npj women's health最新文献

A Foundation Model for Capturing Complexity of Menstrual Health Data. 获取月经健康数据复杂性的基础模型。

npj women's health Pub Date : 2026-04-28 DOI: 10.1038/s44294-026-00142-x

Robin Linzmayer, Chao Pang, Iñigo Urteaga, Gamze Gürsoy, Amanda A Shea, Virginia J Vitzthum, Noémie Elhadad

{"title":"A Foundation Model for Capturing Complexity of Menstrual Health Data.","authors":"Robin Linzmayer, Chao Pang, Iñigo Urteaga, Gamze Gürsoy, Amanda A Shea, Virginia J Vitzthum, Noémie Elhadad","doi":"10.1038/s44294-026-00142-x","DOIUrl":"10.1038/s44294-026-00142-x","url":null,"abstract":"Despite its centrality to women's health, the menstrual cycle remains understudied in computational health research due to its complexity, variability, and limited data availability. Recent advances in generative artificial intelligence (AI) offer new opportunities for modeling large-scale, user-generated menstrual health data. We introduce and evaluate a generative foundation model trained on self-tracked data from over 1.2 million users of a widely used menstrual tracking app. We assess the model's ability to generate physiologically plausible synthetic cycles and realistic tracking behaviors, examine whether learned representations capture meaningful temporal and symptomatic patterns, and evaluate privacy risks. Results show that the model produces high-fidelity synthetic data closely mirroring real-world users, with no evidence of data leakage, while learned representations consistently outperform baseline methods on downstream forecasting tasks. These findings highlight generative AI's potential to advance menstrual health forecasting, support privacy-sensitive data sharing, and enable scientific inquiry in women's health research.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13251539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148230429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality. 对羟基苯甲酸酯和雌激素介导的癌症：揭示巧合，共同发生和因果关系。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-08-28 DOI: 10.1038/s44294-026-00162-7

Zehra Esra Ilhan, Andrea Marchetto, Georgia Lorentzen, Paweł Łaniewski, Leslie V Farland, Melissa M Herbst-Kralovetz

引用次数: 0

Menstrual cycle variations in stress vulnerability and sociability relate to mental health symptoms and libido. 月经周期在压力易感性和社交能力方面的变化与心理健康症状和性欲有关。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-04-17 DOI: 10.1038/s44294-026-00140-z

Belinda Pletzer, Tobias Hausinger, Neele Thoms, Cosima Gierg, Adriene M Beltz

{"title":"Menstrual cycle variations in stress vulnerability and sociability relate to mental health symptoms and libido.","authors":"Belinda Pletzer, Tobias Hausinger, Neele Thoms, Cosima Gierg, Adriene M Beltz","doi":"10.1038/s44294-026-00140-z","DOIUrl":"10.1038/s44294-026-00140-z","url":null,"abstract":"Previous studies have suggested the high-estradiol peri-ovulatory phase as a window of resilience, and the luteal phase, characterised by changing progesterone levels, as a window of vulnerability to stress-related disorders. Using an intensive longitudinal design over 75 days, the current study explored whether stress vulnerability and resilience were reflected in menstrual cycle-related shifts in personality facets. In a sample of 68 healthy female participants aged 18 to 35 years, we observed increased stress vulnerability, decreased sociability, and decreased non-antagonistic orientation during the peri-menstrual phase. Changes in stress vulnerability were both preceded and followed by changes in mental health symptoms (depression, anxiety, mood lability, irritability), while changes in mental health symptoms followed-but did not precede-sociability and non-antagonistic orientation. These results suggest that personality facet shifts along the menstrual cycle precede changes in mental health symptoms, though the personality facets explored in the current study did not fully account for menstrual cycle-related changes in these symptoms.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust forecasting of sedentary bouts in chronic pelvic pain disorders for on-device learning and real-time deployment. 慢性盆腔疼痛疾病久坐发作的稳健预测，用于设备上学习和实时部署。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-09-30 DOI: 10.1038/s44294-026-00156-5

Jannes Jegminat, Samia Shahnawaz, Jovita Rodrigues, Matteo Danieletto, Kyle Landell, Gabriele Campanella, Carol Ewing Garber, Zahi A Fayad, Ipek Ensari

