Journal of Frailty & Aging最新文献

{"title":"Midlife physical activity trajectories are associated with reduced physical pre-frailty/frailty in older age: insights from the prospective ATTICA sub-study 2002-2024.","authors":"Danai Sgouropoulou, Sofia-Panagiota Giannakopoulou, Evangelia Damigou, Fotios Barkas, Evangelos Liberopoulos, Demosthenes B Panagiotakos, Petros P Sfikakis, Evrydiki Kravvariti","doi":"10.1016/j.tjfa.2026.100217","DOIUrl":"https://doi.org/10.1016/j.tjfa.2026.100217","url":null,"abstract":"<p><strong>Background: </strong>Although physical activity in older adults has been associated with lower risk of frailty, it is unclear if midlife physical activity patterns are associated with pre-frailty/frailty status in older age.</p><p><strong>Objectives: </strong>To investigate whether longitudinal midlife physical activity trajectories are associated with physical pre-frailty/frailty development in older age, independent of cardiometabolic risk and other lifestyle factors.</p><p><strong>Design: </strong>Population-based prospective cohort study.</p><p><strong>Settings: </strong>In-person assessments and telephone interviews of persons living in urban communities in Attica, Greece.</p><p><strong>Participants: </strong>Surviving participants of the ATTICA cohort study (2002-2024) who were older than 33 years at baseline.</p><p><strong>Measurements: </strong>Demographic, anthropometric, clinical, and lifestyle parameters were recorded at baseline and throughout the study. According to binary self-reported physical activity levels (<600 vs ≥600 metabolic equivalent minutes per week) at baseline, 5-year and 10-year follow-up, 4 ordered trajectories of physical activity were defined: persistently inactive, declining activity, inclining activity, and persistently active, and their association with the odds of pre-frailty/frailty development according to the phenotypic (FRAIL scale) model were investigated by applying multivariable logistic regression models.</p><p><strong>Results: </strong>Relative to persistent inactivity, persistently active and inclining physical activity lifestyles were associated with 80% and 79% decreased odds of pre-frailty/frailty at 22-year follow-up, respectively, after adjusting for age, sex, years of education, baseline body mass index, hypertension, diabetes, and hypercholesterolemia. The population fraction of pre-frailtand frailty that could be attributed to unhealthy physical activity trajectories throughout midlife is 49.5% (95% confidence interval, 36.3 to 59.9), rising to 64.8% (95% confidence interval, 49.6 to 75.4) when also considering hypertension, diabetes mellitus, hypercholesterolemia, and obesity.</p><p><strong>Conclusion: </strong>Steadily high or rising physical activity trajectories during midlife were associated with lower odds of physical pre-frailty/frailty in older age, independently of cardiometabolic risk factors. These findings support that achieving and maintaining higher physical activity levels across midlife may be one of the keys to healthy aging.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 6","pages":"100217"},"PeriodicalIF":3.2,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty in relation to general and oral health-related quality of life among older adults in municipal acute care.","authors":"Leonor Roa Santervas, Eva Skovlund, Ingrid Beate Ringstad, Espen Saxhaug Kristoffersen, Katrine Gahre Fjeld, Lene Hystad Hove, Janicke Liaaen Jensen, Torgeir Bruun Wyller, Rita Romskaug","doi":"10.1016/j.tjfa.2026.100207","DOIUrl":"https://doi.org/10.1016/j.tjfa.2026.100207","url":null,"abstract":"<p><strong>Background: </strong>Frailty is associated with poorer health-related quality of life (HRQoL) in older adults, but studies rarely assess general and oral HRQoL concurrently in acute care populations.</p><p><strong>Objectives: </strong>To examine the associations between frailty and general as well as oral HRQoL among older adults admitted to a municipal in-patient acute care (MipAC) unit.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Oslo MipAC unit, Norway.</p><p><strong>Participants: </strong>A total of 382 patients aged 70 years or older admitted to the MipAC unit between January and September 2023.