Journal of Frailty & Aging最新文献

{"title":"The bidirectional relationship between knee osteoarthritis and frailty in China: A longitudinal study.","authors":"Ziwei Tian, Huimin Zhao, Yanping Zhai, Zhilan Yang","doi":"10.1016/j.tjfa.2025.100087","DOIUrl":"10.1016/j.tjfa.2025.100087","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis is a common disease that causes disability and loss of independence in middle-aged and older adults, and may interact with frailty through shared pathways. Understanding their bidirectional relationship is clinically meaningful for early intervention. This study aimed to investigate the associations between knee osteoarthritis and frailty among middle-aged and older adults in China.</p><p><strong>Methods: </strong>The data for this study came from three waves (baseline 2011, follow-up 2013 and 2015) of the China Health and Retirement Longitudinal Study (CHARLS). A total of 3560 participants were included. Frailty was assessed with the Frailty Index. Knee osteoarthritis was defined as physician-diagnosed arthritis with self-reported knee pain. Longitudinal bidirectional relationships were found using cross-lagged panel models and random-intercept cross-lagged panel models.</p><p><strong>Results: </strong>A longitudinal bidirectional relationship between knee osteoarthritis and frailty was observed, with a stronger effect of frailty on subsequent knee osteoarthritis (Wald χ² = 11.416, P < 0.001). At the between-person level, individuals with knee osteoarthritis also tend to have a higher risk of frailty (β= 0.454, P < 0.001). At the within-person level, the predictive effect of knee osteoarthritis on frailty was significant only in the long term (β=0.055, P < 0.05). Subgroup analyses showed that this longitudinal bidirectional relationship was particularly strong among females as well as those with low education levels.</p><p><strong>Conclusions: </strong>This study reveals a longitudinal bidirectional relationship between knee osteoarthritis and frailty in middle-aged and older adults. In particular, the dominant role of frailty in the development of knee osteoarthritis was found, as well as the negative impact of knee osteoarthritis accumulation on frailty over time. This result suggests that targeting frailty early interventions in an ageing society may help to interrupt the vicious cycle of knee osteoarthritis and reduce the risk of disability. It provides a scientific basis for public health strategies.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100087"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The conceptualisation and measurement of social frailty in older people: an umbrella review.","authors":"Martin Webber, Beth Casey, Laura Tucker, Kirsty Shires, Mark Wilberforce, Barbara Hanratty, Louise Tomkow, David Sinclair, Jennifer Liddle, Dawn Sissons, Lynette Joubert","doi":"10.1016/j.tjfa.2025.100078","DOIUrl":"10.1016/j.tjfa.2025.100078","url":null,"abstract":"<p><strong>Background: </strong>The social domain of frailty is often poorly defined or missing from measures of frailty. The literature is still inconclusive on the nature and scope of social frailty, although studies indicate that it has a substantial impact on disability and mortality outcomes.</p><p><strong>Aims: </strong>This Umbrella Review aimed to synthesise concepts and measures of social frailty.</p><p><strong>Methods: </strong>A search for reviews was performed in Web of Science, CINAHL, SOCINDEX, Medline, PsychoINFO and COSMIN databases. This Umbrella Review was conducted and reported with reference to the Joanna Briggs Institute (JBI) Reviewer's Manual. The JBI Critical Appraisal Checklist for Systematic Review was used to assess the quality of studies.</p><p><strong>Results: </strong>Sixteen reviews were included. The concept of social frailty was summarised as weakness in a person's social infrastructure compounded by a declining ability to change their circumstances. Forty-two measures of social frailty were identified which included a total of 228 items relating to social frailty. These were grouped into nine domains, of which participation in social activities was most commonly included within measures.</p><p><strong>Conclusion: </strong>The use of diverse indicators creates a challenge for the measurement of social frailty. Their limited use in health and social care practice undermines the practical utility of the concept. This review helps to provide conceptual clarity and a platform for the development and validation of a robust social frailty measure which will facilitate the identification of people at risk and target interventions to prevent or alleviate the impact of social frailty on older people.