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When childbirth triggers a hidden neuropathy: hereditary neuropathy with liability to pressure palsies revealed by postpartum paralysis. 当分娩触发一个隐藏的神经病变：遗传性神经病变与倾向性压力麻痹显示产后瘫痪。
IF 0.7
Obstetric Medicine Pub Date : 2026-08-20 DOI: 10.1177/1753495X261478153
Paula Peydro-Lavoie, Gwendal Le Masson, Stéphane Mathis
{"title":"When childbirth triggers a hidden neuropathy: hereditary neuropathy with liability to pressure palsies revealed by postpartum paralysis.","authors":"Paula Peydro-Lavoie, Gwendal Le Masson, Stéphane Mathis","doi":"10.1177/1753495X261478153","DOIUrl":"10.1177/1753495X261478153","url":null,"abstract":"<p><p>Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant disorder caused by a <i>PMP22</i> gene deletion (or mutations), characterized by recurrent, compression-induced mononeuropathies. Postpartum neurological complications are relatively common, but HNPP is rarely considered in their differential diagnosis. We report a case of a 38-year-old woman who developed acute painless bilateral lower limb paralysis following vaginal delivery complicated by prolonged lithotomy positioning and vacuum extraction. Electroneuromyography revealed a demyelinating sensorimotor polyneuropathy with conduction block at the fibular neck, and genetic testing confirmed HNPP. This case underscores the importance of recognizing HNPP as a cause of postpartum paralysis, particularly in patients with a family history of recurrent nerve palsies. Multidisciplinary management, including genetic counseling and tailored obstetric planning for future pregnancies, is essential to optimize outcomes.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261478153"},"PeriodicalIF":0.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13493632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Voice, airway, and swallowing disorders in pregnancy: A retrospective cohort study. 妊娠期语音、气道和吞咽障碍：一项回顾性队列研究。
IF 0.7
Obstetric Medicine Pub Date : 2026-08-20 DOI: 10.1177/1753495X261470978
Faith Arimoro, Isabelle Newman, Anushka Biswas, Allison Gaonzalez, Mehmet Dilek, Aindy Li, Uriel Kim, Ashley Band, Shaina Twardus, Vanessa Torrecillas
{"title":"Voice, airway, and swallowing disorders in pregnancy: A retrospective cohort study.","authors":"Faith Arimoro, Isabelle Newman, Anushka Biswas, Allison Gaonzalez, Mehmet Dilek, Aindy Li, Uriel Kim, Ashley Band, Shaina Twardus, Vanessa Torrecillas","doi":"10.1177/1753495X261470978","DOIUrl":"10.1177/1753495X261470978","url":null,"abstract":"<p><strong>Objective: </strong>A growing population of people of childbearing age seeks care from an otolaryngologist. This study aims to identify trends in the care of pregnant patients with laryngological disorders related to the voice, airway, and swallowing.</p><p><strong>Methods: </strong>This is a retrospective cohort study of patients aged 18-50 at a single institution who had an ICD diagnosis of a disorder related to the voice, airway, or swallowing during pregnancy between 1 December 2014 and 1 December 2024.</p><p><strong>Results: </strong>One hundred and seventy-eight charts were included in the final analysis. Sinusitis was the most common condition, followed by acute upper respiratory infection (URI) and aphagia/dysphagia. Delaying surgical or medical treatment due to pregnancy was common, but loss to follow-up was a risk.</p><p><strong>Conclusions: </strong>Sinusitis, acute URI, and aphagia/dysphagia were the most common voice, airway, and swallowing disorders identified. While treatment patterns vary, pregnancy represents a unique window for optimizing health, of these and other conditions.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261470978"},"PeriodicalIF":0.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13493619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interstitial lung disease in pregnancy. 妊娠期间质性肺病
IF 0.7
Obstetric Medicine Pub Date : 2026-08-10 DOI: 10.1177/1753495X261474605
Divya Mecheril Balachandran, Abhipreet Bhattachariya, Ananda Datta, Vineeta Singh, Priyanka Rai
{"title":"Interstitial lung disease in pregnancy.","authors":"Divya Mecheril Balachandran, Abhipreet Bhattachariya, Ananda Datta, Vineeta Singh, Priyanka Rai","doi":"10.1177/1753495X261474605","DOIUrl":"10.1177/1753495X261474605","url":null,"abstract":"<p><p>Interstitial lung disease (ILD) comprises a heterogeneous group of chronic pulmonary disorders. ILD is associated with impaired gas exchange and progressive respiratory dysfunction. Due to improved survival and delayed childbearing, healthcare providers increasingly encounter pregnancy in women with ILD, but the evidence on management remains limited. Pregnancy in ILD poses a high risk and necessitates early preconception evaluation, risk stratification and a multidisciplinary management approach. This review aims to summarise current knowledge regarding diagnostic evaluation, treatment strategies, obstetric management and maternal-fetal outcomes in women with ILD. Understanding these aspects is essential for optimising care for women with ILD who are planning to conceive or are already pregnant.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261474605"},"PeriodicalIF":0.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute portal hypertension and oesophageal varices in pregnancy. 妊娠期急性门静脉高压和食管静脉曲张。