</p><p><strong>Measurements: </strong>Frailty was assessed using the Clinical Frailty Scale (CFS). General HRQoL was measured with the 15D instrument and a single-item global life satisfaction question. Oral HRQoL was assessed using the Oral Health Impact Profile-14 (OHIP 14). Associations between frailty and HRQoL were analyzed using linear, ordinal logistic, and binary logistic regression. Exploratory analyses of 15D and OHIP-14 dimensions were performed using non-parametric trend tests.</p><p><strong>Results: </strong>Increasing frailty was significantly associated with lower 15D scores (adjusted B -0.053, 95% CI -0.061 to -0.045), higher odds of lower life satisfaction (adjusted OR 1.19, 95% CI 1.02 to 1.39), and higher odds of reporting oral health impacts on the OHIP-14 (adjusted OR 1.25, 95% CI 1.05 to 1.48). Most 15D dimensions declined with increasing frailty, except distress. For OHIP-14, significant associations were observed for functional limitation, physical pain, and psychological disability.</p><p><strong>Conclusions: </strong>Frailty assessed with the CFS was consistently associated with reduced general and oral HRQoL in older adults admitted to a MipAC unit. These findings support the clinical relevance of simple frailty assessment during acute admission and suggest that it may help identify patients at risk of poorer quality of life.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 5","pages":"100207"},"PeriodicalIF":3.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity impairments are associated with increased risk of incident dementia among community-dwelling older adults: Results from a 9-year follow-up of a nationwide cohort in Taiwan.","authors":"Chia-Lin Li, Fiona F Stanaway, Yu-Hsuan Tsai","doi":"10.1016/j.tjfa.2026.100220","DOIUrl":"https://doi.org/10.1016/j.tjfa.2026.100220","url":null,"abstract":"<p><strong>Objectives: </strong>The main aim of this study was to examine whether screening for intrinsic capacity (IC) impairments could identify those at increased risk of incidence of dementia among community-dwelling older adults.</p><p><strong>Design: </strong>Nine-year longitudinal study.</p><p><strong>Settings and participants: </strong>A total of 2308 community-dwelling persons aged 65 years or older who participated in the National Health Interview Survey (NHIS) in Taiwan, 2013.</p><p><strong>Measurements: </strong>IC impairments were measured using the questionnaire from NHIS based on six domains of cognition, vitality, locomotion, vision, hearing, and psychological. The incidence of dementia was confirmed by the computerized data files of the Taiwan National Health Insurance claims database.</p><p><strong>Results: </strong>In this study, a total of 358 persons developed incident dementia during the 9-year follow-up, giving a cumulative incidence rate of 15.5% (358/2308). Overall, 28.4% of participants had one IC domain impairment, 29.4% of participants had two or more domains impairment. Compared to those participants with no IC impairment, participants with one IC domain impairment had no increased risk of incident dementia (adjusted SHR=1.17; 95% CI=0.89-1.54), but increased risk was observed in participants with impairments in two or more domains (adjusted SHR=1.54; 95% CI=1.18-2.01).</p><p><strong>Conclusions: </strong>Our results highlight the high prevalence of participants with impairments in two or more IC domains and its independent association with increased risk of incident dementia among community-dwelling older adults. Further investigation is needed to explore whether such individuals could benefit from interventions to reduce risk of dementia.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 6","pages":"100220"},"PeriodicalIF":3.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing intrinsic capacity and frailty in healthy ageing research.","authors":"Marco Canevelli, Roger Fielding, Marco Inzitari, Wee Shiong Lim, Emanuele Marzetti, Renuka Visvanathan, Matteo Cesari","doi":"10.1016/j.tjfa.2026.100216","DOIUrl":"https://doi.org/10.1016/j.tjfa.2026.100216","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 5","pages":"100216"},"PeriodicalIF":3.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy aging in humanitarian crises: Addressing the neglect of older adults in nutrition policies.","authors":"Abdisalan Abdikarin Mohamed, Abdikadir Ahmed Hassan, Fartun Ali Haji Aden, Mohamed Daud Mohamed, Yakub Burhan Abdullahi","doi":"10.1016/j.tjfa.2026.100215","DOIUrl":"https://doi.org/10.1016/j.tjfa.2026.100215","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 6","pages":"100215"},"PeriodicalIF":3.