{"title":"Case report: Ulcerative colitis-related spondyloarthritis treated with golimumab until 27 weeks of gestation.","authors":"Ryuichi Okazaki, Ikkou Hirata, Hinako Ikegami, Ryou Rokutanda, Ryohkan Funakoshi","doi":"10.1177/1753495X241297559","DOIUrl":"https://doi.org/10.1177/1753495X241297559","url":null,"abstract":"<p><p>Although tumor necrosis factor inhibitors are recommended for preventing flare-ups in pregnant women with ulcerative colitis (UC), studies on golimumab use during pregnancy are scant. Herein, we present a 39-year-old woman with UC and spondyloarthritis. The patient preferred treatment with a long dosing interval that minimally affects the working life of the patient. Golimumab, considering its long dosing interval, was prescribed after discussion with the patient, physician and pharmacists. Clinical remission was achieved during pregnancy, and the patient delivered a healthy baby. The vaccines were administered according to the vaccine schedule: during the first year after birth, there were neither infections caused by live vaccines nor diseases that the administered vaccines are meant to prevent. Overall, this case suggests that golimumab treatment during pregnancy may be compatible; however, further evaluations, including drug-level analysis, are needed.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241297559"},"PeriodicalIF":0.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in functional status during and after pregnancy in people with cerebral palsy: An international observational study.","authors":"Georgia Condran, Hayley Lipworth, Anne Berndl","doi":"10.1177/1753495X241297560","DOIUrl":"10.1177/1753495X241297560","url":null,"abstract":"<p><strong>Background: </strong>There is limited information surrounding physical changes people with cerebral palsy (CP) experience during pregnancy.</p><p><strong>Methodology: </strong>This is a subgroup analysis of an international online questionnaire, developed with input from individuals with CP. Data collection included demographics, baseline functional status, and functional status changes during pregnancy. Descriptive analysis was used.</p><p><strong>Results: </strong>158 participants from 15 countries participated of which 30 had a total of 49 pregnancies resulting in birth. Worsened strength, spasticity, bladder function and fatigue occurred in 56.5% (13/23), 47.8% (11/23), 56.5% (13/23) and 87.0% (20/23) of participants. 9/23 (40.9%) required new mobility devices. Worsening of fatigue, strength, spasticity and need for a new mobility device was reported by all groups regardless of functional status.</p><p><strong>Conclusions: </strong>People with CP may experience significant functional changes during pregnancy, even those who mobilized independently prior to pregnancy. These findings may inform obstetricians, nurses, neurologists and physiatrists, and contribute to preconception counselling.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241297560"},"PeriodicalIF":0.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review of the use of CT pulmonary angiography in pregnant and postpartum women at an academic centre.","authors":"Wilhelm Herbst, Shastra Bhoora, Halvani Moodley, Ashesh Ranchod, Tracy Westgarth-Taylor, Jarrod Zamparini","doi":"10.1177/1753495X241290551","DOIUrl":"10.1177/1753495X241290551","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary embolism (PE) is a common cause of maternal death during pregnancy and the puerperium yet data on its prevalence in middle-income countries is lacking.</p><p><strong>Methods: </strong>We examined the medical records and CTPA (computed tomography pulmonary angiography) images of 67 women in an obstetric high care unit during pregnancy and the puerperium. We aimed to determine the prevalence of PE in a high-risk obstetric population undergoing CTPA, assess associated clinical features in this cohort, and determine the prevalence of alternative CT findings.</p><p><strong>Results: </strong>CTPA detected PE in 11 women (16.42%) and alternative CT findings in 46 (68.6%). Women with PE had a lower systolic blood pressure than those without PE (<i>P</i> = 0.001). Multiple gestation, preterm rupture of membranes, and gestational diabetes were linked to higher PE prevalence.</p><p><strong>Conclusions: </strong>This study, set in an upper middle-income country, demonstrated a higher CTPA yield for PE and alternative diagnoses than in international literature, emphasising context-specific assessments.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241290551"},"PeriodicalIF":0.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Native kidney biopsy in pregnancy and postpartum: A single centre experience from India.","authors":"Shreya Srinivas Mondemu, Sreejith Parameswaran, Rajesh Nachiappa Ganesh, Anish Keepanasseril","doi":"10.1177/1753495X241290664","DOIUrl":"10.1177/1753495X241290664","url":null,"abstract":"<p><strong>Background: </strong>With the advances in medicine and imaging, renal biopsy is increasingly utilised for identifying pathologies during pregnancy.