Journal of Frailty & Aging最新文献

{"title":"Welcome to the Intrinsic Capacity, Frailty and Sarcopenia Research Conference for Healthy Longevity (ICFSR 2026) in Washington, DC.","authors":"Peter M Abadir","doi":"10.1016/j.tjfa.2026.100174","DOIUrl":"10.1016/j.tjfa.2026.100174","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 Suppl 1 ","pages":"100174"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity: Making health the core outcome of Healthspan research.","authors":"John R Beard","doi":"10.1016/j.tjfa.2026.100175","DOIUrl":"10.1016/j.tjfa.2026.100175","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 Suppl 1 ","pages":"100175"},"PeriodicalIF":3.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing two methods to quantify physical resilience.","authors":"Heather E Whitson, Marissa Ashner, Virginia B Kraus, Sarah Peskoe, Janet L Huebner, Corey B Simon, Katherine Hall, Cathleen Colon-Emeric","doi":"10.1016/j.tjfa.2026.100179","DOIUrl":"10.1016/j.tjfa.2026.100179","url":null,"abstract":"<p><p>Physical resilience, conceptualized as the extent of observed recovery after a health stressor, is an important construct in research on aging and frailty. Various methods have been proposed to quantify physical resilience using repeated measures of health or function following a stressor. The purpose of this analysis is to directly compare two alternative approaches to quantifying physical resilience - the recovery trajectory (RT) and the expected recovery differential (ERD) - using data from 170 older adults in an observational study of elective knee replacement surgery. Each participant's resilience, based on repeated measures of pain interference over 6 months after surgery, was determined using both the RT and the ERD method. The 10 individuals classified as high resilience based on RT also had better-than-expected recovery based on ERD. However, ERD scores were more variable among individuals classified by RT as moderate resilience (n = 82). Of those classified as low resilience (n = 78) by RT, most (85.9%) also had worse-than-expected recovery based on ERD. In this head-to-head comparison of two conceptually distinct approaches for quantifying resilience after a health stressor, the results were most comparable in individuals at extremes of high or low recovery patterns. Each approach has merit for quantifying physical resilience after a health stressor, and factors that may influence the choice of method and interpretation of results are discussed.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 4","pages":"100179"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13314735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148297346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An OLD DOG teaching us new tricks in ageing biology.","authors":"Olga Maria de Silvério Carvalho, Aya Abukwaik, Ola Sultan, Louis J Koizia, Benjamin H L Harris","doi":"10.1016/j.tjfa.2026.100181","DOIUrl":"10.1016/j.tjfa.2026.100181","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 4","pages":"100181"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13321205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty dimensions and cognitive function in relation to dual-task cost: A multidomain analysis in community-dwelling older adults.","authors":"Louise Heyzer, Kristabella Low, Cai Ning Tan, Audrey Yeo, Jia Qian Chia, Justin Chew, Joanne Kua, Wee Shiong Lim","doi":"10.1016/j.tjfa.2026.100166","DOIUrl":"10.1016/j.tjfa.2026.100166","url":null,"abstract":"<p><strong>Background: </strong>Dual-task cost (DTC) is the performance decline observed during simultaneous motor and cognitive tasks. It is associated with cognitive and physiological vulnerability. However, it remains unclear how specific frailty dimensions and cognitive domains contribute to DTC during arithmetic and verbal fluency tasks.</p><p><strong>Objectives: </strong>We aim to investigate the independent associations between physical, social and oral frailty dimensions versus cognition function with DTC in community-dwelling older adults.</p><p><strong>Methods: </strong>We studied 281 participants from the GeriLABS-2 study. Physical frailty was assessed using Fried's Frailty Phenotype, social frailty using the 8-item Social Frailty Scale (SF8) and oral frailty using the Oral Frailty Index-8 (OFI-8). Cognitive function was assessed with Chinese Mini Mental State Examination (CMMSE) and Chinese Frontal Assessment Battery (CFAB). DTC on gait was assessed with arithmetic (counting backwards from 100) and verbal fluency (animal naming) cognitive tasks. Association of DTC with frailty dimensions and cognition were evaluated via hierarchical linear regression, adjusted for demographics.</p><p><strong>Results: </strong>Higher CFAB score was significantly associated with lower DTC in both arithmetic (B=-2.067, p < 0.001) and verbal fluency (B=-1.489, p = 0.020) tasks, suggesting individuals with better executive function showed lower DTC. Social frailty (Factor 2 - social activity and financial resources) and oral frailty (Factor 3 - dietary and social habits) were significantly associated with DTC for arithmetic task (B = 2.664, p = 0.030; B = 3.718, p = 0.007). No significant association was observed for physical frailty. The final composite model showed that CFAB has a significant associated with DTC arithmetic (B=-2.012, p < 0.001) and DTC verbal fluency (B=-1.537, p = 0.016) tasks.