The Eurasian Journal of Medicine最新文献

{"title":"Review of Pharmacotherapy Trialed for Management of the Coronavirus Disease-19.","authors":"Kimberly Hall,&nbsp;Fuhbe Mfone,&nbsp;Michael Shallcross,&nbsp;Vikas Pathak","doi":"10.5152/eurasianjmed.2021.20384","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20384","url":null,"abstract":"<p><p>Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been substantial progress in the pharmacologic treatment and supportive care of patients hospitalized with active COVID-19 infections. To date there have been numerous medications trialed for COVID-19 management. In this review, our objective is to provide a comprehensive review of the primary literature and clinical applications surrounding some of the prominent drugs and medication classes that have been utilized in those suffering from COVID-19 infections. The medications reviewed in this article include: hydroxychloroquine, remdesivir, azithromycin, dexamethasone, melatonin, tocilizumab, ascorbic acid, and zinc. The medication classes reviewed include: anticoagulation, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, convalescent plasma, non-steroidal anti-inflammatory drugs, human recombinant soluble ACE2, and the BNT162b2 mRNA COVID-19 vaccine.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"137-143"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Muscular Ventricular Septal Defect Closure with 2D Transthoracic Echocardiography: Can We Sufficiently Visualize It?","authors":"Deniz Mutlu,&nbsp;Konstantinos Marmagkiolis,&nbsp;Cezar A Iliescu,&nbsp;Ismail Ates,&nbsp;Mehmet Cilingiroglu","doi":"10.5152/eurasianjmed.2021.20131","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20131","url":null,"abstract":"<p><p>Ventricular septal defect (VSD) is one of the most common congenital heart diseases worldwide today. Although the majority close spontaneously, transcatheter VSD closure is a common option for symptomatic patients with suitable anatomy in adult age. Although transesophageal echocardiography (TEE) and intracardiac echocardiography are the most common imaging modalities for the procedure, in patients with poor TEE images, Transthoracic echocardiography (TTE) can be used as a reliable alternative. Here we present an adult patient with pulmonary hypertension associated with a muscular VSD which was closed percutaneously using 2-dimensional TTE because of poor TEE images.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"144-147"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19: Why Algeria's Case Fatality Rate Seems to be Among the Highest in the World?","authors":"Mohamed Lounis","doi":"10.5152/eurasianjmed.2021.20192","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20192","url":null,"abstract":"From the first COVID-19 positive case reported on February 25, Algeria accounts 11,268 cases (June 16) at present. This number makes it the fifth most affected country in Africa after South Africa, Egypt, Nigeria, and Ghana.1,2 However, it is ranked third in the number of deaths, with 799 cases translating to a fatality rate of 7.1 %, which is the 13th highest in the world after those reported in the most affected countries such as France (15.5%), United Kingdom (14.1%), Italy (14.5 %), and Spain (11.1 %).3 Furthermore, from April 12 to April 15, Algeria has shocked the world by reporting the highest fatality rate (number of deaths/number of affected cases) in the world (between 15.1% and 15. 8%).1","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"160-161"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Apoptotic Effects of Resistance Training and Tribulus Terrestris Consumption in the Heart Tissue of Rats Exposed to Stanozolol.","authors":"Ayat Arjmand,&nbsp;Bahram Abedi,&nbsp;Seyed Ali Hosseini","doi":"10.5152/eurasianjmed.2021.20051","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20051","url":null,"abstract":"Objective Nowadays, the use of energetic substances has become a complex problem in sports, such that the role of anabolic-androgenic steroids is undeniable. This study aimed to investigate the antiapoptotic effect of resistance training and Tribulus terrestris in the heart tissue of rats exposed to stanozolol. Materials and Methods 35 rats divided into 7 groups including (1) sham, (2) stanozolol-treated, (3) stanozolol+50 mg/kg Tribulus terrestris-treated, (4) stanozolol+100 mg/kg Tribulus terrestris-treated, (5) stanozolol+resistance training-treated, (6) stanozolol+resistance training+50 mg/kg Tribulus terrestris-treated, and (7) stanozolol+resistance training+100 mg/kg Tribulus terrestris-treated. During 8 weeks, groups 2–7 received 5 mg/kg stanozolol per day peritoneally; groups 5–7 performed resistance training for 3 sessions per week; and groups 