Esther Park, Mandish Dhanjal, Sahana Gupta, Carolyn Millar, Naomi Primrose, Vinnie Sodhi, Charlotte Frise
{"title":"Intrapartum management of anticoagulation in a pregnant woman with acute cerebral venous sinus thrombosis undergoing vaginal delivery.","authors":"Esther Park, Mandish Dhanjal, Sahana Gupta, Carolyn Millar, Naomi Primrose, Vinnie Sodhi, Charlotte Frise","doi":"10.1177/1753495X251361665","DOIUrl":"10.1177/1753495X251361665","url":null,"abstract":"<p><p>Cerebral venous sinus thrombosis (CVST) is a neurological emergency caused by occlusion of the dural venous sinus and/or the cerebral veins. It is more common in women during pregnancy and puerperium. Described here is a woman with an expanding CVST diagnosed at 36 weeks of gestation who had a successful vaginal delivery at 38 weeks of gestation with meticulous anticoagulation and labour management, multidisciplinary team input and close monitoring.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251361665"},"PeriodicalIF":0.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inherited aortopathies and risk of aortic dissection and aortic syndrome in pregnancy.","authors":"Timothy Chalk, Kylie Burns, Adam Morton","doi":"10.1177/1753495X251359834","DOIUrl":"10.1177/1753495X251359834","url":null,"abstract":"<p><p>Acute aortic dissection related to pregnancy is rare, however represented the third most common cause of pregnancy-related cardiovascular death in the 2017 UK-MBBRACE report. The majority of women with pregnancy-related aortic dissection have an underlying inherited syndromic aortopathy, though this is often not recognised until an event. Data regarding the immediate and long-term effects of pregnancy on aortic outcome are not uniform due to publication and ascertainment biases, small sample sizes, inclusion of women whose dissection was the first presentation of the underlying disease, and incompleteness of collected data. Management recommendations are based on relatively low levels of evidence, and there is some variation between society guideline recommendations. This article seeks to review the available evidence regarding pregnancy-related aortic dissection in women inherited syndromic aortopathies, highlighting the importance of pre-conception counselling, genetic testing and a multi-disciplinary team approach to management.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251359834"},"PeriodicalIF":0.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily Wilson, Thomas Ryan, Jacqueline Slater, Lindsay Edwards
{"title":"Successful embolisation of a ruptured splenic artery aneurysm in a high-risk pregnancy.","authors":"Emily Wilson, Thomas Ryan, Jacqueline Slater, Lindsay Edwards","doi":"10.1177/1753495X251358949","DOIUrl":"10.1177/1753495X251358949","url":null,"abstract":"<p><p>Splenic artery aneurysm (SAA) rupture in pregnancy is an unpredictable and rare emergency associated with maternal and fetal mortality. Ruptured SAA is characteristically diagnosed at laparotomy and managed with splenectomy, with embolisation favoured for uncomplicated cases. We report a case of a ruptured SAA in a morbidly obese pregnant woman with medical comorbidities, who presented as a diagnostic dilemma, but was subsequently managed successfully with interventional radiology at the time of caesarean section.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251358949"},"PeriodicalIF":0.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bethan Goulden, Eleanor Singer, Benjamin Bennett, Eman Elfar, Kazi Fardeen, Ian Giles, Elizabeth Rankin, Joanna Girling, Harry Suzuki, Kate Wiles, Maria Mouyis, Rachel Tattersall, Alexis Jones, Jessica Manson
{"title":"Haemophagocytic lymphohistiocytosis in pregnancy and the postpartum: A case series from the national HLH network.","authors":"Bethan Goulden, Eleanor Singer, Benjamin Bennett, Eman Elfar, Kazi Fardeen, Ian Giles, Elizabeth Rankin, Joanna Girling, Harry Suzuki, Kate Wiles, Maria Mouyis, Rachel Tattersall, Alexis Jones, Jessica Manson","doi":"10.1177/1753495X251356108","DOIUrl":"10.1177/1753495X251356108","url":null,"abstract":"<p><p>Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory sepsis-like syndrome that accounts for 1% of maternal deaths in the United Kingdom (UK). In 2019, a UK-wide HLH network was developed to provide specialist advice for patients with HLH. Until September 2024, eight individuals had been referred to this service with HLH onset during pregnancy or within 6 months postpartum, and this article summarises their management. Shared themes were of postpartum predominance, with onset typically within a month of delivery, preceding infection, and underlying immune dysfunction. Common therapies included corticosteroids and the interleukin-1 receptor antagonist, anakinra. Most individuals required level 3 care, three were considered for extracorporeal membrane oxygenation, and one died. HLH should be included in the differential of maternal sepsis, given all cases presented with fever and organ dysfunction, particularly if there is ongoing deterioration despite antimicrobial therapy and/or without an identified source.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251356108"},"PeriodicalIF":0.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harsha Shah, Jessica Phillips, Mandish K Dhanjal, Pooja Dassan, Michael Seckl, Charlotte Frise
