Dosimetric Impact of AAA and AXB Dose Calculation Algorithm in VMAT Treatment Planning for Rectal Tumors.

IF 0.7 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Medical Physics Pub Date : 2025-01-01 Epub Date: 2025-02-24 DOI:10.4103/jmp.jmp_147_24

Karthikeyan Srinivasan, Sureka Chandrasekaran Sekaran, Suresh Thangavelu, M S Belliappa

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引用次数: 0

Abstract

Aim: The study aims to compare the accuracy of Anisotropic Analytical Algorithm (AAA) and acuros XB (AXB) dose calculation algorithms for radiotherapy (RT) planning of rectal tumors.

Materials and methods: Treatment plans from 20 patients with previously treated rectal cancer were retrospectively analyzed. All patients underwent VMAT treatment planning using the AAA algorithm in Eclipse (v15.6) system. These plans were recalculated with AXB in Eclipse (v15.6) while maintaining the original multileaf collimator fluence. Dosimetric parameters and gamma analysis (3%/3 mm and 2%/2 mm criteria) were compared between the two algorithms. A paired two-tailed t-test was used to statistically compare dosimetric and gamma analysis results between the AAA and AXB algorithms.

Results: The results indicate that AAA could be potentially overestimating the dose to planning target volume (PTV). While the mean bowel dose was marginally lower in AAA plans (P = 0.013), doses to other organs at risk (OARs) were slightly higher, suggesting a general overestimation trend. This implies that AAA could be potentially overestimating the dose to OARs and PTV as compared to AXB. The statistical analysis of the Gamma parameters also shows a significant change.

Conclusion: The results indicate that the dose calculation accuracy of AXB is superior to AAA for rectal cancer RT.

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AAA和AXB剂量计算算法在直肠肿瘤VMAT治疗计划中的剂量学影响。

目的：比较各向异性分析算法（AAA）和acros XB （AXB）剂量计算算法在直肠肿瘤放疗（RT）规划中的准确性。材料与方法：回顾性分析20例直肠癌患者的治疗方案。所有患者在Eclipse （v15.6）系统中采用AAA算法进行VMAT治疗计划。在Eclipse （v15.6）中使用AXB重新计算这些计划，同时保持原始的多叶准直器影响。比较两种算法的剂量学参数和γ分析（3%/ 3mm和2%/ 2mm标准）。采用配对双尾t检验对AAA和AXB算法的剂量学和伽马分析结果进行统计学比较。结果：结果表明，AAA可能存在对计划靶体积（PTV）剂量的潜在高估。虽然AAA计划的平均肠道剂量略低（P = 0.013），但其他危险器官（OARs）的剂量略高，表明普遍高估的趋势。这意味着与AXB相比，AAA可能潜在地高估了OARs和PTV的剂量。伽玛参数的统计分析也显示出显著的变化。结论：AXB在直肠癌放疗中的剂量计算精度优于AAA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Physics RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.10

自引率

11.10%

发文量

审稿时长

30 weeks

期刊介绍： JOURNAL OF MEDICAL PHYSICS is the official journal of Association of Medical Physicists of India (AMPI). The association has been bringing out a quarterly publication since 1976. Till the end of 1993, it was known as Medical Physics Bulletin, which then became Journal of Medical Physics. The main objective of the Journal is to serve as a vehicle of communication to highlight all aspects of the practice of medical radiation physics. The areas covered include all aspects of the application of radiation physics to biological sciences, radiotherapy, radiodiagnosis, nuclear medicine, dosimetry and radiation protection. Papers / manuscripts dealing with the aspects of physics related to cancer therapy / radiobiology also fall within the scope of the journal.