npj women's health最新文献

Mimicking women's endocrine milieu in mice for women's health-related studies. 在小鼠中模拟女性内分泌环境，用于女性健康相关研究。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-02-22 DOI: 10.1038/s44294-025-00060-4

Céline Constantin, Daria Matvienko, Csaba László, Valentina Scabia, Laura Battista, Pierre-Alain Binz, Stephen J Bruce, Cathrin Brisken

{"title":"Mimicking women's endocrine milieu in mice for women's health-related studies.","authors":"Céline Constantin, Daria Matvienko, Csaba László, Valentina Scabia, Laura Battista, Pierre-Alain Binz, Stephen J Bruce, Cathrin Brisken","doi":"10.1038/s44294-025-00060-4","DOIUrl":"10.1038/s44294-025-00060-4","url":null,"abstract":"To improve preclinical studies and their translation, patient-derived xenografts (PDXs) are increasingly used. They have human-specific tumor characteristics and reflect intra and inter-tumor heterogeneity. However, the endocrine milieu differs between humans and host mice. In light of sex-specific cancer biology and a rise in endocrine-related cancers there is an urgent need to correctly reflect the hormonal milieu in PDX models. We show that female mice of NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ (NSG) strain widely used for PDXs has 17-β-estradiol (E2) and testosterone (T) levels comparable to C57Bl6 females but higher progesterone (P4) levels. E2 levels are comparable, T levels are lower and P4 levels higher than those observed in postmenopausal women. Ovariectomy increases T to levels observed in postmenopausal women. Subcutaneous E2 and combined E2/P4 silicon pellets provide NSG females with premenopausal ovarian hormone levels. These procedures humanize the endocrine environment of experimental animals, improving PDX relevance in women's health-related research.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Untargeted metabolomics reveals key pathways in miscarriage: steroid, folate, fatty acid & glycosaminoglycan metabolism. 非靶向代谢组学揭示了流产的关键途径：类固醇、叶酸、脂肪酸和糖胺聚糖代谢。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-06-13 DOI: 10.1038/s44294-025-00085-9

Chee Wai Ku, Yu Bin Tan, Kuan Yang Chew, Chee Onn Ku, Shi Tong Carissa Ng, Thiam Chye Tan, Yie Hou Lee

{"title":"Untargeted metabolomics reveals key pathways in miscarriage: steroid, folate, fatty acid & glycosaminoglycan metabolism.","authors":"Chee Wai Ku, Yu Bin Tan, Kuan Yang Chew, Chee Onn Ku, Shi Tong Carissa Ng, Thiam Chye Tan, Yie Hou Lee","doi":"10.1038/s44294-025-00085-9","DOIUrl":"10.1038/s44294-025-00085-9","url":null,"abstract":"Metabolites influencing miscarriage outcomes remain understudied. We hypothesized that aberrant metabolism impacts threatened miscarriage outcomes and that understanding these pathways could offer new management strategies. This case-control study analyzed serum metabolomics from 80 women between 5 and 12 weeks' gestation at KK Women's and Children's Hospital, Singapore, comparing three groups: women with threatened miscarriage who miscarried (TMMC), those with ongoing pregnancies (TMO), and women with normal pregnancies (NP). Using untargeted liquid chromatography-mass spectrometry and pathway analysis through MetaboAnalyst 5.0 and the Kyoto Encyclopedia of Genes and Genomes, 267 metabolites across 12 enriched pathways were identified. Dysregulations in steroid (AUC 0.82), folate (AUC 0.59), fatty acid (AUC 0.70), and glucosaminoglycan (AUC 0.64) pathways distinguished women who miscarried from those with ongoing pregnancies (TMMC vs TMO). We provide initial insights into the metabolic profile associated with miscarriage, highlighting disruptions in steroid hormone, fatty acid, folate, and glucosaminoglycan biosynthesis. Further validation may support biomarker development for prognostication.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence. 通过手术、组学、健康数据和人工智能研究子宫内膜异位症表型的现实世界视角。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1038/s44294-024-00052-w

