Which Has a Superior Dosimetric Profile in Image-guided High-dose-rate Brachytherapy of Cervix - Tandem Ovoid or Tandem Ring Applicator?

IF 0.7 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal of Medical Physics Pub Date : 2025-01-01 Epub Date: 2025-03-07 DOI:10.4103/jmp.jmp_171_24
Ramya Rangarajan
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引用次数: 0

Abstract

Objective: This study aims to evaluate and compare the dosimetric performance of tandem ovoid (TO) and tandem ring (TR) applicators in image-guided high-dose-rate intracavitary brachytherapy for cervical cancer.

Materials and methods: Computed tomography datasets from 45 cervical cancer patients treated with either TO or TR applicators were analyzed. Dose-volume histograms were generated, and dose parameters for the target and organs at risk (OARs) were recorded for each insertion. Key dosimetric metrics, including doses to points A and B, D90 for the clinical target volume (CTV), and 2cc doses for the bladder, rectum, and sigmoid, were compared between the two applicator groups.

Results: Dosimetric outcomes for target volumes showed no significant differences between TO and TR applicators, with comparable doses to point A (P = 0.12), point B (P = 0.43), and D90 CTV (P = 0.10). Similarly, OAR doses for the bladder (P = 0.10), rectum (P = 0.15), and sigmoid (P = 0.10) were statistically equivalent. However, TR applicators consistently delivered significantly higher doses to vaginal dose points (except anterior 5 mm points), highlighting a notable difference in dose distribution patterns.

Conclusion: While both TO and TR applicators achieve similar dosimetric outcomes for the target and major OARs, the TR applicators are associated with significantly higher vaginal dose exposure. This distinction may have clinical implications, particularly for patients at risk of vaginal toxicity, and underscores the importance of applicator selection based on individual patient anatomy and treatment goals.

在图像引导下的高剂量率宫颈近距离放射治疗中,哪个具有更好的剂量学特征——串联卵形器还是串联环形器?
目的:评价和比较双卵圆器(to)和双环器(TR)在图像引导下高剂量率腔内宫颈癌近距离放疗中的剂量学性能。材料和方法:对45例宫颈癌患者的ct数据集进行分析。生成剂量-体积直方图,记录每次插入时靶器官和危险器官(OARs)的剂量参数。关键剂量学指标,包括A点和B点的剂量,临床靶体积(CTV)的D90,膀胱、直肠和乙状结肠的2cc剂量,在两个应用器组之间进行比较。结果:靶体积的剂量学结果显示,TO和TR涂抹器之间没有显著差异,A点(P = 0.12)、B点(P = 0.43)和D90 CTV (P = 0.10)的剂量相当。同样,膀胱(P = 0.10)、直肠(P = 0.15)和乙状结肠(P = 0.10)的OAR剂量在统计学上是相等的。然而,TR涂抹器始终向阴道剂量点(除了前5 mm点)提供显著更高的剂量,突出了剂量分布模式的显着差异。结论:虽然TO和TR涂抹器对目标和主要OARs的剂量学结果相似,但TR涂抹器与阴道剂量暴露明显较高相关。这种区别可能具有临床意义,特别是对于有阴道毒性风险的患者,并强调了基于个体患者解剖结构和治疗目标选择涂抹器的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Medical Physics
Journal of Medical Physics RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.10
自引率
11.10%
发文量
55
审稿时长
30 weeks
期刊介绍: JOURNAL OF MEDICAL PHYSICS is the official journal of Association of Medical Physicists of India (AMPI). The association has been bringing out a quarterly publication since 1976. Till the end of 1993, it was known as Medical Physics Bulletin, which then became Journal of Medical Physics. The main objective of the Journal is to serve as a vehicle of communication to highlight all aspects of the practice of medical radiation physics. The areas covered include all aspects of the application of radiation physics to biological sciences, radiotherapy, radiodiagnosis, nuclear medicine, dosimetry and radiation protection. Papers / manuscripts dealing with the aspects of physics related to cancer therapy / radiobiology also fall within the scope of the journal.
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