npj women's health最新文献_第2页

Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis. 连接人类宫颈和阴道芯片的宫颈粘液调节阴道生态失调。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1038/s44294-025-00054-2

Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E Ingber

{"title":"Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis.","authors":"Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E Ingber","doi":"10.1038/s44294-025-00054-2","DOIUrl":"10.1038/s44294-025-00054-2","url":null,"abstract":"This study explores the protective role of cervicovaginal mucus in maintaining vaginal health, particularly in relation to bacterial vaginosis (BV), using organ chip technology. By integrating human Cervix and Vagina Chips, we demonstrated that cervical mucus significantly reduces inflammation and epithelial damage caused by a dysbiotic microbiome commonly associated with BV. Proteomic analysis of the Vagina Chip, following exposure to mucus from the Cervix Chip, revealed differentially abundant proteins, suggesting potential biomarkers and therapeutic targets for BV management. Our findings highlight the essential function of cervical mucus in preserving vaginal health and underscore the value of organ chip models for studying complex interactions within the female reproductive tract. This research provides new insights into the mechanisms underlying vaginal dysbiosis and opens avenues for developing targeted therapies and diagnostic tools to enhance women's reproductive health.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early pubertal timing is a risk factor for adolescent dysmenorrhea. 青春期时间过早是青少年痛经的危险因素。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-08-22 DOI: 10.1038/s44294-025-00097-5

Christel M Portengen, Tristin Smith, Esmeralda Hidalgo-Lopez, Hannah Becker, Melissa E Lenert, Andrew Schrepf, Steven E Harte, Chelsea M Kaplan, Adriene M Beltz

引用次数: 0

Developing point-of-care tools to inform decisions regarding prescription medication use in pregnancy. 开发护理点工具，为怀孕期间使用处方药的决定提供信息。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-07-25 DOI: 10.1038/s44294-025-00093-9

Animesh Kumar Paul, Sunil Vasu Kalmady, Russell Greiner, Padma Kaul

引用次数: 0

Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics. 胎儿暴露于母体长效注射与口服每日抗精神病药物的比较模型。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.1038/s44294-025-00077-9

Philip Bediako-Kakari, Mariella Monyo, Shakir Atoyebi, Adeniyi Olagunju

{"title":"Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics.","authors":"Philip Bediako-Kakari, Mariella Monyo, Shakir Atoyebi, Adeniyi Olagunju","doi":"10.1038/s44294-025-00077-9","DOIUrl":"10.1038/s44294-025-00077-9","url":null,"abstract":"This study employed physiologically based pharmacokinetic (PBPK) modelling to compare the extent of foetal exposure between oral and long-acting injectable (LAI) aripiprazole and olanzapine. Adult and pregnancy PBPK models were developed and validated with relevant clinical data. Relevant indices of foetal exposure during pregnancy were predicted from concentration-time data at steady-state dosing for both oral and LAI formulations. Foetal Cmax for aripiprazole was 59-78% higher with LAI than oral, and 68-181% higher with LAI olanzapine than the oral formulation. Predicted cord:maternal ratios (range) were 0.59-0.69 for oral aripiprazole and 0.61-0.66 for LAI aripiprazole, 0.34-0.64 for oral olanzapine and 0.89-0.96 for LAI olanzapine. Also, cumulative foetal exposure over 28 days from oral formulations were generally predicted to be lower compared with their therapeutic-equivalent LAI. As in utero foetal exposure to maternal drugs does not necessarily translate to risk, these data should be interpreted in a broader context that includes benefit-risk assessments.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of lactation on postpartum pelvic floor muscle regeneration in preclinical model. 哺乳对产后盆底肌再生的影响。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-06-12 DOI: 10.1038/s44294-025-00079-7

F Boscolo Sesillo, H Manoochehri, P Duran, E Zelus, K L Christman, M Alperin

引用次数: 0

The female intimate microbiome space. 女性亲密的微生物群空间。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-10-01 DOI: 10.1038/s44294-025-00104-9

Leonore Vander Donck, Thies Gehrmann, Sarah Ahannach, Sarah Van den Bosch, Margo Hiel, Lize Delanghe, Camille Nina Allonsius, Eline Cauwenberghs, Irina Spacova, Eline Oerlemans, Stijn Wittouck, Ilke De Boeck, Gilbert Donders, Veronique Verhoeven, Sarah Lebeer

