Karthikeyan Srinivasan, Sureka Chandrasekaran Sekaran, Suresh Thangavelu, M S Belliappa
{"title":"AAA和AXB剂量计算算法在直肠肿瘤VMAT治疗计划中的剂量学影响。","authors":"Karthikeyan Srinivasan, Sureka Chandrasekaran Sekaran, Suresh Thangavelu, M S Belliappa","doi":"10.4103/jmp.jmp_147_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>The study aims to compare the accuracy of Anisotropic Analytical Algorithm (AAA) and acuros XB (AXB) dose calculation algorithms for radiotherapy (RT) planning of rectal tumors.</p><p><strong>Materials and methods: </strong>Treatment plans from 20 patients with previously treated rectal cancer were retrospectively analyzed. All patients underwent VMAT treatment planning using the AAA algorithm in Eclipse (v15.6) system. These plans were recalculated with AXB in Eclipse (v15.6) while maintaining the original multileaf collimator fluence. Dosimetric parameters and gamma analysis (3%/3 mm and 2%/2 mm criteria) were compared between the two algorithms. A paired two-tailed <i>t</i>-test was used to statistically compare dosimetric and gamma analysis results between the AAA and AXB algorithms.</p><p><strong>Results: </strong>The results indicate that AAA could be potentially overestimating the dose to planning target volume (PTV). While the mean bowel dose was marginally lower in AAA plans (<i>P</i> = 0.013), doses to other organs at risk (OARs) were slightly higher, suggesting a general overestimation trend. This implies that AAA could be potentially overestimating the dose to OARs and PTV as compared to AXB. The statistical analysis of the Gamma parameters also shows a significant change.</p><p><strong>Conclusion: </strong>The results indicate that the dose calculation accuracy of AXB is superior to AAA for rectal cancer RT.</p>","PeriodicalId":51719,"journal":{"name":"Journal of Medical Physics","volume":"50 1","pages":"86-92"},"PeriodicalIF":0.7000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005649/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dosimetric Impact of AAA and AXB Dose Calculation Algorithm in VMAT Treatment Planning for Rectal Tumors.\",\"authors\":\"Karthikeyan Srinivasan, Sureka Chandrasekaran Sekaran, Suresh Thangavelu, M S Belliappa\",\"doi\":\"10.4103/jmp.jmp_147_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>The study aims to compare the accuracy of Anisotropic Analytical Algorithm (AAA) and acuros XB (AXB) dose calculation algorithms for radiotherapy (RT) planning of rectal tumors.</p><p><strong>Materials and methods: </strong>Treatment plans from 20 patients with previously treated rectal cancer were retrospectively analyzed. All patients underwent VMAT treatment planning using the AAA algorithm in Eclipse (v15.6) system. These plans were recalculated with AXB in Eclipse (v15.6) while maintaining the original multileaf collimator fluence. Dosimetric parameters and gamma analysis (3%/3 mm and 2%/2 mm criteria) were compared between the two algorithms. A paired two-tailed <i>t</i>-test was used to statistically compare dosimetric and gamma analysis results between the AAA and AXB algorithms.</p><p><strong>Results: </strong>The results indicate that AAA could be potentially overestimating the dose to planning target volume (PTV). While the mean bowel dose was marginally lower in AAA plans (<i>P</i> = 0.013), doses to other organs at risk (OARs) were slightly higher, suggesting a general overestimation trend. This implies that AAA could be potentially overestimating the dose to OARs and PTV as compared to AXB. The statistical analysis of the Gamma parameters also shows a significant change.</p><p><strong>Conclusion: </strong>The results indicate that the dose calculation accuracy of AXB is superior to AAA for rectal cancer RT.</p>\",\"PeriodicalId\":51719,\"journal\":{\"name\":\"Journal of Medical Physics\",\"volume\":\"50 1\",\"pages\":\"86-92\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005649/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Physics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jmp.jmp_147_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Physics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jmp.jmp_147_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/24 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Dosimetric Impact of AAA and AXB Dose Calculation Algorithm in VMAT Treatment Planning for Rectal Tumors.
Aim: The study aims to compare the accuracy of Anisotropic Analytical Algorithm (AAA) and acuros XB (AXB) dose calculation algorithms for radiotherapy (RT) planning of rectal tumors.
Materials and methods: Treatment plans from 20 patients with previously treated rectal cancer were retrospectively analyzed. All patients underwent VMAT treatment planning using the AAA algorithm in Eclipse (v15.6) system. These plans were recalculated with AXB in Eclipse (v15.6) while maintaining the original multileaf collimator fluence. Dosimetric parameters and gamma analysis (3%/3 mm and 2%/2 mm criteria) were compared between the two algorithms. A paired two-tailed t-test was used to statistically compare dosimetric and gamma analysis results between the AAA and AXB algorithms.
Results: The results indicate that AAA could be potentially overestimating the dose to planning target volume (PTV). While the mean bowel dose was marginally lower in AAA plans (P = 0.013), doses to other organs at risk (OARs) were slightly higher, suggesting a general overestimation trend. This implies that AAA could be potentially overestimating the dose to OARs and PTV as compared to AXB. The statistical analysis of the Gamma parameters also shows a significant change.
Conclusion: The results indicate that the dose calculation accuracy of AXB is superior to AAA for rectal cancer RT.
期刊介绍：
JOURNAL OF MEDICAL PHYSICS is the official journal of Association of Medical Physicists of India (AMPI). The association has been bringing out a quarterly publication since 1976. Till the end of 1993, it was known as Medical Physics Bulletin, which then became Journal of Medical Physics. The main objective of the Journal is to serve as a vehicle of communication to highlight all aspects of the practice of medical radiation physics. The areas covered include all aspects of the application of radiation physics to biological sciences, radiotherapy, radiodiagnosis, nuclear medicine, dosimetry and radiation protection. Papers / manuscripts dealing with the aspects of physics related to cancer therapy / radiobiology also fall within the scope of the journal.
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