IJTLD open最新文献_第3页

Children and providers' perspectives on once-weekly rifapentine and isoniazid TB preventive therapy. 儿童和医疗服务提供者对每周一次利福喷丁和异烟肼结核病预防疗法的看法。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0250

A J Marthinus, D T Wademan, Z Saule, Y Hirsch-Moverman, L Viljoen, J Winckler, L van der Laan, M Palmer, S L Barnabas, R Boyd, A C Hesseling, G Hoddinott

{"title":"Children and providers' perspectives on once-weekly rifapentine and isoniazid TB preventive therapy.","authors":"A J Marthinus, D T Wademan, Z Saule, Y Hirsch-Moverman, L Viljoen, J Winckler, L van der Laan, M Palmer, S L Barnabas, R Boyd, A C Hesseling, G Hoddinott","doi":"10.5588/ijtldopen.24.0250","DOIUrl":"10.5588/ijtldopen.24.0250","url":null,"abstract":"Background: TB preventive treatment (TPT) prevents the development of TB disease in individuals at risk of progression from infection to disease. However, implementation of TPT for children is poor in most high-burden settings. The long duration and pill burden of the 6-month once-daily isoniazid regimen (6H) pose significant barriers to completion. We aimed to understand children's, caregivers', and healthcare providers' experiences of the 12-week once-weekly rifapentine and isoniazid (3HP) regimen using a dispersible tablet formulation in South Africa.Methods: Serial, in-depth qualitative interviews with 20 child-caregiver dyads, including 5 children living with HIV (CLWH) and 9 healthcare providers across two study sites implementing a pharmacokinetic and safety trial of 3HP, were analysed deductively.Results: Of those with experience using both 3HP and 6H, caregivers and healthcare providers preferred 3HP, and study participants reported that the 3HP formulation was more palatable and easier to prepare and administer. Caregivers and healthcare providers were concerned about optimally integrating 3HP into routine care, primarily due to its once-weekly administration. Children with HIV preferred the once-daily 6H regimen for its ease of use with their daily antiretroviral therapy.Conclusions: 3HP reduced the administration burden for children and their caregivers. Once weekly, 3HP dosing will require education and adherence support to ensure completion.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of the war in Ukraine on the prevalence of MDR/RR-TB in Poland. 乌克兰战争对波兰耐多药/耐药结核病流行的影响。

IJTLD open Pub Date : 2025-01-01 DOI: 10.5588/ijtldopen.24.0357

A Nowinski, E Augustynowicz-Kopeć, J Garnczarek, A Halicka, M Koszela, W Litwiniuk, D Maj, I Mazur, J Niestrój-Ostrowska, R Podlasin, A Regulska, M Wielopolska, J Wyrwiński, S Wesołowski, M Korzeniewska-Koseła

{"title":"The impact of the war in Ukraine on the prevalence of MDR/RR-TB in Poland.","authors":"A Nowinski, E Augustynowicz-Kopeć, J Garnczarek, A Halicka, M Koszela, W Litwiniuk, D Maj, I Mazur, J Niestrój-Ostrowska, R Podlasin, A Regulska, M Wielopolska, J Wyrwiński, S Wesołowski, M Korzeniewska-Koseła","doi":"10.5588/ijtldopen.24.0357","DOIUrl":"10.5588/ijtldopen.24.0357","url":null,"abstract":"Background: The 2022 invasion of Ukraine by the Russian Federation triggered a refugee crisis, affecting the multidrug-/rifampicin-resistant TB (MDR/RR-TB) prevalence in neighbouring countries. This study examines the epidemiological trends and characteristics of MDR/RR-TB patients in Poland, focusing on the relative contribution of Ukrainian refugees.Methods: Data from the Polish National Tuberculosis Registry and EPIC Project database, covering MDR/RR-TB cases reported between 2010 and Q1 2024, were analysed.Results: The study included 794 MDR/RR-TB cases, showing a demographic shift post-2022. During the 10-year period up to 2021, a median of 48 MDR/RR-TB cases were reported annually in Poland. After 2022, these numbers doubled: 104 cases were reported in 2022 and 101 cases in 2023. Simultaneously, the number of Ukrainian MDR/RR-TB patients increased from 77 (13%) during 2010-2021 to 127 (58%) from 2022 to Q1 2024.Conclusion: Poland is observing an increased number of cases of MDR/RR-TB associated with the large number of displaced Ukrainian citizens who are now residing in Poland. There is a need to monitor the epidemiology of MDR/RR-TB and seek optimal screening and management strategies for TB among refugees from countries with high MDR/RR-TB incidence in Poland and Europe.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 1","pages":"6-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TB survivors: why curing TB is sometimes not enough. 结核病幸存者：为什么治愈结核病有时还不够？

