npj women's health最新文献_第4页

A systematic review of the relationship between neighborhood stressors, discrimination, and cardiometabolic outcomes during pregnancy. 对怀孕期间邻里压力源、歧视和心脏代谢结果之间关系的系统回顾。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-04-25 DOI: 10.1038/s44294-025-00072-0

Roma Dhingra, Kosuke Tamura, Jinani Jayasekera, Amina P Alio, Allana T Forde

{"title":"A systematic review of the relationship between neighborhood stressors, discrimination, and cardiometabolic outcomes during pregnancy.","authors":"Roma Dhingra, Kosuke Tamura, Jinani Jayasekera, Amina P Alio, Allana T Forde","doi":"10.1038/s44294-025-00072-0","DOIUrl":"https://doi.org/10.1038/s44294-025-00072-0","url":null,"abstract":"Cardiometabolic outcomes during pregnancy, including hypertensive disorders of pregnancy (HDP) and gestational diabetes, disproportionately affect racial and/or ethnic minority groups in the United States. These disparities are not fully explained by traditional risk factors, but race-related psychosocial stressors such as perceived neighborhood stressors and discrimination (PNSD) may contribute to adverse health outcomes. This systematic review examined the literature on the impact of PNSD on HDP and gestational diabetes. A comprehensive search of PubMed, PsycINFO, Embase, Web of Science, and CINAHL identified 10 eligible studies: seven cohort and three cross-sectional studies. Five studies reported significant associations between PNSD and increased risk for cardiometabolic outcomes during pregnancy (HDP-1 study, gestational diabetes-3 studies, both hypertension and diabetes during pregnancy-1 study). The included studies demonstrated good methodological quality. These findings suggest that PNSD may be associated with cardiometabolic outcomes during pregnancy, but further research is needed, particularly on perceived neighborhood stressors.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis. 连接人类宫颈和阴道芯片的宫颈粘液调节阴道生态失调。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1038/s44294-025-00054-2

Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E Ingber

{"title":"Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis.","authors":"Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E Ingber","doi":"10.1038/s44294-025-00054-2","DOIUrl":"10.1038/s44294-025-00054-2","url":null,"abstract":"This study explores the protective role of cervicovaginal mucus in maintaining vaginal health, particularly in relation to bacterial vaginosis (BV), using organ chip technology. By integrating human Cervix and Vagina Chips, we demonstrated that cervical mucus significantly reduces inflammation and epithelial damage caused by a dysbiotic microbiome commonly associated with BV. Proteomic analysis of the Vagina Chip, following exposure to mucus from the Cervix Chip, revealed differentially abundant proteins, suggesting potential biomarkers and therapeutic targets for BV management. Our findings highlight the essential function of cervical mucus in preserving vaginal health and underscore the value of organ chip models for studying complex interactions within the female reproductive tract. This research provides new insights into the mechanisms underlying vaginal dysbiosis and opens avenues for developing targeted therapies and diagnostic tools to enhance women's reproductive health.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The intersection of aging and estrogen in osteoarthritis. 老化与雌激素在骨关节炎中的交叉作用。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-02-25 DOI: 10.1038/s44294-025-00063-1

Aysegul Atasoy-Zeybek, Kelly K Showel, Christopher V Nagelli, Jennifer J Westendorf, Christopher H Evans

引用次数: 0

Beyond no harm: Advancing research on artificial intelligence for sexual and reproductive health and rights. 超越无害：推进人工智能促进性健康和生殖健康及权利的研究。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-11-24 DOI: 10.1038/s44294-025-00113-8

Tigest Tamrat, Rohit Malpani, Sara Mengistu, Anja Kovacs, Yu Zhao, Anuj Kapilashrami, Allan Maleche, Sameer Pujari, Andreas Reis, Lale Say

引用次数: 0

Developing point-of-care tools to inform decisions regarding prescription medication use in pregnancy. 开发护理点工具，为怀孕期间使用处方药的决定提供信息。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-07-25 DOI: 10.1038/s44294-025-00093-9

Animesh Kumar Paul, Sunil Vasu Kalmady, Russell Greiner, Padma Kaul

引用次数: 0

Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics. 胎儿暴露于母体长效注射与口服每日抗精神病药物的比较模型。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.1038/s44294-025-00077-9

