J Fletcher, N Reid, R E Hubbard, R Berry, M Weston, E Walpole, R Kimberley, D A Thaker, R Ladwa
{"title":"Frailty Index, Not Age, Predicts Treatment Outcomes and Adverse Events for Older Adults with Cancer.","authors":"J Fletcher, N Reid, R E Hubbard, R Berry, M Weston, E Walpole, R Kimberley, D A Thaker, R Ladwa","doi":"10.14283/jfa.2024.22","DOIUrl":"https://doi.org/10.14283/jfa.2024.22","url":null,"abstract":"<p><strong>Background: </strong>Frailty is an indicator of individual vulnerability and differentiates health status among people of the same chronological age.</p><p><strong>Objectives: </strong>This study aimed to determine whether baseline frailty index (FI) was associated with systemic anticancer therapy treatment outcomes in older adults with solid cancers.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Major metropolitan outpatient oncology service.</p><p><strong>Participants: </strong>Adults aged over 65 years with a solid malignancy who had been referred for consideration of systemic therapy, and had completed a baseline frailty assessment between January 2019 and July 2021.</p><p><strong>Measurements: </strong>Frailty had been prospectively assessed with a 58-item FI derived from a geriatric oncology nurse assessment prior to initial oncologist appointments. Primary outcome was treatment completion, and secondary outcomes included incidence of high-grade treatment-related toxicity or unplanned hospital admissions, and survival outcomes. Univariate and multivariable regression analyses were conducted to test the association between treatment outcomes and baseline FI. Co-variates included age, sex, performance status, treatment intent, and stage. Kaplan-Meier and cox proportional hazard analysis were conducted for survival analysis.</p><p><strong>Results: </strong>The median FI (IQR) was 0.24 (0.15-0.31) and 43% were frail (FI>0.25). FI was positively correlated with ECOG, however 28% of ECOG 0-1 were frail. In multivariable regression analyses, each 0.10 increase in FI was associated with an increased likelihood of not completing or not receiving treatment (OR 1.37, 95% CI 1.02-1.84; p=.04), treatment-related toxicity (OR 1.60, 95% CI 1.14-2.23; p<.01) and unplanned hospital admissions (OR 1.61; 95% CI 1.16-2.25; p<.01). Frail patients had increased mortality (adjusted HR 2.81, 95% CI 1.42-5.56; p<.01). Age did not predict treatment completion, toxicities, or survival.</p><p><strong>Conclusion: </strong>Baseline FI is a granular measure that can help to identify frailer older patients who are more likely to require tailored therapy and support, and less frail older patients who are more likely to tolerate treatment.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 4","pages":"487-494"},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Ji, H-W Jung, S Yoon, H Roh, M Kim, H Jung, R Jang, H Ha, J Y Baek, I-Y Jang, E Lee
{"title":"Comparative Analysis of Gait Speed Measurement Protocols: Static Start Versus Dynamic Start in a Cross-Sectional Study Using Light Detection and Ranging.","authors":"S Ji, H-W Jung, S Yoon, H Roh, M Kim, H Jung, R Jang, H Ha, J Y Baek, I-Y Jang, E Lee","doi":"10.14283/jfa.2024.48","DOIUrl":"https://doi.org/10.14283/jfa.2024.48","url":null,"abstract":"<p><strong>Background: </strong>There is currently no standardized protocol for the measurement of gait speed in older adults, particularly regarding the choice between static versus dynamic start.</p><p><strong>Objectives: </strong>This study aimed to assess the impact of removing the initial phase on gait speed measurement and compare the correlation of different measurement methods with other physical performance metrics.</p><p><strong>Design: </strong>A cross-sectional study.</p><p><strong>Setting: </strong>A geriatric clinic in a tertiary hospital in Seoul, Korea.</p><p><strong>Participants: </strong>Adults aged 65 years or older who underwent physical performance examinations during comprehensive geriatric assessments (n = 511).</p><p><strong>Measurements: </strong>A one-dimensional light detection and ranging device was used to obtain real-time gait signal data and measure the participants' gait speed. Descriptive statistics were obtained for the acceleration phase. Various lengths of the initial phase were removed to determine the point at which gait speed plateaued. Correlations between four-meter gait speeds, with different initial phase lengths, and chair stand and balance test results were examined.