Obstetric Medicine最新文献

Magnesium deficiency and dilated cardiomyopathy diagnosed peripartum. 围生期诊断为缺镁和扩张型心肌病。

IF 0.8

Obstetric Medicine Pub Date : 2025-06-16 DOI: 10.1177/1753495X251349950

Adam Morton

引用次数: 0

Autoimmune anti-D in an RhD-positive pregnant woman: A case report. rhd阳性孕妇自身免疫抗- d 1例报告

IF 0.8

Obstetric Medicine Pub Date : 2025-06-12 DOI: 10.1177/1753495X251346056

Samantha Kurniawan, Laura Gerhardy, Sue Hull, Melanie Janus, Nina Dhondy, Lisa Clarke

{"title":"Autoimmune anti-D in an RhD-positive pregnant woman: A case report.","authors":"Samantha Kurniawan, Laura Gerhardy, Sue Hull, Melanie Janus, Nina Dhondy, Lisa Clarke","doi":"10.1177/1753495X251346056","DOIUrl":"10.1177/1753495X251346056","url":null,"abstract":"Background: Anti-D is usually alloimmune and develops in exposed RhD-negative individuals with potential for haemolytic disease of the fetus and newborn (HDFN). However, autoimmune anti-D is rare with limited understanding of its haemolytic risk to the fetus and mother.Case report: A 30-year-old woman previously typed as B RhD positive was found to have an autoimmune anti-D on antenatal screening in her third pregnancy. RHD genotyping confirmed RhD positivity without D variants. Anti-D titres remained elevated at 1:512 throughout pregnancy with normal Doppler monitoring and no maternal haemolysis. The neonate was born at 38 weeks and 3 days of gestation with no evidence of haemolysis.Conclusion: Autoimmune anti-D in pregnancy is rare and requires a multidisciplinary approach to management. Strategies include RHD genotyping to exclude D variants, close monitoring for HDFN, and careful selection of Rh phenotype matched blood for transfusion if required to avoid alloimmunisation for future pregnancies.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251346056"},"PeriodicalIF":0.8,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of casirivimab/imdevimab (REGEN-COV) in pregnant individuals with COVID-19: Literature review and insights from the COVID-19 International Drug Pregnancy Registry. casirivimab/imdevimab （REGEN-COV）在COVID-19妊娠个体中的有效性和安全性：文献综述和来自COVID-19国际药物妊娠登记处的见解

IF 0.8

Obstetric Medicine Pub Date : 2025-06-09 DOI: 10.1177/1753495X251343113

Diego F Wyszynski, Vincent Yau, Daniel Keebler, Cheryl Renz, Jane Ives, Andrew Fitzgibbon, Lee P Shulman

{"title":"Efficacy and safety of casirivimab/imdevimab (REGEN-COV) in pregnant individuals with COVID-19: Literature review and insights from the COVID-19 International Drug Pregnancy Registry.","authors":"Diego F Wyszynski, Vincent Yau, Daniel Keebler, Cheryl Renz, Jane Ives, Andrew Fitzgibbon, Lee P Shulman","doi":"10.1177/1753495X251343113","DOIUrl":"10.1177/1753495X251343113","url":null,"abstract":"Introduction: Casirivimab/imdevimab (CAS/IMD) comprises two monoclonal antibodies that neutralize SARS-CoV-2. Pregnant individuals were excluded from initial trials, limiting safety data.Methods: The COVID-19 International Drug Pregnancy Registry enrolled 53 pregnant women treated with CAS/IMD, with 34 live births.Results: No safety concerns were identified.Discussion and conclusions: The findings of the COVID-PR study support the safety of CAS/IMD during pregnancy, adding to the growing body of evidence on COVID-19 treatments for this population. The available literature shows that CAS/IMD is effective in preventing the progression to severe COVID-19 in pregnant individuals. The drugs are well-tolerated, and there is no compelling evidence of adverse maternal or neonatal outcomes. The results from the COVID-PR study are consistent with those of the broader literature.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251343113"},"PeriodicalIF":0.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy outcomes following first trimester exposure to semaglutide. 妊娠早期暴露于西马鲁肽后的妊娠结局。

IF 0.8

Obstetric Medicine Pub Date : 2025-06-04 DOI: 10.1177/1753495X251346330

Adam Morton, Jinwen He

引用次数: 0

IF 0.8

Obstetric Medicine Pub Date : 2025-06-03 DOI: 10.1177/1753495X251345041

Elliott B Cohen, Michal Z Sheinis, Frank L Silver, John W Snelgrove

引用次数: 0

Thrombotic thrombocytopenic purpura in pregnancy: A case report and literature review. 妊娠期血栓性血小板减少性紫癜1例报告并文献复习。

IF 0.8

Obstetric Medicine Pub Date : 2025-06-03 DOI: 10.1177/1753495X251338163

Brielle Andreatidis, Nicholas Weber, Ann-Maree Craven, Madeline Duke, Leonie Callaway, Jade Eccles-Smith

引用次数: 0

Delivery of a healthy infant in a woman with breast cancer inadvertently treated with exemestane and goserelin during pregnancy: A case report. 在怀孕期间无意中接受依西美坦和戈舍林治疗的乳腺癌妇女产下健康婴儿：一例报告。

