Journal of Frailty & Aging最新文献

{"title":"Author response to: Enhancing prehabilitation protocols in frail older adults undergoing joint replacement - methodological insights from a pilot randomized controlled trial.","authors":"Alexandra Papaioannou, Ashlee Azizudin, George Ioannidis","doi":"10.1016/j.tjfa.2025.100067","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100067","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100067"},"PeriodicalIF":3.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: enhancing prehabilitation protocols in frail older adults undergoing joint replacement - methodological insights from a pilot randomized controlled trial.","authors":"Xinrui Sun, Fei Gao","doi":"10.1016/j.tjfa.2025.100065","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100065","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100065"},"PeriodicalIF":3.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare utilization, pharmacotherapy prescriptions, and clinical outcomes across a 5-year duration preceding and succeeding the initiation of home health care in a nationwide population-based cohort of 187,547 older adults with disabilities.","authors":"Shih-Tsung Huang, Fei-Yuan Hsiao, Wei-Ju Lee, Ming-Yueh Chou, Chih-Kuang Liang, Chu-Sheng Lin, Ching-Hui Loh, Liang-Kung Chen","doi":"10.1016/j.tjfa.2025.100063","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100063","url":null,"abstract":"<p><strong>Background: </strong>Longitudinal trajectories of healthcare utilization, medication prescription, and clinical outcomes among older adults with disabilities receiving home healthcare (HHC) holds significance but remains elusive.</p><p><strong>Methods: </strong>People aged≥65 years who newly received Taiwan's National Health Insurance funded HHC program from January 2005 to December 2013 were identified. Healthcare utilization, life-sustaining treatment, medication prescriptions (polypharmacy, psychotropics, anticholinergic burden and antibiotics), health status (Charlson's comorbidity index, CCI), and mortality were assessed over a 10-year period spanning 5 years before and after initiating HHC.</p><p><strong>Results: </strong>Overall, 187,547 patients (80.6 ± 7.7 years, 51.2 % females, CCI 3+: 51.2 %) with a high prevalence of dementia (34.0 %), stroke (38.7 %), and pneumonia (49.5 %), and usage of life-sustaining treatment (urinary catheters: 82.8 % and nasogastric feeding: 78.7 %) were obtained. A sudden peak of admission rate at 1 year (91.7 %) before HHC, followed by the 70 % and 60 % admission rate in the first and second year after receiving HHC were found. Quarterly changes of using life-sustaining treatment showed significant increases from as early as 1 year prior to HHC. Gradual increases of polypharmacy, use of psychotropics, and antibiotic (4.5-fold and 3-fold) after HHC further demonstrated the complex needs (both p < 0.01). The 5-year cumulative mortality rate was 81 % (40 % in the first year with an annual rate of 25 %).</p><p><strong>Interpretation: </strong>HHC recipients embody a confluence of complex care needs and high mortality risk, whereby various interventions aim to alleviate symptoms and sustain life. Engaging in proactive advanced care planning and end-of-life care should be prioritized when home healthcare is being contemplated.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100063"},"PeriodicalIF":3.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple test of \"Kami-Tsumami\" (Paper Tug) for pinch strength screening among community-dwelling older adults.","authors":"Weida Lyu, Tomoki Tanaka, Katsuya Iijima","doi":"10.1016/j.tjfa.2025.100060","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100060","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100060"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study.","authors":"Kelly Virecoulon Giudici, Philipe de Souto Barreto, Christelle Cantet, Henrik Zetterberg, Kaj Blennow, Bruno Vellas","doi":"10.1016/j.tjfa.2025.100064","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100064","url":null,"abstract":"<p><strong>Background: </strong>Intrinsic capacity (IC) is a recent key concept proposed by the World Health Organization (WHO) based on aspects of functional ability (both physical and mental) rather than the presence or absence of diseases, with a potential to predict several health outcomes.</p><p><strong>Objective: </strong>To explore associations between IC and cognitive function (prospectively), and between IC and plasma p-tau181 (cross-sectionally and prospectively) among community-dwelling older adults.