</p><p><strong>Methods: </strong>This retrospective observational study aimed to assess indications and complications among 32 women who underwent native renal biopsies during pregnancy and postpartum from 2015 to 2022.</p><p><strong>Results: </strong>The commonest indications for performing the biopsy were nephrotic syndrome and acute kidney injury during pregnancy or immediately postpartum. Most (62.5%) had biopsies performed in the antenatal period. Lupus nephritis was the most common finding on biopsy, and there were no procedure-related serious adverse effects. Most pregnancies were complicated by hypertensive disorders and preterm birth. All except six women with perinatal loss had healthy neonates.</p><p><strong>Conclusions: </strong>Even as kidney biopsy remains the gold standard for diagnosing renal pathologies, it should be reserved for women where management in pregnancy would be altered by the result.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241290664"},"PeriodicalIF":0.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ptyalism gravidarum.","authors":"Adam Morton, Jin-Wen He","doi":"10.1177/1753495X241290668","DOIUrl":"10.1177/1753495X241290668","url":null,"abstract":"<p><p>Ptyalism gravidarum, or sialorrhoea, is a highly distressing maternal condition characterised by excess salivation and difficulty swallowing saliva, requiring the affected woman to frequently expectorate. The literature is sparse and somewhat conflicting. There are marked geographical and cultural differences in prevalence. The aetiology is not known, and no trials have been performed with respect to treatment modalities. A review of the available literature is presented, and possible future directions for research are suggested.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241290668"},"PeriodicalIF":0.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julien Viau Lapointe, Clara Juando-Prats, Roberto Zapata, Julia Kfouri, Joyamor Ortuno-Nacho, Rizwana Ashraf, Rohan D'Souza, Jose Rojas-Suarez, Stephen E Lapinsky
{"title":"Patient-reported outcomes in research on critically ill obstetric patients.","authors":"Julien Viau Lapointe, Clara Juando-Prats, Roberto Zapata, Julia Kfouri, Joyamor Ortuno-Nacho, Rizwana Ashraf, Rohan D'Souza, Jose Rojas-Suarez, Stephen E Lapinsky","doi":"10.1177/1753495X241290681","DOIUrl":"10.1177/1753495X241290681","url":null,"abstract":"<p><strong>Background: </strong>Research benefits from the incorporation of patient-important outcomes. We interviewed individuals after a critical illness during pregnancy to identify outcomes for the development of a core outcome set (COS).</p><p><strong>Methods: </strong>Participants were identified through intensive care unit (ICU) admissions in Toronto, Canada, and Barranquilla, Colombia. Interviewers used a semi-structured guide, and discussions were recorded and transcribed. Transcripts underwent inductive thematic analysis to delineate themes and patient-important outcomes.</p><p><strong>Results: </strong>Twelve individuals were interviewed. Twenty-six patient-important outcomes were elicited, which represented the core outcome areas of mortality (<i>n</i> = 1), physiological/clinical outcomes (<i>n</i> = 7), functioning and life impact (<i>n</i> = 13), resource use (<i>n</i> = 4) and adverse events (<i>n</i> = 1). These related to five identified themes of mental well-being, quality of care delivered, clinicians' communication, regaining functional independence and mother-newborn separation.</p><p><strong>Conclusions: </strong>This qualitative study identified patient-important outcomes from persons with lived experience of critical illness in pregnancy which will inform the development of a COS.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241290681"},"PeriodicalIF":0.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suzanne Luong, Wei-Yun Mak, Daniel L Rolnik, Ryan Hodges, Yang Yang, Yen Chieng, Timothy Crozier
{"title":"Pregnancy-associated pulmonary embolism (PA-PE): catheter-directed thrombolysis as first-line rescue.","authors":"Suzanne Luong, Wei-Yun Mak, Daniel L Rolnik, Ryan Hodges, Yang Yang, Yen Chieng, Timothy Crozier","doi":"10.1177/1753495X241290662","DOIUrl":"10.1177/1753495X241290662","url":null,"abstract":"<p><p>Pregnancy-associated pulmonary embolism (PA-PE) is a life-threatening presentation however literature surrounding its optimal management is limited. This case describes a case of PA-PE treated with catheter-directed thrombolysis after clinical deterioration despite standard anticoagulation therapy. Careful multidisciplinary planning is required to successfully manage the deteriorating patient with PA-PE with catheter-directed thrombolysis being considered as potential first-line therapy in these patients.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241290662"},"PeriodicalIF":0.