Camran R Nezhat, Tomiko T Oskotsky, Joshua F Robinson, Susan J Fisher, Angie Tsuei, Binya Liu, Juan C Irwin, Brice Gaudilliere, Marina Sirota, David K Stevenson, Linda C Giudice

引用次数: 0

Sex differences in sleep apnea and Alzheimer's Disease: role of cerebrovascular dysfunction. 睡眠呼吸暂停和阿尔茨海默病的性别差异：脑血管功能障碍的作用。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-05-05 DOI: 10.1038/s44294-025-00076-w

Ian M Greenlund, Jill N Barnes, Sarah E Baker, Virend K Somers, Joshua M Bock

引用次数: 0

Quantitative and longitudinal assessment of human placental inflammation using diffusion basis spectrum imaging. 利用扩散基谱成像对人类胎盘炎症进行定量和纵向评估。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-01-03 DOI: 10.1038/s44294-024-00049-5

Zhexian Sun, Wenjie Wu, Zezhen Xiang, Hansong Gao, Weina Ju, Cherilyn Uhm, Ian S Hagemann, Pamela K Woodard, Nanbert Zhong, Alison G Cahill, Qing Wang, Yong Wang

{"title":"Quantitative and longitudinal assessment of human placental inflammation using diffusion basis spectrum imaging.","authors":"Zhexian Sun, Wenjie Wu, Zezhen Xiang, Hansong Gao, Weina Ju, Cherilyn Uhm, Ian S Hagemann, Pamela K Woodard, Nanbert Zhong, Alison G Cahill, Qing Wang, Yong Wang","doi":"10.1038/s44294-024-00049-5","DOIUrl":"https://doi.org/10.1038/s44294-024-00049-5","url":null,"abstract":"Besides exchanging nutrients, gases, and wastes, placenta is an intermediary between maternal and fetal immune systems. However, no method exists to safely image and monitor placental inflammation during pregnancy. We customized a Magnetic Resonance Imaging (MRI) method, diffusion basis spectrum imaging (DBSI), to measure immune cells in placenta. We validated placental DBSI in simulations and ex-vivo specimens, then applied it to 202 MRI scans from 82 patients whose placentas were classified as non-inflammation (n = 70) or inflammation (n = 12). Our method imaged the 3D distribution of immune cells, revealing significantly greater infiltration in the inflammation placentas from early (2.8% ± 0.7% vs. 4.8% ± 0.65%, p < 0.01) to late pregnancy (4.75% ± 0.9% vs. 7.25% ± 2.13%, p < 0.01). DBSI detects elevated immune cell infiltration associated with placental inflammation and enables non-invasive imaging of placental inflammation, offering early detection and monitoring throughout pregnancy, facilitating personalized care and potentially improving pregnancy outcomes without ionizing radiation.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The intersection of aging and estrogen in osteoarthritis. 老化与雌激素在骨关节炎中的交叉作用。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-02-25 DOI: 10.1038/s44294-025-00063-1

Aysegul Atasoy-Zeybek, Kelly K Showel, Christopher V Nagelli, Jennifer J Westendorf, Christopher H Evans

引用次数: 0

A systematic review of the relationship between neighborhood stressors, discrimination, and cardiometabolic outcomes during pregnancy. 对怀孕期间邻里压力源、歧视和心脏代谢结果之间关系的系统回顾。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-04-25 DOI: 10.1038/s44294-025-00072-0