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100078"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"15^th International Conference on Frailty & Sarcopenia Research (ICFSR) March 12-14, 2025 Toulouse, France Conference proceedings.","authors":"","doi":"10.1016/j.tjfa.2025.100095","DOIUrl":"10.1016/j.tjfa.2025.100095","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 1S","pages":"100095"},"PeriodicalIF":3.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"15^th International Conference on Frailty & Sarcopenia Research (ICFSR) March 12-14, 2025 Toulouse, France Conference proceedings.","authors":"","doi":"10.1016/j.tjfa.2025.100096","DOIUrl":"10.1016/j.tjfa.2025.100096","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 1S","pages":"100096"},"PeriodicalIF":3.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Built-in healthcare applications reveal step changes associated with temperature, transportation, and marital status among urban cities in Japan.","authors":"Nobuhiko Wakai, Taiga Yamada, Hiroyuki Tomoyama, Shigehiro Iida","doi":"10.1016/j.tjfa.2025.100059","DOIUrl":"10.1016/j.tjfa.2025.100059","url":null,"abstract":"<p><strong>Background: </strong>Walking is a fundamental daily activity representing health status and physical condition. The number of steps taken in a given time period is widely used in research areas such as aging, geriatrics, gerontology, public health, and preventive medicine. However, the underlying mechanisms of step counts are not well understood.</p><p><strong>Objectives: </strong>To investigate daily step counts associated with temperature, transportation, and marital status.</p><p><strong>Design: </strong>Time series analysis of daily steps using built-in healthcare applications on smartphones.</p><p><strong>Setting: </strong>Government-designated, well-developed urban cities in Japan: Fukuoka, Kawasaki, Kobe, Kyoto, and Saitama.</p><p><strong>Participants: </strong>Respondents totaled 622 40- to 79-year-olds, comprising 370 males and 252 females.</p><p><strong>Measurements: </strong>The mean period of our retrospective data was 2,344 days.</p><p><strong>Results: </strong>Seasonal-trend decomposition using loess was applied to time series steps. With the high coefficient of determination R²: 0.798, an absolute value function was fitted between temperature and the mean daily steps of the seasonal component. Furthermore, ordinary train usage in Saitama, Kawasaki, and Fukuoka was significantly greater than that in Kobe and Kyoto by 14.1 points (p=0.001). Moreover, married and divorced or bereaved males' mean daily step counts were significantly larger than those of females' by 1,832 (p=0.001) and 2,480 (p=0.001), respectively. By contrast, the difference in the mean daily step counts for unmarried males and females was only 100.</p><p><strong>Conclusions: </strong>This study presents significant associations between mean daily steps and the factors of temperature, transportation, and marital status. These associations can alleviate biases in step research by area and season to facilitate better step count comparisons in many research fields.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100059"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sarcopenia operationalized using muscle strength or power and health-related parameters.","authors":"Hélio José Coelho Júnior, Alejandro Álvarez-Bustos, Riccardo Calvani, Stefano Cacciatore, Anna Picca, Matteo Tosato, Francesco Landi, Emanuele Marzetti","doi":"10.1016/j.tjfa.2025.100062","DOIUrl":"10.1016/j.tjfa.2025.100062","url":null,"abstract":"<p><strong>Background and objectives: </strong>The present study examined the associations between sarcopenia, operationalized through muscle strength or muscle power, and health parameters in Italian community-dwelling older adults.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Unconventional settings across Italy.</p><p><strong>Participants: </strong>Italian older adults (65+ years) who provided a written informed consent.</p><p><strong>Measurements: </strong>Physical function was evaluated according to isometric handgrip strength (IHG) and 5-time sit-to-stand (5STS) performances. Muscle power parameters were estimated based on 5STS values. Sarcopenia was operationalized according to the presence of low physical function (i.e., IHG or 5STS), or low muscle power, plus low appendicular skeletal muscle mass. Health parameters included the capacity to perform the 400 m test, adherence to the Mediterranean (MED) diet, practice of physical activity (PA), blood pressure (BP) values, blood concentration of total cholesterol and glucose, verbal fluency, sleep quality, and self-reported health status.