Journal of Frailty & Aging最新文献

{"title":"Impacts of sarcopenia and resistance exercise training on mitochondrial quality control proteins.","authors":"Catherine B Springer-Sapp, Olayinka O Ogbara, Odessa Addison, Sarah Kuzmiak-Glancy, Steven J Prior","doi":"10.1016/j.tjfa.2025.100090","DOIUrl":"10.1016/j.tjfa.2025.100090","url":null,"abstract":"<p><strong>Background: </strong>The progression of sarcopenia with aging may be related to mitochondrial dysfunction due in part to altered mitochondrial dynamics (fusion, fission, mitophagy, and biogenesis). Previous work has identified altered expression of proteins associated with these processes in with aging, but whether further changes occur in sarcopenia remains unclear.</p><p><strong>Objectives: </strong>The purpose of this study was to assess protein expression of markers of mitochondrial fusion (Mfn2, Opa1), fission (Drp1, Fis1), mitophagy (Parkin), biogenesis (PGC-1α), and content (Complex IV: CIV) in sarcopenic and non-sarcopenic older adults. We also determined whether resistance training affected skeletal muscle mitochondrial content and expression of mitochondrial quality control proteins in sarcopenic older adults.</p><p><strong>Design: </strong>Longitudinal exercise training study, with cross-sectional baseline comparison.</p><p><strong>Setting and participants: </strong>Ten older adults with mild-moderate sarcopenia, plus ten non-sarcopenic, matched older adults from Maryland, USA.</p><p><strong>Intervention: </strong>Twelve-week resistance training.</p><p><strong>Measurements: </strong>Strength, sarcopenic index (ALM/BMI: appendicular lean mass divided by body mass index), body composition, and mitochondrial morphology and protein expression in vastus lateralis muscle.</p><p><strong>Results: </strong>No differences in protein expression were observed between sarcopenic and non-sarcopenic participants at baseline; however, ALM/BMI was inversely related to CIV expression (r = -0.55, P = 0.013) across all subjects. Similarly, lean body mass and ALM correlated inversely with expression of the fusion protein Opa1-S (r = -0.55 - -0.51, P ≤ 0.022). Resistance training increased strength in sarcopenic older adults by 13 % (P = 0.02), but this group's expression of mitochondrial quality control proteins was mostly unaltered.</p><p><strong>Conclusions: </strong>The presence of sarcopenia identified by ALM/BMI was not associated with changes in protein expression that are consistent with impaired mitochondrial dynamics beyond those changes that might occur with aging alone. While short-term resistance training increased strength in older adults with sarcopenia, this was not accompanied by changes in protein expression, with the possible exception of fusion protein Mfn2.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 6","pages":"100090"},"PeriodicalIF":3.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intersection of mitochondrial dynamics and sarcopenic phenotyping: A call for mechanistic detail.","authors":"Parth Aphale, Himanshu Shekhar, Shashank Dokania","doi":"10.1016/j.tjfa.2025.100116","DOIUrl":"10.1016/j.tjfa.2025.100116","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 6","pages":"100116"},"PeriodicalIF":3.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12790031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty Nexus: Community of practice for frailty researchers and healthcare professionals.","authors":"Benignus Logan, Adrienne Young, Kristiana Ludlow, David Ward, Leila Shafiee Hanjani, Natasha Reid, Ruth E Hubbard","doi":"10.1016/j.tjfa.2025.100074","DOIUrl":"10.1016/j.tjfa.2025.100074","url":null,"abstract":"<p><strong>Background: </strong>There has been success in implementing frailty education for healthcare professionals, but there remains a need to improve the knowledge and skills of researchers and healthcare professionals to develop, implement and evaluate frailty-focused research.</p><p><strong>Objectives: </strong>This paper describes how the Australian Frailty Network developed and evaluated a virtual community of practice (VCOP), a proven model for fostering knowledge mobilisation, to support researchers and healthcare professionals in advancing frailty research and practice in Australia.</p><p><strong>Design: </strong>Mixed methods.</p><p><strong>Setting: </strong>Australian research and healthcare workplaces.</p><p><strong>Participants: </strong>Researchers and healthcare professionals.</p><p><strong>Measurements: </strong>A survey of prospective members sought to define the VCOP's purpose, membership and structure. An evaluation was undertaken 18 months post-commencement, guided by the RE-AIM framework to assess reach, effectiveness, adoption, implementation and maintenance.</p><p><strong>Results: </strong>Fifty-five prospective members completed the initial survey. There was wide agreement from respondents to be inclusive in defining membership. The preferred purposes of the group included networking, opportunities to gain feedback, review frailty research, and knowledge and skill acquisition. In response, Frailty Nexus was launched, with three core components ('Learning Link-Up', online learning events; 'Nexus News', newsletter sharing learning and research opportunities; 'Nexus Nook', a library of shared resources). Membership totalled 618 from 81 organisations. Ninety-six percent of surveyed members expressed satisfaction with Frailty Nexus.