Obstetric Medicine最新文献

Successful embolisation of a ruptured splenic artery aneurysm in a high-risk pregnancy. 高危妊娠中脾动脉瘤破裂的成功栓塞。

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Obstetric Medicine Pub Date : 2025-07-17 DOI: 10.1177/1753495X251358949

Emily Wilson, Thomas Ryan, Jacqueline Slater, Lindsay Edwards

引用次数: 0

Haemophagocytic lymphohistiocytosis in pregnancy and the postpartum: A case series from the national HLH network. 妊娠和产后的噬血细胞淋巴组织细胞增多症：来自国家HLH网络的病例系列。

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Obstetric Medicine Pub Date : 2025-07-08 DOI: 10.1177/1753495X251356108

Bethan Goulden, Eleanor Singer, Benjamin Bennett, Eman Elfar, Kazi Fardeen, Ian Giles, Elizabeth Rankin, Joanna Girling, Harry Suzuki, Kate Wiles, Maria Mouyis, Rachel Tattersall, Alexis Jones, Jessica Manson

{"title":"Haemophagocytic lymphohistiocytosis in pregnancy and the postpartum: A case series from the national HLH network.","authors":"Bethan Goulden, Eleanor Singer, Benjamin Bennett, Eman Elfar, Kazi Fardeen, Ian Giles, Elizabeth Rankin, Joanna Girling, Harry Suzuki, Kate Wiles, Maria Mouyis, Rachel Tattersall, Alexis Jones, Jessica Manson","doi":"10.1177/1753495X251356108","DOIUrl":"10.1177/1753495X251356108","url":null,"abstract":"Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory sepsis-like syndrome that accounts for 1% of maternal deaths in the United Kingdom (UK). In 2019, a UK-wide HLH network was developed to provide specialist advice for patients with HLH. Until September 2024, eight individuals had been referred to this service with HLH onset during pregnancy or within 6 months postpartum, and this article summarises their management. Shared themes were of postpartum predominance, with onset typically within a month of delivery, preceding infection, and underlying immune dysfunction. Common therapies included corticosteroids and the interleukin-1 receptor antagonist, anakinra. Most individuals required level 3 care, three were considered for extracorporeal membrane oxygenation, and one died. HLH should be included in the differential of maternal sepsis, given all cases presented with fever and organ dysfunction, particularly if there is ongoing deterioration despite antimicrobial therapy and/or without an identified source.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251356108"},"PeriodicalIF":0.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation-induced brain necrosis during pregnancy: a delayed complication of gestational trophoblastic neoplasia. 妊娠期辐射引起的脑坏死：妊娠滋养细胞瘤的延迟并发症。

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Obstetric Medicine Pub Date : 2025-07-04 DOI: 10.1177/1753495X251354997

Harsha Shah, Jessica Phillips, Mandish K Dhanjal, Pooja Dassan, Michael Seckl, Charlotte Frise

引用次数: 0

Hydronephrosis in pregnancy: Critical factors determining urinary catheter use. 妊娠期肾积水：决定导尿管使用的关键因素。

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Obstetric Medicine Pub Date : 2025-06-24 DOI: 10.1177/1753495X251332667

Çağdaş Demiroğlu, Mehmet Solakhan

{"title":"Hydronephrosis in pregnancy: Critical factors determining urinary catheter use.","authors":"Çağdaş Demiroğlu, Mehmet Solakhan","doi":"10.1177/1753495X251332667","DOIUrl":"10.1177/1753495X251332667","url":null,"abstract":"Background: Pregnancy causes physiological changes, including ureteral compression by the enlarged uterus, leading to hydronephrosis in 90% of cases, though only 3% are symptomatic. This study evaluates outcomes in pregnant women with hydronephrosis managed with or without ureteral stenting to define criteria for intervention.Methods: A retrospective analysis of 92 symptomatic pregnant women with hydronephrosis diagnosed at MP Hospital (2019-2024) was conducted. Patients were categorized into conservative treatment (Group I) and stenting (Group II). Renal dilation, parenchymal thickness, and infection status were assessed.Results: Patients in Group II also had hydronephrosis at earlier gestational weeks (p < .001), and also had more male fetuses (p = .033), lower parenchymal thickness (p < .001), and higher infection rates (p < .001).Conclusion: Indicators for stenting in pregnancy-related hydronephrosis include parenchymal thickness ≤20 mm, renal dilation >30 mm, early symptoms, and infections.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251332667"},"PeriodicalIF":0.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of pregnancy on bioprosthetic structural valve deterioration: a systematic review and meta-analysis. 妊娠对生物假体结构瓣膜恶化的影响：系统回顾和荟萃分析。

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Obstetric Medicine Pub Date : 2025-06-18 DOI: 10.1177/1753495X251347767

Gianna L Wilkie, Evelyn Semenov, Katherine Leung, Becky Baltich Nelson, Nandita S Scott, Colleen M Harrington

