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Extracellular vesicles: A potential new way to assess cholestasis. 细胞外囊泡：评估胆汁淤积症的潜在新方法。
IF 0.8
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI: 10.1177/1753495X241264325
Zivile Useckaite
{"title":"Extracellular vesicles: A potential new way to assess cholestasis.","authors":"Zivile Useckaite","doi":"10.1177/1753495X241264325","DOIUrl":"https://doi.org/10.1177/1753495X241264325","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) are small, nonreplicating, lipid-encapsulated nanoparticles that carry protein and nucleic acid cargo derived from their tissue of origin. Due to their capacity to provide comparable insights to solid organ biopsy through a minimally invasive collection procedure, EVs provide an attractive biomarker source. This review will provide an insight, how EVs in circulation may provide a novel way to assess cholestasis and will address the possibility of getting a better understanding of the mechanisms of cholestasis of pregnancy through the use of serial hepatic-specific EVs as a window.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring bile acids: Are we all talking the same language? 测量胆汁酸：我们说的是同一种语言吗？
IF 0.8
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-10 DOI: 10.1177/1753495X241259663
Corey Markus, Wm Bill Hague
{"title":"Measuring bile acids: Are we all talking the same language?","authors":"Corey Markus, Wm Bill Hague","doi":"10.1177/1753495X241259663","DOIUrl":"https://doi.org/10.1177/1753495X241259663","url":null,"abstract":"<p><p>In this paper, we discuss the Bile Acid Comparison and Harmonisation project, a sub-study of the Trial of URsodeoxycholic acid vs RIFampicin in early-onset severe Intrahepatic Cholestasis of pregnancy, giving an overview of the current state of affairs for total bile acid measurements.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hanns-Ulrich Marschall (15.2.1954-1.8.2023). 汉斯-乌尔里希-马夏尔（Hanns-Ulrich Marschall）（15.2.1954-1.8.2023）。
IF 0.8
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-10 DOI: 10.1177/1753495X241264961
{"title":"Hanns-Ulrich Marschall (15.2.1954-1.8.2023).","authors":"","doi":"10.1177/1753495X241264961","DOIUrl":"https://doi.org/10.1177/1753495X241264961","url":null,"abstract":"","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ICP: A midwifery perspective. ICP：助产士的视角。
IF 0.8
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-05-28 DOI: 10.1177/1753495X241257709
Annette Briley, Megan Cooper
{"title":"ICP: A midwifery perspective.","authors":"Annette Briley, Megan Cooper","doi":"10.1177/1753495X241257709","DOIUrl":"https://doi.org/10.1177/1753495X241257709","url":null,"abstract":"<p><strong>Background: </strong>ICP is a liver condition specific to pregnancy affecting 0.5-0.6% of pregnancies in Australia.</p><p><strong>Aims: </strong>to review the SOMANZ guidelines and extrapolate information relevant to midwives proving care for women with ICP.</p><p><strong>Findings: </strong>Multidisciplinary input is essential in caring for women with ICP and their families. Non-fasting TSBA samples ≥19 µmol/L are diagnostic in the presence of pruritus. Peak TSBA denotes the severity of the disease. Increased risk of stillbirth is small when peak TSBA ≥100 µmol/L.</p><p><strong>Conclusion: </strong>Midwives play an essential role in supporting women with ICP helping them navigate complex appointments and manage the pruritus and concomitant issues.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analyses in cholestatic pregnancy: The outstanding clinical questions. 胆汁淤积性妊娠的元分析：悬而未决的临床问题。
IF 0.8
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-04-28 DOI: 10.1177/1753495X241251425
Nadejda Capatina, Caroline Ovadia