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Familial chylomicronaemia syndrome in pregnancy - report of two cases managed with plasma exchange.","authors":"Francois Dos Santos, Shahenaz Walji, Jaimini Cegla, Sheba Jarvis, Catherine Nelson-Piercy","doi":"10.1177/1753495X241283628","DOIUrl":"10.1177/1753495X241283628","url":null,"abstract":"<p><p>Familial chylomicronaemia syndrome (FCS) is a rare genetic disorder characterised by significantly elevated triglyceride levels which increases the risk of acute pancreatitis. Due to the changes in lipid metabolism during pregnancy, triglyceride levels may rise further, particularly in the third trimester, and cause challenges in the management of these patients. Apart from strict dietary restriction of all fats, there is limited evidence on the efficacy of pharmacological treatment with omega-3 fatty acids and fibrates in maintaining triglyceride levels below the desired threshold of 10 mmol/L. Familial chylomicronaemia syndromes are particularly resistant to treatment and escalation of treatment to more invasive procedures such as plasma exchange may be required in pregnancy. We present two cases of FCS in pregnancy which posed different challenges and both required management with plasma exchange but led to the safe delivery near term without adverse consequences to the mother or fetus.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241283628"},"PeriodicalIF":0.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does having a patient attend a postpartum vascular risk reduction clinic improve physician knowledge and management of preeclampsia as a cardiovascular risk factor?","authors":"Jaslyn Rasmuson, Winnie Sia","doi":"10.1177/1753495X241275847","DOIUrl":"10.1177/1753495X241275847","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia is an independent risk factor for vascular diseases. The Postpartum Preeclampsia Clinic (PPPC) intervenes in the first year postpartum to address these risks. This study aims to characterize physicians' understanding and management of the cardiovascular risk associated with preeclampsia and whether this differs in physicians who had a patient attend the PPPC.</p><p><strong>Methods: </strong>Family physicians, obstetricians, internists, obstetric internists, and cardiologists in Edmonton were anonymously surveyed. Results were analyzed using SPSS.</p><p><strong>Results: </strong>Sixty-four surveys were returned, with physicians correctly identifying preeclampsia as a vascular risk factor 73% of the time. Physicians who had a patient attend the PPPC were more likely to counsel patients on their increased cardiovascular risk, although increased knowledge did not reach statistical significance.</p><p><strong>Conclusion: </strong>Vascular risk reduction clinics may benefit the long-term management of patients with a history of preeclampsia by improving counseling by physicians, which may reduce the disproportionate vascular morbidity these patients face.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241275847"},"PeriodicalIF":0.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine A Birchenall, Anna L David, Melanie Davies, Victoria Grandage, Melanie Griffin
{"title":"Preconception and antenatal care for women with a history of haematopoietic stem cell transplantation: Results of a UK clinician survey.","authors":"Katherine A Birchenall, Anna L David, Melanie Davies, Victoria Grandage, Melanie Griffin","doi":"10.1177/1753495X241272942","DOIUrl":"10.1177/1753495X241272942","url":null,"abstract":"<p><strong>Background: </strong>Female childhood cancer survivors with history of bone marrow transplant with or without total body irradiation have increased pregnancy risks. Preconception counselling and early referral to appropriate clinical pathways may improve pregnancy outcomes.</p><p><strong>Methods: </strong>UK-wide survey of clinicians, promoted via social media and conferences, jointly funded by Action Medical Research/Borne.</p><p><strong>Results: </strong>Forty responses received between 22 October 2020 and 21 October 2021: 43% reviewed this group monthly, 15% annually, 15% less than annually, and 27% never (for O & G only: 13%, 13%, 26%, and 48%, respectively).Pre-pregnancy, most discussed potential fertility/pregnancy implications.Early pregnancy discussions included late miscarriage (34%), preterm birth (44%), fetal growth restriction (31%), and health risks other than cancer (30%).During pregnancy: 80% refer to specialist clinics; 87% offer extra investigations; 33% prescribed aspirin; 20% offered cervical cerclage; and 13% prescribed progesterone.</p><p><strong>Conclusions: </strong>Evidence of variation in care. As previous observations suggest pregnancy outcomes improve when managed in specialist clinics, clearer guidance is required.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X241272942"},"PeriodicalIF":0.8,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}