</p><p><strong>Methods: </strong>Observational study with 491 subjects ≥70 years (67.4 % female, mean 75.3 years, SD=4.4), participants from the Multidomain Alzheimer Preventive Trial (MAPT). IC domains (locomotion, cognition, psychological, vitality) were combined into a 0-100 score. Alternative classification was based on the number of domains' abnormalities. Plasma p-tau181 was measured at baseline and 36 months of follow-up. A composite cognitive score (CCS) based on four tests was determined at baseline, 6, 12, 24, 36, 48 and 60 months.</p><p><strong>Results: </strong>Inverse cross-sectional associations were observed between baseline IC score and p-tau181 (unadjusted model: β=-0.08, 95 %CI -0.13 to -0.03; p = 0.0025). A significant mean difference in p-tau181 3-year changes was observed between participants with low and normal IC (based on IC score) (adjusted model: 1.71, 95 %CI 0.01 to 3.40; p = 0.0483). Prospective 5-year associations between IC and CCS were only observed in unadjusted analysis according to the alternative IC classification (-0.21, 95 %CI -0.38 to -0.04; p = 0.0156).</p><p><strong>Conclusion: </strong>IC was associated with plasma p-tau181 and cognitive function, but findings varied according to the method of IC classification. Further research may help settle the role of IC as a predictor of neurodegenerative diseases such as AD. In this regard, multidomain interventions have potential to protect IC over the aging process and prevent cognitive impairment, and should also be encouraged.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100064"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of lifestyle modifications with frailty in older adults: A cross-sectional study using NHANES.","authors":"Yuanyuan Wu, Hongyan Peng, Rui Xu, Yingxue Hua, Yanan Zhang","doi":"10.1016/j.tjfa.2025.100061","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100061","url":null,"abstract":"<p><strong>Background: </strong>Background: Frailty significantly impacts healthy aging, yet lifestyle interventions may reduce its prevalence. This study investigated the association between a comprehensive lifestyle score, comprising eight modifiable factors (diet, physical activity, smoking, sleep, body mass index [BMI], non-HDL cholesterol, blood glucose, and blood pressure), and frailty risk in older adults, identifying key components for targeted interventions.</p><p><strong>Methods: </strong>Using data from the National Health and Nutrition Examination Survey (NHANES, 2005-2018), we analyzed 10,065 adults aged ≥60 years (mean age: 69.61, 54.97 % female). Each lifestyle factor was scored from 0 to 100, and frailty was defined using a 49-item index (>0.21). Weighted logistic regression assessed individual associations, restricted cubic spline (RCS) analysis explored dose-response relationships, and quantile g-computation evaluated joint effects.</p><p><strong>Results: </strong>Higher scores for dietary score (OR=0.69, 95 % CI: 0.52-0.90, score 100 vs. 0), non-smoking (OR=0.62, 95 % CI: 0.51-0.75), sleep (OR=0.29, 95 % CI: 0.17-0.49), blood glucose (OR=0.27, 95 % CI: 0.17-0.44), and blood pressure (OR=0.43, 95 % CI: 0.30-0.61, score 25 vs. 0) were associated with lower frailty risk (all P < .05). Diet and non-HDL cholesterol showed no linear association; smoking, BMI, blood glucose, and blood pressure exhibited non-linear patterns (P<.05). A simultaneous one-level increase in all lifestyle factors reduced frailty risk by 94 % (95 % CI: 92-95 %), with physical activity, blood glucose, and sleep as primary contributors.</p><p><strong>Conclusion: </strong>These findings highlighted the association between specific lifestyle factors and reduced frailty risk, underscoring the need for prospective studies to prioritize interventions for frailty prevention.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100061"},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The vitality domain of intrinsic capacity: A scoping review of conceptual frameworks and measurements.","authors":"J Chew, J Lee, H H C Hernandez, Y L Munro, C L Lim, W S Lim","doi":"10.1016/j.tjfa.2025.100058","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100058","url":null,"abstract":"<p><strong>Background: </strong>Intrinsic capacity (IC) is a composite indicator of physical and mental capacities that are critical for healthy aging. IC comprises five domains, with \"vitality\" gaining most attention due to its potential impact on functional and physiological reserves with increasing age. The World Health Organization 2022 framework redefined vitality as an underlying physiological determinant of IC. However, the concept and measurement of vitality and its empirical validation are not well defined.