</p><p><strong>Results: </strong>The mean ± standard deviation of the acceleration phase (m) was 0.92 ± 0.51. The removal of various initial phase lengths showed that 2 m gait speed based on dynamic start (0.5 m) significantly differed from static start (0.7 m/s versus 1.05 m/s, p<0.001). Gait speed showed an increase with the removal of longer initial phases but plateaued after removing 1 meter. This change lacked clinical significance after removing 0.5 meters. Dynamic start gait speed exhibited superior discriminative ability in chair stand and balance tests compared to static start gait speed.</p><p><strong>Conclusion: </strong>Static start underestimates gait speed, while dynamic start aligns better with other physical performance results. An acceleration phase of 0.5 to 1 meter appears sufficient, but further studies are needed to optimize gait measurement methods.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 4","pages":"391-396"},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C H K Ma, D Q L Chua, L Tay, E W C Teo, W C Ng, A Y M Leung
{"title":"The Feasibility of Implementing the WHO Integrated Care for Older People (ICOPE) Framework in Singapore.","authors":"C H K Ma, D Q L Chua, L Tay, E W C Teo, W C Ng, A Y M Leung","doi":"10.14283/jfa.2024.59","DOIUrl":"https://doi.org/10.14283/jfa.2024.59","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organization (WHO) introduced the Integrated Care for Older People (ICOPE) approach to assist communities in evaluating the intrinsic capacities of older adults and proposing strategies to prevent, mitigate, or reverse declines. This study represents the inaugural attempt to assess intrinsic capacities among older adults in Singapore, aligning with the nation's Healthier Singapore (Healthier SG) initiative aimed at enhancing quality of life.</p><p><strong>Objectives: </strong>This study aims to investigate the feasibility of implementing Step 1 screening of the ICOPE framework, which assesses cognition, locomotion, vitality, psychological state, visual and auditory functions, within the Singapore context.</p><p><strong>Design, setting, and participants: </strong>Using a mixed-method approach, this cross-sectional study established a baseline understanding of the levels of intrinsic capacity in 367 community-dwelling older adults in Singapore (mean age 71.8 years), elucidated the experiences of administering the ICOPE Step 1 screening tool and the formulation of personalized care plans from the perspective of 25 assessors.</p><p><strong>Measurements: </strong>Participants completed ICOPE Step 1 screening, providing basic demographic and health profiles, while assessors engaged in focus group discussions.</p><p><strong>Results: </strong>Among older participants, 284 exhibited signs of decline in intrinsic capacity. The primary areas of decline were visual impairment (42.0%), hearing loss (33.5%), and cognitive deterioration (31.3%), followed by limited mobility (24.3%), malnutrition (16.1%), and depressive symptoms (16.1%). Assessors found the ICOPE screening tool user-friendly and appreciated its person-centred approach, noting its integration with care plans, which many other tools lacked. They were confident in Singapore's capacity to adopt the ICOPE approach, citing existing practices in assessing intrinsic capacity domains and integrated care models.</p><p><strong>Conclusion: </strong>Critical steps for successful implementation of the ICOPE framework include follow-up interventions like self-management strategies for declining intrinsic capacity, diagnostic assessments, and routine monitoring. Coordination between healthcare clusters and community care networks is essential for its success.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 4","pages":"514-521"},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Prediction of Healthcare Utilization by Frailty and Disability among Dutch Community-Dwelling People Aged 75 Years or Older.","authors":"T van der Ploeg, R J J Gobbens","doi":"10.14283/jfa.2024.14","DOIUrl":"https://doi.org/10.14283/jfa.2024.14","url":null,"abstract":"<p><strong>Background: </strong>Population aging is occurring worldwide. As a result, frailty and disability are in the full interest of practice, policy, and science. An increase in healthcare utilization is an adverse outcome of frailty and disability.</p><p><strong>Objective: </strong>The aim of the present study was the prediction of six indicators of healthcare utilization by frailty and disability measures. The six indicators of healthcare utilization of interest were: use of informal care, number of visits to a general practitioner, hospital admission, receiving nursing care, receiving personal care, and contacts with (health)care professionals.