IJTLD open最新文献_第2页

Risks and consequences of TB and its prevention in cost-utility analyses among immigrants: a systematic review. 移民中结核病的风险和后果及其预防的成本效用分析：系统回顾。

IJTLD open Pub Date : 2025-10-10 eCollection Date: 2025-10-01 DOI: 10.5588/ijtldopen.25.0355

S D Robayo, C M Tansey, K Romanowski, J R Campbell

{"title":"Risks and consequences of TB and its prevention in cost-utility analyses among immigrants: a systematic review.","authors":"S D Robayo, C M Tansey, K Romanowski, J R Campbell","doi":"10.5588/ijtldopen.25.0355","DOIUrl":"10.5588/ijtldopen.25.0355","url":null,"abstract":"Background: In low-TB incidence countries, foreign-born populations bear a disproportionate share of the TB burden. Cost-utility analyses of TB preventive treatment (TPT) programs among immigrants, however, have yielded divergent conclusions. We conducted a systematic review to evaluate how studies have considered the risks and consequences of TB disease and TPT.Methods: We searched PubMed and Embase for studies published from 1st January 2004 to 25th March 2025. We included modeling studies measuring health utility with quality-adjusted life years (QALYs) and evaluated TPT among immigrants to low TB incidence countries. Using a narrative synthesis, we examined how studies considered risks and consequences of TB disease and TPT and their impacts on health utility.Results: Of the 5,142 records screened, 14 studies met the inclusion criteria. Major adverse events (AEs) were the most frequently considered consequence of TPT with estimated risk ranging from 0% to 6% and mean associated annual disutility from major AEs was 0.017 QALYs, which varied substantially (coefficient of variation [CV)]: 1.2). All studies considered health disutility due to TB disease, with annual disutility ranging from 0.04 to 0.2 (mean: 0.11, CV: 0.4).Conclusions: There is wide variation in how risks and consequences of TPT and TB disease are considered in studies evaluating TB infection treatment programs.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 10","pages":"555-562"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with unfavorable tuberculosis treatment outcomes in the population deprived of liberty. 在被剥夺自由的人群中，与结核病治疗结果不利相关的因素。

IJTLD open Pub Date : 2025-10-10 eCollection Date: 2025-10-01 DOI: 10.5588/ijtldopen.25.0210

K Z Ely, M L Draschler, T N Prado, V G Vendrusculo, I Frighetto, C A Jarczewski, R M Dotta, M M Dall'Soto, E G Boeira, C Busatto, A R M Valim, L G Possuelo

{"title":"Factors associated with unfavorable tuberculosis treatment outcomes in the population deprived of liberty.","authors":"K Z Ely, M L Draschler, T N Prado, V G Vendrusculo, I Frighetto, C A Jarczewski, R M Dotta, M M Dall'Soto, E G Boeira, C Busatto, A R M Valim, L G Possuelo","doi":"10.5588/ijtldopen.25.0210","DOIUrl":"10.5588/ijtldopen.25.0210","url":null,"abstract":"Background: TB represents a significant challenge within the prison context. The objective of this study was to identify factors associated with the unfavourable outcomes (no-cure) of TB treatment in the population deprived of liberty (PDL) in southern Brazil.Methods: A cross-sectional study using secondary data from the national notification system was developed to identify TB outcomes. Bivariate and multivariate logistic regressions were applied to determine the dimensions of care associated with unfavourable outcome of TB treatment in the PDL. Adjusted odds ratios and 95% confidence intervals were provided for each dimension evaluated.Results: A total of 3,022 TB cases in the PDL were analysed, of which 1,077 (35.6%) resulted in unfavourable outcome. After adjustment, the following were associated with unfavourable outcome: living with HIV/AIDS, notification by other teams, entry by transfers, clinical epidemiological diagnosis, and self-administered treatment.Conclusion: The factors associated with unfavourable TB treatment outcomes in PDL are mainly related to non-compliance with public policy determinations and government strategies, such as: lack of health staff in prison institutions, excessive transfers, lack of confirmatory TB tests, and failure to perform directly observed treatment, which should be the rule.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 10","pages":"570-576"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bedaquiline and levofloxacin replacing rifampicin for the treatment of TB. 贝达喹啉和左氧氟沙星替代利福平治疗结核病。

IJTLD open Pub Date : 2025-09-10 eCollection Date: 2025-09-01 DOI: 10.5588/ijtldopen.25.0263

C-Y Chiang, K-J Bai, M-C Yu

引用次数: 0

Host-protein biomarkers distinguish asymptomatic TB in an active case finding study. 在一项积极的病例发现研究中，宿主蛋白生物标志物可区分无症状结核病。

IJTLD open Pub Date : 2025-09-10 eCollection Date: 2025-09-01 DOI: 10.5588/ijtldopen.25.0203

J L Pedersen, J Ho, H C Lai, N J Bokil, T A Nguyen, P T B Nguyen, G J Fox, G B Marks, W J Britton, B M Saunders

引用次数: 0

Ceftaroline pharmacokinetics/pharmacodynamics in the hollow-fibre model of Mycobacterium abscessus lung disease. 头孢他林在脓肿分枝杆菌肺疾病中空纤维模型中的药代动力学/药效学研究

