IJTLD open最新文献_第4页

Accelerating TB regimen development: introducing FAST-TB. 加快结核病治疗方案的开发：引入 FAST-TB。

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.24.0333

T Devezin, C Chisholm, F Jones, K Lacourciere, B Laughon, L Ramachandra, A Vernon, L Zhang, P Kim, C Lienhardt

引用次数: 0

Analysis of panel physician inquiries to U.S. TB Centers of Excellence, 2018-2022. 2018-2022年向美国结核病卓越中心咨询的小组医生分析。

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.24.0056

E Leithead, S Subramanian, K Pimenta, N D Goswami, A Patrawalla, A Lardizabal, C Haley, L Chen, L Armitige, B Seaworth, B Sylvester, R Bhavaraju

{"title":"Analysis of panel physician inquiries to U.S. TB Centers of Excellence, 2018-2022.","authors":"E Leithead, S Subramanian, K Pimenta, N D Goswami, A Patrawalla, A Lardizabal, C Haley, L Chen, L Armitige, B Seaworth, B Sylvester, R Bhavaraju","doi":"10.5588/ijtldopen.24.0056","DOIUrl":"10.5588/ijtldopen.24.0056","url":null,"abstract":"Background: Applicants seeking entry into the United States are examined overseas for TB by panel physicians and international immigration clinicians guided by Centers for Disease Control and Prevention (CDC) TB Technical Instructions. To support this effort, CDC-funded TB Centers of Excellence (COEs) provide web-based expert consultation, with documentation stored in a medical consultation database (MCD). MCD analysis can reveal inquiry trends among panel physicians worldwide.Methods: TB-related queries in the COE MCD from January 1, 2018, to December 31, 2022, were analyzed using a descriptive coding scheme developed through inductive analysis, allowing multiple themes per entry.Results: A total of 215 queries from 126 patients in 28 countries were analyzed. Major themes included evaluating diagnostic criteria, tailoring treatment, and managing comorbidities or adverse reactions. Diagnostic questions (n = 104, 48.4%) included mycobacterial culture, smear, and radiology interpretation. Treatment tailoring inquiries involved optimizing the initial regimen (n = 89, 41.4%) or modifying existing regimens (n = 26, 12.1%). Additionally, 50 consultations (23.2%) mentioned comorbidities, while 47 (21.9%) described adverse reactions.Conclusion: The MCD analysis identified topics where TB expertise was provided in overseas medical evaluation. These topics highlight opportunities for targeted panel physician education to improve the health of individual applicants and advance U.S. TB elimination efforts.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 11","pages":"490-494"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mice infected with M. tuberculosis with Rv0678 mutations still benefit from bedaquiline treatment. 感染 Rv0678 突变结核杆菌的小鼠仍可从贝达喹啉治疗中获益。

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.23.0527

N Lounis, T Gevers, C Villellas, K Andries

引用次数: 0

Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? 耐药性结核病最新治疗指南：基于氯唑明的治疗方案有多安全？

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.24.0490

E Pontali, M Raviglione

引用次数: 0

Sputum availability and quality in country-level TB prevalence surveys. 国家级结核病流行率调查中的痰液供应和质量。

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.24.0117

P Papadopoulou, M Gaeddert, A Gupta-Wright, C M Denkinger, F M Marx

引用次数: 0

Experience of piloting BPaLM/BPaL for DR-TB care at selected sites in Pakistan. 在巴基斯坦选定地点试行 BPaLM/BPaL 治疗 DR-TB 的经验。

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.24.0369

M A Khan, A Ismail, A Ghafoor, N Khan, N Muzaffar, F Zafar, A Gupta, S Foraida, S Juneja, R Fatima, A W Khan, S Shahid, M A Khan

