IJTLD open最新文献_第2页

Patient pathway analysis of rifampicin-resistant TB diagnostic and treatment delays.

IJTLD open Pub Date : 2025-02-01 DOI: 10.5588/ijtldopen.24.0469

S Ge, Z Feng, L Lin, R Li, Y Zhang, L Song, A Wang, Y Lan, Y Li, Z Huang, C Cai, X Wang, Q Ruan, H Yu, M Tang, H Yi, Y Chen, F Sun, Y Li, W Zhang

{"title":"Patient pathway analysis of rifampicin-resistant TB diagnostic and treatment delays.","authors":"S Ge, Z Feng, L Lin, R Li, Y Zhang, L Song, A Wang, Y Lan, Y Li, Z Huang, C Cai, X Wang, Q Ruan, H Yu, M Tang, H Yi, Y Chen, F Sun, Y Li, W Zhang","doi":"10.5588/ijtldopen.24.0469","DOIUrl":"10.5588/ijtldopen.24.0469","url":null,"abstract":"Background: Barriers to the diagnosis and treatment of rifampicin-resistant TB (RR-TB) have not been fully elucidated. This study aimed to map the diagnostic and treatment delays among patients with RR-TB in China and investigate related factors.Methods: Between June and July 2023, the diagnostic and treatment pathways of patients with RR-TB were obtained through interviews at eight hospitals across China. Information on the TB service of hospitals was collected via telephone.Results: Ninety-eight patients were included. On average, each patient required 4.6 visits to start RR-TB treatment. The median delay from illness onset to RR-TB treatment was 238.0 days (IQR 85.8-469.2), primarily driven by the delay between TB diagnosis and identifying rifampicin (RIF) resistance (median: 43.5 days, IQR 3.0-160.5). Referral to appropriate hospitals (adjusted hazard ratio [aHR] 2.32; 95% CI 1.37-3.92) or considering drug susceptibility testing (DST) when initiating treatment (aHR 2.56, 95% CI 1.39-4.72) significantly reduced delay between TB diagnosis and identifying RIF resistance, while stigma regarding TB (aHR 0.61, 95% CI 0.38-0.98) was an independent risk factor.Conclusions: Patients with RR-TB experienced substantial delays in identifying RIF resistance. Referring patients to hospitals with molecular DST capabilities and awareness may reduce these delays.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 2","pages":"90-95"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating socio-economic support into drug-resistant TB care to optimise treatment outcomes. 将社会经济支持纳入耐药结核病护理，以优化治疗效果。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0534

J Limo, C Pahe, I Kathure, L Ndungu, A Mahihu, C Mwashumbe, E Mueni, H Momanyi

{"title":"Integrating socio-economic support into drug-resistant TB care to optimise treatment outcomes.","authors":"J Limo, C Pahe, I Kathure, L Ndungu, A Mahihu, C Mwashumbe, E Mueni, H Momanyi","doi":"10.5588/ijtldopen.24.0534","DOIUrl":"10.5588/ijtldopen.24.0534","url":null,"abstract":"Background: Drug-resistant TB (DR-TB) remains a public health concern in Kenya, with an estimated 2,500 individuals acquiring DR-TB annually. Despite significant progress in DR-TB management, the treatment success rate (TSR) in 2021 stood at 77%, falling short of the 85% target. This low TSR occurs amidst a complex range of treatment challenges, including psychosocial factors. The aim of this study was to assess the impact of integrating psychosocial and economic empowerment interventions into standard DR-TB care.Methods: A convergent mixed-method approach was employed, involving interviews with 217 participants, including persons with DR-TB and key stakeholders, using a structured questionnaire. The study was conducted in Kenya's two highest DR-TB burden counties between October and November 2023.Results: The study found that 55% of respondents experienced psychological depression during treatment, with financial constraints identified as the primary trigger (70.6%). Only 49% of persons with DR-TB joined psychosocial support groups, and of these, 90% demonstrated improved treatment adherence. Additionally, individuals with DR-TB who participated in income-generating activities had a treatment adherence rate of 95%, compared to 88% among those not engaged in such activities.Conclusion: Patient-centred approaches involving socio-economic support systems are crucial in addressing treatment adherence barriers, thereby leading to improved treatment outcomes.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 1","pages":"33-38"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-TB sequelae in adolescent pulmonary TB survivors. 青少年肺结核幸存者的结核后后遗症。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0039