</p><p><strong>Conclusions: </strong>Frailty Nexus is contributing to capacity building in multidisciplinary and translational frailty research. This VCOP could serve as a model that can be adapted by others to improve research outcomes and policy implementation.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100074"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty moderates the relation between moderate-to-vigorous physical activity & stationary time with knee osteoarthritis symptoms.","authors":"Sophie E Rayner, Selena P Maxwell, Jocelyn Waghorn, Rebecca Moyer, Kenneth Rockwood, Olga Theou, Myles W O'Brien","doi":"10.1016/j.tjfa.2025.100077","DOIUrl":"10.1016/j.tjfa.2025.100077","url":null,"abstract":"<p><p>Physical activity is protective against osteoarthritic development and is among the best approaches to manage frailty, which can be characterized as the presence of health deficits. It is unclear whether overall health of a person influences the relation between physical activity and knee-joint health.</p><p><strong>Objective: </strong>Test the hypothesis that physical activity is associated with knee osteoarthritis symptoms and investigate frailty as a moderator.</p><p><strong>Design: </strong>This cohort observational study included participants (n = 1351; 728 females) from the Osteoarthritis Initiative, aged 45-79 (60±9) years. Hip-worn accelerometers were used to quantify free-living stationary time, light (LPA) and moderate-to-vigorous-physical-activity (MVPA). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) defined symptom progression. Baseline frailty was determined via a 31-item Frailty Index and participants grouped into Non-Frail (0-0.09), Very-Mild Frailty (0.1-0.19), and Mild Frailty+ (>0.2). Accelerometry and WOMAC were determined at 72-month follow-up.</p><p><strong>Results: </strong>MVPA (18±19mins/day) was negatively related to WOMAC outcomes (β<-0.0155, p < 0.0022), while LPA (274±79mins/day) was not (β<0.0005, p > 0.3061). Stationary time (606±88mins/day) was positively associated with WOMAC stiffness (β=0.0009, p = 0.0147). Frailty (0.134±0.077) did not moderate LPA and WOMAC relations (p > 0.308). A stronger negative relation between MVPA and WOMAC pain (β=-0.0092, p = 0.041) was observed in the Mild Frailty+ group compared to the Very-Mild Frailty and Non-Frail groups. A stronger positive relation between Stationary time and WOMAC stiffness (β=0.0013, p = 0.012) was observed in the Mild Frailty+ groups compared to the Very-Mild Frailty and Non-Frail groups.</p><p><strong>Conclusion: </strong>Engaging in MVPA and limiting stationary time may be more beneficial on knee osteoarthritis pain and stiffness among frailer older adults.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100077"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive management of frailty. A broader perspective of implementation project \"Systemic Approach to Frailty with a Focus on Pre-Frailty for Healthy and High-Quality Aging\".","authors":"Branko Gabrovec, Nadja Cirar, Katarina Cesar, Rade Pribakovič Brinovec, Matej Vinko, Nina Pirnat, Urška Erklavec, Hajdi Kosednar, Jernej Bevk, Ivan Eržen, Tajda Golja, Anja Jutraž","doi":"10.1016/j.tjfa.2025.100075","DOIUrl":"10.1016/j.tjfa.2025.100075","url":null,"abstract":"<p><p>Managing pre-frailty and frailty is crucial for maintaining the health and independence of older adults. Through \"Systemic Approach to Frailty with a Focus on Pre-Frailty for Healthy and High-Quality Aging\" project, Slovenia is establishing a systematic approach to identify and address frailty, while developing solutions to support preventive measures across healthcare and community levels. Key steps include integrating health and social care systems, strengthening health literacy, adapting and co-creating healthy living environments through a community-based approach and social participation, all essential for promoting healthier and higher-quality aging in the population. This paper outlines the innovative conceptual and methodological approach to project development and its anticipated outcomes.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100075"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the frequency of going outdoors by life space and incident disability among older adults.","authors":"Takehiko Doi, Sho Nakakubo, Fumio Sakimoto, Soichiro Matsuda, Hiroyuki Shimada","doi":"10.1016/j.tjfa.2025.100070","DOIUrl":"10.1016/j.tjfa.2025.100070","url":null,"abstract":"<p><strong>Background: </strong>Going outdoors is crucial in promoting older adults' health. This study examined the association between incident disability and the frequency of going outdoors in certain life spaces.