Holy Bezanahary, Jonathan Thiolon, François Dalmay, Jean-Luc Eyraud, Baher Youssef, Yves Aubard, Philippe Lacroix, Lucie Chastaingt, Perrine Coste-Mazeau
{"title":"ABO blood group and risk of pre-eclampsia. A case-control study.","authors":"Holy Bezanahary, Jonathan Thiolon, François Dalmay, Jean-Luc Eyraud, Baher Youssef, Yves Aubard, Philippe Lacroix, Lucie Chastaingt, Perrine Coste-Mazeau","doi":"10.1177/1753495X251333629","DOIUrl":"https://doi.org/10.1177/1753495X251333629","url":null,"abstract":"<p><strong>Background: </strong>It appears that some ABO blood groups may be a risk factor for venous thrombosis. The association between ABO group and risk of pre-eclampsia remains controversial. The purpose of this study was to evaluate the relationship between pre-eclampsia and ABO groups.</p><p><strong>Methods: </strong>A retrospective case-control (1:2) study in a prospective monocentric registry including 20171 pregnancies was performed. Women with pre-eclampsia and severe pre-eclampsia were identified. Controls were matched according to age, parity, year of delivery and body mass index. Blood groups were considered.</p><p><strong>Results: </strong>Two hundred fifty-three cases and 506 controls were included. No difference in distribution was found between cases and controls for non-O group (57.51% vs 62.56, <i>p</i>: 0.19), group A (39.92% vs 44.05, <i>p</i>: 0.29), group B (13.83% vs 15.42, <i>p</i>: 0.57) group AB (3.75 vs 3.08, <i>p</i>: 0.64). The analysis extended to severe pre-eclampsia showed no difference.</p><p><strong>Conclusion: </strong>This study did not document any relationship between ABO groups and the risk of preeclampsia.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251333629"},"PeriodicalIF":0.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>GNE</i>-related severe congenital macro-thrombocytopenia in pregnancy.","authors":"Sivaranjani P, Bhabani Pegu, Murali Subbaiah, Pooja D, Prabhu Manivannan, Gowri Dorairajan","doi":"10.1177/1753495X251334520","DOIUrl":"https://doi.org/10.1177/1753495X251334520","url":null,"abstract":"<p><p>Congenital thrombocytopenia results from mutations in genes implicated in megakaryocyte differentiation and/or platelet formation and clearance. We report the case of a 25 year old primigravida who presented with severe macro-thrombocytopenia from the age of 12 years. She delivered an alive female baby at 35 weeks of gestation. She was diagnosed to have <i>GNE</i> gene mutation. <i>GNE</i> gene encodes the key enzyme in sialic acid biosynthesis, glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (<i>GNE</i>/MNK). The mutation is responsible for the reduction in sialic acid biosynthesis and consequently leads to severe congenital thrombocytopenia and/or myopathy. Although no sign of myopathy was observed in this patient; it is possible myopathy can be developed later, thus long-term follow-up with neurology is highly advisable. We recommend the genetic counselling and a segregation analysis of this variant in other affected individuals in the family.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251334520"},"PeriodicalIF":0.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chloe Gilkinson, Hannah Beresford, Carol Postlethwaite, Catherine Nelson-Piercy, Karan Sampat
{"title":"A rare example of humoral-related hypercalcaemia in pregnancy secondary to a uterine fibroid: a case report.","authors":"Chloe Gilkinson, Hannah Beresford, Carol Postlethwaite, Catherine Nelson-Piercy, Karan Sampat","doi":"10.1177/1753495X251326130","DOIUrl":"https://doi.org/10.1177/1753495X251326130","url":null,"abstract":"<p><p>Whilst uncommon in pregnancy, hypercalcaemia can lead to significant maternal and fetal morbidity. An important complication of hypercalcaemia is uncontrolled hypertension. This case outlines an example of refractory hypercalcaemia exacerbating an emerging hypertensive crisis. The proposed aetiology was parathyroid hormone-related protein (PTHrP)-mediated hypercalcaemia secondary to a necrotic uterine fibroid. We highlight how effective and prompt involvement of the Maternal Medicine Network and multidisciplinary team led to a successful pregnancy outcome.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251326130"},"PeriodicalIF":0.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implications of the USAID U-turn on women's health globally.","authors":"Zulfiqar A Bhutta, Stephen Rulisa","doi":"10.1177/1753495X251332669","DOIUrl":"https://doi.org/10.1177/1753495X251332669","url":null,"abstract":"","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251332669"},"PeriodicalIF":0.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel A Gladstone, John W Snelgrove, Kelsey McLaughlin, Sebastian R Hobson, Rory C Windrim, Nir Melamed, Michelle Hladunewich, Sascha Drewlo, John C Kingdom
{"title":"Placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt1): powerful new tools to guide obstetric and medical care in pregnancy.","authors":"Rachel A Gladstone, John W Snelgrove, Kelsey McLaughlin, Sebastian R Hobson, Rory C Windrim, Nir Melamed, Michelle Hladunewich, Sascha Drewlo, John C Kingdom","doi":"10.1177/1753495X251327462","DOIUrl":"10.1177/1753495X251327462","url":null,"abstract":"","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251327462"},"PeriodicalIF":0.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Paz-Ibarra, Marcio Concepción-Zavaleta, Juan Quiroz-Aldave, Julia Coronado-Arroyo