C Cesilia, F R Rinawan, P Santoso, H M Nataprawira

{"title":"Post-TB sequelae in adolescent pulmonary TB survivors.","authors":"C Cesilia, F R Rinawan, P Santoso, H M Nataprawira","doi":"10.5588/ijtldopen.24.0039","DOIUrl":"10.5588/ijtldopen.24.0039","url":null,"abstract":"Objective: To compare the persistent clinical symptoms, chest X-ray (CXR), spirometry and echocardiography results in adolescent survivors of drug-susceptible (DS) and drug-resistant (DR) pulmonary TB (PTB).Methods: This retrospective cohort study was conducted in 52 adolescent PTB survivors. We compared persistent clinical symptoms, CXR, spirometry and echocardiography in DS-TB and DR-TB survivors. χ2 test was used to compare groups (P < 0.05 significant), logistic regression analysis was used to identify risk factors, and Many-Factor Rasch Measurement Version Facets 3.86.0 was used to assess the multi-rater agreement of CXR.Results: Significant differences were found in persistent clinical symptoms (higher in DS-TB survivors), CXR, and spirometry abnormalities (higher in DR-TB survivors). The echocardiography revealed a low pulmonary hypertension probability in both groups. Adolescent PTB survivors with comorbidity have 1.5 times the risk of developing pulmonary sequelae compared to non-sequelae.Conclusion: Pulmonary sequelae in adolescent PTB survivors were documented in both DS and DR-TB. Monitoring after treatment completion was necessary for PTB survivors, especially in adolescents.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 1","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type and physical intensity of occupations at pulmonary TB diagnosis. 肺结核诊断时的职业类型和体力强度。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0323

M Saroufim, C Geric, A Majidulla, A Abjani, G Tavaziva, S Saeed, A J Khan, F Ahmad Khan

{"title":"Type and physical intensity of occupations at pulmonary TB diagnosis.","authors":"M Saroufim, C Geric, A Majidulla, A Abjani, G Tavaziva, S Saeed, A J Khan, F Ahmad Khan","doi":"10.5588/ijtldopen.24.0323","DOIUrl":"10.5588/ijtldopen.24.0323","url":null,"abstract":"Background: Pulmonary TB (PTB) predominantly affects individuals of working age. We sought to characterise the occupations of people newly diagnosed with PTB in Karachi, Pakistan, by type and physical intensity.Design/methods: We did a secondary analysis of data from a study evaluating the diagnostic accuracy of artificial intelligence-based chest X-ray (CXR) analysis software, where individuals had been evaluated for active PTB using sputum cultures and had provided information on occupation. We used an accelerometer-validated US National Health and Nutrition Examination Survey-based job categorisation to assign physical activity levels to participant-reported occupations as High, Intermediate, or Low.Results: Among 272 participants with microbiologically confirmed PTB (women: 130/272, 48%; median age: 29 years, IQR 22-45), 78% (211/272) had smear-positive disease, and 96% (260/272) had data on occupation. Unemployment was common (women: 70/122, 57%; men: 23/138, 17%). Most women reporting an occupation were homemakers (21/52, 40%), and 54% (28/52) had an intermediate- or a high physical activity occupation. Among men reporting an occupation, 35% (40/115) were labourers, and 79% (91/115) had an intermediate- or high-physical activity occupation.Conclusion: The majority of individuals with PTB were in their working age, had extensive disease, and had intermediate or high physical activity occupations, suggesting economic vulnerability due to physical impairment.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 1","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-administration of augmentation therapy for alpha 1-antitrypsin deficiency. α-1-抗胰蛋白酶缺乏症的增强疗法的自我管理。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0566

A Vianello, S Lococo, L Corda, M Torrazza, G Zuccarini, P Baderna, F Cinetto, E Bargagli, P Confalonieri, S Sanduzzi Zamparelli, L Bertagna De Marchi, B Molena, F Lionello, M Caminati, G Guarnieri

引用次数: 0

A year in review - evaluating the launch of IJTLD OPEN. 一年回顾-评估IJTLD OPEN的启动。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0613

H D Blackbourn, G B Migliori

引用次数: 0

Reimagining community engagement in TB elimination: a perspective from the field. 重新构想社区参与消除结核病：来自实地的视角。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0578

