Obstetric Medicine最新文献_第5页

The association of plasma pancreastatin levels with insulin resistance in patients with gestational diabetes mellitus 妊娠糖尿病患者血浆胰高血糖素水平与胰岛素抵抗的关系

IF 0.7

Obstetric Medicine Pub Date : 2023-11-19 DOI: 10.1177/1753495x231216032

Gokcen Unal Kocabas, Ilgın Yıldırım Şimşir, Banu Sarer Yurekli, Asli Suner Karakulah, Burak Durmaz, Esma Pehlivan Koroglu, S. Yeral, Busra Ozcan, Ali Akdemir

{"title":"The association of plasma pancreastatin levels with insulin resistance in patients with gestational diabetes mellitus","authors":"Gokcen Unal Kocabas, Ilgın Yıldırım Şimşir, Banu Sarer Yurekli, Asli Suner Karakulah, Burak Durmaz, Esma Pehlivan Koroglu, S. Yeral, Busra Ozcan, Ali Akdemir","doi":"10.1177/1753495x231216032","DOIUrl":"https://doi.org/10.1177/1753495x231216032","url":null,"abstract":"Gestational diabetes mellitus (GDM) occurs on the background of increased insulin resistance. We aimed to investigate the levels of plasma pancreastatin (PST) levels and its association with metabolic, demographic, and anthropometric parameters in gestational diabetic and normal glucose-tolerant pregnant women. A total of 165 pregnant women in the 24th–28th week of pregnancy were enrolled in this cross-sectional study. PST levels were measured using ELISA method. Median PST levels were similar between GDM (n = 62, 37.6%) and normal glucose-tolerant control group (n = 103, 62.4%). In the GDM group, PST level showed a significant positive correlation with fasting insulin and the homeostasis model assessment of insulin resistance (HOMA-IR). In binary logistic regression analysis, PST levels did not predict the presence of GDM significantly. Positive correlation of PST with fasting insulin and HOMA-IR suggests that PST could be associated with insulin resistance. Further studies are needed as regards to the role of PST in GDM pathogenesis.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"110 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139260736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventability of stroke during pregnancy and postpartum 孕期和产后中风的可预防性

IF 0.7

Obstetric Medicine Pub Date : 2023-11-17 DOI: 10.1177/1753495x231213437

Jia Jennifer Ding, S. Mitta, Martha B. Kole-White, Julie Roth, I. Malhamé

引用次数: 0

Generalized lichen amyloidosis in a pregnant woman: Coincidence or association 孕妇全身性苔藓淀粉样变性：巧合还是关联

IF 0.7

Obstetric Medicine Pub Date : 2023-11-14 DOI: 10.1177/1753495x231214820

Phyo Zaw Aung, T. Nararatwanchai

引用次数: 0

The impact of socioeconomic deprivation on the prevalence of gestational diabetes: An observational study 社会经济贫困对妊娠糖尿病发病率的影响：观察研究

IF 0.7

Obstetric Medicine Pub Date : 2023-11-14 DOI: 10.1177/1753495x231213920

Sai Gnanasambanthan, Salma Jabak, Retika Mohan, Nawal Dayoub, Chiamaka Maduanusi, Shuchi Kohli, Tabea Haas-Heger, Calum Lynch, Aisha Hameed

{"title":"The impact of socioeconomic deprivation on the prevalence of gestational diabetes: An observational study","authors":"Sai Gnanasambanthan, Salma Jabak, Retika Mohan, Nawal Dayoub, Chiamaka Maduanusi, Shuchi Kohli, Tabea Haas-Heger, Calum Lynch, Aisha Hameed","doi":"10.1177/1753495x231213920","DOIUrl":"https://doi.org/10.1177/1753495x231213920","url":null,"abstract":"Approximately 3.5% of pregnancies in the United Kingdom are complicated by gestational diabetes mellitus (GDM). Risk factors for this mirror those contributing to type 2 diabetes (T2DM). Though socioeconomic status (SES) is presumed to contribute to GDM, evidence in the United Kingdom is limited. In this unique study, we explored the impact of SES on GDM prevalence in a London suburb population. Four thousand one hundred and sixty-three pregnant women who booked between July 2018 and March 2020 at Princess Royal University Hospital were retrospectively analyzed. Associations between GDM prevalence and SES trends (using multiple deprivation deciles (MDD)), and body mass index (BMI), age, ethnicity, screening uptake, birth-weights and birth outcomes, were analyzed. Patients with BMI >30 kg/m2, older than 35 years, and non-Caucasian ethnicity have an increased risk of developing GDM ( p < 0.0001, p < 0.0001, p < 0.0001, respectively). No association existed between MDD and GDM prevalence ( p-values over 0.05). Patients with risk factors for GDM were highest in the deprived areas p < 0.0001. MDD 1–4 (most deprived) had the highest percentage of missed screening (15% of patients with risk factors missed screening), compared to 8% in the least deprived group ( p < 0.0001). Our data surprisingly suggest that low SES did not increase the incidence of GDM, despite a higher proportion of women with risk factors for GDM living in the most deprived postcodes. However this unclear finding may be due to low screening uptake of deprived populations, and therefore lack of GDM diagnosis, or indicate that GDM is a result of a different aetiology to T2DM. Further research is needed to explore if access to screening services, lack of health education or other health inequalities were responsible for the high proportion of missed screening opportunities in deprived areas.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"21 6","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139277502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postpartum cardiogenic shock with rapid recovery in a Titin gene variant: The role of genetic predisposition in peripartum cardiomyopathy 产后心源性休克与快速恢复的Titin基因变异:遗传易感性在围产期心肌病中的作用