{"title":"Meta-analyses in cholestatic pregnancy: The outstanding clinical questions.","authors":"Nadejda Capatina, Caroline Ovadia","doi":"10.1177/1753495X241251425","DOIUrl":"https://doi.org/10.1177/1753495X241251425","url":null,"abstract":"<p><p>Reports of adverse pregnancy outcomes associated with maternal pruritus and liver impairment have circulated since the 1800s, yet the precise diagnosis and management of intrahepatic cholestasis of pregnancy have varied markedly. Recent evidence, including that from individual participant data meta-analyses, has provided an evidence that brings us closer to standardised, and optimal, management of the condition. Based upon increased adverse perinatal outcomes with higher bile acid concentrations, disease management should be according to severity (defined by peak bile acid concentration) in order to recommend appropriate gestation of birth. Similarly, the reduced spontaneous preterm birth rate for patients receiving ursodeoxycholic acid treatment suggests potential benefit for the treatment of patients with moderate-severe disease.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrahepatic cholestasis of pregnancy: Introduction and overview 2024. 妊娠期肝内胆汁淤积症：简介和概述 2024。
IF 0.8
Obstetric Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-10 DOI: 10.1177/1753495X241265772
Wm Bill Hague, Catherine Williamson, Ulrich Beuers
{"title":"Intrahepatic cholestasis of pregnancy: Introduction and overview 2024.","authors":"Wm Bill Hague, Catherine Williamson, Ulrich Beuers","doi":"10.1177/1753495X241265772","DOIUrl":"https://doi.org/10.1177/1753495X241265772","url":null,"abstract":"<p><p>Considerable progress has been made to explain the aetiology of intrahepatic cholestasis of pregnancy (ICP) and of the adverse pregnancy outcomes associated with high maternal total serum bile acids (TSBAs). The reported thresholds for non-fasting TSBA associated with the risk of stillbirth and spontaneous preterm birth can be used to identify pregnancies at risk of these adverse outcomes to decide on appropriate interventions and to give reassurance to women with lower concentrations of TSBA. Data also support the use of ursodeoxycholic acid to protect against the risk of spontaneous preterm birth. A previous history of ICP may be associated with higher rates of subsequent hepatobiliary disease: if there is a suspicion of underlying susceptibility, clinicians caring for women with ICP should screen for associated disorders or for genetic susceptibility and, where appropriate, refer for ongoing hepatology review.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of the effects of Valsalva manoeuvre in labour and birth 瓦尔萨尔瓦动作对分娩和生产的影响综述
IF 0.8
Obstetric Medicine Pub Date : 2024-08-09 DOI: 10.1177/1753495x241269121
N. Keating, Grainne Rooney, S. McGuinness, F. McAuliffe
{"title":"A review of the effects of Valsalva manoeuvre in labour and birth","authors":"N. Keating, Grainne Rooney, S. McGuinness, F. McAuliffe","doi":"10.1177/1753495x241269121","DOIUrl":"https://doi.org/10.1177/1753495x241269121","url":null,"abstract":"The Valsalva manoeuvre (VM) is a normal physiological event that occurs during the second active phase of labour. In women with medical conditions that may be exacerbated by the Valsalva, caesarean birth may be recommended. This carries with it its own potential for maternal morbidity, and thus it is important that women are appropriately counselled about the mode of delivery most suited to their individual situation. It is possible to avoid VM with spontaneous pushing rather than reverting to caesarean birth. Neuraxial analgesia and instrumental delivery may also be used to avoid prolonged VM. We outline the effect of VM on the various organ systems in pregnancy and summarise the available evidence on its implication.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ICP miniseries: Genetic issues in ICP 国际比较方案迷你系列：ICP 的遗传问题
IF 0.8
Obstetric Medicine Pub Date : 2024-07-26 DOI: 10.1177/1753495x241263441
Julia Zöllner, Catherine Williamson, Peter H. Dixon