Roma Dhingra, Kosuke Tamura, Jinani Jayasekera, Amina P Alio, Allana T Forde

{"title":"A systematic review of the relationship between neighborhood stressors, discrimination, and cardiometabolic outcomes during pregnancy.","authors":"Roma Dhingra, Kosuke Tamura, Jinani Jayasekera, Amina P Alio, Allana T Forde","doi":"10.1038/s44294-025-00072-0","DOIUrl":"https://doi.org/10.1038/s44294-025-00072-0","url":null,"abstract":"Cardiometabolic outcomes during pregnancy, including hypertensive disorders of pregnancy (HDP) and gestational diabetes, disproportionately affect racial and/or ethnic minority groups in the United States. These disparities are not fully explained by traditional risk factors, but race-related psychosocial stressors such as perceived neighborhood stressors and discrimination (PNSD) may contribute to adverse health outcomes. This systematic review examined the literature on the impact of PNSD on HDP and gestational diabetes. A comprehensive search of PubMed, PsycINFO, Embase, Web of Science, and CINAHL identified 10 eligible studies: seven cohort and three cross-sectional studies. Five studies reported significant associations between PNSD and increased risk for cardiometabolic outcomes during pregnancy (HDP-1 study, gestational diabetes-3 studies, both hypertension and diabetes during pregnancy-1 study). The included studies demonstrated good methodological quality. These findings suggest that PNSD may be associated with cardiometabolic outcomes during pregnancy, but further research is needed, particularly on perceived neighborhood stressors.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis. 连接人类宫颈和阴道芯片的宫颈粘液调节阴道生态失调。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1038/s44294-025-00054-2

Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E Ingber

{"title":"Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis.","authors":"Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E Ingber","doi":"10.1038/s44294-025-00054-2","DOIUrl":"10.1038/s44294-025-00054-2","url":null,"abstract":"This study explores the protective role of cervicovaginal mucus in maintaining vaginal health, particularly in relation to bacterial vaginosis (BV), using organ chip technology. By integrating human Cervix and Vagina Chips, we demonstrated that cervical mucus significantly reduces inflammation and epithelial damage caused by a dysbiotic microbiome commonly associated with BV. Proteomic analysis of the Vagina Chip, following exposure to mucus from the Cervix Chip, revealed differentially abundant proteins, suggesting potential biomarkers and therapeutic targets for BV management. Our findings highlight the essential function of cervical mucus in preserving vaginal health and underscore the value of organ chip models for studying complex interactions within the female reproductive tract. This research provides new insights into the mechanisms underlying vaginal dysbiosis and opens avenues for developing targeted therapies and diagnostic tools to enhance women's reproductive health.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics. 胎儿暴露于母体长效注射与口服每日抗精神病药物的比较模型。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.1038/s44294-025-00077-9

Philip Bediako-Kakari, Mariella Monyo, Shakir Atoyebi, Adeniyi Olagunju

{"title":"Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics.","authors":"Philip Bediako-Kakari, Mariella Monyo, Shakir Atoyebi, Adeniyi Olagunju","doi":"10.1038/s44294-025-00077-9","DOIUrl":"10.1038/s44294-025-00077-9","url":null,"abstract":"This study employed physiologically based pharmacokinetic (PBPK) modelling to compare the extent of foetal exposure between oral and long-acting injectable (LAI) aripiprazole and olanzapine. Adult and pregnancy PBPK models were developed and validated with relevant clinical data. Relevant indices of foetal exposure during pregnancy were predicted from concentration-time data at steady-state dosing for both oral and LAI formulations. Foetal Cmax for aripiprazole was 59-78% higher with LAI than oral, and 68-181% higher with LAI olanzapine than the oral formulation. Predicted cord:maternal ratios (range) were 0.59-0.69 for oral aripiprazole and 0.61-0.66 for LAI aripiprazole, 0.34-0.64 for oral olanzapine and 0.89-0.96 for LAI olanzapine. Also, cumulative foetal exposure over 28 days from oral formulations were generally predicted to be lower compared with their therapeutic-equivalent LAI. As in utero foetal exposure to maternal drugs does not necessarily translate to risk, these data should be interpreted in a broader context that includes benefit-risk assessments.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of lactation on postpartum pelvic floor muscle regeneration in preclinical model. 哺乳对产后盆底肌再生的影响。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-06-12 DOI: 10.1038/s44294-025-00079-7

F Boscolo Sesillo, H Manoochehri, P Duran, E Zelus, K L Christman, M Alperin

引用次数: 0