I J Courtney, M Palmer, R Swanepoel, C J Lombard, M van Niekerk, R Dunbar, E D McCollum, H S Schaaf, A Gie, P Goussard, A C Hesseling, V W Jongen, M M van der Zalm
{"title":"肺结核和非结核性下呼吸道感染儿童的肺功能轨迹。","authors":"I J Courtney, M Palmer, R Swanepoel, C J Lombard, M van Niekerk, R Dunbar, E D McCollum, H S Schaaf, A Gie, P Goussard, A C Hesseling, V W Jongen, M M van der Zalm","doi":"10.5588/ijtldopen.25.0080","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This longitudinal study compared lung function in children with pulmonary TB (PTB), children with non-TB lower respiratory tract infections (LRTIs) and healthy controls.</p><p><strong>Methods: </strong>Children aged 4-13 years presenting with presumed PTB and their healthy siblings who could perform spirometry were included. Children were classified as having TB, non-TB LRTIs after careful evaluation and during follow-up. Spirometry measurements were completed at baseline and at subsequent study visits during 52 weeks of follow-up. Measurements included forced expiratory volume in 1 second (FEV<sub>1</sub>), forced vital capacity (FVC), and FEV<sub>1</sub>/FVC using 2022 race-neutral Global Lung Initiative reference ranges.</p><p><strong>Results: </strong>Of 143 children, 46 had TB, 64 had non-TB LRTIs, and 33 were healthy controls. The median age was 6 years (IQR 5-9) and 10 (7%) were living with HIV. Restrictive spirometry patterns were common in both symptomatic groups at the end of follow-up, with a significantly lower FVC in children with TB compared to controls. In multivariable analysis adjusted for time and study group, FEV<sub>1</sub> and FVC decreased for both the TB and non-TB LRTI groups, compared to healthy controls.</p><p><strong>Conclusion: </strong>Lung-function trajectories were similar between children with TB and non-TB LRTI, with low FVC one-year after diagnosis.</p>","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"2 8","pages":"471-477"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352954/pdf/","citationCount":"0","resultStr":"{\"title\":\"Lung function trajectories in children with pulmonary TB and non-TB lower respiratory tract infections.\",\"authors\":\"I J Courtney, M Palmer, R Swanepoel, C J Lombard, M van Niekerk, R Dunbar, E D McCollum, H S Schaaf, A Gie, P Goussard, A C Hesseling, V W Jongen, M M van der Zalm\",\"doi\":\"10.5588/ijtldopen.25.0080\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This longitudinal study compared lung function in children with pulmonary TB (PTB), children with non-TB lower respiratory tract infections (LRTIs) and healthy controls.</p><p><strong>Methods: </strong>Children aged 4-13 years presenting with presumed PTB and their healthy siblings who could perform spirometry were included. Children were classified as having TB, non-TB LRTIs after careful evaluation and during follow-up. Spirometry measurements were completed at baseline and at subsequent study visits during 52 weeks of follow-up. Measurements included forced expiratory volume in 1 second (FEV<sub>1</sub>), forced vital capacity (FVC), and FEV<sub>1</sub>/FVC using 2022 race-neutral Global Lung Initiative reference ranges.</p><p><strong>Results: </strong>Of 143 children, 46 had TB, 64 had non-TB LRTIs, and 33 were healthy controls. The median age was 6 years (IQR 5-9) and 10 (7%) were living with HIV. Restrictive spirometry patterns were common in both symptomatic groups at the end of follow-up, with a significantly lower FVC in children with TB compared to controls. In multivariable analysis adjusted for time and study group, FEV<sub>1</sub> and FVC decreased for both the TB and non-TB LRTI groups, compared to healthy controls.</p><p><strong>Conclusion: </strong>Lung-function trajectories were similar between children with TB and non-TB LRTI, with low FVC one-year after diagnosis.</p>\",\"PeriodicalId\":519984,\"journal\":{\"name\":\"IJTLD open\",\"volume\":\"2 8\",\"pages\":\"471-477\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352954/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IJTLD open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5588/ijtldopen.25.0080\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJTLD open","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5588/ijtldopen.25.0080","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Lung function trajectories in children with pulmonary TB and non-TB lower respiratory tract infections.
Background: This longitudinal study compared lung function in children with pulmonary TB (PTB), children with non-TB lower respiratory tract infections (LRTIs) and healthy controls.
Methods: Children aged 4-13 years presenting with presumed PTB and their healthy siblings who could perform spirometry were included. Children were classified as having TB, non-TB LRTIs after careful evaluation and during follow-up. Spirometry measurements were completed at baseline and at subsequent study visits during 52 weeks of follow-up. Measurements included forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC using 2022 race-neutral Global Lung Initiative reference ranges.
Results: Of 143 children, 46 had TB, 64 had non-TB LRTIs, and 33 were healthy controls. The median age was 6 years (IQR 5-9) and 10 (7%) were living with HIV. Restrictive spirometry patterns were common in both symptomatic groups at the end of follow-up, with a significantly lower FVC in children with TB compared to controls. In multivariable analysis adjusted for time and study group, FEV1 and FVC decreased for both the TB and non-TB LRTI groups, compared to healthy controls.
Conclusion: Lung-function trajectories were similar between children with TB and non-TB LRTI, with low FVC one-year after diagnosis.
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