</p><p><strong>Methods: </strong>We used a sample of 484 people that was randomly drawn from the municipality of Roosendaal (the Netherlands), a municipality with 78,000 inhabitants. A subset of people who completed the Tilburg Frailty Indicator (TFI) at baseline and the Groningen Activity Restriction Scale (GARS) questionnaires was used with a nine-year followup. We used generalized estimation equations (GEE) to predict the six indicators with the frailty measures (physical, psychological, and social scores) and disability measures (ADL and IADL scores). We also performed GEE analyses adjusted for age, gender, and multimorbidity from part A of the TFI at baseline.</p><p><strong>Results: </strong>The significant predictors were different for each indicator. However, the physical frailty score, the ADL score, and the IADL score often emerged as significant predictors. These three variables predicted several indicators of healthcare utilization: use of informal care, number of visits to a general practitioner, hospital admission, receiving nursing care, receiving personal care, and contacts with (health)care professionals. The social score was found to be significant for the indicator use of disciplines.</p><p><strong>Conclusions: </strong>In conclusion, our study showed that in particular physical frailty, and ADL and IADL disability predicted healthcare utilization in community-dwelling people aged 75 years or older. It is important that care and welfare professionals pay attention to physical frailty and both ADL and IADL disability aiming to diminish frailty and disability and preventing intensive healthcare utilization and related costs. Future research will have to focus on more representative Dutch municipalities in order to get a more reliable and accurate picture of the disciplines used by people with frailty and disability.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 4","pages":"474-479"},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Matsuzawa, K Nagai, K Takahashi, T Mori, M Onishi, S Tsuji, K Hashimoto, K Tamaki, Y Wada, H Kusunoki, Y Nagasawa, K Shinmura
{"title":"Serum Creatinine-Cystatin C Based Screening of Sarcopenia in Community Dwelling Older Adults: A Cross-Sectional Analysis.","authors":"R Matsuzawa, K Nagai, K Takahashi, T Mori, M Onishi, S Tsuji, K Hashimoto, K Tamaki, Y Wada, H Kusunoki, Y Nagasawa, K Shinmura","doi":"10.14283/jfa.2024.13","DOIUrl":"https://doi.org/10.14283/jfa.2024.13","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the discriminative capabilities for the manifestation of sarcopenia or physical frailty between serum creatinine- and cystatin C-derived indices among community-dwelling older adults.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Primary Care and Community.</p><p><strong>Participants: </strong>We utilized a subset of data from the Frail Elderly in the Sasayama-Tamba Area (FESTA) study, which was initiated in 2015 to gather comprehensive information on various health-related parameters among community-dwelling older individuals (age ≥65 years).</p><p><strong>Measurements: </strong>Five serum creatinine-cystatin C based indices including the Sarcopenia Index, the serum creatinine/cystatin C ratio, the disparity between serum cystatin-C-based and creatinine-based estimated GFR, the total body muscle mass index (TBMM), and the prediction equation for skeletal muscle mass index (pSMI) were employed. Sarcopenia and physical frailty were identified based on the Asian Working Group for Sarcopenia criteria and the revised Japanese version of the Cardiovascular Health Study criteria, respectively. The receiver operating characteristic (ROC) and logistic regression analyses were performed to assess the discriminative abilities of these tools.</p><p><strong>Results: </strong>In the analysis of 954 participants, 52 (5.5%) were identified with sarcopenia and 35 (3.7%) with physical frailty. Regarding sarcopenia discrimination, TBMM and pSMI both exhibited area under the curve (AUC) values exceeding 0.8 for both men and women. Concerning the identification of physical frailty, AUC values ranged from 0.61 to 0.77 for males and 0.50 to 0.69 for females. In the multivariate logistic regression analyses, only TBMM and pSMI consistently displayed associations with sarcopenia, irrespective of sex (P<0.001, respectively). On the other hand, no consistent associations were observed between the indices and physical frailty.</p><p><strong>Conclusions: </strong>This study provides a robust association of a serum creatinine- and cystatin C-derived indices, especially TBMM and pSMI, with sarcopenia among community-dwelling older adults. Conversely, the application of these indices for the screening of physical frailty has its constraints, necessitating further investigation.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 2","pages":"116-124"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H J Coelho-Junior, R Calvani, M Tosato, A Álvarez-Bustos, F Landi, A Picca, E Marzetti
