npj women's health最新文献_第2页

Menopausal hormone therapy and risk of neuropsychiatric disease: a drug target Mendelian randomisation study. 绝经期激素治疗和神经精神疾病的风险：一项药物靶向孟德尔随机研究。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-02-28 DOI: 10.1038/s44294-026-00130-1

Louise S Schindler, Dipender Gill, Hannah Oppenheimer, Claudia Barth, Ole A Andreassen, Bogdan Draganski, Lars T Westlye, Anya Topiwala, Ann-Marie G de Lange

{"title":"Menopausal hormone therapy and risk of neuropsychiatric disease: a drug target Mendelian randomisation study.","authors":"Louise S Schindler, Dipender Gill, Hannah Oppenheimer, Claudia Barth, Ole A Andreassen, Bogdan Draganski, Lars T Westlye, Anya Topiwala, Ann-Marie G de Lange","doi":"10.1038/s44294-026-00130-1","DOIUrl":"10.1038/s44294-026-00130-1","url":null,"abstract":"Evidence on whether menopausal hormone therapy (MHT) affects neurological or psychiatric disease is conflicting. As MHT acts by binding to oestrogen receptors (ERα and ERβ), we used drug-target Mendelian randomisation (MR) to test whether perturbing these targets alters the risk of Alzheimer's disease (AD), brain structure, depression, or anxiety. Genetic variants in the genes encoding these oestrogen receptors (ESR1 and ESR2) that were associated with positive controls were leveraged as instrumental variables. In two-sample MR analyses using large genome-wide association studies, genetically proxied ERα and ERβ perturbation showed no evidence of effect on AD or on cortical grey matter, hippocampal volume, or white matter hyperintensities. Genetically proxied ERβ perturbation significantly increased risk for depression (β = -0.66, 95% CI [-0.99, -0.32], p = 0.002), but not anxiety. Our study highlights psychiatric considerations when targeting oestrogen receptors with MHT, but provides no evidence for either harmful or protective effects on AD risk.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding menstrual health across the lifespan: a scoping review of digital health tools in research. 解读整个生命周期的月经健康：研究中数字健康工具的范围审查。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-05-25 DOI: 10.1038/s44294-026-00146-7

Sarah C Johnson, Johanna O'Day, Emily Kraus, Scott L Delp, Jennifer L Hicks

{"title":"Decoding menstrual health across the lifespan: a scoping review of digital health tools in research.","authors":"Sarah C Johnson, Johanna O'Day, Emily Kraus, Scott L Delp, Jennifer L Hicks","doi":"10.1038/s44294-026-00146-7","DOIUrl":"10.1038/s44294-026-00146-7","url":null,"abstract":"Digital health tools provide longitudinal physiological and behavioural data that can address knowledge gaps in women's health. This is particularly relevant for understanding hormone-driven physiological changes and symptoms, which impact health and performance across the lifespan. We conducted a scoping review of research using wearables or smartphone applications to identify insights about physiology, health behaviours, and symptoms throughout the menstrual cycle and menopausal transition. We identified 40 original articles. We summarise findings that reproduce lab-based results, giving confidence in the use of digital health tools for studying menstrual health, along with new insights gained. Given the importance of validation against gold standards, and the lack of a prior synthesis of wearable accuracy for women's health applications, we next report the accuracy of wearables that measure biometrics relevant to menstrual health. Finally, we discuss future research needs, including understanding physiological changes during perimenopause, and the role of health behaviours in symptom management.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of telehealth genetic counseling on contralateral prophylactic mastectomy rates among multi-ethnic breast cancer patients. 远程健康遗传咨询对多民族乳腺癌患者对侧预防性乳房切除术率的影响。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-04-01 DOI: 10.1038/s44294-026-00137-8

Alissa Michel, Vicky Ro, Kelly Luo, Meghna S Trivedi, Roshni Rao, Elana Levinson, Carrie Koval, Rita Kukafka, Katherine D Crew

