Journal of Frailty & Aging最新文献

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Beyond mortality prediction: Frail-VIG as a trigger for proactive multidomain interventions in nursing home residents. 超越死亡率预测:衰弱- vig作为养老院居民主动多领域干预的触发因素。
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-02-25 DOI: 10.1016/j.tjfa.2026.100143
Jorge A Sánchez-Duque
{"title":"Beyond mortality prediction: Frail-VIG as a trigger for proactive multidomain interventions in nursing home residents.","authors":"Jorge A Sánchez-Duque","doi":"10.1016/j.tjfa.2026.100143","DOIUrl":"10.1016/j.tjfa.2026.100143","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 2","pages":"100143"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12955158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147312252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening and managing frailty in older nursing home residents with Frail-VIG index: Feasibility, reliability and predictive validity for mortality. 用衰弱- vig指数筛选和管理老年疗养院居民的衰弱:死亡率的可行性、可靠性和预测效度。
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-01-31 DOI: 10.1016/j.tjfa.2025.100130
Cristina Jiménez-Domínguez, Lourdes Rexach-Cano, Carlos Verdejo-Bravo, Manuel Vicente Mejía-Ramírez-Arellano, Carlota Manuela Zárate-Saez, Mª Nieves Vaquero Pinto, Cristina Roldán-Plaza, Nuria Pérez-Panizo, Mª Loreto Álvarez-Nebreda
{"title":"Screening and managing frailty in older nursing home residents with Frail-VIG index: Feasibility, reliability and predictive validity for mortality.","authors":"Cristina Jiménez-Domínguez, Lourdes Rexach-Cano, Carlos Verdejo-Bravo, Manuel Vicente Mejía-Ramírez-Arellano, Carlota Manuela Zárate-Saez, Mª Nieves Vaquero Pinto, Cristina Roldán-Plaza, Nuria Pérez-Panizo, Mª Loreto Álvarez-Nebreda","doi":"10.1016/j.tjfa.2025.100130","DOIUrl":"10.1016/j.tjfa.2025.100130","url":null,"abstract":"<p><p>Frailty is prevalent among older nursing home residents, although there is limited evidence regarding frailty screening and management in this setting.</p><p><strong>Objective: </strong>To evaluate the measurement properties of the Frail Index based on the Comprehensive Geriatric Assessment (Frail-VIG).</p><p><strong>Design: </strong>Prospective observational longitudinal study of 571 residents from 3 nursing homes. Frail-VIG scores were calculated at baseline and at 6 and 12 months. Sociodemographic variables were studied. Feasibility was assessed based on simplicity of application and requirements for score calculation. Reliability was evaluated through inter-rater agreement and test-retest assessments. Construct and content validity were examined by comparing it with other frailty indexes. Predictive validity was evaluated using log-rank tests and AUC-ROC curves for mortality prediction.</p><p><strong>Results: </strong>Mean (SD) resident age was 88.2 (6.5) years, and 80.6 % were women. The mortality rate was 11.4 % at 6 months and 20 % at 12 months. Calculating Frail-VIG scores required 5.15 min and no additional space or equipment, and there was low risk of missing data. The inter-rater consistency and score stability over time indicate strong reliability. The Frail-VIG maintains the characteristics of other established frailty indexes and shows strong convergent validity with the FRAIL-NH and CFS scales. Baseline scores have an AUC-ROC curve (confidence interval) of 0.69 (95 % CI, 0.63-0.76) at 6 months and 0.65 (95 % CI, 0.6-0.71) at 12 months.</p><p><strong>Conclusions: </strong>The measurement properties of the Frail-VIG in older nursing home residents validate its use in this population and setting. Its predictive ability for mortality suggests important implications for advanced care planning.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 2","pages":"100130"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with social frailty in older adults in Colombia. 哥伦比亚老年人社会脆弱的相关因素
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-01-30 DOI: 10.1016/j.tjfa.2026.100133
Carmen-Lucia Curcio, Sebastian Villada, Laura Chica, Claudia Liliana Valencia