IJTLD open Pub Date : 2024-12-01 DOI: 10.5588/ijtldopen.24.0530

E Pontali, R Centis

引用次数: 0

Prevalence of TB-related symptoms and self-reported disability among adult TB survivors. 成年结核病幸存者中结核病相关症状的患病率和自我报告的残疾

IJTLD open Pub Date : 2024-12-01 DOI: 10.5588/ijtldopen.24.0141

A K McDonald, D Nakkonde, P Kaggwa, S Zalwango, A Joseph, E Buregyeya, J N Sekandi

{"title":"Prevalence of TB-related symptoms and self-reported disability among adult TB survivors.","authors":"A K McDonald, D Nakkonde, P Kaggwa, S Zalwango, A Joseph, E Buregyeya, J N Sekandi","doi":"10.5588/ijtldopen.24.0141","DOIUrl":"10.5588/ijtldopen.24.0141","url":null,"abstract":"Background: Growing evidence suggests that post-TB-related morbidity occurs often among TB survivors, but there is limited epidemiological data on the burden of symptoms and disability after successful completion of treatment. We evaluated the prevalence of TB-related symptoms, self-reported disability, and factors associated with disability among adult TB survivors who recently completed treatment in Uganda.Methods: Between January 2022 and October 2023, we conducted a study of adults who completed treatment for drug-susceptible TB in Kampala, Uganda. We collected data on demographics, TB-related symptoms, HIV status, and disability measured using the World Health Organization Disability Assessment Schedule (WHODAS 2.0).Results: Of the 200 participants, the median age was 33.0 years (IQR 26-44.5); 52.5% were male, and 23% were HIV-infected. The prevalence of TB symptoms was 58%, and self-reported disability was 83.5%. Factors significantly associated with disability were having completed treatment within the last 6-8 months and experiencing TB symptoms (aOR 2.87, P = 0.04; and aOR 2.51, P = 0.03, respectively), after adjusting for age, sex and HIV status.Conclusions: TB-related symptoms and self-reporting of any disability were highly prevalent in the study population. There is a need for further longitudinal evaluation and considerations to expand the continuum of care and support to improve the quality of life for TB survivors post-TB treatment.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 12","pages":"540-546"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of other pathologies when utilising computer-assisted digital solutions for TB screening. 在利用计算机辅助数字解决方案进行肺结核筛查时检测其他病症。

IJTLD open Pub Date : 2024-12-01 DOI: 10.5588/ijtldopen.24.0428

J Sebastian, I D Olaru, A Giannakis, M Arentz, S V Kik, M Ruhwald, S Linsen, G Günther, P Wolf, F J Herth, T Weber, C M Denkinger