3, 4, 6 and 7 received daily doses of Tribulus terrestris peritoneally. Results Stanozolol administration significantly increased the BAX, BCL-2, P53, and caspase 3 and BAX/BCL-2 ratio (P < .001). Resistance training, 100 mg/kg Tribulus terrestris administration, 50 mg/kg Tribulus terrestris administration, resistance training+100 mg/kg Tribulus terrestris administration, and resistance training+50 mg/kg Tribulus terrestris administration significantly decreased BAX, BCL-2, P53, and caspase 3 levels and BAX/BCL-2 ratio (P < .001); however, stanozolol+resistance training+100 mg/kg Tribulus terrestris administration caused more decrease than stanozolol+resistance training+50 mg/kg Tribulus terrestris administration in BAX (P < .001). Conclusion Resistance training and Tribulus terrestris administration alone appear to have antiapoptotic effects; however, resistance training combined with Tribulus terrestris administration, especially at higher doses, have more desirable effects than resistance training or Tribulus terrestris administration alone on the apoptosis markers.","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"79-84"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39111479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of COVID-19 Threats among Individuals from Different Countries: A Survey.","authors":"Ibrahim Ethem Gurbuz,&nbsp;Hema Sekhar Reddy Rajula,&nbsp;Halil Koca,&nbsp;Vedat Karadeniz,&nbsp;Vassilios Fanos","doi":"10.5152/eurasianjmed.2021.20260","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20260","url":null,"abstract":"<p><strong>Objective: </strong>The aim is to discover the perceptions of individuals living in different countries relating to Covid-19 and develop a joint initiative against this virus and future outbreaks by making comparisons over a number of sociological factors.</p><p><strong>Materials and methods: </strong>A cross-sectional research design was applied, which is a type of descriptive survey belonging to quantitative research. The sample was selected from various countries: Turkey, USA, France, Germany, Netherlands, Georgia, India, and South Africa. The total number of participants is 1020 people. The data were provided through the One-Way Anova Test and collected based on \"The Covid-19 Perception Questionnaire\" which contained 5 personal information and 10 items.</p><p><strong>Results: </strong>We found that statistically significant differences among the Covid-19 perceptions of individuals. The effect size showed that this difference is at a large level. As the variances did not evenly distribute, the Dunnett C multiple comparison tests were applied. According to this, the highest mean in Georgia and India, the lowest mean in Germany and the USA.</p><p><strong>Conclusion: </strong>The majority have the national and international awareness required to cope with the pandemic. However, the source of the virus has still not been explained so it has been observed that the number of people who believe in conspiracy theories is also high. As a result, people need more reliable sources of information, especially the World Health Organization should make more precise explanations to people about the origin of Covid-19 and updated information should be made available to people constantly. In addition, although a long time passed after the appearance of the Covid-19, people are still confused.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"108-113"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39113406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sigmoid Volvulus: Diagnostic Modalities and Sigmoid Gangrene.","authors":"Sabri Selcuk Atamanalp,&nbsp;Esra Disci","doi":"10.5152/eurasianjmed.2021.21101","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.21101","url":null,"abstract":"In SV, abdominal pain/tenderness, obstipation, and asymmetrical abdominal distention (Figure 1a), which are described as the volvulus triad, are observed in 52%-99% of patients.1,3 In our evaluation, these clinical features were found in 98.9%, 96.6%, and 92.4% of patients, respectively. Other clinical features are vomiting, hyperkinetic or hypokinetic bowel sounds, empty rectum or melanotic stool, and shock.1,3 In endemic regions, the determination of the abovementioned features in a middle aged or elderly man is generally suggestive of SV.3 Plain abdominal X-ray radiography demonstrating an omega-shaped sigmoid colon with small intestinal air-fluid levels is diagnostic in 25%-90% of patients (Figure 1b)1,3; this was observed in 68.2% of our patients. Nevertheless, the diagnostic values of computerized tomography (CT) and magnetic resonance imaging (MRI) are generally reported to be over 90%. In CT and MRI, the pathognomonic finding of SV is mesenteric