{"title":"Radiation-induced brain necrosis during pregnancy: a delayed complication of gestational trophoblastic neoplasia.","authors":"Harsha Shah, Jessica Phillips, Mandish K Dhanjal, Pooja Dassan, Michael Seckl, Charlotte Frise","doi":"10.1177/1753495X251354997","DOIUrl":"10.1177/1753495X251354997","url":null,"abstract":"<p><p>Radiation-induced brain necrosis (RIBN) is a rare but serious delayed complication of intracerebral radiotherapy. We present the case of a 34-year-old woman with a history of gestational trophoblastic neoplasia (GTN) with brain metastases, who presented with symptoms related to RIBN at 20 weeks' gestation in a subsequent pregnancy. These included right homonymous inferior quadrantanopia and headaches. We describe the imaging and diagnostic tests used to assess for GTN recurrence and the specific management of RIBN in pregnancy within a multidisciplinary care setting.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251354997"},"PeriodicalIF":0.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hydronephrosis in pregnancy: Critical factors determining urinary catheter use.","authors":"Çağdaş Demiroğlu, Mehmet Solakhan","doi":"10.1177/1753495X251332667","DOIUrl":"10.1177/1753495X251332667","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy causes physiological changes, including ureteral compression by the enlarged uterus, leading to hydronephrosis in 90% of cases, though only 3% are symptomatic. This study evaluates outcomes in pregnant women with hydronephrosis managed with or without ureteral stenting to define criteria for intervention.</p><p><strong>Methods: </strong>A retrospective analysis of 92 symptomatic pregnant women with hydronephrosis diagnosed at MP Hospital (2019-2024) was conducted. Patients were categorized into conservative treatment (Group I) and stenting (Group II). Renal dilation, parenchymal thickness, and infection status were assessed.</p><p><strong>Results: </strong>Patients in Group II also had hydronephrosis at earlier gestational weeks (<i>p</i> < .001), and also had more male fetuses (<i>p</i> = .033), lower parenchymal thickness (<i>p</i> < .001), and higher infection rates (<i>p</i> < .001).</p><p><strong>Conclusion: </strong>Indicators for stenting in pregnancy-related hydronephrosis include parenchymal thickness ≤20 mm, renal dilation >30 mm, early symptoms, and infections.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251332667"},"PeriodicalIF":0.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gianna L Wilkie, Evelyn Semenov, Katherine Leung, Becky Baltich Nelson, Nandita S Scott, Colleen M Harrington
{"title":"The impact of pregnancy on bioprosthetic structural valve deterioration: a systematic review and meta-analysis.","authors":"Gianna L Wilkie, Evelyn Semenov, Katherine Leung, Becky Baltich Nelson, Nandita S Scott, Colleen M Harrington","doi":"10.1177/1753495X251347767","DOIUrl":"10.1177/1753495X251347767","url":null,"abstract":"<p><p><b>Objective:</b> This systematic review and meta-analysis sought to assess the impact of pregnancy on bioprosthetic valve (BPV) structural valve deterioration. <b>Methods:</b> We searched Ovid MEDLINE, Scopus, Clinicaltrials.gov, and Cochrane Library from inception through October 17, 2022. We included all studies that compared patients with BPV with and without a pregnancy history. The initial search yielded 1748 unique citations that were screened in Covidence by two independent reviewers. Our outcome of interest was structural valve deterioration. <b>Results:</b> We performed random-effects meta-analyses from nine eligible studies. Meta-analysis of 321 individuals with a pregnancy history and 987 control individuals without pregnancy showed there was an increased odds in development of structural valve deterioration among those with a pregnancy history (OR 2.34, 95% CI 1.40-3.89) with an <i>I</i> <sup>2</sup> of 59.8%. <b>Conclusions:</b> A pregnancy history was associated with an increased risk of structural valve deterioration; however, further research is needed due to the heterogeneity of results.