{"title":"Impact of telehealth genetic counseling on contralateral prophylactic mastectomy rates among multi-ethnic breast cancer patients.","authors":"Alissa Michel, Vicky Ro, Kelly Luo, Meghna S Trivedi, Roshni Rao, Elana Levinson, Carrie Koval, Rita Kukafka, Katherine D Crew","doi":"10.1038/s44294-026-00137-8","DOIUrl":"10.1038/s44294-026-00137-8","url":null,"abstract":"Contralateral prophylactic mastectomy (CPM) reduces contralateral breast cancer risk but improves survival only among young BRCA1/2 carriers. With expanded germline testing (GT) and increased use of oncologist-led and telehealth genetic services post-COVID, concerns remain about patients' understanding of results and the impact on surgical decisions. We conducted a retrospective cohort study of 1,054 women with unilateral breast cancer who underwent GT at Columbia University Irving Medical Center from 2013-2022. Mean age was 51.2; 40.5% were non-Hispanic White (NHW), 28.4% Hispanic, 12.1% Black, and 10.3% Asian. Overall, 28% underwent CPM. Testing shifted from 99.7% in-person to 73.9% oncologist-led and 20.1% telehealth post-COVID. In multivariable analysis, CPM was associated with younger age, advanced stage, and pathogenic/likely pathogenic variants, but not with service delivery or VUS results. A trend toward higher CPM rates was observed among Hispanic versus NHW patients (OR = 1.34, 95% CI = 0.99-1.81, p = 0.055). Despite care delivery shifts, CPM rates remained stable.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"4 1","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging multimodal machine learning for accurate risk identification of intimate partner violence. 利用多模态机器学习准确识别亲密伴侣暴力的风险。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-03-13 DOI: 10.1038/s44294-025-00126-3

Jiayi Gu, Kimberly Villalobos Carballo, Yu Ma, Dimitris Bertsimas, Bharti Khurana

引用次数: 0

Mobile device data for the study of miscarriage and its causes. 研究流产及其原因的移动设备数据。

npj women's health Pub Date : 2026-01-01 Epub Date: 2026-03-02 DOI: 10.1038/s44294-026-00129-8

Jenna Nobles, Lindsay Cannon, Sungsik Hwang, Shannon Malloy, Katie Noddin, Allen J Wilcox

引用次数: 0

Endometriosis and autoimmunity: a large-scale case-control study of endometriosis and 10 distinct autoimmune diseases. 子宫内膜异位症与自身免疫：子宫内膜异位症与10种不同自身免疫性疾病的大规模病例对照研究

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-06-18 DOI: 10.1038/s44294-025-00086-8

M Aziz, M A Beaton, M A Aziz, J Opoku-Anane, N Elhadad

{"title":"Endometriosis and autoimmunity: a large-scale case-control study of endometriosis and 10 distinct autoimmune diseases.","authors":"M Aziz, M A Beaton, M A Aziz, J Opoku-Anane, N Elhadad","doi":"10.1038/s44294-025-00086-8","DOIUrl":"10.1038/s44294-025-00086-8","url":null,"abstract":"In this study, we assessed if women with endometriosis have greater odds than matched controls of receiving an autoimmune diagnosis within two-years of their endometriosis diagnosis. We conducted a retrospective cohort study using two large-scale administrative claims databases (2010-2017), identifying 332,409 patients with endometriosis and 1,220,932 matched controls. Compared to matched controls, patients with endometriosis had an increased risk of being diagnosed with rheumatoid arthritis, Hashimoto's disease, systemic lupus erythematosus, multiple sclerosis, pernicious anemia, Sjogren's syndrome or myositis within two-years of their endometriosis diagnosis. The odds of receiving a diagnosis of at least one of the autoimmune conditions among patients with endometriosis were approximately two times greater than matched controls. Our study is the first to show a significant association between endometriosis and autoimmune conditions within a two-year diagnosis window, adding to growing evidence suggesting a potential link between endometriosis and autoimmunity, warranting investigation into shared mechanisms.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common cervicovaginal sequencing methods result in discordant molecular diagnoses of bacterial vaginosis and reveal strain level effects of Gardnerella vaginalis. 常见的宫颈阴道测序方法导致细菌性阴道病的分子诊断不一致，揭示了阴道加德纳菌的菌株水平效应。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-07-05 DOI: 10.1038/s44294-025-00089-5

