Journal of Frailty & Aging最新文献

{"title":"Cross-Sectional Associations of Sarcopenia and Its Components with Neuropsychological Performance among Memory Clinic Patients with Mild Cognitive Impairment and Alzheimer’s Disease","authors":"T. Sugimoto, Y. Kuroda, N. Matsumoto, K. Uchida, Y. Kishino, N. Saji, S. Niida, T. Sakurai","doi":"10.14283/jfa.2022.3","DOIUrl":"https://doi.org/10.14283/jfa.2022.3","url":null,"abstract":"The association of sarcopenia with cognitive function in its specific domains remains poorly understood. To investigate the association of sarcopenia and its components with neuropsychological performance among patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Cross-sectional design. A memory clinic in Japan. The study included 497 MCI/684 AD patients aged 65–89 years. Patients were assessed for muscle mass by bioelectrical impedance analysis, muscle strength by hand grip strength (HGS), and physical performance by timed up and go test (TUG). Sarcopenia was defined as presence of both low muscle strength and low muscle mass. The patients underwent neuropsychological tests, including logical memory, frontal lobe assessment battery, word fluency test, Raven’s colored progressive matrices, digit span, and the Alzheimer’s disease assessment scale-cognitive subscale (ADAS-cog). Results: The prevalence of sarcopenia in men and women was 24.1% and 19.5%, respectively. In multiple regression analyses adjusting for confounders, unlike in men, sarcopenia was associated with memory function in women (ADAS-cog, memory domain, coefficient = 1.08, standard error (SE) = 0.36), which was thought likely due to the relationship between HGS and memory function (immediate recall of logical memory, coefficient = 0.07, SE = 0.03; ADAS-cog, memory domain, coefficient = −0.10, SE = 0.03). Of the components of sarcopenia in both sexes, HGS and TUG were associated with visuospatial function and frontal lobe function, respectively. The specific association of sarcopenia and its components with cognitive domains may provide the key to elucidating the muscle-brain interactions in AD.","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"11 1","pages":"182 - 189"},"PeriodicalIF":3.9,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46696686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty Status and Outcomes of COVID-19 Patients Admitted to an Intensive Care Unit","authors":"M. Jones, C. Subbe, C. Thorpe, C. Pickwick","doi":"10.14283/jfa.2022.5","DOIUrl":"https://doi.org/10.14283/jfa.2022.5","url":null,"abstract":"Frailty assessment using the Clinical Frailty Scale (CFS) has been incorporated into COVID-19 decision aids as frailty highlights risk of poor outcome which can guide future care (1, 2). The critical care patient population continues to trend towards a younger, fitter and less co-morbid population (3). Yet, COVID-19 is a disease that disproportionately effects the elderly; people aged over 65 years represent more than 50% of Intensive Care Unit (ICU) admissions and account for 80% of mortality (1). There are subsequent ethical considerations as to how resources were and continue to be allocated. For this reason, it is relevant we understand how frailty has impacted clinical decisions which may then drive improvements in future practice. Frailty has sustained relevance in a critical care environment with continual scarcity of resources (3). We undertook a service evaluation of the mortality and hospital outcomes of COVID-19 positive patients admitted to Ysbyty Gwynedd (YG) ICU from 01/03/2020 to 01/06/2022. We considered the effect of ICU patients’ pre-admission frailty on their subsequent outcomes as well as comparing how CFS scores of admitted patients changed over the evaluation period. Patients testing positive for COVID-19 that were admitted to ICU were the sole population of interest. Patients aged 18 or over were considered eligible for the evaluation and patients with suspected COVID-19 that tested negative were excluded. Retrospective data was sourced from the Intensive Care National Audit & Research Centre (ICNARC) database, handover notes and clinical files. CFS scores were used to dichotomise the cohort into two distinct groups; one group with CFS scores 1-4 was defined as fit or vulnerable and the second group scoring between 5-9 was defined as frail. Patients were then assigned a pandemic ‘wave’ based on their date of admission: admission between 01/03/2020 to 01/09/2020 were assigned ‘Wave 1’ and between 01/09/2020 to 01/06/2021 ‘Wave 2’. 