IF 0.7
Obstetric Medicine Pub Date : 2026-07-27 DOI: 10.1177/1753495X261468841
Sami Rayanne Lewis, Lisa Long, Karan Sampat
{"title":"Acute portal hypertension and oesophageal varices in pregnancy.","authors":"Sami Rayanne Lewis, Lisa Long, Karan Sampat","doi":"10.1177/1753495X261468841","DOIUrl":"10.1177/1753495X261468841","url":null,"abstract":"<p><p>Non-cirrhotic portal hypertension (PHTN) is often attributed to portal vein thrombosis and may cause serious complications. Described here is a woman with a new portal vein thrombosis in her third pregnancy, complicated by PHTN and oesophageal varices. She was managed using a multi-centre, multidisciplinary approach throughout her pregnancy and delivered a healthy baby at term via induced vaginal birth. Here, the treatment modalities available for pregnant women with PHTN and the management of complications are discussed.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261468841"},"PeriodicalIF":0.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13407667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy in a woman with Bombay blood group. 孟买血型妇女怀孕。
IF 0.7
Obstetric Medicine Pub Date : 2026-07-10 DOI: 10.1177/1753495X261463577
Juliet Bottle, Charlotte Frise, Jasmine Tay, Mamta Sohal
{"title":"Pregnancy in a woman with Bombay blood group.","authors":"Juliet Bottle, Charlotte Frise, Jasmine Tay, Mamta Sohal","doi":"10.1177/1753495X261463577","DOIUrl":"10.1177/1753495X261463577","url":null,"abstract":"<p><p>Bombay phenotype is a rare blood group where individuals produce an anti-H antibody, which agglutinates with antigens on red blood cells from common blood groups. The presence of this antibody has significant implications for the management of pregnancy in these individuals, with both maternal and fetal considerations. Few descriptions of pregnancy with this condition exist in published literature. Described here is the case of a woman who was found to have the Bombay phenotype during her first pregnancy. The multidisciplinary input, logistical considerations and planning for possible complications that were required are described. Despite the onset of pre-term labour, she avoided the need for blood transfusion, and there were no adverse fetal effects. This case highlights the unique challenges that pregnancy poses in this condition.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261463577"},"PeriodicalIF":0.7,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-GAD antibody-associated epilepsy in pregnancy. 妊娠期抗广泛性焦虑症相关癫痫。
IF 0.7
Obstetric Medicine Pub Date : 2026-06-25 DOI: 10.1177/1753495X261463144
Abigail Punt, Mandish K Dhanjal, Pooja Dassan, Michael Johnson, Charlotte Frise
{"title":"Anti-GAD antibody-associated epilepsy in pregnancy.","authors":"Abigail Punt, Mandish K Dhanjal, Pooja Dassan, Michael Johnson, Charlotte Frise","doi":"10.1177/1753495X261463144","DOIUrl":"https://doi.org/10.1177/1753495X261463144","url":null,"abstract":"<p><p>Anti-GAD antibody-associated epilepsy (AAE) is a rare neurological condition arising as a consequence of autoantibodies against the intracellular antigen glutamic acid decarboxylase (GAD) 65. It most commonly manifests in women of childbearing age, with persistent seizures, often refractory to therapy. Here described is a woman in her first pregnancy, with anti-GAD AAE, managed in pregnancy with a combination of anti-seizure medications (ASM) and intravenous immunoglobulin. Escalation of her medication doses was required as her pregnancy progressed in response to falling ASM levels and increased seizure frequency. She delivered a healthy neonate following induction of labour at 38 weeks' gestation due to intrahepatic cholestasis, potentially related to azathioprine use. Early neonatal anti-GAD antibody testing and baseline neurological examination were undertaken with developmental follow-up planned, given the uncertain significance of passively transferred maternal antibodies.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261463144"},"PeriodicalIF":0.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13303265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eplerenone in pregnancy. 每个人都在怀孕。
IF 0.7
Obstetric Medicine Pub Date : 2026-06-24 DOI: 10.1177/1753495X261463148
Adam Morton
{"title":"Eplerenone in pregnancy.","authors":"Adam Morton","doi":"10.1177/1753495X261463148","DOIUrl":"https://doi.org/10.1177/1753495X261463148","url":null,"abstract":"<p><p>Eplerenone is a mineralocorticoid receptor antagonist with minimal affinity for androgen receptors. Mineralocorticoid receptor antagonists are efficacious in the management of resistant hypertension, obstructive sleep apnea, cardiac dysfunction, renal tubular disorders, hepatic cirrhosis, portal hypertension, diabetic nephropathy, proteinuric kidney disease, and chronic central serous chorioretinopathy in the general population. Five cases describing the use of eplerenone in pregnancy are discussed, the previous literature reviewed, and potential indications for the use of eplerenone in pregnancy discussed.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261463148"},"PeriodicalIF":0.7,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postpartum therapeutic anticoagulation and uterine wall haematoma: A case report. 产后抗凝治疗与子宫壁血肿1例。