{"title":"Robust forecasting of sedentary bouts in chronic pelvic pain disorders for on-device learning and real-time deployment.","authors":"Jannes Jegminat, Samia Shahnawaz, Jovita Rodrigues, Matteo Danieletto, Kyle Landell, Gabriele Campanella, Carol Ewing Garber, Zahi A Fayad, Ipek Ensari","doi":"10.1038/s44294-026-00156-5","DOIUrl":"https://doi.org/10.1038/s44294-026-00156-5","url":null,"abstract":"Reducing sedentary behavior through personalized digital interventions holds particular promise for individuals with chronic pelvic pain disorders (CPPDs), who face unique barriers to physical activity. We present a self-contained, missing data-resilient framework for real-time forecasting of a physical activity score (PAS) using wearable Fitbit data from 134 females with CPPDs. Comparing online and offline learning approaches, we demonstrate that models leveraging recent activity and daily recurring patterns perform the best. When applied to 15-min sedentary bouts (SBs), the PAS forecasts support timely alerts, yielding approximately one true alert per day vs 0.6 false alerts at a conservative operating point. By integrating real-time imputation, the system supports forecasting of SBs for potential use in just-in-time adaptive interventions. Our work demonstrates a privacy-preserving, scalable pathway for integrating precision forecasting into just-in-time adaptive interventions, laying the groundwork for more equitable and effective digital health solutions for women with CPPDs.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13626958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A qualitative study exploring patient and healthcare practitioner perspectives about at-home fetal Doppler devices. 一项质性研究探讨病人和保健医生的观点，在家胎儿多普勒设备。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-04-17 DOI: 10.1038/s44294-026-00139-6

Sabrina Keating, Rosa Mackay, Jennifer Maclellan, Abigail McNiven, Sharon Dixon

{"title":"A qualitative study exploring patient and healthcare practitioner perspectives about at-home fetal Doppler devices.","authors":"Sabrina Keating, Rosa Mackay, Jennifer Maclellan, Abigail McNiven, Sharon Dixon","doi":"10.1038/s44294-026-00139-6","DOIUrl":"10.1038/s44294-026-00139-6","url":null,"abstract":"At-home foetal Dopplers are widely sold for use outside of medical supervision, despite safety concerns regarding the potential for false-reassurance leading to delayed care-seeking. To learn more about pregnant peoples' decision-making surrounding using these devices, we conducted semi-structured interviews with 20 women who had considered or used a home Doppler and interviews or focus groups with 15 healthcare practitioners (HCPs) (10 midwives, 1 obstetrician, 4 GPs). We conducted thematic analysis using a mind-mapping approach. Home Doppler users sought early reassurance and bonding, often before perceiving foetal movements. Although the devices were adopted to alleviate anxiety, they could paradoxically exacerbate it. HCPs worried about the potential for false reassurance, misinterpretation, and unregulated consumer devices. In healthcare encounters, both groups tended to avoid discussing home Doppler use, reducing opportunities to explore concerns and offer evidence-based interventions. Care should enable non-judgemental conversations about Dopplers while reiterating that they must not replace timely care-seeking.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of oxidative phosphorylation and platelet-derived growth factor inhibitors for the treatment of ovarian cancers. 氧化磷酸化和血小板衍生生长因子抑制剂联合治疗卵巢癌。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-05-07 DOI: 10.1038/s44294-026-00134-x

Kathleen M Burkhard, Taylor Repetto, Geeta Mehta

引用次数: 0

Striatal (a-)symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson's disease. 纹状体（a-）对称揭示了早期帕金森病中性别特异性的自主神经脆弱性。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1038/s44294-025-00121-8

Anthony Nuber-Champier, Julie Anne Péron

{"title":"Striatal (a-)symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson's disease.","authors":"Anthony Nuber-Champier, Julie Anne Péron","doi":"10.1038/s44294-025-00121-8","DOIUrl":"10.1038/s44294-025-00121-8","url":null,"abstract":"Autonomic symptoms are common in Parkinson's disease and vary according to patterns of dopaminergic neurodegeneration. The impact of sex and striatal denervation asymmetry are interesting avenues for observing distinct patient phenotypes from the early stages of the disease. This exploratory study investigates how striatal denervation asymmetry and sex influence autonomic dysfunction profiles in early-stage, treatment-naive Parkinson's disease. Using data from the Parkinson's Progression Markers Initiative (n = 759), we applied generalized linear mixed models to assess SCOPA-AUT scores across subtypes of striatal denervation (left-predominant, right-predominant, symmetric), modeling the interaction with sex. Patients with symmetric striatal denervation exhibited significantly greater overall autonomic dysfunction, particularly in sexual domains (p = 0.045). Sex-specific effects emerged: women showed more pronounced thermoregulatory symptoms (p = 0.001), whereas men exhibited more severe urinary and sexual dysfunction, especially in the symmetric group (p < 0.0001). These findings suggest the potential of integrating striatal denervation asymmetry and sex into Parkinson's disease subtype characterization, with implications for personalized symptom management.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12768963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Citizen science reveals comorbidities in endometriosis with no shift in vaginal microbiome composition. 公民科学揭示了子宫内膜异位症的合并症，阴道微生物组组成没有变化。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-05-27 DOI: 10.1038/s44294-026-00144-9

Inas Rahou, Thies Gehrmann, Sarah Ahannach, Camille Nina Allonsius, Ilke De Boeck, Tim Van Rillaer, Francesca Donders, Veronique Verhoeven, Gilbert Donders, Stijn Wittouck, Sarah Lebeer