Courtney A Broedlow, Erik Swanson, Emily M Cherenack, Chris Basting, Nicholas Fonseca Nogueira, Michael France, Pan Yue, Ashma Chakrawarti, Ana Salazar, Lunnarie Acosta, Patricia Raccamarich, Michael Gale, Jacques Ravel, Lydia A Fein, Johanna Holm, Maria L Alcaide, Nichole R Klatt

{"title":"Common cervicovaginal sequencing methods result in discordant molecular diagnoses of bacterial vaginosis and reveal strain level effects of Gardnerella vaginalis.","authors":"Courtney A Broedlow, Erik Swanson, Emily M Cherenack, Chris Basting, Nicholas Fonseca Nogueira, Michael France, Pan Yue, Ashma Chakrawarti, Ana Salazar, Lunnarie Acosta, Patricia Raccamarich, Michael Gale, Jacques Ravel, Lydia A Fein, Johanna Holm, Maria L Alcaide, Nichole R Klatt","doi":"10.1038/s44294-025-00089-5","DOIUrl":"10.1038/s44294-025-00089-5","url":null,"abstract":"Bacterial vaginosis (BV) is associated with HIV transmission and pre-term birth, yet the etiology of BV remains unknown. Our analysis addressed that knowledge gap by comparing diagnostic techniques and using Bayesian inference to find species-specific associations with clinical indicators. We also assessed the effect of sequencing methodology on the results of molecular BV profiling. We observed significant differences in microbial diversity within BV-associated CSTs based on clinical diagnosis. CST assignments were substantially influenced by sequencing methodology, with concordance between methods as low as 59% for metatranscriptomic and metataxonomic-based CST assignment. We also found that Gardnerella has a strain-dependent association with individual Amsel's criteria, and that Dialister micraerophilus and Parvimonas micra are positively associated with Amsel's criteria while Lactobacillus is negatively associated. These results highlight the challenge of characterizing a condition without a single etiological agent, reinforcing the need for more granular diagnoses and treatments that are sensitive to BV variability.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12803708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'Support me like a child, respect me like an adult': a qualitative study on pregnancy experiences of adolescents in Zambia. “像支持孩子一样支持我，像尊重成年人一样尊重我”：赞比亚青少年怀孕经历的定性研究。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-12-23 DOI: 10.1038/s44294-025-00119-2

Tina Lavender, Khuzuet Tuwele, Carol Bedwell, Maaheshi Deepika Herath, Bellington Vwalika

{"title":"'Support me like a child, respect me like an adult': a qualitative study on pregnancy experiences of adolescents in Zambia.","authors":"Tina Lavender, Khuzuet Tuwele, Carol Bedwell, Maaheshi Deepika Herath, Bellington Vwalika","doi":"10.1038/s44294-025-00119-2","DOIUrl":"10.1038/s44294-025-00119-2","url":null,"abstract":"Pregnant adolescents often face social, emotional and physical challenges, compounded by inadequate support. Drawing on a Straussian grounded theory approach, we explored the social processes and perspectives that influence adolescent pregnancy experiences in Zambia. Semi-structured interviews were conducted with adolescents (n = 26), partners (n = 8), parents/legal guardians of adolescents (n = 8), healthcare workers (n = 6), and key stakeholders (n = 5). Data were subjected to open, axial and selective coding, and a core category 'Support me like a child, respect me like an adult', generated. Bronfenbrenner's socio-ecological framework was also used as a theoretical lens to aid understanding of the social interactions between three interlinked categories feeling vulnerable and alone, age discrimination, and lack of agency and autonomy. Narratives highlighted social disapproval, influenced by cultural values, beliefs and social norms. Trying to navigate systems and spaces in which adolescents (and others) believed they did not belong, was illuminated. The need for an inclusive and supportive environment in which adolescents can feel cared for whilst also being respected for their own positionality and decisions, is critical.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling. 通过计算模型预测受体遗传变异中的催产素结合动力学。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-02-08 DOI: 10.1038/s44294-025-00058-y