{"title":"Detection of other pathologies when utilising computer-assisted digital solutions for TB screening.","authors":"J Sebastian, I D Olaru, A Giannakis, M Arentz, S V Kik, M Ruhwald, S Linsen, G Günther, P Wolf, F J Herth, T Weber, C M Denkinger","doi":"10.5588/ijtldopen.24.0428","DOIUrl":"10.5588/ijtldopen.24.0428","url":null,"abstract":"Background: Computer-aided detection (CAD) tools for TB detection have the potential to enable screening programmes and reduce the diagnostic gap in settings where access to radiologists is limited. However, there are concerns that other common chest X-ray (CXR) abnormalities not due to TB may be missed.Methods: We assessed the performance of three commercialised CAD tools (qXR, INSIGHT CXR and DrAIDTM TB XR) to detect common non-TB abnormalities against readings with a standardised annotation guide by an expert radiologist. More than 20 well-characterised diagnoses besides TB significant in TB high-burden countries were examined.Results: The 517 CXRs included were deemed abnormal by the three CAD with a sensitivity of respectively 97% (95% CI 95-98), 94% (95% CI 91-95), and 87% (95% CI 84-90) for INSIGHT CXR, qXR, and DrAID. The CAD generally detected abnormalities in patients with critical diagnoses such as lung cancer or heart failure. Performance for detecting other abnormalities was variable.Conclusion: This study showed that the three CAD tools identified CXRs as abnormal when diseases other than TB were present. Our findings alleviate ethical concerns of missing abnormalities other than TB when using commercially available CAD for TB screening and show their potential broader applicability.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 12","pages":"533-539"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated TB associated with acute severe malnutrition in a Roma child. 一名罗姆儿童因急性严重营养不良而感染播散性结核病。

IJTLD open Pub Date : 2024-12-01 DOI: 10.5588/ijtldopen.24.0454

P Kunč, J Fábry, P Ferenc, T Strachan, M Matiščáková, I Solovič, R Péčová, M Dohál

引用次数: 0

Serodiagnosis of M. abscessus species pulmonary disease using anti-glycopeptidolipid-core IgA antibody. 利用抗糖肽多脂核 IgA 抗体对脓肿霉菌肺病进行血清诊断。

IJTLD open Pub Date : 2024-12-01 DOI: 10.5588/ijtldopen.24.0441

T Nii, K Fujiwara, T Kobayashi, E Hagiwara, K Fukushima, K Morimoto, K Tsuyuguchi, T Ogura, H Kida

引用次数: 0

Treatment outcomes in NTM-PD in a high TB burden context. 在结核病负担较重的情况下，非结核性结核病的治疗效果。

IJTLD open Pub Date : 2024-12-01 DOI: 10.5588/ijtldopen.24.0413

S Kang, J E Schmidt, I Chen, S Tiberi

{"title":"Treatment outcomes in NTM-PD in a high TB burden context.","authors":"S Kang, J E Schmidt, I Chen, S Tiberi","doi":"10.5588/ijtldopen.24.0413","DOIUrl":"10.5588/ijtldopen.24.0413","url":null,"abstract":"Background: Non-tuberculous mycobacterial (NTM) pulmonary disease (PD) is a significant concern in China, compounding the existing burden of TB. This review aims to summarise the treatment outcomes for NTM-PD in China.Methods: We reviewed the evidence on NTM-PD, including treatment regimens and clinical outcomes, from 17 studies identified through screening of three Chinese biomedical databases.Results: Antimicrobial treatment showed a microbiological cure rate ranging from 17.2% to 60.0% in studies with ≥50 NTM-PD patients, with lower rates observed among older and malnourished patients. The Mycobacterium chelonae abscessus group (MC-AG) and Mycobacterium avium-intracellulare complex (MAC) were the most prevalent NTM species in China. Higher microbiological cure rates were seen in MAC PD compared with MC-AG PD. The addition of cefoxitin and linezolid improved culture conversion rates in MC-AG-infected patients. One study (n = 24) demonstrated that resecting lesions and chemotherapy led to more favourable clinical outcomes.Conclusion: Treatment regimens recommended in Chinese guidelines yielded poor-to-moderate outcomes for NTM-PD in China, highlighting the need for further research into alternative antimicrobial treatments to improve efficacy.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 12","pages":"547-555"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between mental illness, TB risk and migrant status. 精神疾病、结核病风险与移民身份之间的关联。

