{"title":"Which Has a Superior Dosimetric Profile in Image-guided High-dose-rate Brachytherapy of Cervix - Tandem Ovoid or Tandem Ring Applicator?","authors":"Ramya Rangarajan","doi":"10.4103/jmp.jmp_171_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_171_24","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate and compare the dosimetric performance of tandem ovoid (TO) and tandem ring (TR) applicators in image-guided high-dose-rate intracavitary brachytherapy for cervical cancer.</p><p><strong>Materials and methods: </strong>Computed tomography datasets from 45 cervical cancer patients treated with either TO or TR applicators were analyzed. Dose-volume histograms were generated, and dose parameters for the target and organs at risk (OARs) were recorded for each insertion. Key dosimetric metrics, including doses to points A and B, D90 for the clinical target volume (CTV), and 2cc doses for the bladder, rectum, and sigmoid, were compared between the two applicator groups.</p><p><strong>Results: </strong>Dosimetric outcomes for target volumes showed no significant differences between TO and TR applicators, with comparable doses to point A (<i>P</i> = 0.12), point B (<i>P</i> = 0.43), and D90 CTV (<i>P</i> = 0.10). Similarly, OAR doses for the bladder (<i>P</i> = 0.10), rectum (<i>P</i> = 0.15), and sigmoid (<i>P</i> = 0.10) were statistically equivalent. However, TR applicators consistently delivered significantly higher doses to vaginal dose points (except anterior 5 mm points), highlighting a notable difference in dose distribution patterns.</p><p><strong>Conclusion: </strong>While both TO and TR applicators achieve similar dosimetric outcomes for the target and major OARs, the TR applicators are associated with significantly higher vaginal dose exposure. This distinction may have clinical implications, particularly for patients at risk of vaginal toxicity, and underscores the importance of applicator selection based on individual patient anatomy and treatment goals.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"55-59"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigating the Effects of Reconstruction Conditions on Image Quality and Radiomic Analysis in Photon-counting Computed Tomography.","authors":"Miyu Ohata, Ryohei Fukui, Yusuke Morimitsu, Daichi Kobayashi, Takatsugu Yamauchi, Noriaki Akagi, Mitsugi Honda, Aiko Hayashi, Koshi Hasegawa, Katsuhiro Kida, Sachiko Goto, Takao Hiraki","doi":"10.4103/jmp.jmp_114_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_114_24","url":null,"abstract":"<p><strong>Introduction: </strong>Photon-counting computed tomography (CT) is equipped with an adaptive iterative reconstruction method called quantum iterative reconstruction (QIR), which allows the intensity to be changed during image reconstruction. It is known that the reconstruction conditions of CT images affect the analysis results when performing radiomic analysis. The aim of this study is to investigate the effect of QIR intensity on image quality and radiomic analysis of renal cell carcinoma (RCC).</p><p><strong>Materials and methods: </strong>The QIR intensities were selected as off, 2 and 4. The image quality evaluation items considered were task-based transfer function (TTF), noise power spectrum (NPS), and low-contrast object specific contrast-to-noise ratio (CNR<sub>LO</sub>). The influence on radiomic analysis was assessed using the discrimination accuracy of clear cell RCC.</p><p><strong>Results: </strong>For image quality evaluation, TTF and NPS values were lower and CNR<sub>LO</sub> values were higher with increasing QIR intensity; for radiomic analysis, sensitivity, specificity, and accuracy were higher with increasing QIR intensity. Principal component analysis and receiver operating characteristics analysis also showed higher values with increasing QIR intensity.</p><p><strong>Conclusion: </strong>It was confirmed that the intensity of the QIR intensity affects both the image quality and the radiomic analysis.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"100-107"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Avinash Kuppa Rao, Manikandan Palanisamy, G V Subrahmanyam, S P Swathi, Tamilarasan Mani