{"title":"ICP miniseries: Genetic issues in ICP","authors":"Julia Zöllner, Catherine Williamson, Peter H. Dixon","doi":"10.1177/1753495x241263441","DOIUrl":"https://doi.org/10.1177/1753495x241263441","url":null,"abstract":"Intrahepatic cholestasis of pregnancy (ICP) is the commonest gestational liver disorder with variable global incidence. Genetic susceptibility, combined with hormonal and environmental influences, contributes to ICP aetiology. Adverse pregnancy outcomes linked to elevated serum bile acids highlight the importance of comprehensive risk assessment. ABCB4 and ABCB11 gene variants play a significant role in about 20% of severe ICP cases. Several other genes including ATP8B1, NR1H4, ABCC2, TJP2, SERPINA1, GCKR and HNF4A have also been implicated with ICP. Additionally , ABCB4 variants elevate the risk of drug-induced intrahepatic cholestasis, gallstone disease, gallbladder and bile duct carcinoma, liver cirrhosis and abnormal liver function tests. Genetic variations, both rare and common, intricately contribute to ICP susceptibility. Leveraging genetic insights holds promise for personalised management and intervention strategies. Further research is needed to elucidate variant-specific phenotypic expressions and therapeutic implications, advancing precision medicine in ICP management.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullous lung disease in pregnancy: a case report 妊娠期大疱性肺病：病例报告
IF 0.8
Obstetric Medicine Pub Date : 2024-07-26 DOI: 10.1177/1753495x241265528
Gabriela McMahon, CM McCarthy, Rebecca Weedle, Colm Magee, Donna Eaton, Jennifer C. Donnelly
{"title":"Bullous lung disease in pregnancy: a case report","authors":"Gabriela McMahon, CM McCarthy, Rebecca Weedle, Colm Magee, Donna Eaton, Jennifer C. Donnelly","doi":"10.1177/1753495x241265528","DOIUrl":"https://doi.org/10.1177/1753495x241265528","url":null,"abstract":"Bullous lung disease presenting as a pneumothorax in pregnancy has not been reported in the literature to date. We present the case of a woman in her third pregnancy presenting to routine antenatal clinic with a secondary spontaneous pneumothorax in the third trimester. We describe the multidisciplinary approach to her management with obstetrics, obstetric anaesthesiology, cardiothoracic surgery and midwifery. This included decision making around conservative management in the initial disease course, preparation for delivery and a plan for definitive surgery postnatally. Caesarean section was performed at 36 weeks’ gestation owing to worsening chest pain. The underlying pathological process was deemed to be bullous lung disease which was confirmed on histology obtained from a video-assisted thoracoscopic surgery procedure done postnatally. We demonstrate the importance of the multidisciplinary team approach in the care of complex and rare medical conditions in pregnancy.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of a postpartum vascular risk reduction clinic on behavioral change and long-term cardiovascular outcomes in women who had preeclampsia: a case-control study 产后降低血管风险诊所对子痫前期妇女行为改变和长期心血管预后的影响：一项病例对照研究
IF 0.8
Obstetric Medicine Pub Date : 2024-07-25 DOI: 10.1177/1753495x241260792
Allison Pihelgas, Laura Sevick, Gabriela Pelinska, Winnie Sia
{"title":"Effectiveness of a postpartum vascular risk reduction clinic on behavioral change and long-term cardiovascular outcomes in women who had preeclampsia: a case-control study","authors":"Allison Pihelgas, Laura Sevick, Gabriela Pelinska, Winnie Sia","doi":"10.1177/1753495x241260792","DOIUrl":"https://doi.org/10.1177/1753495x241260792","url":null,"abstract":"We aimed to evaluate the effectiveness of our vascular risk reduction clinic for women who had preeclampsia, in improving patients’ cardiovascular outcomes, self-reported healthy behaviors, and knowledge about their long-term cardiovascular health. Retrospective case-control study where 470 surveys were mailed: half were patients seen in Postpartum Preeclampsia Clinic 2010–2019, and controls were patients who did not attend a scheduled clinic appointment or were seen in Obstetric Medicine clinic postpartum for preeclampsia. Primary outcome was a lack of postpartum weight gain. Secondary outcomes included new vascular diseases, smoking, exercise, and physician follow-up. Ninety-four (43.3%) of clinic attendees returned survey and 30.3% of controls. Fewer clinic attendees gained weight postpartum, and attendees had fewer hypertension and followed up more with family physicians. Most attendees found the clinic helpful. Postpartum Preeclampsia Clinic was effective in affecting some vascular outcomes and in improving knowledge and follow-up behaviors.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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