{"title":"Factors associated with social frailty in older adults in Colombia.","authors":"Carmen-Lucia Curcio, Sebastian Villada, Laura Chica, Claudia Liliana Valencia","doi":"10.1016/j.tjfa.2026.100133","DOIUrl":"10.1016/j.tjfa.2026.100133","url":null,"abstract":"<p><strong>Objectives: </strong>Social frailty (SF) has gained increasing attention in recent years. While several studies have examined SF among older adults living in the community, most have been conducted in specific countries, primarily in Asia, with limited research in Latin America. The main objective of this study was to identify the relationship between SF and demographic, health, and functional conditions among older adults in Colombia.</p><p><strong>Methods: </strong>This study is a secondary analysis of the SABE Colombia study. Social frailty (SF) was assessed using the adapted HALFE Social Frailty Index. The main independent variables included demographic factors and health status indicators such as self-rated health, chronic conditions, depression, ADL/IADL dependence, mobility disability, and life-space assessment. Bivariate analysis and logistic regression in multivariate models were applied.</p><p><strong>Results: </strong>The overall prevalence of SF was 66.3%, increasing with advancing age. Compared to individuals without SF, those with SF were more likely to have a low level of education (<6 years), mobility disability, dependence on IADLs, restricted life space (<55.5), be female, and report poor or very poor self-rated health. In multivariate logistic regression analyses, SF was associated with higher odds of years of education (<6), dependence for IADL, restricted life-space, being female, mobility disability, and bad and very bad self-rated health. In contrast, depressive symptoms, rural areas, and marital status lose significance.</p><p><strong>Conclusion: </strong>SF is prevalent among Colombian elderly individuals, affecting nearly seven in ten community-dwelling older adults. It is also significantly associated with demographic, health, and functional conditions. Additionally, social issues such as economic status, social isolation, loneliness, and social participation are increasingly prominent among older adults. Thus, SF resulting from social issues requires greater attention, particularly in non-developed countries. Consequently, to promote healthy aging, it is imperative to implement measures aimed at preventing and mitigating SF among older adults in light of these findings.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 2","pages":"100133"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12874411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing frailty with clinical and laboratory measures in hospitalized older adults: A comparison of all-cause mortality across two geriatric departments. 用临床和实验室措施评估住院老年人的虚弱:两个老年科全因死亡率的比较
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.tjfa.2025.100128
Giulia Venturelli, Francesco Canepa, Luca Tagliafico, Silvia Ottaviani, Stefania Peruzzo, Alessio Nencioni, Aldo Bellora, Fiammetta Monacelli
{"title":"Assessing frailty with clinical and laboratory measures in hospitalized older adults: A comparison of all-cause mortality across two geriatric departments.","authors":"Giulia Venturelli, Francesco Canepa, Luca Tagliafico, Silvia Ottaviani, Stefania Peruzzo, Alessio Nencioni, Aldo Bellora, Fiammetta Monacelli","doi":"10.1016/j.tjfa.2025.100128","DOIUrl":"10.1016/j.tjfa.2025.100128","url":null,"abstract":"<p><p>By 2030, one in six people globally will be over 60, potentially increasing the burden of frailty, a condition characterized by reduced physiological resilience and poor clinical outcomes. Although frailty affects up to 49 % of hospitalized patients, it is frequently under-recognized. Tools like the Clinical Frailty Scale (CFS) and the FI-Lab aim to assess frailty, though each has limitations. This retrospective cohort study evaluated the predictive value of CFS and FI-Lab, separately and in combination, for in-hospital and three-month post-discharge mortality in older adults. The study included 410 hospitalized patients (median age 87) admitted to two geriatric units between 2023 and 2025. Frailty was assessed using the CFS and a 22-item FI-Lab derived from blood tests within 48 h of admission. In-hospital and post-discharge mortality rates were 12.6 % and 24.7 %, respectively. Both FI-Lab and CFS were independently associated with increased mortality risk. A weak correlation between the two tools (r = 0.19, p < 0.001) suggests they capture distinct but complementary aspects of frailty. These findings support the combined use of FI-Lab and CFS for more accurate risk stratification in acutely ill older adults. FI-Lab may reflect acute physiological stress not captured by clinical measures alone, aiding early identification of vulnerable patients. Despite limitations, including modest sample size and lack of adjustment for multimorbidity, this study highlights the potential utility of integrating lab-based frailty assessments into routine hospital care for personalized geriatric management.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 2","pages":"100128"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12873719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between the frailty index and all-cause and cardiovascular mortality in a population with cardiovascular-kidney-metabolic syndrome: Insights from the NHANES 2011-2018. 心血管-肾-代谢综合征人群中虚弱指数与全因死亡率和心血管死亡率之间的关系:来自NHANES 2011-2018的见解