{"title":"Investigation of Radiation Isocenter Accuracy of Linear Accelerator - New Approach of Comprehensive Evaluation of Gantry, Couch, and Collimator Isocenters.","authors":"Avinash Kuppa Rao, Manikandan Palanisamy, G V Subrahmanyam, S P Swathi, Tamilarasan Mani","doi":"10.4103/jmp.jmp_131_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_131_24","url":null,"abstract":"<p><strong>Objective: </strong>For stereotactic machines, recommendations demand stringent localization and precise delivery, as reflected by isocenter verification. Determining and analyzing the radiation isocenter for all clinical combinations of gantry, collimator, and couch are crucial for the quality of radiation therapy delivered. Although several radiation isocenter verification devices exist, there is no time-efficient system available for verifying the combined radiation isocenter. This paper presents a newly patented approach for the combined accuracy verification of the gantry, collimator, and couch radiation isocenter.</p><p><strong>Methods: </strong>The novel combined radiation isocenter verification tool is used to expose a star test pattern on the dosimetric film at various angular combinations of the gantry, collimator, and couch. The exposed dosimetric film was evaluated using Radiochromic.com's standard third-party film analysis software.</p><p><strong>Results: </strong>According to the results, the combined radiation isocenter for unit 1 is 0.74 mm dia (0.37 mm radius), and for unit 2, it is 0.62 mm dia (0.31 mm radius). These results are in good agreement with the requirements for three-dimensional conformal radiotherapy, intensity-modulated radiation therapy, volumetric-modulated arc therapy, stereotactic radiosurgery, and stereotactic body radiotherapy techniques.</p><p><strong>Conclusion: </strong>This combined radiation isocenter verification tool aids in comprehensive evaluation of gantry, couch and collimator isocenters using radiographic film. It is easier to implement and faster to analyse compared to existing techniques, using a PC-based program that minimizes human error and increases measurement accuracy. This new approach can be used for routine quality assurance checks.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"160-163"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of Aperture-based Complexity Metrics and Their Effect on Patient-specific Quality Assurance in Intensity-modulated Radiation Therapy Planning.","authors":"Dinesh Kumar Saroj, Suresh Yadav, Neetu Paliwal, Ravindra Bhagwat Shende, Gaurav Gupta","doi":"10.4103/jmp.jmp_195_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_195_24","url":null,"abstract":"<p><strong>Background: </strong>Identifying plans at risk of patient-specific quality assurance (PSQA) failure through complexity metrics can reduce the workload while maintaining quality. This study evaluates complexity metrics as predictors of PSQA outcomes.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on 192 IMRT plans for head-and-neck cancer. Complexity metrics were calculated using an in-house Python program. PSQA was performed with 3%/2-mm gamma passing rate (GPR) criteria, with plans classified as \"Pass\" (GPR ≥95%) or \"Fail.\" Statistical analyses, including Spearman's correlation and receiver operating characteristic analysis, assessed the metrics' predictive value.</p><p><strong>Results: </strong>Passing plans had an average GPR of 98.64 ± 1.33%, compared to 92.17 ± 2.35% for failing plans. The mean small area segment (MSAS) 5mm metric, with a threshold of 0.085, achieved a true positive rate of 38.17% and a false positive rate of 3.1%. Beam modulation and beam area indices also significantly differed between passing and failing plans.</p><p><strong>Conclusion: </strong>MSAS5 and edge metrics showed strong potential for identifying high-risk plans. These metrics can guide targeted PSQA, improving workflow efficiency without compromising treatment safety.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"46-54"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prabhakar Ramachandran, Darcie Anderson, Zachery Colbert, Daniel Arrington, Michael Huo, Mark B Pinkham, Matthew Foote, Andrew Fielding
