{"title":"Pregnancy in solid organ transplant recipients: An Australian quaternary hospital experience and literature review.","authors":"Monique Kowitz, Ann-Maree Craven, Karin Lust, Renuka Sekar, Penny Wolski, Leonie Callaway","doi":"10.1177/1753495X261499127","DOIUrl":"10.1177/1753495X261499127","url":null,"abstract":"<p><strong>Background: </strong>Pregnancies in solid organ transplant recipients are increasing.</p><p><strong>Method: </strong>This retrospective observational study aims to evaluate the management and outcomes of pregnancies in heart, lung, liver and kidney transplant recipients at the Royal Brisbane and Women's Hospital from January 2009 to December 2024.</p><p><strong>Results: </strong>Thirty-four pregnancies in 25 women resulted in 29 live births, two terminations and three miscarriages. Median maternal age was 31 years. Median time from transplantation to conception was 6 years. Preconception comorbidities included hypertension (36%), chronic kidney disease (72%) and diabetes mellitus (24%). Maternal complications included pre-eclampsia (35.3%), gestational diabetes mellitus (11.5%), acute kidney injury (55.9%), permanent renal dysfunction (20.6%), infection (35.3%), caesarean section (72.4%), graft rejection (5.9%), graft failure (8.8%) and death (2.9%). Neonatal complications included preterm birth (75.9%), extreme preterm birth (10.3%), low birth weight (64.5%), small for gestational age (9.7%) and neonatal care (87.1%).</p><p><strong>Conclusion: </strong>Pregnancy following solid organ transplantation remains challenging.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261499127"},"PeriodicalIF":0.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biphasic hypertriglyceridemia in pregnancy with apolipoprotein C-II deficiency.","authors":"Yukina Murai, Koutarou Doi, Chihiro Tose, Tetsuo Nakayama, Kayo Tomimori, Nozomi Yoshimoto, Satoshi Matsuzawa, Yuki Kodama, Shinji Katsuragi","doi":"10.1177/1753495X261492750","DOIUrl":"https://doi.org/10.1177/1753495X261492750","url":null,"abstract":"<p><p>Apolipoprotein C-II (ApoC-II) deficiency is a rare genetic cause of familial chylomicronemia syndrome (FCS) that predisposes affected individuals to severe hypertriglyceridemia and acute pancreatitis. Evidence guiding management during pregnancy is limited. We report a woman with ApoC-II deficiency (ApoC-II Wakayama mutation) who showed a biphasic triglyceride (TG) elevation. TG increased markedly in the second trimester, improved with intensified dietary restriction, and rose again to 1400 mg/dL (15.8 mmol/L) in the third trimester. Because she remained asymptomatic and TG had responded to dietary therapy, medical therapy and plasma exchange were not initiated. Labour was induced at 36 weeks, resulting in uncomplicated vaginal delivery and rapid postpartum TG reduction. This case highlights trimester-specific monitoring and individualized reassessment of dietary, medical, plasma exchange, and delivery strategies in FCS.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261492750"},"PeriodicalIF":0.7,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alanna Downey-Orr, Mary Guirguis, Ruth Mason, Suneeta Kochhar
{"title":"Preconceptual counselling for women with epilepsy - is it happening? A retrospective observational medical records review.","authors":"Alanna Downey-Orr, Mary Guirguis, Ruth Mason, Suneeta Kochhar","doi":"10.1177/1753495X261490376","DOIUrl":"10.1177/1753495X261490376","url":null,"abstract":"<p><p>Epilepsy in pregnancy is common, but it remains a major risk factor for maternal morbidity and mortality. Over the last decade, neurological causes have remained in the top three indirect causes of maternal death in the UK. National reports, including the recent maternity care bundle, have emphasised the importance of preconceptual counselling to optimise maternal health and reduce complications for epileptic women during pregnancy and postpartum. This study is a retrospective medical record review, examining records of epileptic women of childbearing age, taken from a general practitioner (GP) surgery covering more than 17,000 patients. It aims to assess whether documented preconceptual counselling is taking place for these patients. It was found that, excluding those on a legally required sodium valproate risk record, 93% of the patients did not have documented preconceptual counselling. A recommendation for a set of concise questions for GPs to utilise to normalise pregnancy planning and prompt referrals is proposed.