IF 0.7
Obstetric Medicine Pub Date : 2026-06-23 DOI: 10.1177/1753495X261460131
Satoshi Shinohara, Taiga Matsudo, Genki Yasuda, Mayuko Kasai, Ken Umetani, Rei Sunami
{"title":"Postpartum therapeutic anticoagulation and uterine wall haematoma: A case report.","authors":"Satoshi Shinohara, Taiga Matsudo, Genki Yasuda, Mayuko Kasai, Ken Umetani, Rei Sunami","doi":"10.1177/1753495X261460131","DOIUrl":"https://doi.org/10.1177/1753495X261460131","url":null,"abstract":"<p><p>Deep vein thrombosis (DVT) during pregnancy requires timely anticoagulation to prevent complications; however, the early postpartum period is associated with an inherently elevated risk of hemorrhage, creating competing management priorities. Herein, we describe the case of a woman with dichorionic diamniotic twin pregnancy who developed progressive femoral DVT despite therapeutic unfractionated heparin (UFH) and concurrent preeclampsia and acute kidney injury. Although postoperative hemostasis after caesarean delivery initially appeared stable, therapeutic UFH was restarted early as DVT continued to progress, requiring the resumption of standard treatment. Despite seemingly adequate early hemostasis, the woman developed a massive uterine wall hematoma that required uterine artery embolization. This case illustrates the complexity of balancing thrombotic urgency against fragile postpartum hemostasis and highlights the importance of individualized anticoagulation strategies for obstetricians, surgeons, anesthesiologists, and perioperative teams caring for high-risk patients.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261460131"},"PeriodicalIF":0.7,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence of the common LCHAD c.1528G>C p.(Glu510Gln) pathogenic variant in women diagnosed with acute fatty liver of pregnancy. 妊娠期急性脂肪肝女性常见LCHAD C . 1528g . > . C . p.（Glu510Gln）致病变异的患病率
IF 0.7
Obstetric Medicine Pub Date : 2026-06-19 DOI: 10.1177/1753495X261460139
Jinwen He, Liza Phillips, Janelle Nisbet, Adam Morton
{"title":"The prevalence of the common LCHAD c.1528G>C p.(Glu510Gln) pathogenic variant in women diagnosed with acute fatty liver of pregnancy.","authors":"Jinwen He, Liza Phillips, Janelle Nisbet, Adam Morton","doi":"10.1177/1753495X261460139","DOIUrl":"https://doi.org/10.1177/1753495X261460139","url":null,"abstract":"<p><p>The prevalence of the common LCHAD c.1528G>C p.(Glu510Gln) pathogenic variant in the <i>HADHA</i> gene in women and neonates with acute fatty liver of pregnancy is unclear. A review of nine case series comprising 113 pregnancies complicated by acute fatty liver of pregnancy, where maternal and/or fetal genetic testing was performed, found the LCHAD c.1528G>C p.(Glu510Gln) variant in only five cases (4.4%). In addition, an online survey disclosed no maternal and/or fetal pathogenic variants in 23 women who recalled the results of gene testing. Only a small minority of women with a clinical diagnosis of acute fatty liver of pregnancy have the common LCHAD c.1528G>C p.(Glu510Gln) variant on genetic testing.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261460139"},"PeriodicalIF":0.7,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13283609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal tubular acidosis (RTA) complicated pregnancies: A tertiary centre experience. 肾小管酸中毒（RTA）并发症妊娠：三级中心经验。
IF 0.5
Obstetric Medicine Pub Date : 2026-06-10 DOI: 10.1177/1753495X261456364
Arati Singh, Tarakeswari Surapaneni, Hemamalini Vadlamani
{"title":"Renal tubular acidosis (RTA) complicated pregnancies: A tertiary centre experience.","authors":"Arati Singh, Tarakeswari Surapaneni, Hemamalini Vadlamani","doi":"10.1177/1753495X261456364","DOIUrl":"https://doi.org/10.1177/1753495X261456364","url":null,"abstract":"<p><strong>Background: </strong>Renal tubular acidosis (RTA) is a disorder of renal acid-base regulation causing normal anion gap metabolic acidosis. Among its three types, distal RTA (dRTA) is the most common form.</p><p><strong>Methods: </strong>This retrospective case series included pregnancies complicated by RTA managed at Fernandez Hospital, Hyderabad, India, between 2008 and 2024. Maternal and perinatal outcomes data were obtained from medical records.</p><p><strong>Results: </strong>Among 133,542 deliveries, 19 pregnancies were complicated by RTA, giving an incidence of 0.014%. All cases were Type I dRTA, with 84% secondary to connective tissue disorders, predominantly Sjögren's syndrome. Recurrent hypokalaemic periodic paralysis was the most common complication. With early diagnosis and meticulous metabolic correction, most women achieved term deliveries with favourable maternal and neonatal outcomes.</p><p><strong>Conclusions: </strong>Renal tubular acidosis in pregnancy may worsen due to physiological changes. Untreated disease poses risks from chronic acidosis and electrolyte imbalance. Early recognition and multidisciplinary management are crucial for optimal outcomes.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261456364"},"PeriodicalIF":0.5,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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