IJTLD open最新文献_第5页

Timing of recurrence after treatment of pulmonary TB. 肺结核治疗后复发的时间。

IJTLD open Pub Date : 2024-10-01 DOI: 10.5588/ijtldopen.24.0222

C T Mithunage, D W Denning

{"title":"Timing of recurrence after treatment of pulmonary TB.","authors":"C T Mithunage, D W Denning","doi":"10.5588/ijtldopen.24.0222","DOIUrl":"https://doi.org/10.5588/ijtldopen.24.0222","url":null,"abstract":"Pulmonary TB (PTB) may recur due to reinfection or relapse after initial successful treatment. Based on microbiologically documented cases, we searched Embase, PubMed, Web of Science, and Medline for PTB recurrence. The timeframe of overall recurrences, relapse, reinfection, and risk factors were assessed. We compared the time to recurrence, relapse, and reinfection from treatment completion and plotted this using Kaplan-Meier curves. This systematic review included 23 articles describing 2,153 PTB recurrences in 75,224 treated people across all continents. Genotyping data to distinguish relapse from reinfection was available for 402 recurrences. The cumulative recurrence percentage was 2.9% over 5 years, and the median time for recurrence was 18 months (95% CI 16.99-19.0). Most recurrences (93%) were in HIV-negative people. Relapse occurred earlier than reinfection at 12 months (95% CI 10.86-13.14) vs 24 months (95% CI 21.61-26.39) (P < 0.001, χ2 59.89). In low TB burden settings, recurrences were mainly caused by relapse (85%), whereas in high-burden settings, relapses comprised 56% of recurrences. Recurrences occurred slightly earlier in HIV-positive patients (P = 0.038, χ2 4.30). The emergence of resistance to one or more first-line anti-TB agents was documented in 40 of 421 cases (9.5%). Early recurrences are mainly relapses, while late recurrences are mainly reinfections.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 10","pages":"456-465"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perceptions and clinical practices associated with post-TB health and well-being in the Netherlands. 荷兰与结核病后健康和福祉相关的观念和临床实践。

IJTLD open Pub Date : 2024-10-01 DOI: 10.5588/ijtldopen.24.0377

I Spruijt, A Verhage, F Procee, N Vrubleuskaya, C Mulder, O Akkerman

引用次数: 0

Addressing gaps in the diagnosis of TB in children. 缩小儿童结核病诊断方面的差距。

IJTLD open Pub Date : 2024-10-01 DOI: 10.5588/ijtldopen.24.0239

J Hoffmann, C R Horsburgh

引用次数: 0

Stool Xpert^® MTB/RIF Ultra for TB diagnosis in children: experience from a national scale-up programme. 用于儿童结核病诊断的粪便 Xpert® MTB/RIF Ultra：全国推广计划的经验。

IJTLD open Pub Date : 2024-10-01 DOI: 10.5588/ijtldopen.24.0334

S Kabir, S Choudhury, T Rahman, S M M Rahman, M K M Uddin, A Nashra, A Hossain, S Naher, K M S Towhid, L Shahrin, S Ahmed, P Daru, J Hoffmann, S Banu

{"title":"Stool Xpert® MTB/RIF Ultra for TB diagnosis in children: experience from a national scale-up programme.","authors":"S Kabir, S Choudhury, T Rahman, S M M Rahman, M K M Uddin, A Nashra, A Hossain, S Naher, K M S Towhid, L Shahrin, S Ahmed, P Daru, J Hoffmann, S Banu","doi":"10.5588/ijtldopen.24.0334","DOIUrl":"https://doi.org/10.5588/ijtldopen.24.0334","url":null,"abstract":"Introduction: We describe the programmatic scale-up of stool testing using Xpert® MTB/RIF Ultra (Ultra), as recommended by the WHO to improve childhood pulmonary TB (PTB) diagnosis.Methods: USAID's Alliance for Combating TB in Bangladesh Activity, in collaboration with the National TB Control Programme, is implementing a stool-based diagnostic approach at 51 healthcare facilities in Bangladesh to improve PTB detection. Specimens from children (<15 years) with presumptive TB were tested using 'stool Ultra' with routine TB diagnostics. Physicians confirmed TB diagnosis and provided treatment as per national guidelines.Results: Between March 2022 and December 2023, 16,429 specimens were tested, 871 (5.3%) were positive, and 642 (73.7%) showed 'trace detected' results. Positivity was significantly higher among females, and children presented with 'only cough ≥2 weeks', 'cough ≥2 weeks + weight loss', or 'fever ≥2 weeks, weight loss, fatigue + contact history'. Positivity was higher among '10-14 years old' children; however, 'trace detected' was highest among '5-9 years', followed by children aged '>2-<5 years' and '0-2 years'.Conclusions: Testing stools using Ultra provides a more effective way of diagnosing bacteriologically positive PTB in children. However, positivity varies with presenting symptoms/criteria, highlighting the need for careful diagnostic evaluation to ensure optimum use of limited diagnostic resources.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 10","pages":"437-442"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of heteroresistance on treatment outcomes of people with drug-resistant TB. 异质性耐药性对耐药性肺结核患者治疗效果的影响。