{"title":"Citizen science reveals comorbidities in endometriosis with no shift in vaginal microbiome composition.","authors":"Inas Rahou, Thies Gehrmann, Sarah Ahannach, Camille Nina Allonsius, Ilke De Boeck, Tim Van Rillaer, Francesca Donders, Veronique Verhoeven, Gilbert Donders, Stijn Wittouck, Sarah Lebeer","doi":"10.1038/s44294-026-00144-9","DOIUrl":"10.1038/s44294-026-00144-9","url":null,"abstract":"Endometriosis is a chronic inflammatory condition affecting 2-10% of reproductive-aged women, most commonly presenting with pelvic pain and subfertility. While its impact on reproductive health is increasingly recognized, the vaginal microbiome's role in the pathogenesis of endometriosis is still unclear and a comprehensive map of potential co-occurring conditions remains underexplored. Leveraging data from the Isala citizen-science platform in Flanders (Belgium), we analysed vaginal microbiome profiles obtained through 16S rRNA sequencing and health data from 95 women with self-reported endometriosis and 2,279 without. While no differences were observed in vaginal microbiome composition or diversity, we identified significant associations between endometriosis and polyendocrine metabolic ovarian syndrome (previously named polycystic ovarian syndrome; OR = 2.92, 95% CI 1.71-4.78, p < 0.001), migraine (OR = 3.75, 95% CI 1.38-8.60, p = 0.025), irritable bowel syndrome (OR = 2.57, 95% CI 1.43-4.36, p = 0.008) and dyspareunia (OR = 1.67, 95% CI 1.14-2.40, p = 0.033). These findings suggest that the vaginal microbiome composition plays at most a limited role in endometriosis and highlights how citizen science can effectively complement clinical research by capturing underrecognized comorbidities.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a person-centered antenatal care scale for low- and middle-income countries. 为低收入和中等收入国家制定和验证以人为本的产前保健量表。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-06-08 DOI: 10.1038/s44294-026-00149-4

Patience A Afulani, Hawa Malechi, Daniel Enos Sekwo, Jaffer Okiring, Moro Ali, Osamuedeme J Odiase, Beryl Ogolla, Joyceline Kinyua, Linnet Ongeri, Raymond A Aborigo

{"title":"Development and validation of a person-centered antenatal care scale for low- and middle-income countries.","authors":"Patience A Afulani, Hawa Malechi, Daniel Enos Sekwo, Jaffer Okiring, Moro Ali, Osamuedeme J Odiase, Beryl Ogolla, Joyceline Kinyua, Linnet Ongeri, Raymond A Aborigo","doi":"10.1038/s44294-026-00149-4","DOIUrl":"10.1038/s44294-026-00149-4","url":null,"abstract":"We aimed to develop and validate a tool to comprehensively measure person-centered antenatal care (PCANC) in low- and middle-income countries (LMICs). We followed standard procedures for scale development, including literature review, expert reviews, cognitive interviews, and pretesting to ensure content validity. Questions were iteratively revised at each stage and administered in surveys with pregnant and postpartum women in Ghana and Kenya. The survey data were used for psychometric analysis, resulting in a 36-item PCANC scale with three subscales: \"dignity and respect,\" \"communication and autonomy,\" and \"responsive and supportive care.\" The Cronbach's alpha is 0.90 for the full scale and >0.7 for each subscale. The summative PCANC scores correlate with global measures of antenatal care quality, satisfaction, and future care location, suggesting good criterion validity. The PCANC scale has high validity and reliability and will facilitate efforts to measure and improve respectful and responsive antenatal care in LMICs.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13581594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Callascope: A portable, user-friendly, speculum-free device for diagnostic imaging of cervical cancer precursor lesions. Callascope：一种便携式，用户友好的，无窥镜的设备，用于宫颈癌前驱病变的诊断成像。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-06-11 DOI: 10.1038/s44294-026-00148-5

Kerry Eller, Erica Skerrett, Megan J Huchko, Nicole Kerner, Megan Richards, Nimmi Ramanujam

{"title":"The Callascope: A portable, user-friendly, speculum-free device for diagnostic imaging of cervical cancer precursor lesions.","authors":"Kerry Eller, Erica Skerrett, Megan J Huchko, Nicole Kerner, Megan Richards, Nimmi Ramanujam","doi":"10.1038/s44294-026-00148-5","DOIUrl":"10.1038/s44294-026-00148-5","url":null,"abstract":"Cervical cancer remains a leading cause of preventable mortality in low- and middle-income countries, where visual inspection with acetic acid (VIA) is often used for screening. VIA's reliability is limited by the lack of magnification, absence of imaging for review, and high inter-operator variability. We developed the Callascope, a portable colposcope designed to address these limitations by integrating high-resolution imaging and acetic acid application in a single device. The Callascope can be used with or without a speculum and incorporates an asymmetrical tip for cervix positioning, an integrated camera with illumination, and a built-in atomizer for uniform contrast application. Bench testing confirmed image quality and contrast application were comparable to a standard colposcope. In clinical studies, the Callascope enabled consistent cervical visualization, effective acetowhitening, and reliable image interpretation while improving patient comfort. By addressing VIA's limitations, it has the potential to expand screening access and support global cervical cancer elimination.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0