{"title":"Associations Between Hypertension, Angiotensin-Converting Enzyme Inhibitors, and Physical Performance in Very Old Adults: Results from the ilSIRENTE Study.","authors":"H J Coelho-Junior, R Calvani, M Tosato, A Álvarez-Bustos, F Landi, A Picca, E Marzetti","doi":"10.14283/jfa.2024.15","DOIUrl":"https://doi.org/10.14283/jfa.2024.15","url":null,"abstract":"<p><strong>Background: </strong>Results regarding the associations between hypertension-related parameters and physical performance in older adults are conflicting. A possible explanation for these divergent results is that investigations may not have adjusted their analyses according to the use of angiotensin-converting enzyme inhibitors (ACEIs).</p><p><strong>Objectives: </strong>To examine the associations between hypertension-related parameters, ACEI use, and a set of physical performance tests in very old adults.</p><p><strong>Design: </strong>Cross-sectional study from the ilSIRENTE database.</p><p><strong>Setting: </strong>Mountain community of the Sirente geographic area (L'Aquila, Abruzzo, Italy).</p><p><strong>Participants: </strong>All persons born in the Sirente area (13 municipalities) before 1 January 1924 and living in that region at the time of study were identified and invited to participate. The final sample included 364 older adults (mean age: 85.8 ± standard deviation [SD] 4.8).</p><p><strong>Measurements: </strong>Physical performance was assessed using isometric handgrip strength (IHG), walking speed (WS) at normal and fast pace, 5-time sit-to-stand test (5STS), and muscle power measures. Blood pressure (BP) was measured after 20 to 40 min of rest, while participants sat in an upright position. Drugs were coded according to the Anatomical Therapeutic and Chemical codes. ACEIs were categorized in centrally (ACEI-c) and peripherally (ACEI-p) acting. Blood inflammatory markers, free insulin-like growth factor 1 (IGF-1), and IGF-binding protein 3 (IGFBP-3) were assayed.</p><p><strong>Results: </strong>Results indicated that 5STS test was significantly and negatively associated with diastolic BP values. However, significance was lost when results were adjusted for ACEI use. Participants on ACEIs were more likely to have greater specific muscle power and higher blood levels of IGFBP-3 than non-ACEI users. When participants were categorized according to ACEI subtypes, those on ACEI-p had higher blood IGF-1 levels compared with ACEI-c users.</p><p><strong>Conclusions: </strong>The main findings of the present study indicate that ACEI use might influence the association between hypertension-related parameters and neuromuscular parameters in very old adults. Such results may possibly be linked to the effects of ACEI-p on the IGF-1 pathway.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 2","pages":"74-81"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H Nygaard, R S Kamper, A Ekmann, S K Hansen, P Hansen, M Schultz, J Rasmussen, E Pressel, C Suetta
{"title":"Co-Occurrence of Sarcopenia and Frailty in Acutely Admitted Older Medical Patients: Results from the Copenhagen PROTECT Study.","authors":"H Nygaard, R S Kamper, A Ekmann, S K Hansen, P Hansen, M Schultz, J Rasmussen, E Pressel, C Suetta","doi":"10.14283/jfa.2024.23","DOIUrl":"https://doi.org/10.14283/jfa.2024.23","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia and frailty are often used interchangeably in clinical practice yet represent two distinct conditions and require different therapeutic approaches. The literature regarding the co-occurrence of both conditions in older patients is scarce as most studies have investigated the prevalence of sarcopenia and frailty separately.</p><p><strong>Objectives: </strong>We aim to evaluate the prevalence and co-occurrence of sarcopenia and frailty in a large sample of acutely admitted older medical patients.</p><p><strong>Design: </strong>Secondary analyses using cross-sectional data from the Copenhagen PROTECT study.</p><p><strong>Setting: </strong>Patients were included from the acute medical ward at Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, between November 2019 and November 2021.