whirl sign arising from rotated sigmoid mesentery in addition to the dilated sigmoid colon and small intestinal air-fluid levels (Figures 1c, 1d).3 In our evaluation, the diagnostic accuracy of CT and MRI were 97.3% and 95.6%, respectively. Endoscopic sign of SV is a spiral torsion of the lumen, usually 20-30 cm from the anal verge (Figure 1e). Endoscopy is diagnostic in 76%-100% of patients3; this was observed in 98.7% of our patients. When CT, MRI, or endoscopy are not used, SV is easily misdiagnosed as an intestinal obstruction, which generally requires an emergency laparotomy.1,3","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"166-167"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Management of Giant Intracranial Meningiomas.","authors":"Soner Yaşar,&nbsp;Alparslan Kırık","doi":"10.5152/eurasianjmed.2021.20155","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20155","url":null,"abstract":"<p><strong>Objective: </strong>Giant intracranial meningiomas are a challenge for neurosurgeons because of their size and location in the cranium. Difficult tumor dissection and encasement of important neurovascular structures make them a horrible nightmare. The aims of this study are to present our giant intracranial meningioma series and to compare our experience using advanced surgical technology with the current literature.</p><p><strong>Materials and methods: </strong>The data of patients with the diagnosis of giant intracranial meningioma between 2014 and 2020 who underwent surgical treatment were retrospectively reviewed. The demographic, radiological, and surgical characteristics of patients were documented. The size and location of tumors as well as surgical technique were analyzed in detail.</p><p><strong>Results: </strong>A total of 61 patients with intracranial meningioma underwent surgical treatment over a 7-year period, and 10 (16.4%) tumors were larger than 5 cm in diameter, which were classified as giant meningioma. Seven patients were male and 3 were female, with a mean age of 64.9 years. Four tumors were located at the skull base. Histological diagnosis was meningioma World Health Organization grade I in 7 patients and grade II in 3 patients. Simpson grade 1 resection was achieved in 6 patients and grade 2 resection in 4 patients. No mortality was observed.</p><p><strong>Conclusion: </strong>Careful surgical planning should be made for giant intracranial meningiomas. Their location, adjacent neurovascular structures, and vascular supply affect the resection level of these giant tumors. Simpson grade 1 resection is seldom possible for skull base meningiomas.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"73-78"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39111478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral Respiratory Tract Pathogens During the COVID-19 Pandemic.","authors":"Özgür Çelebi,&nbsp;Demet Çelebi","doi":"10.5152/eurasianjmed.2021.20459","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20459","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to report viral respiratory pathogens during the coronavirus disease 2019 (COVID-19) pandemic.</p><p><strong>Materials and methods: </strong>Other viral pathogens were identified. COVID-19 immunoglobulin M and immunoglobulin G were detected.</p><p><strong>Results: </strong>Of the 56 samples collected from women, 2 (3.5%) were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), whereas 8 (10%) of the 80 samples from men were positive for SARS-CoV-2. The number of respiratory syncytial virus-A-positive cases was 6 (10.7%) in women and 14 (17.5%) in men. Two (3.5%) of the women were positive for parainfluenza-3, and 6 of the men were positive for influenza-B. The number of human metapneumovirus (HMPV)-positive women and men was 6 (10.7%) and 6 (7.5%), respectively. Rhinovirus caused 14.2% and 10% of the cases in men and women, respectively. With a ratio of 10.7% in women and 7.5% in men; SARS-CoV-2, with a ratio of 10% in men and 3.5% in women; influenza-B, with a ratio of 7.5% in men; and parainfluenza-3 and 4, with a ratio of 3.5% in women. SARS-CoV-2 had a mean incidence rate of 7% in men and women. The antibody screening results reveal that antibody formation did not occur in 3 women among the 10 patients who were diagnosed with COVID-19, and antibody formation occurred in 2 of 7 men. Antibody formation occurred in 5 women (16.6%) and 7 men (20.5%) among the 58 patients who were positive for other respiratory tract pathogens. However, 23 (29.5%) of the blood samples collected from 78 individuals who were negative for the COVID-19 agent and other respiratory tract viral pathogens were positive for the COVID-19 antibody.