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From social isolation to frailty: the chain mediating roles of depression and cognitive decline among Chinese older adults.","authors":"Hujia Yang, Chunduo Liang, Junqian Ma, Ning Ma, Rui Guo, Shusong Deng","doi":"10.1016/j.tjfa.2026.100218","DOIUrl":"https://doi.org/10.1016/j.tjfa.2026.100218","url":null,"abstract":"<p><strong>Background: </strong>As global aging accelerates, frailty has emerged as a critical public health challenge. Although social isolation is recognized as a prevalent psychosocial risk factor among older adults, the longitudinal mechanisms linking it to frailty-specifically via the chain mediating pathways of depression and cognitive decline-remain underexplored.</p><p><strong>Objective: </strong>This study aimed to investigate the presence and magnitude of the \"social isolation → depression → cognitive function → frailty\" chain mediation pathway in the Chinese elderly population.</p><p><strong>Methods: </strong>Using four waves of data (2011-2018) over 7 years from the China Health and Retirement Longitudinal Study (CHARLS), we analyzed a final sample of 3316 participants aged ≥60 years who were non-frail at baseline. The chain mediation pathways were tested by integrating logistic regression analyses within a structural equation modeling framework. The significance of direct and indirect effects was examined using the bias-corrected bootstrap method with 5000 resamples.</p><p><strong>Results: </strong>Among the 3316 participants (mean age: 68.9 ± 5.9 years; 60.5% female), 1947 (58.7%) developed frailty during follow-up. After full adjustment for covariates, social isolation exhibited no significant direct effect on frailty. Instead, its impact was exclusively indirect through three distinct pathways: (1) the independent mediating route of depression (effect value = 0.976; 95% CI: 0.200-1.735); (2) the independent mediating route of cognitive function (effect value = 0.490; 95% CI: 0.003-0.985); and (3) the chain mediating route from depression to cognitive function (effect value = 0.173; 95% CI: 0.035-0.311). The total indirect effect value was 1.638 (95% CI: 0.637-2.611), confirming a full mediation mechanism.</p><p><strong>Conclusion: </strong>Social isolation functions as a distal determinant that indirectly escalates the risk of frailty by potentially inducing depression, which subsequently accelerates cognitive decline. These findings highlight the need for integrated interventions targeting social engagement, mental health, and cognitive function to prevent or delay frailty in older populations.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 6","pages":"100218"},"PeriodicalIF":3.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of alkaline phosphatase and segmented neutrophils count with low appendicular lean mass in middle-aged women: Evidence from an American cross-sectional survey.","authors":"Shanlan Yang, Jiaofeng Wang, Dayoung Kim, Han Xu, Sheng Zhou, Fan Yang, Zhijun Bao","doi":"10.1016/j.tjfa.2026.100213","DOIUrl":"https://doi.org/10.1016/j.tjfa.2026.100213","url":null,"abstract":"<p><strong>Objectives: </strong>Sarcopenia is associated with an increased risk of frailty, falls, and mortality. Women exhibit distinct characteristics in appendicular lean mass and metabolism compared with men, and hormonal changes may further accelerate appendicular lean mass. This study aimed to identify key blood biomarkers associated with appendicular lean muscle mass index adjusted by body mass index (ALMBMI) in women and to explore their potential relationship with chronic inflammation.</p><p><strong>Methods: </strong>Based on NHANES 2015-2018 data from middle-aged women, the ALMBMI was calculated. A multimodal machine learning framework was constructed using elastic net logistic regression and generalized linear models (GLMs) to screen core variables affecting ALMBMI. Weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) jointly determined variable weights and effect directions, and restricted cubic spline (RCS) models characterized dose-response curves to identify key blood indicators and their magnitudes of change associated with low appendicular lean mass risk.