IJTLD open Pub Date : 2024-10-01 DOI: 10.5588/ijtldopen.24.0343

R Crowder, M Kato-Maeda, B Schwem, A Dela Tonga, D M Geocaniga-Gaviola, E Lopez, C L Valdez, A R Lim, N Hunat, A G Sedusta, C A Sacopon, G A M Atienza, E Bulag, D Lim, J Bascuña, K Shah, R P Basillio, C A Berger, M C D P Lopez, S Sen, C Allender, M Folkerts, U Karaoz, E Brodie, S Mitarai, A M C Garfin, M C Ama, D M Engelthaler, A Cattamanchi, R Destura

{"title":"Impact of heteroresistance on treatment outcomes of people with drug-resistant TB.","authors":"R Crowder, M Kato-Maeda, B Schwem, A Dela Tonga, D M Geocaniga-Gaviola, E Lopez, C L Valdez, A R Lim, N Hunat, A G Sedusta, C A Sacopon, G A M Atienza, E Bulag, D Lim, J Bascuña, K Shah, R P Basillio, C A Berger, M C D P Lopez, S Sen, C Allender, M Folkerts, U Karaoz, E Brodie, S Mitarai, A M C Garfin, M C Ama, D M Engelthaler, A Cattamanchi, R Destura","doi":"10.5588/ijtldopen.24.0343","DOIUrl":"https://doi.org/10.5588/ijtldopen.24.0343","url":null,"abstract":"Background: Poor treatment outcomes among people with drug-resistant TB (DR-TB) are a major concern. Heteroresistance (presence of susceptible and resistant Mycobacterium tuberculosis in the same sample) has been identified in some people with TB, but its impact on treatment outcomes is unknown.Methods: We used targeted deep sequencing to identify mutations associated with DR-TB and heteroresistance in culture samples of 624 people with DR-TB. We evaluated the association between heteroresistance and time to unfavorable treatment outcome using Cox proportional hazards regression.Results: The proportion of drug-resistant isolates with a known mutation conferring resistance was lower for streptomycin (45.2%) and second-line injectables (79.1%) than for fluoroquinolones (86.7%), isoniazid (93.2%) and rifampin (96.5%). Fifty-two (8.3%) had heteroresistance, and it was more common for fluoroquinolones (4.6%) than rifampin (2.2%), second-line injectables (1.4%), streptomycin (1.7%), or isoniazid (1.3%). There was no association between heteroresistance and time to unfavorable outcome among people with multidrug-resistant TB (adjusted hazard ratio [aHR] 1.74, 95% CI 0.39-7.72) or pre-extensively DR-TB (aHR 0.65, 95% CI 0.24-1.72).Conclusions: Heteroresistance was relatively common (8.3%) among people with DR-TB in the Philippines. However, we found insufficient evidence to demonstrate an impact on unfavorable treatment outcomes.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 10","pages":"466-472"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes. 干扰素-γ释放检测结果的预测因素及其与 COVID-19 感染结果的关联。

IJTLD open Pub Date : 2024-10-01 DOI: 10.5588/ijtldopen.24.0180

S J W Kang, G W Eather, F Qureshi, J R Scott

{"title":"Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes.","authors":"S J W Kang, G W Eather, F Qureshi, J R Scott","doi":"10.5588/ijtldopen.24.0180","DOIUrl":"https://doi.org/10.5588/ijtldopen.24.0180","url":null,"abstract":"Background: An 'indeterminate' interferon-gamma release assay (IGRA) result used in the diagnosis of latent TB infection (LTBI) is most commonly due to an inadequate control (or 'mitogen') response, which may reflect underlying T-cell dysfunction.Methods: We performed a single-centre, retrospective study on COVID-19 patients admitted to a tertiary referral hospital who had IGRA testing conducted over a 5-month period. The primary outcomes included predictors of indeterminate IGRA results and associations with COVID-19 outcomes.Results: A total of 181 patients were included for analysis. Approximately one-third of patients hospitalised with COVID-19 with IGRA testing performed (60/181) had an indeterminate result. The likelihood of an indeterminate IGRA was increased in patients with a history of solid organ transplant and a higher severity of COVID-19 at the time of testing. An indeterminate IGRA was associated with a higher risk of severe COVID-19 and a higher risk of admission to the ICU during admission to the hospital. No difference in mortality between the two subgroups was found.Conclusion: Our study demonstrated that COVID-19 patients on immunosuppression had a high likelihood of an indeterminate IGRA result, which was associated with markers of disease severity and immunosuppression. In this cohort, an indeterminate result was associated with worse COVID-19 outcomes.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 10","pages":"443-448"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spirometric reference equations and lung function testing in adults from Southwestern Tanzania. 坦桑尼亚西南部成年人的肺活量参考方程和肺功能测试。

