{"title":"Visual loss during pregnancy due to physiological pituitary hyperplasia.","authors":"Andrew Peel, Stephanie Teasdale, Adam Morton","doi":"10.1177/1753495X251338154","DOIUrl":"10.1177/1753495X251338154","url":null,"abstract":"<p><p>Physiological pituitary hyperplasia is due to adenohypophyseal cell number increase and is characterised by diffuse isodense pituitary enlargement beyond age-appropriate sizes. It most commonly occurs in females undergoing reproductive changes (puberty, pregnancy, menopause). We report a case of pituitary hyperplasia (pituitary height 14 mm) in a 33-year-old female presenting as vision changes at 34 weeks 'gestation. Computer visual fields identified right sided superotemporal visual field loss with current retinal nerve fibre layer assessment suggestive of compressive optic neuropathy. Serial visual assessment was performed, and due to progression, a caesarean section was performed at 38 weeks' gestation. Cabergoline was not utilised, and one month following delivery, visual findings had resolved, and pituitary height had reduced to 11 mm. There is limited data regarding management for pituitary hyperplasia causing compressive neuropathy irrespective of pregnancy. This case highlights the temporary nature of hypertrophy during pregnancy and positive visual outcome with conservative interventions.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251338154"},"PeriodicalIF":0.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Man Ho Kwok, Angeliki Taniskidi, Louise Bowles, Sonia Wolf, Matthew Hogg, Mandeep K Kaler
{"title":"Impact of a Maternal Medicine Hub on post-partum haemorrhage in women with inherited bleeding disorders: A retrospective service evaluation.","authors":"Man Ho Kwok, Angeliki Taniskidi, Louise Bowles, Sonia Wolf, Matthew Hogg, Mandeep K Kaler","doi":"10.1177/1753495X251338642","DOIUrl":"10.1177/1753495X251338642","url":null,"abstract":"<p><strong>Background: </strong>We investigated the impact of the Maternal Medicine Network Hub, established at our centre in 2019, on post-partum haemorrhage (PPH) management in women with inherited bleeding disorders (IBDs).</p><p><strong>Methods: </strong>Data from 63 patients with IBDs between 2020 and 2023 were compared to a general obstetric cohort. Specific data collected included haemoglobin levels, estimated blood loss, and PPH severity.</p><p><strong>Results: </strong>Post-partum haemorrhage rates above 500 mL and 1000 mL were significantly higher in the IBD group (<i>p</i> = .02 and <i>p</i> = .002, respectively). However very severe PPH (>1500 mL) also known as massive obstetric haemorrhage (MOH) was not significantly different from the general obstetric population (<i>p</i> = .7) in our tertiary centre (The Royal London Hospital).</p><p><strong>Conclusion: </strong>Multidisciplinary care at the Maternal Medicine Hub may mitigate the risk of extreme blood loss (MOH) in women with IBDs. This highlights the necessity of specialised care in improving outcomes for women with IBDs during childbirth.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251338642"},"PeriodicalIF":0.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roger Gonzales-Valdivieso, Jenyfer María Fuentes-Mendoza, Julia Cristina Coronado-Arroyo, Edwin Augusto Acho-Carranza, Marcio Concepción-Zavaleta
{"title":"Diabetes and pregnancy: The need for standardized terminology.","authors":"Roger Gonzales-Valdivieso, Jenyfer María Fuentes-Mendoza, Julia Cristina Coronado-Arroyo, Edwin Augusto Acho-Carranza, Marcio Concepción-Zavaleta","doi":"10.1177/1753495X251342929","DOIUrl":"10.1177/1753495X251342929","url":null,"abstract":"","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251342929"},"PeriodicalIF":0.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chani Tromop-van Dalen, Sarah L Fairley, Jade S Lodge