</p><p><strong>Objectives: </strong>This scoping review aims to: (1) map the conceptual frameworks underpinning vitality within the IC domain and (2) identify existing measures used to assess vitality.</p><p><strong>Methods: </strong>A systematic search of MEDLINE, PubMed, Embase, Web of Science, and WHO databases (2003-2023) using Arksey and O'Malley's framework and PRISMA-ScR guidelines. Studies involving adults ≥50 years old that addressed vitality in IC were included. We extracted data on conceptual frameworks, measurement tools, and construct validity.</p><p><strong>Results: </strong>Eighty-one studies met the inclusion criteria. Initial frameworks of vitality focused on nutritional indicators, while recent concepts include neuromuscular function, metabolism, and immune-stress responses. However, operationalization of these concepts remains inconsistent, with most studies relying on anthropometry, appetite, weight loss, and handgrip strength, while immune and stress response-related biomarkers were rarely assessed. Only 10.5 % of studies evaluated construct validity of vitality, and limited studies validated the potential roles of vitality underpinning the other expressed capacities.</p><p><strong>Conclusions: </strong>Currently, vitality within IC varies in definitions and measurement approaches, with a predominant focus on nutrition and muscle strength. Empirical validation of vitality's role as a foundational IC domain remains limited. Expanding the scope of vitality to include metabolic and immune markers, and deeper examination of the interactions between vitality with other IC domains may enhance understanding and improve assessment frameworks for healthy aging.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100058"},"PeriodicalIF":3.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Framework for a short muscle function battery using electronic handgrip dynamometry and accelerometry in older adults.","authors":"Ryan McGrath, Grant R Tomkinson, Sarah Andrew, Joshua Batesole, Chloe Carling, Bryan K Christensen, Samantha FitzSimmons, Halli Heimbuch, Tyler Hoang, Donald Jurivich, Jacob Kieser, Kelly Knoll, Peyton Lahr, Matthew Langford, Michaela Mastrud, Megan Orr, Yeong Rhee, Kyle J Hackney","doi":"10.1016/j.tjfa.2025.100045","DOIUrl":"10.1016/j.tjfa.2025.100045","url":null,"abstract":"<p><strong>Background: </strong>Electronic handgrip dynamometry and accelerometry enables novel opportunities to collect additional attributes of muscle function beyond just maximal strength, but some muscle function attributes may already be related, which may warrant discerning these attributes into a short muscle function battery (SMFB).</p><p><strong>Objectives: </strong>We sought to determine the multivariate relationships between maximal strength, asymmetry, submaximal control, rate of force development, bimanual coordination, fatigability, and contractile steadiness in older adults.</p><p><strong>Design: </strong>A cross-sectional design was used for this investigation.</p><p><strong>Setting: </strong>Laboratory.</p><p><strong>Participants: </strong>The analytic sample included 121 generally healthy older adults aged 70.7 ± 4.7 years.</p><p><strong>Measurements: </strong>Electronic handgrip dynamometry and accelerometry measured strength, asymmetry, submaximal control, rate of force development, bimanual coordination, fatigability, and contractile steadiness. The handgrip variables were standardized before they were included in a factor analysis. Factors with eigenvalues >1.0 were kept. Items within a factor with a loading |>0.30| were similarly retained.</p><p><strong>Results: </strong>There were 3 factors retained with eigenvalues of 1.88, 1.56, and 1.10. The first factor (functional strength), which explained 39.9 % of the variance, included strength, submaximal control, and rate of force development. Factor 2 (lateral function), which explained 35.8 % of the variance, included asymmetry and bimanual coordination. The third factor (muscle endurance), which explained 24.3 % of the variance, included fatigability and contractile steadiness.</p><p><strong>Conclusions: </strong>Our findings suggest the surfacing of themes in the additional muscle function measures, thereby providing framework for a SMFB. More research is needed for electronic handgrip dynamometry and accelerometry derived muscle function on health before consideration of implementation in clinical practice.