</p><p><strong>Results: </strong>A total of 1,082 participants were included in this study. Following variable screening, 12 variables were identified as significantly associated with ALMBMI. WQS regression indicated that segmented neutrophil count (weight: 0.25) and alkaline phosphatase (ALP) (weight: 0.22) were the predominant factors associated with low ALMBMI. BKMR analysis, which assesses all variables jointly, identified segmented neutrophil count (36.0%), and ALP (27.6%) as the core variables. RCS analysis revealed that segmented neutrophil count and alkaline phosphatase showed an L-shaped trend with ALMBMI, with inflection points at 4.00 (1000 cells/μL) and 76.00 IU/L, respectively. In each case, the curves plateaued to the right of the inflection point. Relative to participants classified as having low ALMBMI according to FNIH criteria, those with normal ALMBMI exhibited reductions of 16.01% in ALP and 11.17% in segmented neutrophil count, respectively.</p><p><strong>Conclusion: </strong>Among middle-aged women, higher segmented neutrophil count and ALP levels were identified as positive correlates of low ALMBMI, with both biomarkers demonstrating threshold phenomena. Such hematological alterations are consistent with chronic low-grade inflammation, underscoring their potential utility in early sarcopenia screening and prevention.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 6","pages":"100213"},"PeriodicalIF":3.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced total arterial compliance in frail older adults is associated with orthostatic blood pressure variability but not baroreflex sensitivity.","authors":"Dihogo Gama de Matos, Felipe J Aidar, Albena Nunes-Silva, Govind Peringod, Vincenzo Giambusso, Roman Romero-Ortuno, Todd A Duhamel, Rodrigo Villar","doi":"10.1016/j.tjfa.2026.100214","DOIUrl":"https://doi.org/10.1016/j.tjfa.2026.100214","url":null,"abstract":"<p><strong>Background: </strong>Total arterial compliance (TAC) reflects arterial elasticity and may be associated with baroreflex sensitivity (BRS) and beat-by-beat blood pressure variability (BPV) during postural transitions. Frailty is also associated with impaired autonomic cardiovascular regulation, which may further compromise blood pressure control during orthostatic stress. However, these relationships have not been investigated in frail older adults. We hypothesized that frail participants would exhibit lower TAC than non-frail participants and that reduced TAC would be associated with impaired autonomic regulation.</p><p><strong>Methods: </strong>Community-dwelling older adults aged 60-79 years were classified as non-frail (n=28) or frail (n=22) using the Frailty Index. Participants completed sitting-to-standing and lying-to-standing transitions with continuous cardiovascular monitoring. TAC was estimated as the stroke volume-to-pulse pressure ratio, BRS using the sequence method, and BPV using frequency-domain analysis. General linear models compared TAC between groups. Correlation and regression analyses examined associations between TAC, BRS, and BPV, adjusting for frailty status and medication use.</p><p><strong>Results: </strong>Frail participants exhibited lower TAC than non-frail participants during both conditions (all p < 0.05). TAC was not associated with BRS during either orthostatic transition (both p > 0.05). In contrast, lower TAC was associated with greater systolic BPV during sitting-to-standing (SBPV-VLF: β = -0.46, p = 0.006) and lying-to-standing (SBPV-VLF: β = -0.60, p < 0.001; SBPV-LF: β = -0.56, p < 0.001; SBPV-HF: β = -0.32, p = 0.04).</p><p><strong>Conclusions: </strong>These findings suggest that impaired arterial compliance contributes to orthostatic autonomic dysfunction in frail older adults primarily through reduced vascular buffering rather than impaired cardiovagal baroreflex function.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 6","pages":"100214"},"PeriodicalIF":3.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in physical performance and frailty-associated risk associated with participation in a community exercise programme: Findings from the ExWell cohort.","authors":"Muireann O'Shea, Paul Doody, Noel McCaffrey, Aodhaghan O'Deasmhunaigh, Fiona Skelly, Lisa Kelly, Sean P Kennelly, Susan M Smith, Noel McCarthy","doi":"10.1016/j.tjfa.2026.100199","DOIUrl":"10.1016/j.tjfa.2026.100199","url":null,"abstract":"<p><strong>Introduction: </strong>Exercise can improve physical function and reduce disability in older adults living with frailty. ExWell Medical is a national, community-based, medically supported group exercise program for people living with chronic conditions in Ireland.