</p><p><strong>Results: </strong>Results indicated that sarcopenic indexes had a poor-to-moderate level of agreement. Moreover, results indicated that operationalizing sarcopenia using muscle power measures provided exclusive or stronger associations with health parameters. Specifically, older adults classified as sarcopenic based on muscle power values were less likely to complete the 400-meter walk test, more likely to engage in PA, reported poorer self-rated health, and showed lower adherence to the MED diet.</p><p><strong>Conclusions: </strong>Findings of the present study indicated that sarcopenia indexes based on muscle strength or muscle power capture different aspects of older adults' health. Specifically, operationalizing sarcopenia using muscle power measures provided exclusive or stronger associations with health parameters.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100062"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain as a mediator in the falls-frailty association: Evidence from middle-aged and older ethnic minorities in Yunnan, China.","authors":"Xuan Wen, Rui Deng, Xinping Wang, Chunyan Deng, Xiaoju Li, Yafang Zhang, Ying Chen, Yuan Huang","doi":"10.1016/j.tjfa.2025.100050","DOIUrl":"10.1016/j.tjfa.2025.100050","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Falls are associated with an increased risk of frailty in middle-aged and older adults; however, the mediating role between falls and frailty remains underexplored, particularly among ethnic minority groups with distinct sociocultural and environmental exposures. Ethnic minority populations exhibit significant disparities in the prevalence of falls, frailty, and chronic pain compared to the majority. The primary objective of this study is to examine the relationship between falls and frailty in middle-aged and elderly individuals residing in Yunnan Province, China, with a specific emphasis on exploring the potential mediating effect of chronic pain across different ethnic groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Employing a cross-sectional design, data were collected from July to December 2022 from adults aged ≥45 years in five ethnically diverse counties of Yunnan Province, China. Structured face-to-face interviews and stratified multistage cluster sampling were used for data collection. Baron and Kenny's causal steps method was used to explore the mediating effect of chronic pain on the relationship between falls and frailty. Spearman correlation analysis, multiple linear regression models, and bootstrap method were used for data analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 2710 respondents participated in this study. The age distribution was as follows: 1161 (42.84 %) aged 45-59 years, 863 (31.85 %) aged 60-69 years, and 686 (25.31 %) aged 70 years or older. The sample comprised 1218 males (44.94 %) and 1492 females (55.06 %). The prevalence of falls among middle-aged and older individuals was 12.77 %, while the prevalence of frailty in the same population was observed to be 21.62 %. Spearman correlation analysis revealed significant positive association between chronic pain and both falls (r = 0.135, P &lt; 0.05) as well as frailty (r = 0.383, P &lt; 0.05). Frailty also exhibited a significant positive correlation with falls (r = 0.162, P &lt; 0.05). After adjusting for all covariates, the total effect of falls on frailty was estimated to be 1.065 (95 % bootstrap CI: 0.804∼1.326), with a direct effect estimate of 0.797 (95 % bootstrap CI: 0.511∼1.083). The indirect effect of chronic pain on this association was found to be approximately one-quarter at 0.268 (95 % bootstrap CI: 0.170∼0.366). The subgroup analysis discovered differences in the mediating effects across different ethnic groups; specifically, the proportions mediated by chronic pain were found to be 28.2 %, 18.4 %, and 21.5 % for Han majority group, Zhiguo ethnic minorities, and other ethnic minority groups, respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study provides valuable insights into the intricate association between frailty, falls, and chronic pain among middle-aged and older adults from diverse ethnic backgrounds in a western province of China. Effective