IJTLD open Pub Date : 2024-10-01 DOI: 10.5588/ijtldopen.24.0339

R Wenzel, E Siyame, O Ivanova, A Bakuli, J Lalashowi, F C Zekoll, M Hoelscher, I Sabi, A Rachow, N E Ntinginya

{"title":"Spirometric reference equations and lung function testing in adults from Southwestern Tanzania.","authors":"R Wenzel, E Siyame, O Ivanova, A Bakuli, J Lalashowi, F C Zekoll, M Hoelscher, I Sabi, A Rachow, N E Ntinginya","doi":"10.5588/ijtldopen.24.0339","DOIUrl":"https://doi.org/10.5588/ijtldopen.24.0339","url":null,"abstract":"Background: The increasing relevance of lung function testing in diagnosing and treating pulmonary diseases globally requires adequate spirometric reference equations. However, locally derived reference standards from African countries are widely missing.Methods: This cross-sectional study was conducted in Southwestern Tanzania. Participants underwent a socio-demographic interview, anthropometric measurements and standardised spirometric lung function testing. Regression modelling was used to generate Tanzanian prediction equations for spirometry parameters forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1) and the FEV1/FVC ratio.Results: Out of 400 recruited participants, 343 had usable spirometry results with respect to the American Thoracic Society (ATS)/European Respiratory Society (ERS) reproducibility and acceptability criteria. The mean age of participants was 32.65 years (SD 12.11), and 44,9% were females. Spirometric parameters increased with height but decreased with older age. The coefficients of our new prediction equations for spirometry parameters differed substantially from those of existing reference standards.Conclusion: This study provides prediction equations for spirometric lung function in a non-smoking Tanzanian population. The differences in existing equations underline the heterogeneity of locally derived reference equations in Africa and contribute insights and data to discussing global respiratory health care reference standards.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 10","pages":"473-479"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considering best practice standards for routine whole-genome sequencing for TB care and control. 考虑用于结核病护理和控制的常规全基因组测序的最佳实践标准。

IJTLD open Pub Date : 2024-10-01 DOI: 10.5588/ijtldopen.24.0320

J T Denholm, G de Vries, R Anthony, E Robinson, M Backx, I F Laurenson, A L Seagar, H Modestil, L Trieu, J S Meissner, D H L Ng, J Y Tay, H H Lin, R Lee, V Sintchenko, B J Marais, E J Donnan

{"title":"Considering best practice standards for routine whole-genome sequencing for TB care and control.","authors":"J T Denholm, G de Vries, R Anthony, E Robinson, M Backx, I F Laurenson, A L Seagar, H Modestil, L Trieu, J S Meissner, D H L Ng, J Y Tay, H H Lin, R Lee, V Sintchenko, B J Marais, E J Donnan","doi":"10.5588/ijtldopen.24.0320","DOIUrl":"https://doi.org/10.5588/ijtldopen.24.0320","url":null,"abstract":"TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. In low-incidence settings, a growing number of services have begun to incorporate routine WGS into standard practice. The increasing availability of real-time genomic information supports a variety of aspects of the public health response, including the detection of drug resistance, monitoring of laboratory and clinical practices, contact tracing investigations and active case finding. Optimal structures and approaches are needed to support the rapid translation of genomic information into practice and to evaluate outcomes and impact. In this consensus paper, we outline the elements needed to systemically incorporate routine WGS into the TB public health response, including the sustainability of services, multidisciplinary team models and monitoring and evaluation frameworks. If integrated in an efficient and thoughtful manner, routine WGS has the potential to significantly improve clinical TB care for individuals and the overall public health response.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 10","pages":"431-436"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

External quality assurance of chest X-ray interpretation to strengthen diagnosis of childhood TB. 对胸部 X 光片判读进行外部质量保证，以加强对儿童结核病的诊断。