IJTLD open Pub Date : 2025-09-10 eCollection Date: 2025-09-01 DOI: 10.5588/ijtldopen.25.0173

B E Ferro, S Srivastava, T Gumbo

{"title":"Ceftaroline pharmacokinetics/pharmacodynamics in the hollow-fibre model of Mycobacterium abscessus lung disease.","authors":"B E Ferro, S Srivastava, T Gumbo","doi":"10.5588/ijtldopen.25.0173","DOIUrl":"10.5588/ijtldopen.25.0173","url":null,"abstract":"Background: Guideline-based therapy (GBT) of Mycobacterium abscessus (MAB) lung disease (LD) achieves a sputum culture conversion rate in ∼35% of patients. The β-lactam antibiotics, imipenem and cefoxitin, are the cornerstone of GBT. However, a 1-h half-life means multiple infusions per day, which is difficult for months-long therapy.Methods: As an alternative, we tested ceftaroline-avibactam, with a 3-h half-life, in the hollow-fibre model system of MAB-LD (HFS-MAB). Eight ceftaroline-avibactam exposures were administered twice daily based on human intrapulmonary pharmacokinetics. Next, we compared GBT (cefoxitin-clarithromycin-amikacin) to standard-dose and to high-dose ceftaroline-avibactam-tigecycline-moxifloxacin regimens, in the HFS-MAB, mimicking the intrapulmonary pharmacokinetics of all drugs.Results: Ceftaroline-avibactam maximal microbial kill was 0.72 log10 colony-forming units (CFUs) per millilitre below day 0 burden (stasis). The ceftaroline pharmacokinetic-pharmacodynamic parameter linked to microbial kill and anti-microbial resistance was 0-24-h area under the concentration-time curve (AUC0-24) to minimum inhibitory concentration. GBT killed 1.21 ± 0.25 log10 CFU/mL versus 0.45 ± 0.42 log10 CFU/mL below stasis for high-dose ceftaroline combination (P = 0.20). In combination regimens, proportion of the ceftaroline-resistant subpopulation was 41.22 ± 13.11 times lower than the cefoxitin-resistant subpopulation (P = 0.002).Conclusion: Ceftaroline-avibactam administered twice a day would be an adequate replacement for the four-times-a-day cefoxitin treatments for MAB-LD.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 9","pages":"519-526"},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An economic analysis of BPaL for multidrug-resistant TB in South Africa and the Philippines. 南非和菲律宾耐多药结核病BPaL的经济分析。

IJTLD open Pub Date : 2025-09-10 eCollection Date: 2025-09-01 DOI: 10.5588/ijtldopen.25.0294

S D Masuku, C Nattey, L Coetzee, K Hirasen, A Mabhula, D J Casalme, M T Gler, A Gupta, S Juneja, N Ndjeka, D Evans, B E Nichols

{"title":"An economic analysis of BPaL for multidrug-resistant TB in South Africa and the Philippines.","authors":"S D Masuku, C Nattey, L Coetzee, K Hirasen, A Mabhula, D J Casalme, M T Gler, A Gupta, S Juneja, N Ndjeka, D Evans, B E Nichols","doi":"10.5588/ijtldopen.25.0294","DOIUrl":"10.5588/ijtldopen.25.0294","url":null,"abstract":"Background: The WHO endorses bedaquiline, pretomanid, and linezolid (BPaL)-based regimens for multidrug-resistant/rifampicin-resistant TB, and both the Philippines (PH) and South Africa (SA) have adopted these regimens.Methods: Using a Markov model, we assessed the cost per successful treatment and 5-year budgetary and economic impact of BPaL-based regimens in SA and PH. Treatment outcomes were informed by national electronic registries, SA BPaL Clinical Access Program, and PH operational research. Costs were estimated from the provider perspective.Results: Over 5 years, BPaL-based regimens reduce total costs by 20%-25% in SA and 9%-11% in PH compared with a standard short oral regimen (SSOR) when achieving the same number of successful treatments, due to lower cost per successful treatment from reduced loss to follow-up and mortality. BPaL-based regimens improve treatment success by 22%, leading to more patients completing full treatment and higher overall resource use. Therefore, the budget for BPaL-based regimens is projected to increase by 7%-8% (SA) and 6% (PH) from 2023/24 to 2027/28.Conclusion: BPaL-based regimens reduce cost per successful treatment compared with SSOR and require smaller budgets for similar treatment outcomes. Implementation may involve initial budget increases, but improvements in treatment success and long-term health outcomes outweigh these costs, presenting a strong rationale for rollout.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 9","pages":"535-541"},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global child-friendly anti-TB medicines - where do we stand? 全球儿童友好型抗结核药物——我们的进展如何？

IJTLD open Pub Date : 2025-09-10 eCollection Date: 2025-09-01 DOI: 10.5588/ijtldopen.25.0446