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 3","pages":"100045"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoas muscle density predicts elective colorectal surgical outcomes more accurately than psoas muscle area or indexed area.","authors":"Louis Scarrold, Douglas Stupart, David Watters","doi":"10.1016/j.tjfa.2025.100037","DOIUrl":"10.1016/j.tjfa.2025.100037","url":null,"abstract":"<p><strong>Background: </strong>CT measurements of psoas muscle density (PMD) and area (PMA) (with or without indexing to height-squared or body-surface-area) are used interchangeably as sarcopenia measures - it is unknown which best correlates with surgical risk.</p><p><strong>Objectives: </strong>1.Determine the correlation between psoas muscle density, area, and indexed area; 2.Identify which psoas measures most strongly associated with surgical outcomes DESIGN: The University Hospital Geelong Colorectal database included all patients who underwent elective colorectal surgery from 2007 to 2014 (minimum five-years follow-up). Pre-operative CT scans were reviewed, psoas measures correlated with each other and with outcomes.</p><p><strong>Setting: </strong>University Hospital Geelong is a regional referral hospital in Victoria, Australia.</p><p><strong>Participants: </strong>This database listed 552 patients, 120 were excluded as pre-operative CT-films were not accessible, leaving 432 patients included.</p><p><strong>Exposure: </strong>Psoas muscle density, area, and area indexed by height-squared and body-surface-area.</p><p><strong>Measurements: </strong>Pearson correlations investigated correlations between psoas muscle measures. Logistic regression and ROC-analysis investigated each psoas measures association with peri‑operative morbidity. Kaplan-Meier survival-analysis investigated the association of each psoas measure with long-term survival.</p><p><strong>Results: </strong>Mean age was 70.4 years, 41 % were female. Psoas muscle density correlated poorly with area (R²=0.15). Unindexed psoas muscle area correlated well with area indexed by height-squared (R²=0.950) and body-surface-area (R²=0.938). Long-term survival was associated with psoas muscle density (HR1.515(95 %CI 1.062-2.161)) and area (HR1.886(95 %CI 1.322-2.692)). Increasing psoas muscle density (reduced sarcopenia) was associated with decreased major-complications (OR0.963(95 %CI 0.938-0.989)) and peri‑operative mortality (OR0.903(95 %CI 0.847-0.962)), with ROC-curve AUC=0.829 indicating an accurate test. There was no association between psoas muscle area and major-complications (OR1.000(95 %CI 1.000-1.000)), nor peri‑operative mortality (OR1.000(95 %CI 0.999-1.001)), with ROC-curves AUC=0.507-0.521. Indexed area measures were not associated with outcomes.</p><p><strong>Conclusions: </strong>Psoas muscle density and area did not correlate. Both were associated with long-term survival, but only density was associated major-complications and mortality. Indexing removed the correlation of area with long-term survival.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 3","pages":"100037"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maximising inclusivity in care home research: Lessons learned from the AFRI-c randomised controlled trial.","authors":"Laurel Campbell-Smith, Sophie Rees, Jane Sprackman, Karen Sargent, Alastair D Hay, Rachel Cm Brierley","doi":"10.1016/j.tjfa.2025.100038","DOIUrl":"10.1016/j.tjfa.2025.100038","url":null,"abstract":"<p><p>Ethical and procedural requirements make research in care homes challenging. With people living longer globally, it is essential that older people are included in research, including within the care home setting. We conducted a randomised controlled trial (AFRI-c) in 91 care homes across England, aiming to make the study available to every eligible resident. Facilitators included flexible models for receiving consent; commitment from care home staff, residents and families; tailored and specific training for care home staff; and support from national research infrastructure to engage care homes in research. To facilitate inclusive care home research, we recommend consulting with care homes about their research priorities; continuing investment in national research infrastructure for care homes; using advance directives for research planning for care home residents; embedding research nurses in care home environments; and more guidance for researchers and ethics committees on applying legal frameworks regarding capacity to research settings.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 3","pages":"100038"},"PeriodicalIF":3.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}