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261490376"},"PeriodicalIF":0.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The safety of radiological examinations and radiological interventional procedures in pregnancy - a structured narrative review.","authors":"Adam Morton","doi":"10.1177/1753495X261488725","DOIUrl":"10.1177/1753495X261488725","url":null,"abstract":"<p><p>Obstetric physicians may encounter reluctance from health professionals in performing radiological examinations and interventional procedures during pregnancy. This article seeks to review the maternal and fetal safety of investigations and procedures that may be informative and/or of benefit in pregnant women.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261488725"},"PeriodicalIF":0.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Severe factor XIII deficiency in pregnancy: A case report.","authors":"Kamakshi Mam, Avantika Gupta, Ayushi Sethi, Gaurav Dhingra, Arun Kumar Dora","doi":"10.1177/1753495X261489465","DOIUrl":"10.1177/1753495X261489465","url":null,"abstract":"<p><p>Factor XIII (FXIII) deficiency is a rare inherited coagulation disorder that can cause recurrent pregnancy loss, placental complications and postpartum haemorrhage due to loss of clot stabilization. Managing pregnancy in affected women is challenging especially in low-resource settings where availability of FXIII concentrates and investigations for monitoring are limited. We report a case of severe congenital FXIII deficiency in a woman with four recurrent first-trimester pregnancy losses for whom diagnosis was confirmed by clot solubility testing and quantitative FXIII assays. Due to financial constraints, prophylactic cryoprecipitate was given instead of Factor XIII concentrate. Even in the absence of serial quantitative factor XIII levels, with multidisciplinary care, structured antenatal surveillance and planned peripartum FXIII replacement using cryoprecipitate, she could achieve two successful term deliveries without major maternal or neonatal bleeding complications. Thus, cryoprecipitate is an effective alternative when FXIII concentrate is unavailable.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261489465"},"PeriodicalIF":0.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ariane Hébert Métellus, François-Pierre Mongeon, Doan Hoa Do, Évelyne Raîche, Mandy Malick, Nadine Sauvé
{"title":"Neo-Aortic Root Dilation in Pregnancy After Arterial Switch for Complete Transposition of the Great Arteries.","authors":"Ariane Hébert Métellus, François-Pierre Mongeon, Doan Hoa Do, Évelyne Raîche, Mandy Malick, Nadine Sauvé","doi":"10.1177/1753495X261484223","DOIUrl":"10.1177/1753495X261484223","url":null,"abstract":"<p><strong>Background: </strong>The arterial switch operation (ASO) is standard treatment for D-transposition of the great arteries, and neo-aortic dilation is common afterward. Its behavior during pregnancy remains uncertain, especially the risk of dissection.</p><p><strong>Case: </strong>We describe a 30-year-old woman (G6P0A5) with neo-aortic dilation (44 mm) during her first pregnancy, which remained stable on beta blockers until an uncomplicated caesarean delivery. In her subsequent pregnancy, an initial measurement of 47 mm raised concern. Expert review highlighted the challenges of accurately measuring asymmetric neo-aortas post-ASO and confirmed that the neo-aorta was stable (43 mm). The pregnancy continued without complications under beta-blocker therapy.</p><p><strong>Discussion: </strong>No neo-aortic dissections have been reported after ASO, and progression above 2 mm was reported only in a few (2/131). Preconception evaluation, standardized measurement techniques, and trimester-based surveillance are essential. Mode of delivery should be individualized; caesarean delivery may be reasonable when dilation exceeds 45 mm.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261484223"},"PeriodicalIF":0.7,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Connection and collaboration in obstetric medicine.","authors":"Shital Gandhi","doi":"10.1177/1753495X261482081","DOIUrl":"10.1177/1753495X261482081","url":null,"abstract":"","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261482081"},"PeriodicalIF":0.