The Eurasian Journal of Medicine最新文献

{"title":"Favipiravir Experience in Covid-19 Positive Myasthenia Gravis Patients.","authors":"Recep Yevgi, Nuray Bilge, Fatma Şimşek","doi":"10.5152/eurasianjmed.2021.20364","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20364","url":null,"abstract":"Myasthenia gravis (MG) is a disease that occurs as a result of an immunological attack against various proteins in the postsynaptic membrane, especially the postsynaptic acetylcholine receptors at the neuromuscular junction. Coronavirus disease (COVID-19), caused by the new virus severe acute respiratory syndrome coronavirus 2, became a worldwide pandemic. Although there is no definitive treatment for the disease as of yet, agents such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir, and remdesivir are used in many countries based on in vitro or observational studies. Considering that certain drugs can cause myasthenic exacerbation in patients with MG, the consequences of using drugs such as favipiravir in these patients are unknown. We aim to share our experience using favipiravir in 2 patients previously diagnosed with MG who tested positive for COVID-19.","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"164-165"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effects of Pectoral Nerve Block and Local Infiltration Anesthesia on Postoperative Pain for Breast Reduction Surgery: A Prospective Observational Study.","authors":"Orcun Sercan,&nbsp;Arzu Karaveli,&nbsp;Sadik Ozmen,&nbsp;Asim Uslu","doi":"10.5152/eurasianjmed.2021.20111","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20111","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of the Pecs II block on postoperative pain in patients undergoing breast reduction surgery.</p><p><strong>Materials and methods: </strong>This prospective, comparative, and observational study was conducted with 53 patients, with American Society of Anesthesiologists I-II, between the ages of 18 and 65, and undergoing bilateral breast reduction surgery. The patients were divided into two groups: Pecs II block with general anesthesia (Pecs group; n = 26) and local infiltration anesthesia with general anesthesia (control group; n = 27). The patients' demographic data, duration of surgery and anesthesia, hemodynamic parameters, perioperative analgesia requirements, postoperative visual analog scale (VAS) scores (at zero, one, three, six, nine, and 12 hours postoperative), the number of patients who needed analgesia at least once, the length of the hospital stay, and block-related complications were recorded.</p><p><strong>Results: </strong>There was no statistical difference in terms of the duration of surgery and anesthesia and hemodynamic parameters. Intraoperative total fentanyl consumption (128.85 ± 25.19 mcg in the Pecs group and 227.77 ± 44.58 mcg in the control group; <i>P</i> < .001) and postoperative analgesic requirement were significantly lower in the Pecs group (<i>P</i> < .001). The number of patients who needed analgesia at least once in the Pecs group was four (15.3%). Postoperative VAS scores were significantly lower (<i>P</i> < .001) and the length of the hospital stay was significantly shorter in the Pecs group (<i>P</i> < .001). No block-related complications were observed.</p><p><strong>Conclusion: </strong>Pecs II block with general anesthesia may significantly contribute to reducing intraoperative and postoperative analgesia requirements and provide long-lasting and more effective postoperative pain in breast reduction surgery.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"102-107"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39113405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Polypharmacy on the Charlson Comorbidity Index and Katz Index in Aging People with and without Diabetes Mellitus.","authors":"Gulcin Sahingoz Erdal,&nbsp;Hakan Kocoglu,&nbsp;Faruk Karandere,&nbsp;Pinar Kasapoglu,&nbsp;Nilgun Isiksacan,&nbsp;Mehmet Hursitoglu","doi":"10.5152/eurasianjmed.2021.20070","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20070","url":null,"abstract":"<p><strong>Objective: </strong>The prevalence of diabetes mellitus is growing worldwide, as well as in the aging population, and its comorbidity and mortality rates are higher in aging people than they are in young people. It has been observed that the number of drugs used increases in aging patients, especially in diabetic patients. This study aimed to investigate the relationship between polypharmacy and modified Charlson Comorbidity Index (CCI) and Katz Index of Independence in Activities of Daily Living (Katz ADL) scores in aging diabetic and non-diabetic patients.</p><p><strong>Materials and methods: </strong>This prospective study included 184 diabetic and 62 non-diabetic subjects who were ≥65 years old. Comorbidity was determined with CCI, and dependency on daily basic activities was assessed with Katz ADL.</p><p><strong>Results: </strong>CCI and the number of drugs were significantly higher in diabetic groups (<i>P</i> = .001). In all subjects and in the diabetic group, there was a negative correlation between CCI and Katz ADL (r = -0.343, <i>P</i> = .001; r = -0.383, <i>P</i> = .001, respectively); there was a positive correlation between CCI and number of drugs (r = 0.430, <i>P</i> = .001; r = 0.248, <i>P</i> = .001, respectively).