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.tjfa.2025.100131
Xin Wang, Xinrui Hai, Ali Ma, Xiaolan Liang, Hua Cheng, Peng Wu, Yu Hao, Dapeng Chen, Ning Yan
{"title":"Association between the frailty index and all-cause and cardiovascular mortality in a population with cardiovascular-kidney-metabolic syndrome: Insights from the NHANES 2011-2018.","authors":"Xin Wang, Xinrui Hai, Ali Ma, Xiaolan Liang, Hua Cheng, Peng Wu, Yu Hao, Dapeng Chen, Ning Yan","doi":"10.1016/j.tjfa.2025.100131","DOIUrl":"10.1016/j.tjfa.2025.100131","url":null,"abstract":"<p><strong>Background: </strong>The Frailty Index (FI) is a well-established predictor of accelerated biological aging and a reliable tool for estimating all-cause and cardiovascular disease (CVD) mortality in older adults in the United States. However, its predictive value remains unclear in other U.S. population subgroups. This study aimed to examine the association between FI levels and both all-cause and CVD mortality among patients diagnosed with Cardiovascular-Kidney-Metabolic Syndrome (CKM syndrome).</p><p><strong>Methods: </strong>This study utilized the data from the National Health and Nutrition Examination Survey (NHANES 2011-2018), which included 7049 participants with complete information for CKM staging (stages 0-4). We employed multivariate Cox proportional hazards models in conjunction with restricted cubic splines (RCS) to account for potential non-linear relationships in the data. Additionally, segmented Cox proportional hazards models were used to examine the association between FI levels and both all-cause and CVD mortality in the CKM syndrome population. Subgroup analyses stratified by demographic and clinical factors, along with interaction tests, were performed to evaluate the consistency of these associations.</p><p><strong>Results: </strong>After adjusting for potential confounding variables, a nonlinear association was observed between the FI and CKM syndrome. Multivariable Cox regression analysis based on nationally representative data demonstrated that higher FI levels were significantly associated with increased risks of both all-cause and CVD mortality among patients with CKM syndrome. Multivariable analysis indicated a robust association between higher FI levels and the presence of CKM syndrome. Among patients diagnosed with CKM syndrome, each 10-unit increase in the FI was associated with a 54% higher risk of CVD mortality (HR = 1.54, 95% CI: 1.24-1.91; P < 0.001) and a 55% higher risk of all-cause mortality (HR = 1.55; 95% CI: 1.38-1.73, P < 0.0001). Stratified analyses revealed no significant interaction effects between the FI and demographic or clinical factors on mortality outcomes.</p><p><strong>Conclusion: </strong>The results highlight a robust and statistically significant association between FI and increased risk of both all-cause and CVD mortality among individuals with KM syndrome. Notably, FI may serve as a valuable marker for CKM stage stratification and for identifying high-risk patients.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 2","pages":"100131"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12873725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation for healthy ageing: An integrated educational intervention for enhancing knowledge and self-efficacy in intrinsic capacity preservation, midlife condition management, and caregiving in midlife women. 为健康老龄化做准备:提高中年妇女内在能力保持、中年状况管理和护理方面的知识和自我效能感的综合教育干预。
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.tjfa.2025.100126
Ruby Yu, Matthew Yu, Cecilia Tong, Florence Ho, Angel Hui, Emily Lui, Jean Woo
{"title":"Preparation for healthy ageing: An integrated educational intervention for enhancing knowledge and self-efficacy in intrinsic capacity preservation, midlife condition management, and caregiving in midlife women.","authors":"Ruby Yu, Matthew Yu, Cecilia Tong, Florence Ho, Angel Hui, Emily Lui, Jean Woo","doi":"10.1016/j.tjfa.2025.100126","DOIUrl":"10.1016/j.tjfa.2025.100126","url":null,"abstract":"<p><strong>Objectives: </strong>Midlife women often experience concurrent declines in intrinsic capacity (IC) and increasing caregiving responsibilities. This study evaluated the effectiveness of an educational intervention designed to enhance knowledge of IC preservation, self-care efficacy, and caregiving competencies among midlife women.