</p><p><strong>Conclusion: </strong>Because the climate is colder than normal in areas settled at higher altitudes, more than one pathogens act together. In addition, respiratory infections are seen in all seasons. This causes the diseases to be fewer and milder than in other regions.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"123-126"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39113409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Incidentally Diagnosed Patients with Coronavirus Disease 2019 at the Emergency Department: Single-Center Clinical Experience.","authors":"Ali Gur,&nbsp;Erdal Tekin,&nbsp;Ibrahim Ozlu","doi":"10.5152/eurasianjmed.2021.20291","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20291","url":null,"abstract":"<p><strong>Objective: </strong>Asymptomatic patients with coronavirus disease 2019 can present with signs of various diseases to hospitals. We aimed to present patients who presented to the emergency department without any coronavirus disease 2019 symptoms and were incidentally diagnosed with coronavirus disease 2019 in addition to the diagnosis related to their complaints on presentation.</p><p><strong>Materials and methods: </strong>The study included patients presented to the emergency department of a hospital in Erzurum (Turkey) with non-coronavirus disease 2019 symptoms and were incidentally diagnosed with coronavirus disease 2019 on the basis of their chest computed tomography findings. The patients' primary diagnoses were evaluated, and a reverse transcriptase-polymerase chain reaction was performed to confirm the incidental coronavirus disease 2019 diagnoses.</p><p><strong>Results: </strong>The 42 patients included in the study had various complaints, and the most common complaint was abdominal pain in 8 patients (19%). The other complaints were at different rates. The most common diagnose was ST-elevated myocardial infarction in 6 patients (14.3%), and the other diagnoses were rib fracture in 3 patients (7.1%) and other similar diseases in the remaining patients.</p><p><strong>Conclusion: </strong>Patients with highly the contagious coronavirus disease 2019 can sometimes be asymptomatic and can be incidentally diagnosed with coronavirus disease 2019 after presenting to emergency departments with symptoms and manifestations other than those of coronavirus disease 2019. Therefore, healthcare professionals working in the emergency department should approach all patients who present to the emergency service as potential coronavirus disease 2019 carriers and wear their protective equipment and take necessary precautions.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"114-117"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39113407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid Rate Is Important As Much As Fluid Tonicity: An Experimental Study.","authors":"Halil Keskin,&nbsp;Filiz Keskin,&nbsp;Zuhal Keskin Yildirim,&nbsp;Muhammet Akif Guler,&nbsp;Nurinnisa Ozturk,&nbsp;Berna Ozturk Karagoz,&nbsp;Zekai Halici","doi":"10.5152/eurasianjmed.2021.20276","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20276","url":null,"abstract":"<p><strong>Objective: </strong>There is no study evaluating the effect on plasma osmolality of both fluid tonicity and high fluid rate at the same time. The aim of this experimental study was to determine the change in the plasma osmolality by different fluid tonicity and rate, and to suggest the safest and the most appropriate fluids based on the plasma osmolality for medical situations requiring fluid therapy with high or maintenance rates.</p><p><strong>Materials and methods: </strong>The rats were randomly divided into seven groups (six rats in each group): [D₅] D₅ administered at 100 ml/kg/24h; [D₅150] D₅ administered at 150 ml/kg/24h; [D₅(½)100] D₅ 0.45% NaCl administered at 100 ml/kg/24h; [D₅(½)150] D₅ 0.45% NaCl administered at 150 ml/kg/24h; [D₅(1)100] D₅ 0.9% NaCl administered at 100 ml/kg/24h; [D₅(1)150] D5 0.9% NaCl administered at 150 ml/kg/24h; [Control group] non-treated control rats. Intracardiac blood samples were collected from all the groups at the end of 24 h.</p><p><strong>Results: </strong>[D₅(1)150] and [D5(½)100] were the group closest to the control group in terms of both sodium (<i>P</i> = .937; <i>P</i> = .699, respectively) and effective osmolality (<i>P</i> = 1, <i>P</i> = .818, respectively).</p><p><strong>Conclusion: </strong>Our results showed that 0.9% NaCl and 0.45% NaCl solutions might be the safest and the most appropriate fluids to maintain normal plasma osmolality in medical situations requiring fluid therapy with high or maintenance rates, respectively.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"118-122"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39113408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}