{"title":"Successful aortic valve and ascending aorta replacement during pregnancy.","authors":"Chani Tromop-van Dalen, Sarah L Fairley, Jade S Lodge","doi":"10.1177/1753495X251339843","DOIUrl":"10.1177/1753495X251339843","url":null,"abstract":"<p><p>A 35-year-old woman with a bicuspid aortic valve, moderate-severe aortic stenosis and severe aortic dilatation underwent aortic valve and ascending aorta replacement when 14 weeks pregnant. We discuss the risks of aortic dilatation associated with bicuspid aortic valves during pregnancy and options for management. Included is a summary of the management of mechanical valves during pregnancy and delivery. This case emphasises the importance of multi-disciplinary counselling and patient-centred, informed decision making.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251339843"},"PeriodicalIF":0.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute fatty liver in pregnancy presenting in the second trimester: A systematic literature review.","authors":"Laurence Bourque, Michèle Mahone","doi":"10.1177/1753495X251338746","DOIUrl":"https://doi.org/10.1177/1753495X251338746","url":null,"abstract":"<p><strong>Objective: </strong>We present clinical features and outcomes of second-trimester acute fatty liver of pregnancy (AFLP), a serious but rare condition.</p><p><strong>Results: </strong>Fourteen pregnant women with AFLP or compatible biopsy were identified in the literature. Diagnosis occurred between 20 and 27 + 6 weeks of gestational age. In total, 50% were primigravid. Thirteen cases met the Swansea criteria while the other case had a compatible liver biopsy. In total, 10 out of 11 cases had microvesicular steatosis on their liver biopsy. Common maternal complications included acute renal failure, hypoglycaemia, liver failure, encephalopathy, intensive care unit admission and need for blood transfusions. Seven deliveries were on the day of diagnosis, five within four weeks, and two within three months. One maternal death, seven fetal deaths and three neonatal deaths occurred.</p><p><strong>Conclusion: </strong>AFLP diagnosed in the second trimester is a rare condition. Neonatal mortality and maternal morbidity are high. Most cases had nonspecific symptoms and clinical findings, but a majority had compatible biopsies.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251338746"},"PeriodicalIF":0.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PICC-associated tricuspid valve endocarditis in pregnancy managed with AngioVac.","authors":"Lindsay Anderson, Lisa Nguyen","doi":"10.1177/1753495X251335360","DOIUrl":"https://doi.org/10.1177/1753495X251335360","url":null,"abstract":"<p><p>We report the case of a 21-year-old woman at 29 weeks and four days of gestation who presented with one-week history of severe epigastric pain, pleuritic chest pain, dyspnoea, and chills. A peripherally inserted central catheter line had been placed at 14 weeks of gestation for outpatient management of hyperemesis gravidarum. Initial investigations included a transthoracic echocardiogram which revealed a large tricuspid valve vegetation with mild tricuspid regurgitation and CT pulmonary angiogram which identified multiple septic pulmonary emboli. Blood cultures grew methicillin-susceptible <i>Staphylococcus aureus</i>. Despite appropriate antimicrobial therapy, they remained bacteraemic and underwent percutaneous mechanical debulking of tricuspid valve infective endocarditis using an AngioVac aspiration thrombectomy device. Their clinical course post-AngioVac was complicated by the development of multiple pulmonary emboli and suspected left-sided empyema. They delivered by caesarean section at 32 weeks and one day of gestation due to maternal health reasons.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251335360"},"PeriodicalIF":0.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Holy Bezanahary, Jonathan Thiolon, François Dalmay, Jean-Luc Eyraud, Baher Youssef, Yves Aubard, Philippe Lacroix, Lucie Chastaingt, Perrine Coste-Mazeau