IJTLD open Pub Date : 2024-10-01 DOI: 10.5588/ijtldopen.24.0328

B F Melingui, E Leroy-Terquem, J V Taguebue, T C Eap, L Borand, C Khosa, R Moh, J Mwanga-Amumpaire, S Beneteau, M T Eang, I Manhiça, A Mustapha, O Marcy, E Wobudeya, P Y Norval, M Bonnet

{"title":"External quality assurance of chest X-ray interpretation to strengthen diagnosis of childhood TB.","authors":"B F Melingui, E Leroy-Terquem, J V Taguebue, T C Eap, L Borand, C Khosa, R Moh, J Mwanga-Amumpaire, S Beneteau, M T Eang, I Manhiça, A Mustapha, O Marcy, E Wobudeya, P Y Norval, M Bonnet","doi":"10.5588/ijtldopen.24.0328","DOIUrl":"https://doi.org/10.5588/ijtldopen.24.0328","url":null,"abstract":"Background: Chest X-ray (CXR) misinterpretation negatively affects the accuracy of childhood TB diagnosis. External quality assurance (EQA) could strengthen CXR reading skills. We assessed the uptake, performance and challenges of an EQA of CXR interpretation within the childhood TB-Speed decentralisation study in six resource-limited countries.Methods: Every quarter, TB suggestive or unreadable CXRs and 10% of remaining CXRs from children with presumptive TB were selected for blind re-reading by national re-readers. The proportion of CXRs selected for EQA and re-read assessed the uptake. The performance was assessed by the proportion of discordant interpretations and the sensitivity and specificity of clinicians' vs re-readers' interpretations. Challenges were retrieved from country reports.Results: Of 513 eligible CXRs, 309 (60.8%) were selected for EQA and 278/309 (90.0%) re-read. The proportion of discordant interpretation was between 13/48 (27%) in Sierra Leone and 7/13 (53.8%) in Cote d'Ivoire during the first EQA and decreased after the EQAs periods in 3/5 countries. Clinician sensitivity reached 100% in all countries over EQA. Specificity ranged between 13% in Sierra Leone and 65% in Cambodia (first EQA) and increased in 4/5 countries after the EQA periods. CXR transfer and re-readers' workload were the main challenges.Conclusion: EQA can enhance CXR interpretation for childhood TB diagnosis, provided operational challenges are overcome.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 10","pages":"449-455"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3HP preventive treatment among children and adolescents with HIV and child household contacts of TB patients. 对感染艾滋病毒的儿童和青少年以及与结核病患者有家庭接触的儿童进行 3HP 预防性治疗。

IJTLD open Pub Date : 2024-09-01 DOI: 10.5588/ijtldopen.24.0305

A Kinikar, R Borse, B Randive, P Kamath, S K Mattoo, M Parmar, H Solanki, V Mave, A Gupta, R E Chaisson, N Suryavanshi

{"title":"3HP preventive treatment among children and adolescents with HIV and child household contacts of TB patients.","authors":"A Kinikar, R Borse, B Randive, P Kamath, S K Mattoo, M Parmar, H Solanki, V Mave, A Gupta, R E Chaisson, N Suryavanshi","doi":"10.5588/ijtldopen.24.0305","DOIUrl":"10.5588/ijtldopen.24.0305","url":null,"abstract":"Introduction: India's National TB Elimination Programme plans to roll out short-course TB preventive therapy (TPT) using 3 months of rifapentine and isoniazid (3HP). Understanding the feasibility and safety of children in programmatic settings is critical for widespread implementation. We present the findings of a targeted scale-up of 3HP among children and adolescents living with HIV (CALHIV) and child household contacts (>2 to <6 years) of pulmonary TB patients (CHHC).Methods: Between December 2021 and July 2023, eligible CALHIV and CHHC participants were given weekly dosages of 3HP for 3 months at antiretroviral therapy (ART) and TB clinics, respectively, of a public hospital in Pune, India.Results: Of 97 children screened, 91 initiated 3HP (32 CALHIV and 59 CHHC). The median age of CALHIV was 14 years; 66% were male and on dolutegravir-based ART. The median age of CHHC was 4 years; 47% were males. Thirty-one (97%) CALHIV and 56 (95%) CHHC completed 3HP without dolutegravir dose adjustment. None of the child participants discontinued 3HP due to adverse events. No child participant developed TB during 1 year of follow-up post-3HP.Conclusion: Our study provides evidence of the uptake and feasibility of the planned nationwide rollout of 3HP.","PeriodicalId":519984,"journal":{"name":"IJTLD open","volume":"1 9","pages":"413-417"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142306121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0