72 COVID-19 patients were included in the service evaluation; 65% of patients were male and the mean age was 59 years (SD 13). The population had a mean ICNARC score © Serdi and Springer Nature Switzerland AG 2022","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"11 1","pages":"242 - 243"},"PeriodicalIF":3.9,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48540499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia in Distal Radius Fractures: A Scoping Review","authors":"M. Yam, H. Ng, C. L. Lim, Y. Munro, W. Lim","doi":"10.14283/jfa.2022.6","DOIUrl":"https://doi.org/10.14283/jfa.2022.6","url":null,"abstract":"Sarcopenia is an emerging disease that adversely impacts outcomes of older adults across the spectrum of fragility fractures. Few studies have examined sarcopenia in upstream fragility fractures such as the distal radius. Understanding the state of current evidence is essential in defining a research agenda in this critical area of sentinel distal radius fractures and sarcopenia. The aim of this scoping review was to summarize existing literature on sarcopenia in distal radius fracture in older adults, and to identify research areas and gaps to guide future studies. We utilized the 5-stage framework of Arksey and O’Malley. We searched studies from 2010 to 2020 relating to «Sarcopenia» and «Distal radius fractures» in major databases. Two reviewers independently screened articles for inclusion and conducted full text reviews of shortlisted articles. We extracted data on research areas, key findings, and study limitations. Thirteen studies met the inclusion and exclusion criteria. They covered the areas of epidemiology (N=9), risk factors (N=4), basic science (N=2), outcomes (N=1), and diagnostic modalities (N=1). There were no studies on screening/case finding, prognostic scoring, intervention, or health economics. Identified limitations included the lack of clear definition and diagnostic criteria for sarcopenia, and lack of, or inappropriate, control group. Majority of studies were retrospective or cross-sectional in study design. This scoping review on sarcopenia in distal radius fractures highlighted gaps in research areas and in the rigor of studies conducted, and the need for more prospective cohort and interventional studies. Building upon current consensus criteria, we propose setting a research agenda along the timeline of sarcopenia management, from screening through to intervention and follow-up, which will inform future research in this early disease cohort of fragility fractures.","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"11 1","pages":"169 - 176"},"PeriodicalIF":3.9,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47074315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Detachment Influenced Muscle Mass and Strength during the COVID-19 Pandemic in Japanese Community-Dwelling Older Women","authors":"B. Son, T. Imoto, T. Inoue, T. Nishimura, T. Tanaka, K. Iijima","doi":"10.14283/jfa.2022.4","DOIUrl":"https://doi.org/10.14283/jfa.2022.4","url":null,"abstract":"Social detachment due to Coronavirus disease (COVID-19) has caused a decline in physical activity, leading to sarcopenia and frailty in older adults. This study aimed to compare muscle mass, strength, and function values in older women before and after the first wave of the COVID-19 pandemic (April–May 2020). Furthermore, changes in muscle measures across women who experienced different levels of impact on their social participation due to the COVID-19 pandemic were examined. Muscle mass (total, trunk, and appendicular muscle), grip strength, oral motor skills, social interactions (social network and participation), and social support were assessed in 46 Japanese community-dwelling older women (mean, 77.5 y; range 66–93 y) before and after the first wave of the COVID-19 pandemic. Trunk muscle mass significantly decreased after the first wave of the pandemic. When comparing changed values between the enhanced/maintained and reduced group during the pandemic, significant group difference was observed in trunk muscular mass, grip strength, and oral motor skills. Intriguingly, those who enhanced social participation had a positive change of grip strength values, showing that social participation might influence muscle function during the COVID-19 pandemic.","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"11 1","pages":"231 - 235"},"PeriodicalIF":3.9,"publicationDate":"2022-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45335025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant Psychosocial Influence in Frail People Living with HIV Independent of Frailty Instrument Used","authors":"S. Abdul-Aziz, M. Chong, M. McStea, P. Wong, S. Ponnampalavanar, I. Azwa, A. Kamarulzaman, S. Kamaruzzaman, R. Rajasuriar","doi":"10.14283/jfa.2021.48","DOIUrl":"https://doi.org/10.14283/jfa.2021.48","url":null,"abstract":"Antiretroviral therapy (ART) usage among people living with HIV (PLWH) has led to significant mortality declines and increasing lifespan. However, high incidence and early onset of aging-related conditions such as frailty, pose as a new threat to this population. OBJECTIVES: We aimed to characterize frailty by comparing health domains consisting of psychosocial, functional and physical deficits between frail PLWH and matched uninfected controls; identify associated risk factors and the impact on negative health outcomes including mortality risk score, quality of life, healthcare utilization, functional disability and history of falls among virally suppressed PLWH. Cross-sectional study Infectious disease clinic in a tertiary institution Individuals aged >25 years, on ART > 12 months, not pregnant and without acute illness; multi-ethnic, Asian Frailty instruments included Frailty phenotype (FP), FRAIL scale (FS) and Frailty index (FI). FI health deficits were categorized into health domains (psychosocial, functional and physical) and used as standard comparator to characterize