{"title":"ABO blood group and risk of pre-eclampsia. A case-control study.","authors":"Holy Bezanahary, Jonathan Thiolon, François Dalmay, Jean-Luc Eyraud, Baher Youssef, Yves Aubard, Philippe Lacroix, Lucie Chastaingt, Perrine Coste-Mazeau","doi":"10.1177/1753495X251333629","DOIUrl":"https://doi.org/10.1177/1753495X251333629","url":null,"abstract":"<p><strong>Background: </strong>It appears that some ABO blood groups may be a risk factor for venous thrombosis. The association between ABO group and risk of pre-eclampsia remains controversial. The purpose of this study was to evaluate the relationship between pre-eclampsia and ABO groups.</p><p><strong>Methods: </strong>A retrospective case-control (1:2) study in a prospective monocentric registry including 20171 pregnancies was performed. Women with pre-eclampsia and severe pre-eclampsia were identified. Controls were matched according to age, parity, year of delivery and body mass index. Blood groups were considered.</p><p><strong>Results: </strong>Two hundred fifty-three cases and 506 controls were included. No difference in distribution was found between cases and controls for non-O group (57.51% vs 62.56, <i>p</i>: 0.19), group A (39.92% vs 44.05, <i>p</i>: 0.29), group B (13.83% vs 15.42, <i>p</i>: 0.57) group AB (3.75 vs 3.08, <i>p</i>: 0.64). The analysis extended to severe pre-eclampsia showed no difference.</p><p><strong>Conclusion: </strong>This study did not document any relationship between ABO groups and the risk of preeclampsia.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251333629"},"PeriodicalIF":0.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>GNE</i>-related severe congenital macro-thrombocytopenia in pregnancy.","authors":"Sivaranjani P, Bhabani Pegu, Murali Subbaiah, Pooja D, Prabhu Manivannan, Gowri Dorairajan","doi":"10.1177/1753495X251334520","DOIUrl":"https://doi.org/10.1177/1753495X251334520","url":null,"abstract":"<p><p>Congenital thrombocytopenia results from mutations in genes implicated in megakaryocyte differentiation and/or platelet formation and clearance. We report the case of a 25 year old primigravida who presented with severe macro-thrombocytopenia from the age of 12 years. She delivered an alive female baby at 35 weeks of gestation. She was diagnosed to have <i>GNE</i> gene mutation. <i>GNE</i> gene encodes the key enzyme in sialic acid biosynthesis, glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (<i>GNE</i>/MNK). The mutation is responsible for the reduction in sialic acid biosynthesis and consequently leads to severe congenital thrombocytopenia and/or myopathy. Although no sign of myopathy was observed in this patient; it is possible myopathy can be developed later, thus long-term follow-up with neurology is highly advisable. We recommend the genetic counselling and a segregation analysis of this variant in other affected individuals in the family.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251334520"},"PeriodicalIF":0.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chloe Gilkinson, Hannah Beresford, Carol Postlethwaite, Catherine Nelson-Piercy, Karan Sampat
{"title":"A rare example of humoral-related hypercalcaemia in pregnancy secondary to a uterine fibroid: a case report.","authors":"Chloe Gilkinson, Hannah Beresford, Carol Postlethwaite, Catherine Nelson-Piercy, Karan Sampat","doi":"10.1177/1753495X251326130","DOIUrl":"https://doi.org/10.1177/1753495X251326130","url":null,"abstract":"<p><p>Whilst uncommon in pregnancy, hypercalcaemia can lead to significant maternal and fetal morbidity. An important complication of hypercalcaemia is uncontrolled hypertension. This case outlines an example of refractory hypercalcaemia exacerbating an emerging hypertensive crisis. The proposed aetiology was parathyroid hormone-related protein (PTHrP)-mediated hypercalcaemia secondary to a necrotic uterine fibroid. We highlight how effective and prompt involvement of the Maternal Medicine Network and multidisciplinary team led to a successful pregnancy outcome.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251326130"},"PeriodicalIF":0.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implications of the USAID U-turn on women's health globally.","authors":"Zulfiqar A Bhutta, Stephen Rulisa","doi":"10.1177/1753495X251332669","DOIUrl":"https://doi.org/10.1177/1753495X251332669","url":null,"abstract":"","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251332669"},"PeriodicalIF":0.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}