</p><p><strong>Methods: </strong>This prospective study included 19,822 older adults (mean age ± standard deviation: 73.5 ± 5.8 years; 53.6 % women). The frequency of going outdoors within the past month was collected based on life space, categorized by distance from home (up to 1 km; 1-10 km; and >10 km). Participants were classified into three groups (called \"Rarely\": less than 1 day, \"Sometimes\": 1 to 3 days, and \"Often\": 4 days or more) for each life space. Incident disability was defined using the Long-Term Care Insurance system data (mean follow-up: 23.3 months). A Cox proportional hazards model was used to examine the association between incident disability and the frequency of going outdoors for each life space, adjusted for covariates.</p><p><strong>Results: </strong>A total of 1038 (5.2 %) participants had an incident disability. Within the \"up to 1 km\" category, no frequency group was associated with disability; within \"1-10 km,\" two frequency groups were associated with disability (\"Sometimes\" group: hazard ratio [HR] 0.85, [95 % confidence interval [CI]: 0.73-0.99]; \"Often\" group: HR 0.68, [95 % CI: 0.57-0.81]); within \">10 km,\" similar results were observed (\"Sometimes\" group: HR 0.84, [95 % CI: 0.72-0.98]; \"Often\" group: HR 0.75, [95 % CI: 0.53-1.07]).</p><p><strong>Conclusions: </strong>The frequency of going outdoors at specific distances from home is associated with disability.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100070"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of physical activity on cognitive function in patients with neurocognitive disorders: A systematic review.","authors":"Théodore Decaix, Claire Bonnin, Karl Götze, Véronique François, Camille Petit, Clémentine Rivière, Sandrine Greffard, Emmanuel Cognat, Jacques Hugon, Claire Paquet, Louise Sindzingre, Matthieu Lilamand","doi":"10.1016/j.tjfa.2025.100069","DOIUrl":"10.1016/j.tjfa.2025.100069","url":null,"abstract":"<p><p>Neurocognitive disorders, particularly in older adults, significantly affect functional abilities and global health. Physical activity has emerged as a potential non-pharmacological intervention to improve cognitive performance in patients with neurodegenerative diseases. This review specifically addressed the issue of tailored physical activity interventions for individuals with various neurocognitive disorders. This literature review analyzed studies investigating the effects of physical activity on cognitive function in patients with Alzheimer's disease (AD), vascular cognitive impairment, Parkinson's disease, and Lewy body dementia. The studies were evaluated for methodological rigor, participant characteristics, types of physical activities, and cognitive outcomes. Of the 21 studies reviewed, 14 reported beneficial effects of physical exercise on cognitive function, particularly with aerobic activities. While most studies observed improvements in cognitive performance and physical functional capacity, results were inconsistent, and effect sizes were modest. Mechanisms proposed for cognitive improvement in AD included reductions in β-amyloid and tau protein burdens, improved glucose metabolism, and enhanced brain-derived neurotrophic factor levels. Specific improvements were noted in Parkinson's disease, with evidence suggesting mediation through dopamine pathways. Despite evidence of short-term benefits, significant variability exists among studies, highlighting the need for individualized exercise programs tailored to specific neurocognitive conditions. Physical activity stands as a cornerstone non-pharmacological intervention, essential for supporting cognitive health in individuals with neurodegenerative diseases. Further research is necessary to establish long-term effects and optimal exercise modalities, along with standardized evaluation criteria to assess the cognitive impacts of physical activity reliably.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100069"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of sarcopenia and sarcopenic obesity in a German geriatric day clinic.","authors":"Basel Habboub, Emmanuel Oludowole, Robert Speer, Johanna Masuch, Ursula Berger, Markus Gosch, Katrin Singler","doi":"10.1016/j.tjfa.2025.100072","DOIUrl":"10.1016/j.tjfa.2025.100072","url":null,"abstract":"<p><strong>Purpose: </strong>Sarcopenia and sarcopenic obesity are defined by the loss of muscle strength and mass. Both diseases pose a growing global challenge. Their prevalences vary between studied populations. The aim of this study is to estimate the prevalences of sarcopenia and sarcopenic obesity in sample of community-dwelling older adults attending a geriatric day clinic.</p><p><strong>Methods: </strong>A secondary analysis of the Paint-II Data (single-center randomized controlled trial on the effects of art therapy) was used to estimate the prevalence of sarcopenia and sarcopenic obesity. Furthermore, a machine learning model predicted factors associated with both diseases.</p><p><strong>Results: </strong>We had body composition information on 255 of the 409 Paint-II participants. Their mean age was 81 ± 5 years and 78 % were female. Depending on the appendicular skeletal muscle mass (ASM) definition, the prevalence of sarcopenia ranged between 10 % and 24 % using ASM/height² or absolute ASM respectively. The prevalence of sarcopenic obesity was 15 %. Weight was the most influential predictor, with higher weight being linked to sarcopenic obesity and lower weight associated with sarcopenia.