{"title":"Experience of piloting BPaLM/BPaL for DR-TB care at selected sites in Pakistan.","authors":"M A Khan, A Ismail, A Ghafoor, N Khan, N Muzaffar, F Zafar, A Gupta, S Foraida, S Juneja, R Fatima, A W Khan, S Shahid, M A Khan","doi":"10.5588/ijtldopen.24.0369","DOIUrl":"10.5588/ijtldopen.24.0369","url":null,"abstract":"Background: Pakistan ranks fourth globally in terms of high drug-resistant TB (DR-TB) burden, with approximately one-third of cases resistant to fluoroquinolones. Bedaquiline, pretomanid, linezolid and moxifloxacin (BPaLM/BPaL) offers an opportunity for most DR-TB patients to benefit from a shorter, all-oral, well-tolerated and more effective treatment.Methods: We conducted a retrospective cohort study to pilot the BPaLM/BPaL regimen at four selected sites in two provinces of Pakistan, i.e. Punjab and Khyber Pakhtunkhwa. Data were extracted and analysed using electronic medical records from the program. Descriptive statistics, survival analysis and binary logistic regression analysis were employed.Results: A total of 116 patients took treatment between October 2022 and February 2023. The treatment success rate was 96%, with 3% deaths and <1% loss to follow-up. Patients typically completed treatment in 26.2-26.7 weeks for BPaLM and BPaL, respectively. No serious adverse events were observed. The most common side effects included QTcF prolongation (BPaLM: 55%, BPaL: 84%), haematological events (BPaLM: 32%, BPaL: 34%), and gastrointestinal problems (BPaLM: 36%, BPaL: 25%).Conclusion: The BPaLM/BPaL regimens for DR-TB are highly effective with minimal adverse events and feasible to implement in routine program circumstances.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 11","pages":"508-515"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical treatment outcomes and risk factors for post-TB lung disease. 结核病后肺部疾病的手术治疗效果和风险因素。

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.24.0322

C Guo, Q Li, L Wei, Y Liu, D Sun, C Ding

{"title":"Surgical treatment outcomes and risk factors for post-TB lung disease.","authors":"C Guo, Q Li, L Wei, Y Liu, D Sun, C Ding","doi":"10.5588/ijtldopen.24.0322","DOIUrl":"10.5588/ijtldopen.24.0322","url":null,"abstract":"Objective: This study aims to investigate the effectiveness and safety of surgical treatment for post-TB lung disease (PTLD) and to analyse its risk factors.Methods: Data were collected from 268 patients who underwent pulmonary resection for TB in Xi'an Chest Hospital, Xi'an, Shaanxi, China, between January 2014 and December 2023. The efficacy and safety of the three groups were compared, and the TB group was used as the control group to analyse the risk factors of PTLD.Results: The results indicated the three groups in intraoperative blood loss, post-operative drainage volume, post-operative complications, and post-operative hospital stay also varied significantly among the three groups (all P < 0.01). Additionally, factors such as pre-operative anti-TB therapy duration (OR = 1.02, P = 0.007), age (OR = 1.03, P = 0.030), and comorbid diabetes mellitus (OR = 3.00, P = 0.046) were identified as significant contributors to PTLD. While pre-operative haemoptysis demonstrates a statistically significant correlation with both precursor PTLDs, this association likely reflects the clinical expression of the underlying disease process.Conclusion: The study confirms that surgery for PTLD is safe and efficacious. Patients with advanced age, an extended duration of pre-operative anti-TB therapy, comorbid diabetes mellitus and pre-operative haemoptysis should maintain vigilance regarding the potential development of PTLD.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 11","pages":"516-521"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health-related quality of life in children with presumptive TB. 推定肺结核患儿的健康相关生活质量。

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.24.0355

M G Anthony, L S Johnson, M van Niekerk, A Mfwaze, B Bavuma, A C Hesseling, G Hoddinott, M M van der Zalm