frailty. Health domains of frail PLWH were compared with frail matched, uninfected controls. Regression analyses were applied to explore associated risk factors and health-related frailty outcomes. We recruited 336 PLWH. Majority were male (83%), Chinese (71%) with CD4+ count 561 (397–738) cells/µl. Frailty prevalence among PLWH were 7% (FP); 16% (FS) and 22% (FI). Proportions of psychosocial, functional, and physical domains were similarly distributed among frail PLWH measured by different frailty instruments. When compared with matched controls, psychosocial dominance was significant among the PLWH, but not in functional and physical domains. Identified frailty risk factors included poor nutritional status, higher CD4+ count nadir, depression, metabolic syndrome, higher highly sensitive C-reactive protein (hsCRP) and history of AIDS-defining illness (ADI). Frailty influenced the risk for negative health outcomes including increased mortality risk scores, poor quality of life (QOL), frequent healthcare utilization and increased functional disability (p<0.05). This study highlighted the importance of psychosocial influence in the development of frailty among treated PLWH in a multiethnic, Asian setting.","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"11 1","pages":"190 - 198"},"PeriodicalIF":3.9,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44553950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Design and Rationale of a Phase 2b, Randomized, Double-Blinded, and Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Lomecel-B in Older Adults with Frailty","authors":"K. Yousefi, K. Ramdas, J. Ruiz, J. Walston, H. Arai, E. Volpi, A. Newman, C. Wang, B. Hitchinson, L. Mcclain-Moss, L. Diaz, G. Green, J. Hare, A. Oliva","doi":"10.14283/jfa.2022.2","DOIUrl":"https://doi.org/10.14283/jfa.2022.2","url":null,"abstract":"Background Frailty in older adults is a rapidly growing unmet medical need. It is an aging-related syndrome characterized by physical decline leading to higher risk of adverse health outcomes. Objectives To evaluate the efficacy of Lomecel-B, an allogeneic medicinal signaling cell (MSC) formulation, in older adults with frailty. DESIGN: This multicenter, randomized, parallel-arm, double-blinded, and placebo-controlled phase 2b trial is designed to evaluate doserange effects of Lomecel-B for frailty on physical functioning, patient-reported outcomes (PROs), frailty status, and biomarkers. Setting Eight enrolling clinical research centers, including the Miami Veterans Affairs Medical Center. Participants Target enrollment is 150 subjects aged 70–85 years of any race, ethnicity, or gender. Enrollment criteria include a Clinical Frailty Score of 5 (“mild”) or 6 (“moderate”), a 6MWT of 200–400 m, and serum tumor necrosis factor-alpha (TNF-α) ≥2.5 pg/mL. Intervention A single intravenous infusion of Lomecel-B (25, 50, 100, or 200 million cells) or placebo (N=30/arm). Patients are followed for 365 days for safety, and the efficacy assessments performed at 90, 180, and 270 days. Measurements The primary endpoint is change in 6MWT in the Lomecel-B-treated arms versus placebo at 180 days post-infusion. Secondary and exploratory endpoints include change in: 6MWT and other physical function measures at all time points; PROs; frailty status; cognitive status; and an inflammatory biomarkers panel. A pre-specified sub-study examines vascular/endothelial biomarkers. Safety is evaluated throughout the trial. Results The trial is conducted under a Food and Drug Administration Investigational New Drug (IND), with Institutional Review Board approval, and monitoring by an NIH-appointed independent Data Safety Monitoring Board. Conclusion This clinical trial investigates the use of a regenerative medicine strategy for frailty in older adults. The results will further the understanding of the potential for Lomecel-B in the geriatric condition of frailty.","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"1 1","pages":"1-10"},"PeriodicalIF":3.9,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48509441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12th International Conference on Frailty & Sarcopenia Research (ICFSR) April 20-22, 2022, Boston, USA, POSTER","authors":"","doi":"10.14283/jfa.2022.23","DOIUrl":"https://doi.org/10.14283/jfa.2022.23","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"1 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66892270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty among Older Adults and Its Distribution in England","authors":"D. Sinclair, A. Maharani, T. Chandola, P. Bower, B. Hanratty, J. Nazroo, T. O’Neill, G. Tampubolon, C. Todd, R. Wittenberg, F. Matthews, N. Pendleton","doi":"10.14283/jfa.2021.55","DOIUrl":"https://doi.org/10.14283/jfa.2021.55","url":null,"abstract":"Information on the spatial distribution of the frail population is crucial to inform service planning in health and social care. To estimate small-area frailty prevalence among older adults using survey data. To assess whether prevalence differs between urban, rural, coastal and inland areas of England. Using data from the English Longitudinal Study of Ageing (ELSA), ordinal logistic regression was used to predict the probability of