</p><p><strong>Participants: </strong>Acutely admitted older medical patients (≥65 years).</p><p><strong>Measurements: </strong>Handgrip strength (HGS) was investigated using a handheld dynamometer. Lean mass (SMI) was investigated using direct-segmental multifrequency bioelectrical impedance analyses (DSM-BIA). Low HGS, low SMI, and sarcopenia were defined according to the recent definitions from the European Working Group on Sarcopenia in Older People (EWGSOP2). The Clinical Frailty Scale (CFS) was used to evaluate frailty, with a value > 5 indicating the presence of frailty. Patients were enrolled and tested within 24 hours of admission.</p><p><strong>Results: </strong>This study included 638 patients (mean age: 78.2±7.6, 55% female) with complete records of SMI, HGS, and the CFS. The prevalence of low HGS, low SMI, sarcopenia, and frailty were 39.0%, 33.1%, 19.7%, and 39.0%, respectively. Sarcopenia and frailty co-occurred in 12.1% of the patients.</p><p><strong>Conclusions: </strong>It is well-known that sarcopenia and frailty represent clinical manifestations of ageing and overlap in terms of the impairment in physical function observed in both conditions. Our results demonstrate that sarcopenia and frailty do not necessarily co-occur within the older acutely admitted patient, highlighting the need for separate assessments of frailty and sarcopenia to ensure the accurate characterization of the health status of older patients.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 2","pages":"91-97"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y Taniguchi, A Kitamura, T Hata, K Fujita, T Abe, Y Nofuji, S Seino, Y Yokoyama, S Shinkai, Y Fujiwara
{"title":"Frailty Trajectories and Its Associated Factors in Japanese Older Adults.","authors":"Y Taniguchi, A Kitamura, T Hata, K Fujita, T Abe, Y Nofuji, S Seino, Y Yokoyama, S Shinkai, Y Fujiwara","doi":"10.14283/jfa.2024.51","DOIUrl":"https://doi.org/10.14283/jfa.2024.51","url":null,"abstract":"<p><strong>Background: </strong>Associated factors for frailty development according to age group remain unclear.</p><p><strong>Objectives: </strong>To identify frailty score trajectories among community-dwelling older Japanese individuals and examine their associated factors.</p><p><strong>Design: </strong>13-year longitudinal study.</p><p><strong>Setting: </strong>Kusatsu Town in Gunma Prefecture, Japan.</p><p><strong>Participants: </strong>1706 older adults aged ≥ 65 years who completed an annual frailty assessment at least once between 2007 and 2019.</p><p><strong>Measurements: </strong>Frailty status was determined using an index based on the Fried frailty phenotype criteria. Potential associated factors for frailty trajectory included physical, biological, lifestyle-related, and psychological factors, as well as comorbidities.</p><p><strong>Results: </strong>We identified five trajectory patterns in the frailty score from age of 65 to 90 years -individuals who were robust (Group 1, 10.5%) as well as individuals with late-onset frailty (Group 2, 16.1%), middle-onset frailty (Group 3, 25.6% and Group 4, 35.2%), and early-onset frailty (Group 5, 12.7%). Compared with the other groups, the early-onset group showed a higher prevalence of cerebrovascular diseases, bone and joint diseases, poor nutrition, sarcopenia, hospitalization, low cognitive function, and smoking at the end of follow-up. Associated factors in the middle-onset group largely overlapped with those of the early-onset group. The late-onset frailty group tended to have a higher association with heart disease and bone and joint diseases compared with the robust group.</p><p><strong>Conclusion: </strong>Our findings from a 13-year longitudinal study identified five frailty trajectory patterns and seven associated factors for frailty trajectory. Proposed effective population-based frailty prevention strategies in each age group may contribute to effective strategies to extend healthy life expectancy in aging, aged, and super-aged communities.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 3","pages":"233-239"},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Shi, W Hao, W Zhao, T Kimura, T Mizuguchi, S Ukawa, K Kondo, A Tamakoshi