引用次数: 0

Investigating racial disparities in drug prescriptions for patients with endometriosis. 研究子宫内膜异位症患者药物处方的种族差异。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1038/s44294-025-00053-3

Aparajita Kashyap, Maryam Aziz, Tony Y Sun, Sharon Lipsky Gorman, Jessica Opoku-Anane, Noémie Elhadad

{"title":"Investigating racial disparities in drug prescriptions for patients with endometriosis.","authors":"Aparajita Kashyap, Maryam Aziz, Tony Y Sun, Sharon Lipsky Gorman, Jessica Opoku-Anane, Noémie Elhadad","doi":"10.1038/s44294-025-00053-3","DOIUrl":"10.1038/s44294-025-00053-3","url":null,"abstract":"We assess racial disparities in medication prescription patterns for endometriosis patients across Medicaid administrative claims data. We use ATC 3rd level drug codes to identify drug classes prescribed significantly more frequently for endometriosis patients than a comparison cohort of non-endometriosis patients. Temporal prevalence differences of prescriptions (pre- vs. post-diagnosis) were also examined. The endometriosis cohort comprised 16,372 endometriosis patients (23.3% Black, 66.0% White). Of the 28 drug classes examined, 17 were prescribed significantly less in Black patients and 4 were prescribed significantly more in Black patients. Of the 17 drugs prescribed more often in White patients, 13 have larger disparities pre-diagnosis than post-diagnosis. In the non-endometriosis cohort (n = 3,663,904), 21 drug classes were prescribed significantly more in White patients and 6 were prescribed significantly more in Black patients. Our analysis identifies disparities in prescriptions practices between White and Black endometriosis patients, notably in pain management and comorbidity treatment.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical lactation studies. Acting on key recommendations over the last decade. 临床哺乳研究。根据过去十年的主要建议采取行动。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-02-28 DOI: 10.1038/s44294-025-00064-0

Karen Rowland Yeo, Jacqueline Gerhart, Aarti Sawant-Basak, Francis Williams Ojara, Aida N Kawuma, Catriona Waitt

引用次数: 0

Associations between individual and structural level discrimination and psychological and physiological stress indicators during pregnancy. 妊娠期个体和结构水平歧视与心理和生理应激指标的关系。

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-09-22 DOI: 10.1038/s44294-025-00100-z

Özlü Aran, Melissa Nevarez-Brewster, Kimberly D'Anna-Hernandez, Julia Dmitrieva, Curt A Sandman, Laura M Glynn, Elysia Poggi Davis

{"title":"Associations between individual and structural level discrimination and psychological and physiological stress indicators during pregnancy.","authors":"Özlü Aran, Melissa Nevarez-Brewster, Kimberly D'Anna-Hernandez, Julia Dmitrieva, Curt A Sandman, Laura M Glynn, Elysia Poggi Davis","doi":"10.1038/s44294-025-00100-z","DOIUrl":"10.1038/s44294-025-00100-z","url":null,"abstract":"In the United States (U.S.) pervasive health disparities in prenatal care disproportionately impact marginalized individuals. The present study investigates whether discrimination at the individual and structural levels are associated with indicators of psychological and physiological stress among pregnant Latinx people living in the U.S., including both U.S. and foreign-born individuals. Pregnant participants (n = 109) reported on birthplace, lifetime experiences of racial and ethnic discrimination, perceived levels of stress, acculturation, social support, and provided residential address data and hair samples for cortisol analysis. Regression analysis revealed that individual level discrimination was linked to higher psychological stress during pregnancy (p = .003), and structural level discrimination was related to lower physiological stress (cortisol; p = .056). Notably, these associations varied by birthplace: U.S.-born individuals showed higher levels of psychological stress in response to individual level discrimination, while foreign-born individuals appeared more resilient to structural level discrimination. The results are discussed within the framework of immigrant health paradox.","PeriodicalId":520241,"journal":{"name":"npj women's health","volume":"3 1","pages":"52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy and cardiovascular disease in developing countries of South Asia-A narrative review. 南亚发展中国家的妊娠和心血管疾病——述评

npj women's health Pub Date : 2025-01-01 Epub Date: 2025-10-07 DOI: 10.1038/s44294-025-00101-y

Farhala Baloch, Alveena Zafar, Momina Faisal, Anoosha Marium, Lumaan Sheikh, Haleema Yasmin, Pamela Susan Douglas, Zainab Samad

引用次数: 0