{"title":"Enhancing Gamma Knife Cone-beam Computed Tomography Image Quality Using Pix2pix Generative Adversarial Networks: A Deep Learning Approach.","authors":"Prabhakar Ramachandran, Darcie Anderson, Zachery Colbert, Daniel Arrington, Michael Huo, Mark B Pinkham, Matthew Foote, Andrew Fielding","doi":"10.4103/jmp.jmp_140_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_140_24","url":null,"abstract":"<p><strong>Aims: </strong>The study aims to develop a modified Pix2Pix convolutional neural network framework to enhance the quality of cone-beam computed tomography (CBCT) images. It also seeks to reduce the Hounsfield unit (HU) variations, making CBCT images closely resemble the internal anatomy as depicted in computed tomography (CT) images.</p><p><strong>Materials and methods: </strong>We used datasets from 50 patients who underwent Gamma Knife treatment to develop a deep learning model that translates CBCT images into high-quality synthetic CT (sCT) images. Paired CBCT and ground truth CT images from 40 patients were used for training and 10 for testing on 7484 slices of 512 × 512 pixels with the Pix2Pix model. The sCT images were evaluated against ground truth CT scans using image quality assessment metrics, including the structural similarity index (SSIM), mean absolute error (MAE), root mean square error (RMSE), peak signal-to-noise ratio (PSNR), normalized cross-correlation, and dice similarity coefficient.</p><p><strong>Results: </strong>The results demonstrate significant improvements in image quality when comparing sCT images to CBCT, with SSIM increasing from 0.85 ± 0.05 to 0.95 ± 0.03 and MAE dropping from 77.37 ± 20.05 to 18.81 ± 7.22 (<i>p</i> < 0.0001 for both). PSNR and RMSE also improved, from 26.50 ± 1.72 to 30.76 ± 2.23 and 228.52 ± 53.76 to 82.30 ± 23.81, respectively (<i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>The sCT images show reduced noise and artifacts, closely matching CT in HU values, and demonstrate a high degree of similarity to CT images, highlighting the potential of deep learning to significantly improve CBCT image quality for radiosurgery applications.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"30-37"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dosimetric Evaluation of Three-dimensional Conformal Radiotherapy, RapidArc, and Hybrid RapidArc Radiotherapy Techniques for Left-sided Breast Cancer.","authors":"Atul Mishra, Neha Yadav, Madhu Sharma, Kailash Kumar Mittal, Surendra Prasad Mishra, Teerth Raj Verma, Shilpa Tiwari","doi":"10.4103/jmp.jmp_108_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_108_24","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the irradiation techniques-three-dimensional conformal radiotherapy (3DCRT), RapidArc (RArc), and hybrid RapidArc (h-RArc)-for left-sided breast cancer patients, focusing on dose distribution in the planning target volume (PTV) and organs at risks (OARs).</p><p><strong>Materials and methods: </strong>This study enrolled 20 patients diagnosed with early-stage left-sided breast cancer. All patients received a prescribed dose of 40.05 Gy in 15 fractions (2.67 Gy per fraction), optimized to achieve 95% dose coverage to 95% of the PTV. The dosimetric variations across the three treatment plans for the 20 patients were examined using a one-way ANOVA test. <i>P</i> <0.05 was regarded as statistically significant.</p><p><strong>Results: </strong>In the 3DRCT plan, D95% of the PTV was 37.21 ± 0.51 Gy. This value was significantly increased to 39.43 ± 0.27 Gy in the RArc plan (<i>P</i> = 0.001) and to 38.47 ± 0.19 Gy in the h-RArc plan (<i>P</i> = 0.630). The RArc plans demonstrated a superior homogeneity index of 0.12 ± 0.02 compared to both 3DCRT (0.18 ± 0.02) and h-RArc (0.13 ± 0.02). When comparing the increase in monitor units (MUs), h-RArc showed a 62.82% increase over 3D-CRT, whereas demonstrating a 38.05% decrease compared to RArc (<i>P</i> = 0.000).</p><p><strong>Conclusions: </strong>h-RArc treatment plans for breast cancer may be recommended due to their superior and consistent PTV dose coverage and sparing of OARs, in comparison to both 3DRCT and RArc plans. These h-RArc plans are characterized by reduced MU and beam on time, as well as a less low volume dose when compared to RArc plans.