{"title":"Association of Finger Tapping Movements with Frailty Status in older Japanese Adults: A Cross-Sectional Study.","authors":"R Shi, W Hao, W Zhao, T Kimura, T Mizuguchi, S Ukawa, K Kondo, A Tamakoshi","doi":"10.14283/jfa.2024.34","DOIUrl":"https://doi.org/10.14283/jfa.2024.34","url":null,"abstract":"<p><strong>Background: </strong>Finger tapping impairment and frailty share overlapping pathophysiology and symptoms in older adults, however, the relationship between each other has not been previously studied.</p><p><strong>Objectives: </strong>To investigate how finger tapping movements correlate with frail status in older Japanese adults.</p><p><strong>Design, setting, and participants: </strong>Data were from a cross-sectional study called the Cognition and Activity in Rural Environment of Hokkaido Senior Survey 2018. A total of 244 community-dwelling older adults (mean age 75.3 years) were included.</p><p><strong>Measurements: </strong>Participants underwent physical examinations, gait and finger tapping tests, and completed self-administered questionnaires. Frailty was assessed using Fried's frailty phenotype, and factor analysis was conducted to extract relevant finger tapping factors. Multinomial logistic regression was employed to analyze associations, generating adjusted odds ratios.</p><p><strong>Results: </strong>Of the participants, 18 were frail, and 145 pre-frail. Analysis identified three distinct finger tapping patterns: \"Range of Motion - Nondominant Hand,\" \"Variability - Dominant Hand - Anti,\" and \"Variability - Nondominant Hand - Anti.\" These patterns showed significant associations with aspects of Fried's frailty phenotype, particularly low physical activity (P = 0.002), weakness (P = 0.003), and slowness (P = 0.004). A larger range of motion in the nondominant hand correlated with a lower frailty risk (Odds Ratio: 0.09, 95% CI: 0.02-0.46), while higher variability in the same hand increased the risk of pre-frailty (Odds Ratio: 2.19, 95% CI: 1.09-4.39).</p><p><strong>Conclusion: </strong>Finger tapping movements are significantly associated with frailty status as determined by Fried's phenotype. The findings underscore the importance of further longitudinal studies to understand the relationship between motor function and frailty.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 3","pages":"218-223"},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Byrne, J Cooke, E McNeela, P Bambrick, R P Murphy, M Harrison
{"title":"Circulating Angiogenic and Senescent T Lymphocytes in Ageing and Frailty.","authors":"T Byrne, J Cooke, E McNeela, P Bambrick, R P Murphy, M Harrison","doi":"10.14283/jfa.2024.38","DOIUrl":"https://doi.org/10.14283/jfa.2024.38","url":null,"abstract":"<p><strong>Background: </strong>There is a need to identify vascular and geroscience-relevant markers and mediators that can physiologically link ageing to vascular disease. There is evidence of specific T cell subsets, all influenced by age, that exert positive and negative effects on vascular health. CD31+, termed angiogenic T cells, have been linked to vascular repair whereas CD28null, termed senescent T cells, display pro-inflammatory and cytotoxic effector functions.</p><p><strong>Objective: </strong>This study sought to determine the combined influence of increasing age and frailty status on these circulating CD31+ and CD28null T cell subsets.</p><p><strong>Methods: </strong>This cross-sectional study recruited four different cohorts of men and women; young (20-30 years, n=22), older (65-75 years, n=17), robust non-frail (76+ years, n=17), and frail (76+ years, n=15) adults. Frailty was determined using the Fried Frailty method. T cell subsets were determined by whole blood flow cytometry based on the expression of CD3, CD4, CD8, CD31 and CD28. Cognitive impairment (CI) was measured via the Montreal Cognitive Assessment test.</p><p><strong>Results: </strong>Whether expressed as circulating counts or as a % of total T cells, there was a progressive decrease (p<0.05) in CD31+ T cells with increasing age but paradoxically higher values (p<0.05) in the frail compared to the robust non-frail group. These changes were similar in the CD4+ and CD8+ fractions. CD28null T cells were considerably higher (p<0.05) in the frail compared to the robust non-frail group, including in the CD8+ (47% vs 29%, p<0.05) and CD4+ (4% vs 1%, p<0.05) fractions. CD28null T cell percentage was also higher (p<0.05) in those with moderate CI compared to mild CI and normal function.</p><p><strong>Conclusion: </strong>CD8+CD28null T cells are considerably elevated in frailty and with cognitive impairment and may serve as a useful target for intervention. Currently, the utility of CD31+ T cells as an ageing biomarker may be confined to healthy ageing cohorts.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"13 3","pages":"203-212"},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}