{"title":"Author's response to Letter to the Editor re: Paz-Ilbarra C-ZM et al. A giant parathyroid cyst causing primary hyperparathyroidism in a pregnant woman: Case report and literature review. <i>Obstetric Medicine</i> 2024: 1-6. DOI: https://doi.org/10.1177/1753495X2412492.","authors":"José Paz-Ibarra, Marcio Concepción-Zavaleta, Juan Quiroz-Aldave, Julia Coronado-Arroyo","doi":"10.1177/1753495X251328111","DOIUrl":"10.1177/1753495X251328111","url":null,"abstract":"","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251328111"},"PeriodicalIF":0.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuyun Lisnawati, Budi Haryanto, Sri Pudyastuti, D Cahyarini, P Rinaldi, Agnes Yunie P, Jully Neily Kasie, Rita Rogayah
{"title":"Investigation of the presence of SARS-CoV-2 in the maternal-fetal compartment: Study of pregnant women with confirmed COVID-19 at Persahabatan Hospital, Jakarta.","authors":"Yuyun Lisnawati, Budi Haryanto, Sri Pudyastuti, D Cahyarini, P Rinaldi, Agnes Yunie P, Jully Neily Kasie, Rita Rogayah","doi":"10.1177/1753495X251326458","DOIUrl":"10.1177/1753495X251326458","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in amniotic fluid, umbilical cord blood, both the maternal and fetal sides of placenta, as well as neonatal nasopharyngeal among infants born to mothers with COVID-19.</p><p><strong>Methods: </strong>The inclusion criteria was pregnant women with confirmed COVID-19 who delivered by caesarean section at Persahabatan General Hospital, University of Indonesia, Jakarta, Indonesia, from May 2020 to August 2020. SARS-CoV-2 presence was assessed in vaginal mucus, anal, amniotic fluid, umbilical cord blood, both maternal and fetal sides of placenta, as well as neonatal nasopharynx.</p><p><strong>Results: </strong>During the study period, 24 pregnant women met the criteria. A total of 132 swab samples were obtained from vaginal mucus, anal swab, amniotic fluid, umbilical cord blood, both maternal and fetal sides of placenta, as well as neonatal nasopharynx. Reverse transcription polymerase chain reaction test yielded negative results for SARS-CoV-2 in all samples except one sample from anal.</p><p><strong>Conclusions: </strong>There was no evidence of SARS-CoV-2 in vaginal mucus, anal, amniotic fluid, umbilical cord blood, placenta, and neonatal nasopharyngeal samples. The exception of one positive anal sample, necessitating further investigation.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251326458"},"PeriodicalIF":0.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amniotic fluid embolism: A case-series.","authors":"Sandra Lynn Jaya-Bodestyne, Wei Ching Tan, Devendra Kanagalingam, Tze Tein Yong, Ravichandran Nadarajah, Lay Kok Tan, Liying Yang","doi":"10.1177/1753495X251326125","DOIUrl":"10.1177/1753495X251326125","url":null,"abstract":"<p><p>Amniotic fluid embolism (AFE) is a rare but potentially catastrophic pregnancy complication. This is a 10-year retrospective study on women with AFE from 2014 to 2023. Cases that met Clark's criteria or in whom a clinical diagnosis was made after exclusion of other causes were included. Information on clinical characteristics, treatment, complications and outcomes were collected and analysed. Four cases of AFE were identified. Two met Clark's criteria and presented with cardiac arrest requiring extracorporeal membrane oxygenation, of which one had cognitive and functional impairment. Two women had atypical AFE, one with disseminated intravascular coagulation (DIC)-type AFE who did not survive, and another who had paradoxical intracranial emboli from a patent foramen ovale, who had full recovery. All had coagulopathy and postpartum haemorrhage. Early recognition and initiation of cardiovascular support is crucial in AFE. DIC and haemorrhage should be treated aggressively. Survival and good outcomes of AFE are possible.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251326125"},"PeriodicalIF":0.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica Phillips, Isra Iftikhar, Gargeswari Sunanda, Lisa Jeffs
{"title":"Refractory hypokalaemia and hypertension in pregnancy in a woman with renal artery stenosis.","authors":"Jessica Phillips, Isra Iftikhar, Gargeswari Sunanda, Lisa Jeffs","doi":"10.1177/1753495X251321893","DOIUrl":"https://doi.org/10.1177/1753495X251321893","url":null,"abstract":"<p><p>Renal artery stenosis is rare in pregnancy. Patients generally present with hypertension and/or pre-eclampsia. Accompanying hypokalaemia is usually mild or absent. Our case demonstrates the unusual finding of severe and refractory hypokalaemia together with hypertension in a woman with renal artery stenosis in pregnancy. The differential diagnosis of hypokalaemia with hypertension in pregnancy is discussed.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251321893"},"PeriodicalIF":0.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor re: Paz-Ilbarra C-ZM et al. A giant parathyroid cyst causing primary hyperparathyroidism in a pregnant woman: Case report and literature review. <i>Obstetric Medicine</i> 2024: 1-6. DOI: https://doi.org/10.1177/1753495X2412492.","authors":"Adam Morton","doi":"10.1177/1753495X241301818","DOIUrl":"10.1177/1753495X241301818","url":null,"abstract":"","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241301818"},"PeriodicalIF":0.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}