</p><p><strong>Conclusion: </strong>We found an increase in the number of drugs taken by the aging patients, positively correlated with the CCI score. The increase in the number of drugs used is closely related to the insufficiency in daily life activity and comorbidity, and this predicts 10-year survival. Patients should be directed to special centers or physicians who will be scheduled for multidisciplinary treatment for the prevention of polypharmacy, especially in the aging.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"85-89"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39111480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Arterial Stiffness with Cardio-Ankle Vascular Index in Patients with Mitral Annular Calcification.","authors":"Faruk Boyaci,&nbsp;Murat Akcay,&nbsp;Engin Hatem,&nbsp;Ahmet Yanik,&nbsp;Tayyar Gokdeniz","doi":"10.5152/eurasianjmed.2021.19235","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.19235","url":null,"abstract":"<p><strong>Objective: </strong>Arterial stiffness is related to arteriolosclerotic diseases and is a marker of adverse cardiovascular events. Mitral annular calcification (MAC) is progressive calcium deposition on the posterior and inferior mitral annulus and is associated with atherosclerotic cardiovascular diseases. Cardio-ankle vascular index (CAVI) is a measurement technique used to estimate the degree of arterial stiffness without effect from blood pressure. The aim of this study is to research arterial stiffness using CAVI in patients with MAC.</p><p><strong>Materials and methods: </strong>The study was cross-sectional and observational and included 98 patients with MAC confirmed by echocardiography who referred to the cardiology clinics and met study inclusion criteria and 38 controls without MAC. CAVI measurements were obtained by using the Vascular Screening System VaSera VS-1000 (Fukuda Denshi, Tokyo, Japan) device.</p><p><strong>Results: </strong>The two groups were similar in terms of demographic characteristics, including age, sex, hypertension, coronary artery disease, body surface area, and smoking (<i>P</i> > .05). Left atrial volume index was significantly higher in patients with MAC compared with the control group (<i>P</i> < .001). Right arm CAVI, left arm CAVI, and mean CAVI were significantly higher in the MAC group than the control group (<i>P</i> = .037, <i>P</i> = .005, and <i>P</i> = .014, respectively) and increased with MAC severity. There was a significant positive correlation between mean CAVI and MAC grade (r = 0.278, <i>P</i> = .001). Also, when ankle-brachial index (ABI) was measured with CAVI, left and right extremity ABI values were significantly lower in patients with MAC (<i>P</i> = .017 and <i>P</i> = .005, respectively).</p><p><strong>Conclusion: </strong>CAVI increased in all patients with MAC and associated with increasing grade of calcification.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"90-95"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39111481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Langerhans Cell Histiocytosis of Thyroid Gland in a Child: A Case Report and Literature Review.","authors":"Rashad Ismayilov,&nbsp;Anar Aliyev,&nbsp;Aziz Aliyev,&nbsp;Ilgar Hasanov","doi":"10.5152/eurasianjmed.2021.20144","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20144","url":null,"abstract":"Introduction Langerhans cell histiocytosis (LCH) is a rare neoplastic disease of dendritic cells with indefinite etiology and pathogenesis.1 The incidence rate of the disease is 4.0–5.4 per 1 million individuals, and the mortality rate is about 3% in adults.2,3 LCH is often encountered in pediatric patients and can be observed as single-organ involvement or multisystemic disease. The disease affects almost every organ in the body, including bone, skin, lung, lymph nodes, hypothalamopituitary axis, liver, spleen, and other sites.2,4 Thyroid involvement in LCH is rare and usually seen in adults.5 When it occurs in children, it is often accompanied by multisystemic involvement.6,7 Because of its rarity, LCH with involvement of the thyroid gland can cause delays in diagnosis and misdiagnosis.","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"148-151"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic Cervical Deciduosis: A Rare Cause of Antepartum Hemorrhage in Mid Trimester.","authors":"Mishu Mangla,&nbsp;Ruchira Nautiyal,&nbsp;Nadia Shirazi,&nbsp;Banishree Pati","doi":"10.5152/eurasianjmed.2021.20163","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20163","url":null,"abstract":"<p><p>Decidual change is a key process required by the uterus to make itself ready for implantation. Presence of ectopic decidual tissue outside the uterine cavity is known as deciduosis. The clinical presentation can vary from being totally asymptomatic and subtle to presenting in the form of life-threatening emergencies like hemoperitoneum, recurrent pneumothorax, or even bowel perforation. Here, we present a case of ectopic deciduosis of cervix presenting in the form of severe life-threatening antepartum hemorrhage in second trimester of pregnancy.