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251347767"},"PeriodicalIF":0.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Magnesium deficiency and dilated cardiomyopathy diagnosed peripartum.","authors":"Adam Morton","doi":"10.1177/1753495X251349950","DOIUrl":"10.1177/1753495X251349950","url":null,"abstract":"<p><p>Dilated cardiomyopathy in pregnancy, whether diagnosed pre-conception, or occurring de novo during pregnancy, may be associated with significant maternal morbidity and mortality. Hypomagnesaemia is associated with ventricular arrhythmias and may be a risk factor for heart failure, coronary artery disease and atrial fibrillation in the general population. Pregnancy is associated with a progressive physiological fall in serum magnesium concentration. Intracellular magnesium deficiency may exist despite normal serum magnesium concentration. Three cases of dilated cardiomyopathy developing in the peripartum period with hypomagnesaemia are presented. The literature regarding associations between magnesium deficiency and dilated cardiomyopathy is reviewed. Potential future research examining magnesium deficiency as a potential contributor to dilated cardiomyopathy in pregnancy is proposed, and possible implications for management are discussed.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251349950"},"PeriodicalIF":0.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samantha Kurniawan, Laura Gerhardy, Sue Hull, Melanie Janus, Nina Dhondy, Lisa Clarke
{"title":"Autoimmune anti-D in an RhD-positive pregnant woman: A case report.","authors":"Samantha Kurniawan, Laura Gerhardy, Sue Hull, Melanie Janus, Nina Dhondy, Lisa Clarke","doi":"10.1177/1753495X251346056","DOIUrl":"10.1177/1753495X251346056","url":null,"abstract":"<p><strong>Background: </strong>Anti-D is usually alloimmune and develops in exposed RhD-negative individuals with potential for haemolytic disease of the fetus and newborn (HDFN). However, autoimmune anti-D is rare with limited understanding of its haemolytic risk to the fetus and mother.</p><p><strong>Case report: </strong>A 30-year-old woman previously typed as B RhD positive was found to have an autoimmune anti-D on antenatal screening in her third pregnancy. RHD genotyping confirmed RhD positivity without D variants. Anti-D titres remained elevated at 1:512 throughout pregnancy with normal Doppler monitoring and no maternal haemolysis. The neonate was born at 38 weeks and 3 days of gestation with no evidence of haemolysis.</p><p><strong>Conclusion: </strong>Autoimmune anti-D in pregnancy is rare and requires a multidisciplinary approach to management. Strategies include RHD genotyping to exclude D variants, close monitoring for HDFN, and careful selection of Rh phenotype matched blood for transfusion if required to avoid alloimmunisation for future pregnancies.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251346056"},"PeriodicalIF":0.8,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diego F Wyszynski, Vincent Yau, Daniel Keebler, Cheryl Renz, Jane Ives, Andrew Fitzgibbon, Lee P Shulman
{"title":"Efficacy and safety of casirivimab/imdevimab (REGEN-COV) in pregnant individuals with COVID-19: Literature review and insights from the COVID-19 International Drug Pregnancy Registry.","authors":"Diego F Wyszynski, Vincent Yau, Daniel Keebler, Cheryl Renz, Jane Ives, Andrew Fitzgibbon, Lee P Shulman","doi":"10.1177/1753495X251343113","DOIUrl":"10.1177/1753495X251343113","url":null,"abstract":"<p><strong>Introduction: </strong>Casirivimab/imdevimab (CAS/IMD) comprises two monoclonal antibodies that neutralize SARS-CoV-2. Pregnant individuals were excluded from initial trials, limiting safety data.</p><p><strong>Methods: </strong>The COVID-19 International Drug Pregnancy Registry enrolled 53 pregnant women treated with CAS/IMD, with 34 live births.</p><p><strong>Results: </strong>No safety concerns were identified.</p><p><strong>Discussion and conclusions: </strong>The findings of the COVID-PR study support the safety of CAS/IMD during pregnancy, adding to the growing body of evidence on COVID-19 treatments for this population. The available literature shows that CAS/IMD is effective in preventing the progression to severe COVID-19 in pregnant individuals. The drugs are well-tolerated, and there is no compelling evidence of adverse maternal or neonatal outcomes. The results from the COVID-PR study are consistent with those of the broader literature.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X251343113"},"PeriodicalIF":0.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}