frailty, according to age, sex and area deprivation. Probabilities were applied to demographic and economic information in 2020 population projections to estimate the district-level prevalence of frailty. The prevalence of frailty in adults aged 50+ (2020) in England was estimated to be 8.1 [95% CI 7.3–8.8]%. We found substantial geographic variation, with the prevalence of frailty varying by a factor of 4.0 [3.5–4.4] between the most and least frail areas. A higher prevalence of frailty was found for urban than rural areas, and coastal than inland areas. There are widespread geographic inequalities in healthy ageing in England, with older people in urban and coastal areas disproportionately frail relative to those in rural and inland areas. Interventions aimed at reducing inequalities in healthy ageing should be targeted at urban and coastal areas, where the greatest benefit may be achieved.","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"11 1","pages":"163 - 168"},"PeriodicalIF":3.9,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42913534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Supplementation Is Associated with a Reduction in Self-Reported Falls among Older Adults with Previous Fall History — Feasibility Study","authors":"S. Anton, R. Mankowski, P. Qiu, L. You, B. Bensadon, E. J. Audino, C. Custodero, J. H. Lee, J. Hincapie, C. McLaren, C. Leeuwenburgh, S. Ganesh","doi":"10.14283/jfa.2021.46","DOIUrl":"https://doi.org/10.14283/jfa.2021.46","url":null,"abstract":"Vitamin D insufficiency contributes to muscle weakness and a higher risk of falls in older adults. This study explored the impact of vitamin D supplementation on self-reported falls and physical function in older adults with low vitamin D levels and a recent fall history. Twenty-five older adults ≥ 70 years with two or more falls during the past year, low vitamin D blood levels (≥10 ng/ml and < 30 ng/mL), and slow gait speed (1.2 m/s) participated in a 6-month vitamin D supplementation (800 IU/day) study. A modified version of the Morse Fall Scale questionnaire was used to assess frequency of falls over one-year prior to study enrollment. Functional outcomes (short physical performance battery, handgrip strength, gait Timed Up and Go, and six-minute walk), and vitamin D levels were assessed at baseline and 6-month follow-up. Based on diaries and pill counts, participants were generally adherent to the intervention (6 of 7 days per week). Supplementation with 800 IU/day of vitamin D for 6 months increased blood vitamin D levels from 23.25±4.8 ng/ml to 29.13±6.9 ng/ml (p<0.001). Self-reported number of falls decreased from an average of 3.76 ± 2.2 falls in one-year to 0.76 ± 1.4 falls (p <0.0001) over the 6-month intervention. No changes in functional outcome measures were observed. Vitamin D supplementation at the currently recommended dose of 800 IU/day increased blood vitamin D levels and reduced frequency of falls in older adults with low vitamin D levels and a recent fall history.","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"11 1","pages":"224 - 230"},"PeriodicalIF":3.9,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49012118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of a Novel Handheld Bioelectrical Impedance Device for Assessing Muscle Mass in Older Inpatients","authors":"A. Stuck, A. Weber, R. Wittwer, A. Limacher, R. Kressig","doi":"10.14283/jfa.2021.40","DOIUrl":"https://doi.org/10.14283/jfa.2021.40","url":null,"abstract":"To investigate practicality and repeatability of a handheld compared to a state-of-the-art multisegmental bioelectrical impedance analysis (BIA) device to facilitate screening of sarcopenia in older inpatients. Cross-sectional study in a geriatric rehabilitation hospital. 207 inpatients aged 70+. In a first phase, appendicular skeletal muscle mass index (ASMI) was measured using the handheld Biody xpertZm II BIA device (n=100). In a second phase, ASMI was obtained using the multisegmental Biacorpus RX 4004M device (n=107). Repeatability of BIA devices was compared in subgroups of patients (handheld BIA device: n=36, multisegmental BIA device: n=46) by intra-class correlation (ICC) and Bland-Altman plots. Overall, measurement failure was seen in 31 patients (31%) tested with the handheld BIA device compared to one patient (0.9%) using the multisegmental BIA device (p<0.001). Main reasons for measurement failure were inability of patients to adopt the position necessary to use the handheld BIA device and device failure. The mean difference of two ASMI measurements in the same patient was 0.32 (sd 0.85) using the handheld BIA device compared to 0.02 kg/m2 (sd 0.07) using the multisegmental device (adjusted mean difference between both groups −0.35, 95% confidence interval (CI) −0.61 to −0.09 kg/m2). Congruently, Bland-Altman plots showed poor agreement with the handheld compared to the multisegmental BIA device. The handheld BIA device is neither a practical nor reliable device for assessing muscle mass in older rehabilitation inpatients.","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"11 1","pages":"156 - 162"},"PeriodicalIF":3.9,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43434740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}