imaging of placental inflammation, offering early detection and monitoring throughout pregnancy, facilitating personalized care and potentially improving pregnancy outcomes without ionizing radiation.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early pubertal timing is a risk factor for adolescent dysmenorrhea. 青春期时间过早是青少年痛经的危险因素。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-08-22 DOI: 10.1038/s44294-025-00097-5

Christel M Portengen, Tristin Smith, Esmeralda Hidalgo-Lopez, Hannah Becker, Melissa E Lenert, Andrew Schrepf, Steven E Harte, Chelsea M Kaplan, Adriene M Beltz

引用次数: 0