Philip Bediako-Kakari, Mariella Monyo, Shakir Atoyebi, Adeniyi Olagunju

{"title":"Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics.","authors":"Philip Bediako-Kakari, Mariella Monyo, Shakir Atoyebi, Adeniyi Olagunju","doi":"10.1038/s44294-025-00077-9","DOIUrl":"10.1038/s44294-025-00077-9","url":null,"abstract":"This study employed physiologically based pharmacokinetic (PBPK) modelling to compare the extent of foetal exposure between oral and long-acting injectable (LAI) aripiprazole and olanzapine. Adult and pregnancy PBPK models were developed and validated with relevant clinical data. Relevant indices of foetal exposure during pregnancy were predicted from concentration-time data at steady-state dosing for both oral and LAI formulations. Foetal Cmax for aripiprazole was 59-78% higher with LAI than oral, and 68-181% higher with LAI olanzapine than the oral formulation. Predicted cord:maternal ratios (range) were 0.59-0.69 for oral aripiprazole and 0.61-0.66 for LAI aripiprazole, 0.34-0.64 for oral olanzapine and 0.89-0.96 for LAI olanzapine. Also, cumulative foetal exposure over 28 days from oral formulations were generally predicted to be lower compared with their therapeutic-equivalent LAI. As in utero foetal exposure to maternal drugs does not necessarily translate to risk, these data should be interpreted in a broader context that includes benefit-risk assessments.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The female intimate microbiome space. 女性亲密的微生物群空间。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-10-01 DOI: 10.1038/s44294-025-00104-9

Leonore Vander Donck, Thies Gehrmann, Sarah Ahannach, Sarah Van den Bosch, Margo Hiel, Lize Delanghe, Camille Nina Allonsius, Eline Cauwenberghs, Irina Spacova, Eline Oerlemans, Stijn Wittouck, Ilke De Boeck, Gilbert Donders, Veronique Verhoeven, Sarah Lebeer

引用次数: 0

Identifying nutraceutical targets to treat polycystic ovary syndrome using graph representation learning. 利用图表示学习识别治疗多囊卵巢综合征的营养靶点。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-12-01 DOI: 10.1038/s44294-025-00117-4

Simon Hanassab, Joshua Southern, Ayomide V Olabode, Ivan Laponogov, Michael Bronstein, Alexander N Comninos, Thomas Heinis, Ali Abbara, Chioma Izzi-Engbeaya, Kirill Veselkov, Waljit S Dhillo

{"title":"Identifying nutraceutical targets to treat polycystic ovary syndrome using graph representation learning.","authors":"Simon Hanassab, Joshua Southern, Ayomide V Olabode, Ivan Laponogov, Michael Bronstein, Alexander N Comninos, Thomas Heinis, Ali Abbara, Chioma Izzi-Engbeaya, Kirill Veselkov, Waljit S Dhillo","doi":"10.1038/s44294-025-00117-4","DOIUrl":"10.1038/s44294-025-00117-4","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a complex, multifactorial, and polygenic disorder. Here, we employed machine learning (ML) techniques to analyze large open-source datasets to identify bioactive molecules in foods and pharmacological agents that interact with genes and biological functions central to PCOS pathophysiology. We selected 13 PCOS-associated genes as targets, and the network propagation algorithm systematically identified bioactive molecules that interact with pathways relevant to PCOS. Among the top-ranked molecules, epicatechin-3-gallate (found in green tea) and 24-methylenecycloartan-3-ol (found in almonds) were newly identified, with green tea and almonds previously demonstrated to have anti-androgenic and anti-inflammatory properties. Validation of the ML pipeline with clinically available drugs revealed significant interactions with gonadotropin-releasing hormone receptor modulators, consistent with their established role in PCOS pathophysiology. These findings identify novel therapeutic targets for further research in precision nutrition and drug repurposing for PCOS treatment.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12669042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of lactation on postpartum pelvic floor muscle regeneration in preclinical model. 哺乳对产后盆底肌再生的影响。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-06-12 DOI: 10.1038/s44294-025-00079-7

F Boscolo Sesillo, H Manoochehri, P Duran, E Zelus, K L Christman, M Alperin

引用次数: 0

Clinical lactation studies. Acting on key recommendations over the last decade. 临床哺乳研究。根据过去十年的主要建议采取行动。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-02-28 DOI: 10.1038/s44294-025-00064-0

Karen Rowland Yeo, Jacqueline Gerhart, Aarti Sawant-Basak, Francis Williams Ojara, Aida N Kawuma, Catriona Waitt

引用次数: 0