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"93-99"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commissioning of a Commercial Secondary Dose Check Software and Clinical Implementation for the Magnetic Resonance-guided Linear Accelerator Adaptive Workflow.","authors":"José Alejandro Rojas-López, Alexis Cabrera-Santiago, Jorge Ramiro Corral-Beltrán, Albin Ariel García-Andino","doi":"10.4103/jmp.jmp_150_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_150_24","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to report the commissioning the secondary dose calculation software ThinkQA (TQA) for an magnetic resonance-guided linear accelerator (MR-linac).</p><p><strong>Methods: </strong>The Medical Physics Practice Guideline 5.a. (MPPG5a) tests, and dose in inhomogeneities, beam profiles, and depth dose curves were calculated and compared between Monaco and TQA. Five intensity modulated radiotherapy (IMRT) plans (anal, abdominal, head and neck, prostate, and lung), based on TG-244 guidelines were evaluated varying the gamma criteria. Furthermore, the initial and adapted plans for the first session for 17 patients in different anatomical regions were calculated in TQA using different gamma criteria. For five patients, six measurements were made at different fractions using ArcCheck and compared with TQA.</p><p><strong>Results: </strong>The majority of tests met the tolerances defined in the MPPG5a with the exception of dose profiles (>10%), and large multileaf collimator-shaped fields with extensive blocking (>2%). For the IMRT plans, tight criteria such as 2%/2 mm may not be suitable for all scenarios. Thus, we adopt a reasonable 3%/2 mm without compromising the quality of the plan that included significant high-to-low-density interfaces. It is observed that, the values obtained for clinical cases are in the range from 94.6% to 99.8% (TQA), 97.0% to 99.6% (ArcCheck), except in a prostate case with 87.8% (TQA) and 99.3% (ArcCheck).</p><p><strong>Conclusion: </strong>We commissioned TQA as a secondary dose calculation for MR-linac and we introduced it clinically for adaptive treatment workflow using 3%/2 mm with 95% as tolerance limit and 90% as action limit.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"20-29"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karthikeyan Srinivasan, Sureka Chandrasekaran Sekaran, Suresh Thangavelu, M S Belliappa
{"title":"Dosimetric Impact of AAA and AXB Dose Calculation Algorithm in VMAT Treatment Planning for Rectal Tumors.","authors":"Karthikeyan Srinivasan, Sureka Chandrasekaran Sekaran, Suresh Thangavelu, M S Belliappa","doi":"10.4103/jmp.jmp_147_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_147_24","url":null,"abstract":"<p><strong>Aim: </strong>The study aims to compare the accuracy of Anisotropic Analytical Algorithm (AAA) and acuros XB (AXB) dose calculation algorithms for radiotherapy (RT) planning of rectal tumors.</p><p><strong>Materials and methods: </strong>Treatment plans from 20 patients with previously treated rectal cancer were retrospectively analyzed. All patients underwent VMAT treatment planning using the AAA algorithm in Eclipse (v15.6) system. These plans were recalculated with AXB in Eclipse (v15.6) while maintaining the original multileaf collimator fluence. Dosimetric parameters and gamma analysis (3%/3 mm and 2%/2 mm criteria) were compared between the two algorithms. A paired two-tailed <i>t</i>-test was used to statistically compare dosimetric and gamma analysis results between the AAA and AXB algorithms.</p><p><strong>Results: </strong>The results indicate that AAA could be potentially overestimating the dose to planning target volume (PTV). While the mean bowel dose was marginally lower in AAA plans (<i>P</i> = 0.013), doses to other organs at risk (OARs) were slightly higher, suggesting a general overestimation trend. This implies that AAA could be potentially overestimating the dose to OARs and PTV as compared to AXB. The statistical analysis of the Gamma parameters also shows a significant change.</p><p><strong>Conclusion: </strong>The results indicate that the dose calculation accuracy of AXB is superior to AAA for rectal cancer RT.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"86-92"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fara Farisa Dhaifina, Raushan Fikr Ilham Ibrahim, Hanendya Disha Randy Raharja, Lukmanda Evan Lubis