IJTLD open Pub Date : 2024-12-01 DOI: 10.5588/ijtldopen.24.0260

S E Hayward, K L Kristensen, A Deal, J H Petersen, T Lillebaek, S Hargreaves, M Norredam, J S Friedland

{"title":"Associations between mental illness, TB risk and migrant status.","authors":"S E Hayward, K L Kristensen, A Deal, J H Petersen, T Lillebaek, S Hargreaves, M Norredam, J S Friedland","doi":"10.5588/ijtldopen.24.0260","DOIUrl":"10.5588/ijtldopen.24.0260","url":null,"abstract":"Background: TB and mental illnesses are public health priorities that often co-exist, with migrants in high-income countries being at risk for both conditions. This study investigates whether mental illness influences TB risk and examines the impact of migration status.Methods: A nationwide prospective cohort study was conducted in Denmark from 1994-2015, involving migrants matched 1:6 to Danish-born individuals. Cox regression models, adjusted for age, sex and migrant status, were used to assess the effect of mental disorders on TB risk.Results: Both migrants and non-migrants with mental disorders showed elevated TB incidence (n = 1,189,273). After adjusting for age and sex, the hazard ratio (HR) for TB in those with any mental disorder was 3.62 (95% CI 2.99-4.39, P < 0.001) compared to those without mental disorders. The effect was more substantial in Danish-born individuals (HR 15.51, 95% CI 12.05-19.95, P < 0.001) than in migrants (HR 1.37, 95% CI 0.99-1.90, P = 0.055). Sub-analyses highlighted a significant effect of substance use (HR 5.49, 95% CI 4.46-6.76, P < 0.001) and psychosis (HR 4.19, 95% CI 1.74-10.08, P = 0.001) and borderline significance for affective/anxiety/stress-related disorders (HR 1.64, 95% CI 0.98-2.73, P = 0.058) on TB risk.Conclusions: People with mental illnesses, particularly psychotic and substance use disorders, have increased TB incidence and represent a high-risk population for targeted screening and treatment. TB programmes should integrate holistic mental health care.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 12","pages":"564-570"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of a score to characterise adequate contact among the social network of persons with TB. 对肺结核患者社会网络中的充分接触进行评分。

IJTLD open Pub Date : 2024-12-01 DOI: 10.5588/ijtldopen.24.0376

M E Castellanos, S Zalwango, T H T Quach, R Kakaire, L Martínez, M H Ebell, K K Dobbin, N Kiwanuka, C C Whalen

{"title":"Performance of a score to characterise adequate contact among the social network of persons with TB.","authors":"M E Castellanos, S Zalwango, T H T Quach, R Kakaire, L Martínez, M H Ebell, K K Dobbin, N Kiwanuka, C C Whalen","doi":"10.5588/ijtldopen.24.0376","DOIUrl":"10.5588/ijtldopen.24.0376","url":null,"abstract":"Background: Transmission of Mycobacterium tuberculosis requires adequate contact between an infectious case and a susceptible host. The aim of this analysis was to validate a recently developed contact score that assessed settings of exposure and relationships between the case and contact.Methods: In a cross-sectional study from Kampala, Uganda, we estimated the prevalence of tuberculous infection (TBI) in social contacts of adult TB cases according to the setting and relationship domains of the contact score. We calculated the prevalence ratio (PR) for the association between contact scores (by domain) with TBI using modified Poisson regression models.Results: We enrolled 955 household and community contacts from 119 TB cases. The prevalence of TBI in the social network was 52% (95% CI 48-55). The prevalence of TBI increased by quartile for both the setting score (44%, 40%, 53%, 70%; P trend <0.0001) and the relationship score (41%, 47%, 53%, 66%; P trend <0.0001). The setting score was associated with a higher prevalence of infection among children aged 5-14 years, whereas the relationship score was associated with infection in children aged 0-4 years.Conclusion: In urban Africa, contacts of TB with higher settings and relationship scores were more likely infected with M. tuberculosis.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 12","pages":"556-563"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0