management strategies targeting chronic pain and falls prevention could serve as ","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100050"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple test of \"Kami-Tsumami\" (Paper Tug) for pinch strength screening among community-dwelling older adults.","authors":"Weida Lyu, Tomoki Tanaka, Katsuya Iijima","doi":"10.1016/j.tjfa.2025.100060","DOIUrl":"10.1016/j.tjfa.2025.100060","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100060"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of lifestyle modifications with frailty in older adults: A cross-sectional study using NHANES.","authors":"Yuanyuan Wu, Hongyan Peng, Rui Xu, Yingxue Hua, Yanan Zhang","doi":"10.1016/j.tjfa.2025.100061","DOIUrl":"10.1016/j.tjfa.2025.100061","url":null,"abstract":"<p><strong>Background: </strong>Background: Frailty significantly impacts healthy aging, yet lifestyle interventions may reduce its prevalence. This study investigated the association between a comprehensive lifestyle score, comprising eight modifiable factors (diet, physical activity, smoking, sleep, body mass index [BMI], non-HDL cholesterol, blood glucose, and blood pressure), and frailty risk in older adults, identifying key components for targeted interventions.</p><p><strong>Methods: </strong>Using data from the National Health and Nutrition Examination Survey (NHANES, 2005-2018), we analyzed 10,065 adults aged ≥60 years (mean age: 69.61, 54.97 % female). Each lifestyle factor was scored from 0 to 100, and frailty was defined using a 49-item index (>0.21). Weighted logistic regression assessed individual associations, restricted cubic spline (RCS) analysis explored dose-response relationships, and quantile g-computation evaluated joint effects.</p><p><strong>Results: </strong>Higher scores for dietary score (OR=0.69, 95 % CI: 0.52-0.90, score 100 vs. 0), non-smoking (OR=0.62, 95 % CI: 0.51-0.75), sleep (OR=0.29, 95 % CI: 0.17-0.49), blood glucose (OR=0.27, 95 % CI: 0.17-0.44), and blood pressure (OR=0.43, 95 % CI: 0.30-0.61, score 25 vs. 0) were associated with lower frailty risk (all P < .05). Diet and non-HDL cholesterol showed no linear association; smoking, BMI, blood glucose, and blood pressure exhibited non-linear patterns (P<.05). A simultaneous one-level increase in all lifestyle factors reduced frailty risk by 94 % (95 % CI: 92-95 %), with physical activity, blood glucose, and sleep as primary contributors.</p><p><strong>Conclusion: </strong>These findings highlighted the association between specific lifestyle factors and reduced frailty risk, underscoring the need for prospective studies to prioritize interventions for frailty prevention.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100061"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity in Lewy body dementia: a review.","authors":"Federica Sanapo, Marie Signoret, Mihaela Nodit, Antoine Garnier-Crussard","doi":"10.1016/j.tjfa.2025.100076","DOIUrl":"10.1016/j.tjfa.2025.100076","url":null,"abstract":"<p><p>Frailty is a clinical syndrome characterized by diminished physiological reserves and increased vulnerability to stressors. While frailty has been largely studied in Alzheimer's disease, few study focused on Lewy body dementia (LBD). Beyond frailty, the World Health Organization recently highlights the concept of intrinsic capacity (IC), offering a promising framework for the early identification and intervention to mitigate the risk of frailty and disability in older adults. IC refers to an individual's physical and mental abilities (including five dimensions: sensory, psychology, locomotion, vitality and cognition), which support the maintenance of functional capacity and promote healthy aging. In this review, we aimed to describe the prevalence of IC decline in LBD and its potential consequences. While few studies focused specifically on this question, we found evidence in the literature of a higher prevalence of IC decline in LBD, compared to cognitively unimpaired older adults and to Alzheimer's disease patients. If future studies are needed to confirm these results, we assume that IC assessment and monitoring in LBD may be a further step towards a better integrated and personalized care for patients. This may open the avenue to develop specific tailored interventions, to decrease disability and increase quality of life and \"healthy ageing\" of patients despite the presence of LBD.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100076"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}