</p><p><strong>Methods: </strong>The Pursuit of Wellness Program was developed and evaluated through a multicentre mixed methods study. This program comprised nine modules addressing IC domains (cognitive, vitality, psychological) and six modules focused on priority midlife conditions (e.g., urinary incontinence). Each module integrated health education, self care practices, and caregiving training. Program's effectiveness was assessed using a mixed methods evaluation. Outcomes included pre- and post-changes in domain- or condition-specific knowledge (summative score range: 0-3) and self-care efficacy (visual analogue scale: 0-10), post-intervention caregiving confidence (Likert scale: 1-5), and qualitative feedback from program coordinators.</p><p><strong>Results: </strong>A total of 690 women aged 50-64 years were assessed. Pre-tests revealed knowledge gaps in pain management, bladder health, and dementia care, with mean health knowledge scores ranging from 1.3-1.6. Post-intervention improvements were most significant for bladder health (+69.0%, p<0.001), followed by nutrition for muscle & bone health (+56.3%, p<0.001). Self efficacy increased significantly across all IC domains and midlife conditions (ps<0.01), while caregiving confidence reached from 68.7 to 89.3% agreement, highest for skin and bathing care (89.3%) and dementia support (86.3%). Qualitative findings from program coordinators (n=18) confirmed high participant engagement with nutrition strategies and stress management techniques, corroborating quantitative outcomes.</p><p><strong>Conclusions: </strong>The program significantly enhanced knowledge related to IC preservation and management of midlife conditions, self-care practices, and caregiving competencies among midlife women. It addresses a critical gap by concurrently promoting IC preservation and caregiving proficiency during the midlife transition.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 2","pages":"100126"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12874410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying sarcopenia and sarcopenic obesity in a lower extremity arthroplasty clinical setting: a pragmatic pilot study. 在下肢关节置换术临床环境中识别肌肉减少症和肌肉减少性肥胖:一项实用的试点研究。
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-01-31 DOI: 10.1016/j.tjfa.2025.100125
K Godziuk, I Hollyer, G Loughran, N J Giori
{"title":"Identifying sarcopenia and sarcopenic obesity in a lower extremity arthroplasty clinical setting: a pragmatic pilot study.","authors":"K Godziuk, I Hollyer, G Loughran, N J Giori","doi":"10.1016/j.tjfa.2025.100125","DOIUrl":"10.1016/j.tjfa.2025.100125","url":null,"abstract":"<p><p>Sarcopenia and sarcopenic obesity may increase surgical complications and impact recovery and function after total joint arthroplasty (TJA). We assessed the feasibility of identifying these conditions in an orthopedic practice setting using published consensus criteria. Patients in a lower extremity TJA clinic were assessed for sarcopenia and sarcopenic obesity using EWGSOP2 and ESPEN/EASO diagnostic frameworks, respectively. Low strength testing involved maximal handgrip strength (HGS) and number of chair sit-to-stands in 30 seconds (CSTS). Same day dual-energy x-ray absorptiometry (DXA) testing was used to assess for low muscle mass (i.e. appendicular lean soft tissue) in patients with low strength. One hundred-one of a possible 128 patients were assessed in clinic (93% male, mean age 69.6±8.9 years and BMI 31.7±7.9 kg/m<sup>2</sup>). HGS was completed in 99% of screened patients; only 44.5% completed CSTS due to joint pain and balance limitations. Thirty-nine patients had low strength and were recommended for DXA. In 16 patients who completed DXA, 3 had sarcopenia and 5 had sarcopenic obesity. Screening for sarcopenia and sarcopenic obesity was challenging to complete in all patients during routine clinic flow with dedicated personnel. Despite our pragmatic approach and limited screening completion in all patients, we identified sarcopenic and sarcopenic obesity in 6.25% of patients. This is likely a lower bound for the true prevalence but suggests an opportunity to assess and intervene for these conditions before surgery to improve total joint arthroplasty outcomes.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 2","pages":"100125"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12878573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of physical activity and frailty on mortality and utilization among middle-aged and older adults in South Korea. 体力活动和虚弱对韩国中老年人死亡率和利用率的影响。