</p><p><strong>Conclusions: </strong>The prevalence of sarcopenia and sarcopenic obesity among community-dwelling older adults attending geriatric day clinics is higher than among the general geriatric population. There is a significant discrepancy in sarcopenia prevalence depending on whether muscle mass is measured absolutely or adjusted for body size. Diagnosis is further complicated by varying recommended cut-offs. We support efforts to simplify and standardize the diagnostic criteria.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100072"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of hand grip strength in a cohort of older Nigerian Africans: Findings from the population-based VALIANT project.","authors":"Rufus O Akinyemi, Oladotun V Olalusi, Gabriel O Ogunde, Tolulope O Akinyemi, Joseph O Yaria, Olabode Oguntiloye, Ayotomiwa Fagbemi, Eniola O Cadmus, Femi O Popoola, Mayowa Ogunronbi, Dorcas Olujobi, Olaoluwa Famuyiwa, Joshua O Akinyemi, Mayowa O Owolabi, Roman Romero-Ortuno, Adesola Ogunniyi, Raj Kalaria, Brian Lawlor","doi":"10.1016/j.tjfa.2025.100068","DOIUrl":"10.1016/j.tjfa.2025.100068","url":null,"abstract":"<p><p>Previous evidence suggests there are racial, genetic, and geographic differences in hand grip strength (HGS) underlying the need to define population-specific normative values and their determinants. We determined the normative values of HGS and investigated its correlates in an urban community sample in Nigeria. We assessed 607 participants from the Vascular heAlth, fraiLty, and cognItion in Ageing Nigerians sTudy [VALIANT] - a population-based cohort of 1031 older persons in Ibadan, a city in Southwestern Nigeria. They were recruited through a multi-stage, stratified cluster random sampling method. HGS was defined as the highest recorded/maximum HGS (max. HGS) of both hands. The determinants (β coefficient, p values) of HGS were identified using linear regression model. The mean (SD) age of the participants was 64.6 (11.5) with 67.8 % females. The mean (SD) max. HGS (in kg) of the study population was 19.65±10.16 overall; 24.51(14.01) among males and 17.31(6.51) among females (p < 0.001). Overall, female sex (β=-6.38, p < 0.001), clinical frailty (β=-1.35, p < 0.001), and baseline MoCA scores (β=0.37, p 0.001) were independently associated with max. HGS. In the subgroup analysis, presence of hypertension (β=2.64, p < 0.001) and diabetes mellitus (β=-2.61, p 0.05) were independently associated with max. HGS among females, but not males. Our findings buttress the intricate link between overall physical, cardiometabolic as well as cognitive health in this unique West African population.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100068"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase angle is related to physical function in high-risk Dutch older adults: implications for sarcopenia screening.","authors":"Pol Grootswagers, Alice Ricco, Paul Hulshof, Lisette de Groot","doi":"10.1016/j.tjfa.2025.100071","DOIUrl":"10.1016/j.tjfa.2025.100071","url":null,"abstract":"<p><strong>Introduction: </strong>Sarcopenia, a progressive age-related loss of skeletal muscle mass and function, poses significant health risks in older adults. Phase angle (PhA), derived from bioimpedance analysis, has been proposed as an indicator of muscle quality and physical functioning. This study investigates the association between PhA and physical function, and its potential utility in case-finding phase of sarcopenia assessment based on EWGSOP2 functional cut-offs.</p><p><strong>Methods: </strong>This cross-sectional observational study used baseline data from two clinical trials involving Dutch older adults (≥65 years, n=228) at risk of malnutrition or frailty. PhA was measured using multi-frequency bioimpedance vector analysis. Physical functioning was assessed through handgrip strength, knee extension strength, chair rise test, and gait speed (4m and 400-m/6-min walk tests). Associations were evaluated using linear mixed models adjusted for age, gender, height, and lean body mass. Receiver-operating characteristic (ROC) analyses identified PhA thresholds for low performance based on EWGSOP2 cut-offs.</p><p><strong>Results: </strong>PhA was significantly associated with all performance outcomes in crude models. After adjustment, each unit increase in PhA was associated with a 43.5 ± 8.4 N increase in knee extension strength (P < 0.0001), a 1.5 ± 0.4 s reduction in chair rise time (P = 0.0004), and a 0.14 ± 0.02 m/s increase in gait speed (P < 0.0001). Associations with handgrip strength became non-significant after full adjustment. A PhA threshold of 5.4° showed high sensitivity (0.96) for detecting low physical performance via the chair rise test. However, misclassification rates exceeded 25 %.</p><p><strong>Conclusions: </strong>PhA is associated with physical function, particularly lower-body performance measures, but without muscle mass assessment, it cannot support a complete diagnosis of sarcopenia. It may be valuable as a case-finding tool in older adults at risk.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100071"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}