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"152-154"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and Cannabis: Playing Saint or Devil?","authors":"Heena Garg,&nbsp;Puneet Khanna","doi":"10.5152/eurasianjmed.2021.20275","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20275","url":null,"abstract":"","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"162-163"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine and Home-Based Treatment of COVID-19 in Resource-Limited Countries. Report of 3 Cases.","authors":"Killen H Briones-Claudett,&nbsp;H Briones-Claudett Mónica,&nbsp;Killen H Briones-Zamora,&nbsp;Diana C Briones-Márquez,&nbsp;Andrea Icaza-Freire,&nbsp;Michelle Grunauer","doi":"10.5152/eurasianjmed.2021.20227","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20227","url":null,"abstract":"<p><p>Ecuador, despite having taken aggressive and early measures to stop the progression of the pandemic (COVID-19), ended up becoming an epicenter of the pandemic in Latin America, and with the collapse of its health care system. The authors describe three patients who had confirmed COVID-19 and met the criteria for hospital admission but could not be assigned a hospital bed in a resource-limited country. The patients included a 72-year-old male, an 82-year-old female, and a 56-year-old male. They typically presented with fever, dyspnea, loss of taste and smell, diarrhea, and abdominal pain. Oxygen saturation during the initial evaluation ranged from 80-89%. Laboratory results reported lymphopenia and neutrophilia, with leukocytosis in two patients. Inflammatory markers were also elevated for all three patients. CT scan findings showed bilateral ground-glass pulmonary opacities. SARS-CoV-2 was confirmed in all three patients by real time polymerase chain reaction (RT-PCR) testing. Home-based treatment was established. At the time of writing this report, all patients remain asymptomatic and with negative COVID-19 testing. Telemedicine and home-based treatment were essential assets in the care of these severely ill patients living in a low-resource setting where not all patients who have criteria to be admitted into the hospital are able to find a place in a collapsed health care system.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"155-157"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative Treatment Method for Novel Coronavirus Disease 2019: Coupled Plasma Filtration Adsorption.","authors":"Bahadir Ciftci,&nbsp;Cem Erdogan,&nbsp;Deniz Kizilaslan,&nbsp;Mursel Ekinci,&nbsp;Oktay Olmuscelik,&nbsp;Yunus Oktay Atalay","doi":"10.5152/eurasianjmed.2021.20151","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20151","url":null,"abstract":"Patients infected with severe acute respiratory syndrome corona virus 2 may have mild symptoms such as fever and cough in the early stage of this disease and these symptoms may deteriorate to acute respiratory distress syndrome, multiple-organ failure, and death in the late phase.1 It has been reported that the cytokine levels increase and damage the tissues.2 As some agents used to decrease cytokine levels such as intravenous immunoglobulin and selective cytokine blockade (eg, anakinra or tocilizumab) may cause adverse events (infections, allergic reactions, and changes in blood pressure), there is a need of alternative treatment methods.3 Herein, we present our coupled plasma filtration adsorption (CPFA) (a detoxification system combining a plasma adsorption circuit) with a continuous renal replacement therapy (CRRT) experiences to treat 2 patients with coronavirus disease (COVID-19) in our tertiary university hospital intensive care unit (ICU).","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"158-159"},"PeriodicalIF":1.5,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39132711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There an Association Between Nasal Polyposis and ADAMTS Genes Expressions?","authors":"Cigdem Yuce Kahraman,&nbsp;Arzu Tatar,&nbsp;Muzaffer Keles,&nbsp;Zeynep Ipek Ocak,&nbsp;Abdulgani Tatar","doi":"10.5152/eurasianjmed.2021.20006","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2021.20006","url":null,"abstract":"<p><strong>Objective: </strong>Nasal polyposis (NP) is an inflammatory chronic disease in which polyps are located in the nose or paranasal sinuses. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes have roles in vascular biology, inflammation, tissue morphogenesis, and pathophysiological remodeling. Therefore, some members of the ADAMTS gene family may contribute to pathogenesis of NPs. This study aimed to detect the potential relation between NP and the expression levels of ADAMTS 5, 8, and 9 genes.</p><p><strong>Materials and methods: </strong>This study consisted of nasal polyp tissues from 34 patients in whom nasal polyps had been diagnosed clinically, and healthy nasal mucosal tissues from 14 controls. RNA was isolated from the nasal polyps and normal nasal mucosal tissue in each subject. The expression levels of ADAMTS 5, 8, and 9 genes in the patients and controls were detected by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) method.</p><p><strong>Results: </strong>The expression levels of ADAMTS 5 and 9 genes were significantly decreased in NP tissues. In contrast, the expression levels of ADAMTS 8 genes were also decreased in NP tissues, but they were not significantly different from those in the normal nasal tissues.</p><p><strong>Conclusion: </strong>An association was detected between the expression levels of ADAMTS genes and NP. ADAMTS 5 and 9 genes may have an effect on the formation of NP.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":" ","pages":"19-21"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929586/pdf/eajm-53-1-19.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25477467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}