{"title":"The impact of pregnancy on bioprosthetic structural valve deterioration: a systematic review and meta-analysis.","authors":"Gianna L Wilkie, Evelyn Semenov, Katherine Leung, Becky Baltich Nelson, Nandita S Scott, Colleen M Harrington","doi":"10.1177/1753495X251347767","DOIUrl":"10.1177/1753495X251347767","url":null,"abstract":"Objective: This systematic review and meta-analysis sought to assess the impact of pregnancy on bioprosthetic valve (BPV) structural valve deterioration. Methods: We searched Ovid MEDLINE, Scopus, Clinicaltrials.gov, and Cochrane Library from inception through October 17, 2022. We included all studies that compared patients with BPV with and without a pregnancy history. The initial search yielded 1748 unique citations that were screened in Covidence by two independent reviewers. Our outcome of interest was structural valve deterioration. Results: We performed random-effects meta-analyses from nine eligible studies. Meta-analysis of 321 individuals with a pregnancy history and 987 control individuals without pregnancy showed there was an increased odds in development of structural valve deterioration among those with a pregnancy history (OR 2.34, 95% CI 1.40-3.89) with an I 2 of 59.8%. Conclusions: A pregnancy history was associated with an increased risk of structural valve deterioration; however, further research is needed due to the heterogeneity of results.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251347767"},"PeriodicalIF":0.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnesium deficiency and dilated cardiomyopathy diagnosed peripartum. 围生期诊断为缺镁和扩张型心肌病。

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Obstetric Medicine Pub Date : 2025-06-16 DOI: 10.1177/1753495X251349950

Adam Morton

引用次数: 0

Autoimmune anti-D in an RhD-positive pregnant woman: A case report. rhd阳性孕妇自身免疫抗- d 1例报告

IF 0.8

Obstetric Medicine Pub Date : 2025-06-12 DOI: 10.1177/1753495X251346056

Samantha Kurniawan, Laura Gerhardy, Sue Hull, Melanie Janus, Nina Dhondy, Lisa Clarke

{"title":"Autoimmune anti-D in an RhD-positive pregnant woman: A case report.","authors":"Samantha Kurniawan, Laura Gerhardy, Sue Hull, Melanie Janus, Nina Dhondy, Lisa Clarke","doi":"10.1177/1753495X251346056","DOIUrl":"10.1177/1753495X251346056","url":null,"abstract":"Background: Anti-D is usually alloimmune and develops in exposed RhD-negative individuals with potential for haemolytic disease of the fetus and newborn (HDFN). However, autoimmune anti-D is rare with limited understanding of its haemolytic risk to the fetus and mother.Case report: A 30-year-old woman previously typed as B RhD positive was found to have an autoimmune anti-D on antenatal screening in her third pregnancy. RHD genotyping confirmed RhD positivity without D variants. Anti-D titres remained elevated at 1:512 throughout pregnancy with normal Doppler monitoring and no maternal haemolysis. The neonate was born at 38 weeks and 3 days of gestation with no evidence of haemolysis.Conclusion: Autoimmune anti-D in pregnancy is rare and requires a multidisciplinary approach to management. Strategies include RHD genotyping to exclude D variants, close monitoring for HDFN, and careful selection of Rh phenotype matched blood for transfusion if required to avoid alloimmunisation for future pregnancies.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251346056"},"PeriodicalIF":0.8,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of casirivimab/imdevimab (REGEN-COV) in pregnant individuals with COVID-19: Literature review and insights from the COVID-19 International Drug Pregnancy Registry. casirivimab/imdevimab （REGEN-COV）在COVID-19妊娠个体中的有效性和安全性：文献综述和来自COVID-19国际药物妊娠登记处的见解

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Obstetric Medicine Pub Date : 2025-06-09 DOI: 10.1177/1753495X251343113

Diego F Wyszynski, Vincent Yau, Daniel Keebler, Cheryl Renz, Jane Ives, Andrew Fitzgibbon, Lee P Shulman

{"title":"Efficacy and safety of casirivimab/imdevimab (REGEN-COV) in pregnant individuals with COVID-19: Literature review and insights from the COVID-19 International Drug Pregnancy Registry.","authors":"Diego F Wyszynski, Vincent Yau, Daniel Keebler, Cheryl Renz, Jane Ives, Andrew Fitzgibbon, Lee P Shulman","doi":"10.1177/1753495X251343113","DOIUrl":"10.1177/1753495X251343113","url":null,"abstract":"Introduction: Casirivimab/imdevimab (CAS/IMD) comprises two monoclonal antibodies that neutralize SARS-CoV-2. Pregnant individuals were excluded from initial trials, limiting safety data.Methods: The COVID-19 International Drug Pregnancy Registry enrolled 53 pregnant women treated with CAS/IMD, with 34 live births.Results: No safety concerns were identified.Discussion and conclusions: The findings of the COVID-PR study support the safety of CAS/IMD during pregnancy, adding to the growing body of evidence on COVID-19 treatments for this population. The available literature shows that CAS/IMD is effective in preventing the progression to severe COVID-19 in pregnant individuals. The drugs are well-tolerated, and there is no compelling evidence of adverse maternal or neonatal outcomes. The results from the COVID-PR study are consistent with those of the broader literature.","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251343113"},"PeriodicalIF":0.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy outcomes following first trimester exposure to semaglutide. 妊娠早期暴露于西马鲁肽后的妊娠结局。

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Obstetric Medicine Pub Date : 2025-06-04 DOI: 10.1177/1753495X251346330

Adam Morton, Jinwen He

引用次数: 0

Thrombotic thrombocytopenic purpura in pregnancy: A case report and literature review. 妊娠期血栓性血小板减少性紫癜1例报告并文献复习。

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Obstetric Medicine Pub Date : 2025-06-03 DOI: 10.1177/1753495X251338163

Brielle Andreatidis, Nicholas Weber, Ann-Maree Craven, Madeline Duke, Leonie Callaway, Jade Eccles-Smith

引用次数: 0