{"title":"Practical <i>In situ</i> Calibration for Dose-area Product Meter in Interventional Fluoroscopy: Beam-area Method.","authors":"Fara Farisa Dhaifina, Raushan Fikr Ilham Ibrahim, Hanendya Disha Randy Raharja, Lukmanda Evan Lubis","doi":"10.4103/jmp.jmp_172_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_172_24","url":null,"abstract":"<p><p>The radiation dosimetry used to measure the ionizing radiation dose delivered during X-ray imaging procedures in planar radiography units, especially in fluoroscopy, is the dose-area product (DAP). DAP is used as the primary parameter for recording diagnostic reference levels, which are guidance values for optimizing patient radiation dose. DAP is reported by the system's DAP meter, which needs to be calibrated appropriately. This study evaluates the influence of dosimeters and field markers on the accuracy of DAP levels in the DAP meter <i>in situ</i> calibration method. The aim of this study is to recommend a combination of dosimeter types and field markers with the highest accuracy for the beam-area method. Two methods of DAP meter <i>in situ</i> calibration were compared: the tandem method with a reference DAP meter as the reference DA<i>P</i> value and the beam-area method using ion chamber dosimeters, solid-state dosimeters, as well as field markers from digital radiography (DR) and computed radiography. This method was applied to the DAP meter in the Allura XPER FD 20 angiography (Philips, Amsterdam, the Netherlands) unit. The results showed that the combination of ion chamber dosimeter and DR field markers at a distance of 55 cm produced the most accurate DA<i>P</i> values (lowest root mean square error value, 0.10). The recommended calibration method can be used to confirm the actual DA<i>P</i> value in X-ray imaging in a planar radiography unit.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"167-172"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the Mini-ridge Filter's Impact on the Generation of Secondary Radiation in Synchrotron-based Proton Beam Therapy.","authors":"Takahiro Shimo, Shintaro Shiba, Hiroyuki Watanabe, Masashi Yamanaka, Kazuki Matsumoto, Akihiro Yamano, Kohichi Tokuuye","doi":"10.4103/jmp.jmp_206_24","DOIUrl":"https://doi.org/10.4103/jmp.jmp_206_24","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated whether the mini-ridge filter (MRF) used for beam energy optimization in a synchrotron-based proton beam therapy (PBT) affects the generation of secondary neutrons and photons.</p><p><strong>Materials and methods: </strong>Secondary radiation from the PBT was evaluated using a Monte Carlo simulation (MCS) with the Particle and Heavy-ion Transport code System (version 3.31), and the PROBEAT-M1 system (Hitachi, Japan) was modeled. In the analysis, we focused on the production of neutrons and photons in a 35 cm ×35 cm ×35 cm water phantom with and without MRF to ensure the accuracy of the dose calculation.</p><p><strong>Results: </strong>The MCS results were in good agreement with the measurement results, and the off-axis ratio at the center of the spread-out Bragg peak was 100% at a gamma analysis pass rate of 2 mm/2%. The photon fluence decreased by 4.0 and 0.9% at 70.2 and 228.7 MeV, respectively, but no significant effect on total neutron and photon production was observed (<i>P</i> > 0.05). The MRF effect on the dose was <0.11 μGy Gy<sup>-1</sup>, suggesting that a clinically significant effect is negligible.</p><p><strong>Conclusions: </strong>These results demonstrated that MRF had a limited effect on the generation of secondary radiation in PBT. MRF, which is used to improve dose distribution, has the potential to be safely used without increasing secondary radiation, and MRF might not affected to generate secondary radiation to clinically meaningful levels.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"14-19"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}