IF 0.8

Obstetric Medicine Pub Date : 2025-05-29 DOI: 10.1177/1753495X251344768

Andrea Sit, Amy Hicks, Georgina Davis

{"title":"Delivery of a healthy infant in a woman with breast cancer inadvertently treated with exemestane and goserelin during pregnancy: A case report.","authors":"Andrea Sit, Amy Hicks, Georgina Davis","doi":"10.1177/1753495X251344768","DOIUrl":"10.1177/1753495X251344768","url":null,"abstract":"Exemestane and goserelin combination therapy is a well-established adjuvant treatment for hormone receptor-positive breast cancer. Both medications are contraindicated during pregnancy as their safety in the pregnant population is not yet established. We report a rare case of a 40-year-old multigravida with T1N0M0 breast cancer, receiving exemestane and goserelin post bilateral mastectomy. Despite over four years of amenorrhoea on goserelin, she conceived unexpectedly, and inadvertently continued both medications until she discovered she was pregnant at 13 weeks' gestation. The pregnancy was uncomplicated. A healthy female infant was delivered via caesarean section at 40 weeks. The notable features of this case are inadvertent pregnancy despite induction of amenorrhoea, and no evidence of congenital fetal anomaly despite exposure to exemestane and goserelin until 13 weeks' gestation. Women of child-bearing age receiving adjuvant endocrine therapy for breast cancer should be counselled to use effective contraception to minimise risk of harmful effects in pregnancy.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251344768"},"PeriodicalIF":0.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual loss during pregnancy due to physiological pituitary hyperplasia. 怀孕期间因生理性垂体增生导致的视力丧失。

IF 0.8

Obstetric Medicine Pub Date : 2025-05-21 DOI: 10.1177/1753495X251338154

Andrew Peel, Stephanie Teasdale, Adam Morton

{"title":"Visual loss during pregnancy due to physiological pituitary hyperplasia.","authors":"Andrew Peel, Stephanie Teasdale, Adam Morton","doi":"10.1177/1753495X251338154","DOIUrl":"10.1177/1753495X251338154","url":null,"abstract":"Physiological pituitary hyperplasia is due to adenohypophyseal cell number increase and is characterised by diffuse isodense pituitary enlargement beyond age-appropriate sizes. It most commonly occurs in females undergoing reproductive changes (puberty, pregnancy, menopause). We report a case of pituitary hyperplasia (pituitary height 14 mm) in a 33-year-old female presenting as vision changes at 34 weeks 'gestation. Computer visual fields identified right sided superotemporal visual field loss with current retinal nerve fibre layer assessment suggestive of compressive optic neuropathy. Serial visual assessment was performed, and due to progression, a caesarean section was performed at 38 weeks' gestation. Cabergoline was not utilised, and one month following delivery, visual findings had resolved, and pituitary height had reduced to 11 mm. There is limited data regarding management for pituitary hyperplasia causing compressive neuropathy irrespective of pregnancy. This case highlights the temporary nature of hypertrophy during pregnancy and positive visual outcome with conservative interventions.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251338154"},"PeriodicalIF":0.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of a Maternal Medicine Hub on post-partum haemorrhage in women with inherited bleeding disorders: A retrospective service evaluation. 产妇医学中心对遗传性出血性疾病妇女产后出血的影响：一项回顾性服务评价。

IF 0.8

Obstetric Medicine Pub Date : 2025-05-20 DOI: 10.1177/1753495X251338642

Man Ho Kwok, Angeliki Taniskidi, Louise Bowles, Sonia Wolf, Matthew Hogg, Mandeep K Kaler

{"title":"Impact of a Maternal Medicine Hub on post-partum haemorrhage in women with inherited bleeding disorders: A retrospective service evaluation.","authors":"Man Ho Kwok, Angeliki Taniskidi, Louise Bowles, Sonia Wolf, Matthew Hogg, Mandeep K Kaler","doi":"10.1177/1753495X251338642","DOIUrl":"10.1177/1753495X251338642","url":null,"abstract":"Background: We investigated the impact of the Maternal Medicine Network Hub, established at our centre in 2019, on post-partum haemorrhage (PPH) management in women with inherited bleeding disorders (IBDs).Methods: Data from 63 patients with IBDs between 2020 and 2023 were compared to a general obstetric cohort. Specific data collected included haemoglobin levels, estimated blood loss, and PPH severity.Results: Post-partum haemorrhage rates above 500 mL and 1000 mL were significantly higher in the IBD group (p = .02 and p = .002, respectively). However very severe PPH (>1500 mL) also known as massive obstetric haemorrhage (MOH) was not significantly different from the general obstetric population (p = .7) in our tertiary centre (The Royal London Hospital).Conclusion: Multidisciplinary care at the Maternal Medicine Hub may mitigate the risk of extreme blood loss (MOH) in women with IBDs. This highlights the necessity of specialised care in improving outcomes for women with IBDs during childbirth.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251338642"},"PeriodicalIF":0.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes and pregnancy: The need for standardized terminology. 糖尿病和妊娠：标准化术语的需要。

IF 0.8

Obstetric Medicine Pub Date : 2025-05-19 DOI: 10.1177/1753495X251342929

Roger Gonzales-Valdivieso, Jenyfer María Fuentes-Mendoza, Julia Cristina Coronado-Arroyo, Edwin Augusto Acho-Carranza, Marcio Concepción-Zavaleta

引用次数: 0