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-03-19 DOI: 10.1016/j.tjfa.2026.100142
Ho-Jun Kim, Kyu-Ri Hong, Xiao-Lin Wen, Da-San Kim, Jung-Min Lee
{"title":"Impact of physical activity and frailty on mortality and utilization among middle-aged and older adults in South Korea.","authors":"Ho-Jun Kim, Kyu-Ri Hong, Xiao-Lin Wen, Da-San Kim, Jung-Min Lee","doi":"10.1016/j.tjfa.2026.100142","DOIUrl":"10.1016/j.tjfa.2026.100142","url":null,"abstract":"<p><p>This study examined the influence of frailty status and physical activity (PA) compliance on all-cause mortality and healthcare utilization among Korean adults aged 45 years and older. Data from 2104 participants in the Korean Longitudinal Study of Aging (KLoSA; 2006 - 2022) were analyzed. Frailty was assessed using a 38-item frailty index (FI), and PA was defined according to adherence to the World Health Organization guideline of at least 150 min per week. Participants were classified as robust, pre-frail, or frail. Cox proportional hazards models and generalized linear mixed models were used to evaluate associations with mortality and healthcare utilization. Compared with robust individuals, frail participants exhibited a markedly higher risk of all-cause mortality (hazard ratio [HR] = 3.37, 95% confidence interval [CI]: 2.42-4.69), while pre-frail individuals also showed an elevated mortality risk (HR = 1.72, 95% CI: 1.43-2.07). Frailty was consistently associated with greater healthcare utilization across outpatient visits, hospital admissions, length of hospital stay, and healthcare costs. Adherence to PA guidelines was not independently associated with reduced mortality among pre-frail and frail individuals after multivariable adjustment; however, a significant interaction indicated higher healthcare costs among frail individuals who met PA guidelines. In addition, higher BMI was associated with lower mortality risk, consistent with patterns described as the obesity paradox. These findings highlight frailty as a key, independent predictor of mortality and healthcare utilization beginning in midlife. Standardized PA recommendations alone may be insufficient for physiologically vulnerable populations, underscoring the importance of early frailty screening and individualized, function-sensitive intervention strategies to promote healthy aging.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 2","pages":"100142"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13018972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025. 2025内在能力、虚弱和肌肉减少症研究工作组对促进健康老龄化的老年科学临床前和临床试验的见解
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-03-19 DOI: 10.1016/j.tjfa.2026.100147
Luca Tagliafico, Marco Canevelli, Philipe De Souto Barreto, Matteo Cesari, Luigi Ferrucci, Bruno Vellas, Yves Rolland
{"title":"Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025.","authors":"Luca Tagliafico, Marco Canevelli, Philipe De Souto Barreto, Matteo Cesari, Luigi Ferrucci, Bruno Vellas, Yves Rolland","doi":"10.1016/j.tjfa.2026.100147","DOIUrl":"10.1016/j.tjfa.2026.100147","url":null,"abstract":"<p><p>The Intrinsic Capacity, Frailty and Sarcopenia Research (ICFSR) Task Force convened in March 2025 to discuss geroscience-oriented pre-clinical and clinical trials aimed at promoting healthy aging. Key topics included the use of aging biomarkers in clinical trials, senotherapeutics, metabolism-targeting medications, and therapeutic strategies beyond pharmacological approaches. The discussions highlighted the growing interest in, and accumulating evidence for, geroscience interventions. Several future challenges were identified, including the need for a deeper understanding of the biology of aging and the validation of aging biomarkers against relevant clinical outcomes, such as frailty and intrinsic capacity. Furthermore, to accelerate innovation in the field, there is a need to enhance clinical trial methodologies and harmonization-for example, by defining a minimum common dataset of biological, physiological, and clinical factors for geroscience clinical studies-and to foster a paradigm shift, particularly among regulatory authorities.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 2","pages":"100147"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of a best practice advisory alert for inpatient frailty screening and intervention: A pilot quality improvement program. 对住院病人虚弱筛查和干预的最佳实践咨询警报的实施:质量改进试点项目。
IF 3.3
Journal of Frailty & Aging Pub Date : 2026-04-01 Epub Date: 2026-03-21 DOI: 10.1016/j.tjfa.2026.100146
L M Teo, J A Abengana, H Tan, Z Y Koh, A P Chew, T L Tan
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