H S Schaaf, D T Wademan, L E van der Laan

引用次数: 0

Eosinophilic cytokines and small airway dysfunction in women with COPD: correlation with exposure to biomass smoke versus tobacco smoking. 女性COPD患者嗜酸性细胞因子和小气道功能障碍：暴露于生物质烟雾与吸烟的相关性

IJTLD open Pub Date : 2025-09-10 eCollection Date: 2025-09-01 DOI: 10.5588/ijtldopen.24.0666

R Robles-Hernández, R Pérez-Padilla, A Ramírez-Venegas, Y Velasco-Torres, M Montaño, C Ramos, A S Ramírez-GarciaLuna, O Pérez-Bautista

{"title":"Eosinophilic cytokines and small airway dysfunction in women with COPD: correlation with exposure to biomass smoke versus tobacco smoking.","authors":"R Robles-Hernández, R Pérez-Padilla, A Ramírez-Venegas, Y Velasco-Torres, M Montaño, C Ramos, A S Ramírez-GarciaLuna, O Pérez-Bautista","doi":"10.5588/ijtldopen.24.0666","DOIUrl":"10.5588/ijtldopen.24.0666","url":null,"abstract":"Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterised by progressive airflow obstruction. Tobacco smoking is the leading cause of COPD (COPD-TS); however, chronic exposure to biomass smoke (COPD-BS) is the second risk factor. COPD-TS and COPD-BS are now considered different phenotypes, with COPD-BS having small airway dysfunction (SAD).Objectives: Our primary aim was to investigate the correlation between SAD and the serum levels of interleukins implicated in the maturation and recruitment of eosinophils in women with COPD-BS and COPD-TS.Methods: This cross-sectional study included 25 women with COPD-BS and 25 women with COPD-TS, and the relationship with SAD was assessed by impulse oscillometry (IOS), alongside measurements of interleukins (IL-1ra, IL-2, IL-4, IL-8, IL-9, IL-13, and IL-17) and eotaxin using the multiplex test (Bio-Plex), in addition to eosinophils total blood.Results: Blood eosinophil count, cytokines, and eotaxin were higher in COPD-BS relative to COPD-TS. IOS measurements were higher in COPD-BS than in COPD-TS. R5-R20 positively correlated with the concentrations of all measured cytokines noted if COPD groups were analysed separately (P < 0.01).Conclusion: Eosinophil counts and cytokines in COPD-BS positively correlate with small airway resistance as measured by IOS in R5-R20.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 9","pages":"527-534"},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated TB with central nervous system involvement. 弥散性结核伴中枢神经系统受累。

IJTLD open Pub Date : 2025-09-10 eCollection Date: 2025-09-01 DOI: 10.5588/ijtldopen.25.0258

S Chi

引用次数: 0

'It makes us sick': experiences of air pollution among children with asthma and their caregivers in African countries. “它让我们生病”：非洲国家哮喘儿童及其照顾者的空气污染经历。

IJTLD open Pub Date : 2025-09-10 eCollection Date: 2025-09-01 DOI: 10.5588/ijtldopen.24.0659

Y A Kuyinu, O O Adeyeye, E Addo-Yobo, B Arhin, B Barratt, B Chinoko, O Goodman, M Kasekete, R Masekela, E Mkutumula, R Mphahlele, B T Mmbaga, H A Mujuru, S Muyemayema, R Nantanda, J S Ngocho, L M Nkhalamba, S K Owusu, B Said, S Shaibu, A Ssemata, I Ticklay, L J Zurba, G Mosler, J Grigg

{"title":"'It makes us sick': experiences of air pollution among children with asthma and their caregivers in African countries.","authors":"Y A Kuyinu, O O Adeyeye, E Addo-Yobo, B Arhin, B Barratt, B Chinoko, O Goodman, M Kasekete, R Masekela, E Mkutumula, R Mphahlele, B T Mmbaga, H A Mujuru, S Muyemayema, R Nantanda, J S Ngocho, L M Nkhalamba, S K Owusu, B Said, S Shaibu, A Ssemata, I Ticklay, L J Zurba, G Mosler, J Grigg","doi":"10.5588/ijtldopen.24.0659","DOIUrl":"10.5588/ijtldopen.24.0659","url":null,"abstract":"Background: This study was carried out to document experiences and perceptions of air pollution among adolescents with asthma symptoms, and their caregivers.Method: A qualitative study among children with symptoms of asthma (aged 12-16 years) and their caregivers was conducted in seven African countries (Ghana, Nigeria, Malawi, South Africa, Tanzania, Uganda and Zimbabwe). Focus group discussions were used to collect data from children and caregivers and a total of 41 sessions (children 21, caregivers 20) were held. Analysis of the data gave rise to two major themes (perception of air pollution and mitigation against air pollution) from which subthemes were derived.Results: Participants identified causes of air pollution as cigarette smoking, use of wood for cooking, burning of garbage, generator, presence of industries in residential areas; and that these worsened asthma symptoms. The experiences the children had encountered were at home, while commuting to school and in school. Personal mitigation measures and governmental measures were suggested.Conclusion: It is recommended that governments implement policies to mitigate air pollution and to encourage individuals to adopt personal measures to mitigate its impact.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 9","pages":"505-511"},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0