A Ashesh, C Mehra, V Madan, J Furin

引用次数: 0

Applicability of TB-LAMP test for diagnosis of pulmonary TB among HIV-positive individuals. TB- lamp检测在hiv阳性人群中诊断肺结核的适用性

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0410

B Muriithi, M M Bundi, T Moriyasu, A Ahmed, M Mwamzuka, M Karama, S Kaneko

{"title":"Applicability of TB-LAMP test for diagnosis of pulmonary TB among HIV-positive individuals.","authors":"B Muriithi, M M Bundi, T Moriyasu, A Ahmed, M Mwamzuka, M Karama, S Kaneko","doi":"10.5588/ijtldopen.24.0410","DOIUrl":"10.5588/ijtldopen.24.0410","url":null,"abstract":"Background: The loop-mediated isothermal amplification for TB (TB-LAMP) assay is more cost-effective and accessible than the Xpert® MTB/RIF assay. This study aimed to evaluate the diagnostic performance of the TB-LAMP assay in individuals with and without HIV infection.Methods: Patients aged ≥15 years presenting with symptoms of TB were included in the study. The TB-LAMP assay was performed alongside routine TB diagnostic methods, including the Xpert assay and smear microscopy, to evaluate discrepancies in test results and associated factors.Results: A total of 903 patients were enrolled in the study. The positive percentage agreement for smear microscopy and TB-LAMP compared with the Xpert assay was respectively 54.3% (95% CI 46.6-61.8) and 76.6% (95% CI 69.9-82.6). Among HIV-positive individuals, the positive percentage agreement was 42.5% (95% CI 32.9-52.4) for smear microscopy and 68.9% (95% CI 59.1-77.5) for TB-LAMP. Factors such as age >60 years (adjusted OR 3.29, 95% CI 0.32-33.83), loss of appetite (aOR 0.30, 95% CI 0.13-0.70), and HIV-positive status (aOR 3.29, 95% CI 1.12-9.63) were associated with discrepancies between TB-LAMP and Xpert results.Conclusions: TB-LAMP demonstrated better agreement with the Xpert assay compared with smear microscopy in detecting TB among HIV-positive patients, suggesting that TB-LAMP could effectively replace smear microscopy.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 1","pages":"26-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of TB disease in individuals with cancer. 癌症患者患结核病的风险。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0440

T Diefenbach-Elstob, S Tabrizi, P Rivest, A Benedetti, L Azoulay, K Schwartzman, C Greenaway

{"title":"Risk of TB disease in individuals with cancer.","authors":"T Diefenbach-Elstob, S Tabrizi, P Rivest, A Benedetti, L Azoulay, K Schwartzman, C Greenaway","doi":"10.5588/ijtldopen.24.0440","DOIUrl":"10.5588/ijtldopen.24.0440","url":null,"abstract":"Background: Cancer increases the risk of developing TB disease; however, there are limited data on the magnitude of risk by cancer type and timing after diagnosis of cancer in low TB incidence settings.Methods: We conducted a nested case-control study of persons in Quebec between 1993 and 2017, including people with TB disease and matched controls. Conditional logistic regression was used to estimate adjusted odds ratios (aORs) of developing TB among people with cancer overall, by sub-type, and by time from cancer to TB diagnosis.Results: There were 4,283 people with TB disease and 268,420 matched controls. The median age for people with TB disease and controls was respectively 46 years (IQR 30-67) and 36 years (24-47). Prior exposure to cancer was associated with TB disease (aOR 6.3, 95% CI 5.3-7.6). The risk of TB diagnosis was highest within 3 months of cancer diagnosis (aOR 26.6, 95% CI 19.6-36.2), with 60% of diagnoses of TB disease occurring within 6 months of cancer diagnosis.Conclusion: Risk of TB varies over time and by cancer type. Screening and treatment should be considered for potentially preventable TB (diagnosed more than 6 months post-cancer), particularly in those with respiratory, haematologic, and head and neck cancers.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Person-centred language for describing stratified approaches to TB treatment. 以人为本，描述结核病分层治疗方法的语言。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0593

M Nash, A Deluca, E Lessem, N West, L McKenna, E V McConnell, K Angami, R Herrera, A Makone, G E Velásquez, R E Chaisson, P P J Phillips

引用次数: 0