{"title":"Health-related quality of life in children with presumptive TB.","authors":"M G Anthony, L S Johnson, M van Niekerk, A Mfwaze, B Bavuma, A C Hesseling, G Hoddinott, M M van der Zalm","doi":"10.5588/ijtldopen.24.0355","DOIUrl":"10.5588/ijtldopen.24.0355","url":null,"abstract":"Background: Respiratory illnesses, including pulmonary TB (PTB), cause significant morbidity. We aimed to understand the health-related quality of life (HRQoL) of children with presumptive PTB.Methods: Children aged 0-13 years presenting with presumptive PTB were enrolled. This study includes children who started TB treatment and children in whom TB was excluded (symptomatic controls). Quantitative data were collected using the Toddler and Infant quality of life Instrument (TANDI) (<3 years) and European Quality of Life-5 Dimensions-Youth (EQ-5D-Y) (>3 years) measures. Qualitative data were collected through in-depth interviews using thematic analysis.Results: Quantitative data from caregivers of 201 children (TANDI: n = 170; EQ-5D-Y: n = 31) showed 77 (38.3%) were diagnosed with TB, while 124 (61.7%) were symptomatic controls. Qualitative data from 15 caregivers of 21 children included 10 (67%) children with TB and 5 (33%) symptomatic controls. The median TANDI Visual Analogue Score (VAS) for overall health was 90% (IQR 80-100); the EQ-5D-Y VAS median was 95% (IQR 80-100). Caregivers described decreased energy, difficulty eating, and increased sleep using qualitative interviews, which were not reflected in the quantitative data. No differences were found between children with TB and symptomatic controls.Conclusions: HRQoL was high in children with TB, but discrepancies between quantitative and qualitative measures highlight the limitations of the current HRQoL measures.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 11","pages":"495-500"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying sputum production success during community-based screening for TB. 量化社区结核病筛查中的产痰成功率。

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.24.0319

P J Kitonsa, J Sung, D Isooba, S Birabwa, I Naluyima, J Kakeeto, W Kamya, A Nalutaaya, P Biché, D W Dowdy, A Katamba, E A Kendall

引用次数: 0

Burden and challenges in managing TB infection among people with occupational exposure to silica in India. 印度因职业原因接触二氧化硅的人群中结核病感染的负担和管理挑战。

IJTLD open Pub Date : 2024-11-01 DOI: 10.5588/ijtldopen.24.0402

B Kalottee, P Mahajan, A Nuken, D Nair, P Thekkur, A M V Kumar, V Rai, M Parmar, H Solanki, R Rao, S K Mattoo, R Kumar

{"title":"Burden and challenges in managing TB infection among people with occupational exposure to silica in India.","authors":"B Kalottee, P Mahajan, A Nuken, D Nair, P Thekkur, A M V Kumar, V Rai, M Parmar, H Solanki, R Rao, S K Mattoo, R Kumar","doi":"10.5588/ijtldopen.24.0402","DOIUrl":"10.5588/ijtldopen.24.0402","url":null,"abstract":"Background: Occupational exposure to silica increases the risk of TB infection (TBI) and disease. This study aimed to determine the prevalence of TBI and explore challenges in TBI management in such individuals in two districts of India during 2023.Methods: This was an explanatory mixed-methods study with a quantitative cohort design and qualitative descriptive in-depth interviews.Results: Among 1,555 individuals with occupational exposure to silica, 593 (38%, 95% CI 36-41) underwent interferon-gamma release assay (IGRA) for TBI, of whom 255 (43%, 95% CI 39-47) were found IGRA-positive. Males with occupational silica exposure for ≥20 years had a significantly higher risk of TBI. Of these 160 individuals eligible for TB preventive therapy (TPT), 153 (96%, 95% CI 92-98) were initiated on TPT and 124 (81%, 95% CI 74-88) completed TPT. The low uptake of IGRA was attributed to the stigma associated with TB and reluctance to undergo any medical evaluation.Conclusions: Compared to the general population, individuals with occupational exposure to silica have an almost two times higher prevalence of TBI. Further research is required to identify the threshold of silica exposure to be considered for screening for TBI. Efforts to increase awareness and decrease stigma can improve the uptake of testing for TBI and TB disease.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 11","pages":"501-507"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0