</p><p><strong>Conclusion: </strong>Cognitive frailty, particularly executive dysfunction, is a key factor contributing to difficulties with dual tasking. Social and oral frailty factors may influence DTC during arithmetic tasks, however their effects were attenuated after adjusting for cognition. Interventions addressing cognitive frailty may be a promising target for mitigating DTC in older adults.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 4","pages":"100166"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of interventions using activity trackers and smartphone applications for increasing physical activity in older adults with health conditions: a systematic review with meta-analysis.","authors":"Nusrat Hamdani, Bruno T Saragiotto, Peter Stubbs, Juliana Oliveira, Anne Tiedemann, Catherine Sherrington, Paloma Santana, Gabriel Ferretti, Arianne Verhagen, Poonam Mehta","doi":"10.1016/j.tjfa.2026.100180","DOIUrl":"10.1016/j.tjfa.2026.100180","url":null,"abstract":"<p><strong>Background: </strong>Evidence suggests that physical activity is fundamental to healthy ageing and is associated with prevention of chronic diseases, reduced frailty risk, and premature mortality in older adults.</p><p><strong>Objective: </strong>To evaluate the effectiveness of interventions using activity trackers and smartphone applications for increasing physical activity (steps per day) in people aged ≥60 years with an underlying health condition.</p><p><strong>Methods: </strong>Six databases were searched from inception to January 2025. We included randomised controlled trials of interventions that used activity trackers or smartphone applications, to promote physical activity among people aged ≥60 years with an underlying health condition, compared to minimal interventions or other active interventions.</p><p><strong>Results: </strong>We identified 44 trials (n = 4148). Compared with minimal intervention, the evidence is very uncertain about the effect of activity trackers on physical activity in the short term (near to intervention completion) (MD 1671 steps, 95% CI 1113 to 2229; I² = 90%, 37 trials). At 12 months, activity trackers probably increase physical activity compared with no or minimal intervention (MD 1838 steps, 95% CI 980 to 2696; I² = 64%, 6 trials; moderate certainty). At 6 months and 24 months, the effect of activity trackers on steps was uncertain. Subgroup analyses suggest activity trackers may improve physical activity across metabolic, neurological, and pulmonary conditions based on moderate to low certainty evidence.</p><p><strong>Conclusion: </strong>Interventions using activity trackers may increase physical activity in the short term, although the evidence is very uncertain, and probably increase physical activity at approximately 12 months. Effects at intermediate-term and 24-month follow-up remain uncertain. Effects on mobility, quality of life and mental health were unclear or small.</p><p><strong>Registration: </strong>CRD42024622697.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 4","pages":"100180"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13558122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"This has no flavor\": balancing nutrition, taste, and salt restriction in geriatric care units.","authors":"Emanuele Marzetti, Riccardo Calvani, Isabel Rodriguez Sanchez, Hélio Jose Coelho-Junior","doi":"10.1016/j.tjfa.2026.100183","DOIUrl":"10.1016/j.tjfa.2026.100183","url":null,"abstract":"<p><p>Salt (sodium chloride, NaCl) has played a fundamental role in human history, not only as a dietary component but also as a cultural, symbolic, and economic resource. Global salt intake remains high and heterogeneous, with marked geographical variation in both consumption levels and dietary sources. Numerous studies have shown significant associations between salt consumption and adverse health outcomes. Hospitals have implemented salt-restriction strategies that may have unintended consequences for food palatability and nutritional intake, particularly among older adults. In geriatric settings, where appetite-related disorders such as dysgeusia, dysphagia, and xerostomia are common, strict dietary sodium restriction may further compromise food consumption and increase the risk of malnutrition. Here, we discuss the potential implications of salt restriction in acute geriatric care, highlighting its possible impact on dietary intake, palatability and nutritional status.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 4","pages":"100183"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13321211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring sex differences in frailty and hospitalization among older adults with diabetes in Vietnam.","authors":"Tan Van Nguyen, Dung Ngoc Truong, Wei Jin Wong, Mark Woodward, Tu Nguyen","doi":"10.1016/j.tjfa.2026.100168","DOIUrl":"10.1016/j.tjfa.2026.100168","url":null,"abstract":"<p><strong>Background: </strong>Older adults with diabetes often face multiple health challenges such as frailty. Sex-related differences in frailty may influence health outcomes in this population. This study sought to examine the prevalence of frailty in older adults with type 2 diabetes in an older cohort in Vietnam, and the association between frailty and hospitalizations, with a focus on sex disparities.</p><p><strong>Research design and methods: </strong>An observational cohort study was conducted at two tertiary hospitals in Vietnam from November 2022 to June 2023. Patients aged 60 years or above with type 2 diabetes that visited the cardio-metabolic clinics during the study period were recruited. Frailty was measured using Fried's frailty criteria. Logistic regression models were applied to examine the association between frailty and all-cause hospitalization over 6 months. Ratios of odds ratios (ORs) were computed to quantify the sex difference.