</p><p><strong>Study aims/objectives: </strong>We aimed to evaluate the longitudinal association between baseline frailty status and outcomes including gait speed in ExWell programme participants.</p><p><strong>Methods: </strong>This is a secondary data analysis of a prospective cohort study. All participants attending an ExWell Medical induction in the Dublin/Kildare regions January-September 2023 were invited to participate. At baseline, 12, and 24 weeks we collected data on socio-demographics; health behaviours; measures of physical function; patient-reported outcomes. The cohort were stratified by Clinical Frailty Scale category at baseline.</p><p><strong>Results: </strong>We recruited 1290 participants (mean age 69 (SD:10.9) years; 60% female. At baseline 15% of participants were classified as frail, 23% prefrail, 62% robust. Baseline frailty was associated with a higher chronic condition count, higher health service use, poorer scores on measures of physical function, EQVAS, EQ5D5L index scores. There was an inverse association between frailty and class attendance (p < 0.001). Attrition increased with increasing baseline frailty status (p = 0.006). Participants who were frail at baseline had improvements between baseline and 24-week reassessment in gait speed, timed up and go, six-minute time trial, EQVAS; prefrail participants in the sit to stand test, six-minute time trial, EQVAS, but no improvement in timed up and go. Robust participants recorded improvements in all measures.</p><p><strong>Conclusion: </strong>Participation in the ExWell programme was associated with improvements across frailty groups in community-dwelling adults living with chronic conditions.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 5","pages":"100199"},"PeriodicalIF":3.2,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scaling of an evidence-based intervention program in older people with diabetes and frailty in Latin America. Diabfrail-Latam clinical trial protocol.","authors":"O Laosa, C A Cano-Gutierrez, W Sepulveda-Loyola, P Morsch, E Vega, J F Parodi, C Zuñiga, S Aruachan, J Luque, F Araya-Quintanilla, N Osorio, R Calvani, A Picca, L Peña-Longobardo, L Pedraza, M Izquierdo, M C Gomez-Cabrera, J Viña, M A Rol, A J Sinclair, L Rodriguez-Mañas","doi":"10.1016/j.tjfa.2026.100211","DOIUrl":"10.1016/j.tjfa.2026.100211","url":null,"abstract":"<p><strong>Objectives: </strong>Diabfrail-Latam is a project funded by the Horizon 2020 program of the European Commission (EC) and the Global Alliance for Chronic Diseases (GACD). The main objective of this protocol is to describe the clinical validation of a multimodal intervention aimed at older people with type 2 diabetes mellitus (T2DM) and frailty in Latin America, involving multicomponent physical exercise (based on VIVIFRAIL), nutritional education, and adjustment of therapeutic targets to be scaled up to other countries in Latin American region.</p><p><strong>Methods: </strong>The Diabfrail-Latam CE is international, multicenter, single-blind and with two parallel groups with 1:1 randomization (multimodal intervention or usual clinical practice). More than 700 people over 65 years of age, frail or pre-frail, with T2DM, are expected to be recruited in four countries (Colombia, Peru, Mexico and Chile). The primary objective of this clinical validation is to evaluate the effectiveness of the multimodal intervention in improving functionality (measured by the Short Physical Performance Battery, SPPB) after one year of follow-up. Secondary objectives include changes in frailty status, adherence, feasibility, economic impact, biomarkers and caregiver burden. The intervention is expected to significantly improve functionality, reduce frailty progression, and demonstrate feasibility for large-scale implementation in Latin American health systems.</p><p><strong>Conclusion: </strong>Diabfrail-Latam will allow to validate and adapt interventions that have demonstrated efficacy in previous studies in European population, providing solid evidence for scaling and replication in the Latin American region and its context.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"15 5","pages":"100211"},"PeriodicalIF":3.2,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}