Preeti Dubey, Yingye Fang, K Lionel Tukei, Shobhan Kuila, Xinming Liu, Annika Sahota, Antonina I Frolova, Erin L Reinl, Manasi Malik, Sarah K England, Princess I Imoukhuede

{"title":"Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling.","authors":"Preeti Dubey, Yingye Fang, K Lionel Tukei, Shobhan Kuila, Xinming Liu, Annika Sahota, Antonina I Frolova, Erin L Reinl, Manasi Malik, Sarah K England, Princess I Imoukhuede","doi":"10.1038/s44294-025-00058-y","DOIUrl":"https://doi.org/10.1038/s44294-025-00058-y","url":null,"abstract":"Approximately half of U.S. women giving birth annually receive Pitocin, a synthetic form of oxytocin (OXT), yet the optimal dosing remains challenging due to significant individual variability in response. To address this, we developed a mathematical model examining the effects of five OXT receptor (OXTR) variants (V45L, P108A, L206V, V281M, and E339K) on OXT-OXTR binding dynamics in human embryonic kidney cells (HEK293T) and myometrial smooth muscle cells. The model was parameterized using experimentally derived, cell-specific OXTR surface localization measurements and literature-reported OXT-OXTR-binding kinetics. The model revealed differences in time to equilibrium between HEK293T and myometrial cells, distinct dynamics among genetic variants, and that early increases in OXT could partially rescue diminished responses in V281M and E339K variants. This model provides key insights into how genetic variants influence OXT dose responses and offers a framework for tailoring OXT dosing to patient-specific genetic profiles.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomic comparison of early onset preeclampsia and placenta accreta identifies inverse trophoblast and decidua functions at the maternal-fetal interface. 早期子痫前期和胎盘增生的转录组学比较鉴定了母胎界面上滋养细胞和蜕膜的逆功能。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-10-24 DOI: 10.1038/s44294-025-00106-7

Ophelia Yin, Ana Almonte-Loya, Romina Appierdo, Monica Yang, Bahar D Yilmaz, Tomiko T Oskotsky, Juan M Gonzalez-Velez, Linda C Giudice, Yalda Afshar, Marina Sirota

{"title":"Transcriptomic comparison of early onset preeclampsia and placenta accreta identifies inverse trophoblast and decidua functions at the maternal-fetal interface.","authors":"Ophelia Yin, Ana Almonte-Loya, Romina Appierdo, Monica Yang, Bahar D Yilmaz, Tomiko T Oskotsky, Juan M Gonzalez-Velez, Linda C Giudice, Yalda Afshar, Marina Sirota","doi":"10.1038/s44294-025-00106-7","DOIUrl":"10.1038/s44294-025-00106-7","url":null,"abstract":"Early onset preeclampsia is a placental disorder characterized by shallow implantation, whereas placenta accreta spectrum is a placental disorder of deep placental attachment. This study compares the transcriptome of these two obstetric syndromes. By integrating available microarray and single-cell placenta/decidua transcriptomic datasets, we demonstrated that early onset preeclampsia genes are inversely expressed in placenta accreta, with the most marked differences noted in cell types of decidua, endothelial, and extravillous trophoblasts. Our findings highlight the key functions of trophoblast cell migration and invasion, decidua cell signaling, hypoxia pathways, and global growth factor and collagen contributions to these pregnancy disorders. This research provides new insights into the mechanisms of placentation and unifies these clinical siloes of disease by focusing on the fundamental biology of placental development at the maternal-fetal interface.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12549338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0