</p><p><strong>Results: </strong>There were 644 participants, with a mean age of 71.8 years (SD 7.6), and 30.0% were classified as frail. The prevalence of frailty in women was higher compared to men (31.3%vs 28.8%, p < 0.001). The adjusted ORs of frailty on 6-month all-cause hospitalization were 3.30 (95% CI 1.37-7.98) in women, and 2.01 (95% CI 0.88-4.59) in men.</p><p><strong>Conclusions: </strong>In this study, frailty was more prevalent in women and was associated with an increased risk of hospitalizations in women than in men. This study adds to the understanding of how frailty and sex influence health outcomes in older adults with diabetes, implying the need for sex-specific approaches in managing diabetes in older adults.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 4","pages":"100168"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic profiles of dietary exposure associated with frailty in older adults: A systematic review.","authors":"Samar El Sherbiny, Evgeniia Puzankova, Miriam Martínez-Huélamo, Natàlia Garcia-Giralt, Jose Antonio Carnicero Carreño, Leocadio Rodriguez Mañas, Jose Antonio Serra Rexach, Francisco José García García, Xavier Nogués, Pedro Abizanda Soler, Cristina Andrés-Lacueva, Montserrat Rabassa","doi":"10.1016/j.tjfa.2026.100163","DOIUrl":"10.1016/j.tjfa.2026.100163","url":null,"abstract":"<p><p>Frailty is defined by the World Health Organization as a state of increased vulnerability in older adults, characterized by a decline in physiological functions across multiple systems and heightened sensitivity to external stressors. The global prevalence of frailty is expected to rise due to population ageing, highlighting the need for effective preventive strategies. However, while diet can play a crucial role in this context, their relationship is complex and potentially bidirectional: unhealthy dietary patterns may contribute to the onset of frailty, whereas early stages of frailty may influence food choices through limitations in meal preparation, and appetite. Hence, identifying biomarkers associated with frailty phenotypes may help clarify these mechanisms and improve prevention strategies. This systematic review aims to summarize current evidence on metabolomics-derived biomarkers potentially involved in the relationship between dietary patterns and frailty. A comprehensive literature search was conducted across three electronic databases (PubMed, Web of Science, Scopus) in accordance with the PRISMA guidelines, yielding 1661 studies, of which five met the inclusion criteria. Three dietary exposures were identified and analyzed: fruit and vegetable, plant/animal protein intake, and adherence to the Mediterranean diet. The findings suggest that specific metabolites, such as hippuric acid, different amino acids, and lipid derived compounds may represent potential candidates for establishing a metabolic signature of frailty. Nevertheless, current evidence remains limited and unclear about the direction of associations. Further research is needed, particularly in healthy populations, to validate the effectiveness of these biomarkers, and tailor guidelines specific for older adults.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 4","pages":"100163"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incident dementia risk by frailty status and living arrangements in older adults.","authors":"Kate McEwen, Suraj Samtani, Rory Chen, John D Crawford, Perminder S Sachdev, Henry Brodaty, Katya Numbers","doi":"10.1016/j.tjfa.2026.100185","DOIUrl":"10.1016/j.tjfa.2026.100185","url":null,"abstract":"<p><strong>Background: </strong>Frailty and social isolation are independently associated with dementia risk. This study examined whether frailty predicts dementia differently for older adults living alone versus with others.</p><p><strong>Methods: </strong>Participants were 967 community-dwelling, dementia-free older adults from the Sydney Memory and Ageing Study (2005-2020). Frailty was assessed using an adapted Fried Frailty Phenotype (robust, pre-frail, frail). Dementia was diagnosed via biennial neuropsychological testing and clinical consensus. Cox regressions analysed associations between baseline frailty, living arrangements (alone vs. with others), and incident dementia over 12 years.</p><p><strong>Result: </strong>Frail individuals had 1.74 times higher dementia risk than robust individuals (HR = 1.74, 95% CI: 1.16-2.60, p = .007). Living alone was not independently associated with dementia (HR = 1.03, p = .825). The interaction between frailty and living arrangements was non-significant (HR = 1.23, p = 0.600). Exploratory stratified analyses showed frailty predicted dementia among those living alone (HR = 1.92, 95% CI: 1.06-3.51, p = .033) but not those living with others (HR = 1.42, p = 0.224).</p><p><strong>Conclusion: </strong>Frailty is a significant predictor of dementia risk in older adults. While the formal interaction test was non-significant, exploratory findings suggest frail individuals living alone may be particularly vulnerable, warranting further investigation and potential targeting for combined physical and social interventions, pending replication.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 4","pages":"100185"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13520889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}