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of amlodipine to treat postpartum hypertension.","authors":"Hannah Gerretsen, Melanie Nana, Catherine Nelson-Piercy","doi":"10.1177/1753495X261478144","DOIUrl":"10.1177/1753495X261478144","url":null,"abstract":"<p><strong>Background: </strong>Hypertension can arise de novo or persist in the postnatal period. Limited data exist regarding the use of amlodipine in the postpartum period.</p><p><strong>Materials and methods: </strong>A service evaluation of women prescribed amlodipine postnatally in the maternity department at Guy's and St Thomas' NHS Foundation Trust from April to November 2020 was conducted. Data were obtained by reviewing hospital records and conducting a telephone survey.</p><p><strong>Results: </strong>Of the 100 women who were prescribed postnatal amlodipine, 43 completed the telephone survey and were included in the analysis. There were no stillbirths, neonatal deaths or significant congenital malformations. Duration of treatment varied from less than 1 week to 1 year postpartum. None of the women taking amlodipine during breastfeeding reported any problems: 23/43 (53.5%) exclusively breastfed and 10/43 (23.3%) mixed-fed.</p><p><strong>Discussion: </strong>We report the largest case series of postpartum amlodipine use, providing reassuring data regarding its safety and efficacy in this population.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261478144"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sitosterolemia in pregnancy: A rare lipid disorder and its obstetric management.","authors":"Kanagavarshani Murali, Sai Vidya Muthineni, Sasirekha Rengaraj, Veena Pampapati, Sanjay Sriram","doi":"10.1177/1753495X261474609","DOIUrl":"10.1177/1753495X261474609","url":null,"abstract":"<p><p>Sitosterolemia is an autosomal recessive condition leading to increased absorption of plant sterols from the intestine. A woman in her first pregnancy presented with thrombocytopenia and a family history of sitosterolaemia. Genetic analysis confirmed an <i>ABCG8</i> (G-ATP binding cassette transporters) mutation. She was started on ezetimibe and had no complications other than thrombocytopenia. She underwent an emergency cesarean delivery at 37 weeks of gestation. Post-operatively both the mother and the baby did well. While sitosterolaemia is not directly linked to pregnancy complications such as diabetes and pre-eclampsia, its impact on lipid metabolism can indirectly increase the risk. It is important to distinguish it from familial hypercholesterolemia as sitosterolemia responds better to ezetimibe and is relatively non-responsive to statins. This case report shows that sitosterolemia, though an uncommon diagnosis, can manifest in many ways, in this case being thrombocytopenia. With dietary modifications and appropriate therapy, these patients can have a normal pregnancy.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261474609"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Douglas White, Zhaochu Geng, Nikki Tugnet, May Ching Soh, Chunhuan Lao
{"title":"Pregnancy outcomes among women with systemic lupus erythematosus in Aotearoa/New Zealand.","authors":"Douglas White, Zhaochu Geng, Nikki Tugnet, May Ching Soh, Chunhuan Lao","doi":"10.1177/1753495X261474606","DOIUrl":"10.1177/1753495X261474606","url":null,"abstract":"<p><strong>Aims: </strong>To describe pregnancy outcomes in those with systemic lupus erythematosus (SLE) in Aotearoa/New Zealand.</p><p><strong>Methods: </strong>We conducted a retrospective population-based cohort study using linked national datasets from 2005 to 2022. Multivariable logistic regression estimated associations between birth outcomes and timing of SLE diagnosis, end-stage kidney disease (ESKD), ethnicity, maternal age, deprivation quintile and year of parturition.</p><p><strong>Results: </strong>Among 2450 females with SLE, 1532 were aged 18-45 years. There were 971 births, with a live birth rate of 96.1%. Preterm birth occurred in 19.3%, caesarean section in 36.6%, and induction in 48.1%. Births occurring after the diagnosis of SLE were associated with higher odds of preterm birth (OR 1.77, 95%CI 1.17-2.71), induction (OR 2.21, 95%CI 1.58-3.11) and ESKD (OR 23.7, 95%CI 4.05-450).</p><p><strong>Conclusions: </strong>SLE is associated with increased obstetric risk in New Zealand, particularly for pregnancies after diagnosis, and among those with ESKD, with trends toward higher risk in Māori and Pacific ethnicities.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261474606"},"PeriodicalIF":0.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13493620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}