Obstetric Medicine Pub Date : 2023-11-13 DOI: 10.1177/1753495x231214379

Eva Karner, Hans Keller, Lilian Schäffl-Doweik, Franco Laccone, Claudia Stöllberger

{"title":"Postpartum cardiogenic shock with rapid recovery in a Titin gene variant: The role of genetic predisposition in peripartum cardiomyopathy","authors":"Eva Karner, Hans Keller, Lilian Schäffl-Doweik, Franco Laccone, Claudia Stöllberger","doi":"10.1177/1753495x231214379","DOIUrl":"https://doi.org/10.1177/1753495x231214379","url":null,"abstract":"Peripartum cardiomyopathy is defined as heart failure secondary to left ventricular (LV) dysfunction with a left ventricular ejection fraction <45% occurring towards the end of pregnancy or in the months following delivery without other identifiable cause. Pathogenesis of peripartum cardiomyopathy and the role of genetic variants are unknown. We present a previously healthy 33-year-old woman in her first pregnancy with acute onset of heart failure postpartum. She developed cardiogenic shock four days after caesarean section and was treated with levosimendan, cabergoline, ramipril and bisoprolol. She used a wearable cardioverter/defibrillator for 3 months. After 8 months, she was free of symptoms with normal left ventricular function and brain-natriuretic-peptide-levels. Genetic analysis was carried out due to a positive family history and disclosed a heterozygous variant c7627dupA in the TTN gene. Genetic analysis in patients with a positive family history should be carried out since that may provide insights in the pathogenesis of heart failure due to systolic dysfunction including peripartum cardiomyopathy.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"128 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postpartum diagnosis and management of pulmonary arterial hypertension 肺动脉高压的产后诊断与处理

Obstetric Medicine Pub Date : 2023-10-30 DOI: 10.1177/1753495x231207436

Micaela J Tobin, Gianna L Wilkie, Alejandro Folch, Margaret M Cabral, Theo E Meyer, Lara C Kovell

引用次数: 0

Late pregnancy in women with renal transplants: A multidisciplinary guide 肾移植后晚期妊娠:多学科指南

Obstetric Medicine Pub Date : 2023-10-26 DOI: 10.1177/1753495x231209647

Carmen Mallett, Rachel Scale, Yavor Metodiev, Aamna Ali, Helen Thomas, Usman Khalid, Sian Griffin

引用次数: 0

Thalassemia screening by third-generation sequencing: Pilot study in a Thai population 通过第三代测序筛查地中海贫血:在泰国人群中的试点研究

Obstetric Medicine Pub Date : 2023-10-26 DOI: 10.1177/1753495x231207676

Kuntharee Traisrisilp, Yu Zheng, Kwong Wai Choy, Pimlak Chareonkwan

引用次数: 0

Report of the ISTH registry on pregnancy and COVID-19-associated coagulopathy (COV-PREG-COAG) ISTH妊娠和covid -19相关凝血功能(COV-PREG-COAG)登记报告

Obstetric Medicine Pub Date : 2023-10-16 DOI: 10.1177/1753495x231206931

Sajida Kazi, Maha Othman, Rasha Khoury, Peter S Bernstein, Jecko Thachil, Etienne Ciantar, Laura Ferrara, Manju Netto, Rezan Abdul-Kadir, A Kinga Malinowski

{"title":"Report of the ISTH registry on pregnancy and COVID-19-associated coagulopathy (COV-PREG-COAG)","authors":"Sajida Kazi, Maha Othman, Rasha Khoury, Peter S Bernstein, Jecko Thachil, Etienne Ciantar, Laura Ferrara, Manju Netto, Rezan Abdul-Kadir, A Kinga Malinowski","doi":"10.1177/1753495x231206931","DOIUrl":"https://doi.org/10.1177/1753495x231206931","url":null,"abstract":"Background Concerns about COVID-19-associated coagulopathy (CAC) in pregnant individuals were raised in early pandemic. Methods An ISTH-sponsored COVID-19 coagulopathy in pregnancy (COV-PREG-COAG) international registry was developed to describe incidence of coagulopathy, VTE, and anticoagulation in this group. Results All pregnant patients with COVID-19 from participating centers were entered, providing 430 pregnancies for the first pandemic wave. Isolated abnormal coagulation parameters were seen in 20%; more often with moderate/severe disease than asymptomatic/mild disease (49% vs 15%; p < 0.0001). No one met the ISTH criteria for DIC, though 5/21 (24%) met the pregnancy DIC score. There was no difference in APH with asymptomatic/mild disease versus moderate/severe disease (3.4% vs 7.7%; p = 0.135). More individuals with moderate/severe disease experienced PPH (22.4% vs 9.3%; p = 0.006). There were no arterial thrombotic events. Only one COVID-associated VTE was reported. Conclusions Low rates of coagulopathy, bleeding, and thrombosis were observed among pregnant people in the first pandemic wave.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136078840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating gastrointestinal disorders in pregnancy 调查妊娠期胃肠道疾病

Obstetric Medicine Pub Date : 2023-10-16 DOI: 10.1177/1753495x231206211

Adam Morton

引用次数: 0