Journal of Frailty & Aging最新文献

{"title":"The interrelationship of frailty, multimorbidity and disability in Parkinson's disease: PRIME-UK cross-sectional study.","authors":"Emma Tenison, Yoav Ben-Shlomo, Anahita Nodehi, Emily J Henderson","doi":"10.1016/j.tjfa.2025.100073","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100073","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of Parkinson's disease rises with age and so patients may also be living with multimorbidity, two or more long-term conditions, and frailty, a loss of physiological reserve. However, these individuals are typically under-represented in clinical research. The aim was to describe the prevalence and interrelationship of frailty, multimorbidity, disability, sarcopenia and polypharmacy in a representative sample of people with parkinsonism recruited to the PRIME-UK cross-sectional study.</p><p><strong>Methods: </strong>In this single-centre cross-sectional study of people with parkinsonism, we supported the inclusion of typically under-represented groups including those with impaired capacity to consent to the research. Participants, or their representative, completed questionnaires including self-reported comorbidities, medications, a sarcopenia screening tool and measures of frailty and disability. Venn diagrams were used to show the overlap between these domains and a hierarchical cluster analysis was performed to explore clustering.</p><p><strong>Results: </strong>Only 78 (16.8 %) were categorised as neither frail nor multimorbid nor disabled. Almost all patients living with frailty were additionally living with disability and/or multimorbidity. It was uncommon to have multimorbidity and frailty without disability. Only 6 (1.3 %) had frailty without probable sarcopenia. Individuals clustered into three groups based on co-occurrence of some or all of these five domains.</p><p><strong>Conclusions: </strong>Amongst a representative sample of people with parkinsonism, there was a high frequency and co-occurrence of pre-frailty/frailty, sarcopenia, multimorbidity, polypharmacy and disability. This has implications for the structuring of health services for people with parkinsonism. There may also be opportunities to intervene to stop or slow the trajectory towards disability.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 6","pages":"100073"},"PeriodicalIF":3.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frail2Fit study: it was feasible and acceptable for volunteers to deliver a remote health intervention to older adults with frailty.","authors":"S J Meredith, L Holt, J Varkonyi-Sepp, A Bates, K A Mackintosh, M A McNarry, S Jack, J Murphy, Mpw Grocott, Ser Lim","doi":"10.1016/j.tjfa.2025.100092","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100092","url":null,"abstract":"<p><strong>Background: </strong>Physical activity (PA) and good nutrition are key to maintaining independence and reversing frailty among older adults.</p><p><strong>Objective: </strong>To evaluate the feasibility and acceptability of training volunteers to deliver a remote multimodal intervention to older people with frailty after hospital discharge.</p><p><strong>Design: </strong>Quasi-experimental mixed-methods feasibility study.</p><p><strong>Setting, and participants: </strong>Twenty-seven older adults (mean age 80 years, 15 female) with frailty (Clinical Frailty Status ≥5) were enrolled from a National Health Service South England hospital, UK.</p><p><strong>Intervention: </strong>Volunteers were trained to deliver a 3-month intervention, comprising exercise, behaviour change, and nutrition guidance in a group, or one-to-one, using telephone or online platforms.</p><p><strong>Measurements: </strong>Feasibility was assessed by determining the number of volunteers recruited, trained, and retained; participant recruitment; and intervention adherence. Interviews were conducted with 16 older adults, 1 carer, and 5 volunteers to explore intervention acceptability, and were analysed using reflexive thematic analysis. Secondary health outcomes, such as physical activity and appetite, were compared at baseline, post-intervention, and follow-up (3-months).</p><p><strong>Results: </strong>The intervention was safe and acceptable to volunteers, and older adults with frailty. Five volunteers (mean age 16 years, 3 female) completed training, and 60 % (n = 3) were retained. Seventeen participants completed the intervention (8 online; 9 telephone). Participants attended 75 % (IQR 38-92) online sessions, and 80 % (IQR 68.5-94.5) telephone support. Volunteers provided emotional support to older people with frailty and encouraged health behaviour change. Older people learnt from each other's shared experiences in the online group, and telephone calls provided them with reassurance and monitoring. Key components to success were volunteers received comprehensive training and support from a health practitioner, while key barriers were that participants lacked social support and experienced exercise discomfort.</p><p><strong>Conclusion: </strong>With appropriate training and support, volunteers can safely deliver a remote multimodal intervention for older adults with frailty following discharge from hospital.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 6","pages":"100092"},"PeriodicalIF":3.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty assessment utilization around the globe-a systematic review.","authors":"Samantha Gaston, Elle Billman, Lichy Han, David Drover","doi":"10.1016/j.tjfa.2025.100088","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100088","url":null,"abstract":"<p><strong>Background: </strong>Recent expert guidelines recommend that frailty assessments (FAs) encompass physical, functional, cognitive, social, and mental health domains. This systematic review examines FAs administered globally between 2015 to 2022 in geriatric participants (65 years and older) to characterize the parameters used to assess frailty.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we screened 3,859 articles and included 202 in the final analysis. FA parameters were coded into 45 health-related categories defined by the authors to evaluate the domains most frequently used.</p><p><strong>Results: </strong>Across 39 countries, 291 FAs were identified, with an average number of 17.36 parameters per instrument. Of the 4,995 total parameters analyzed, 22.32 % assessed functional health or physical performance. Cognitive, mental, and social health were assessed by only 6.09 %, 6.35 %, and 5.01 % of parameters, respectively.</p><p><strong>Conclusions: </strong>FAs overwhelmingly measure functional and physical health parameters with limited attention to cognitive, mental, and social domains. This imbalance suggests that instruments may fall short of capturing the multidimensional nature of frailty as recommended by recent guidelines. By cataloging current FAs, their components, and the degree to which they reflect comprehensive frailty definitions, this review highlights the need for further research and refinement of FAs to ensure accurate, holistic assessment across diverse clinical settings.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 6","pages":"100088"},"PeriodicalIF":3.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A two-stage analysis of social media use patterns, psychosocial well-being, and frailty in an aging Japan.","authors":"Yuki Nakada, Yuna Seo","doi":"10.1016/j.tjfa.2025.100091","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100091","url":null,"abstract":"<p><strong>Background: </strong>In Japan's super-aged society, frailty prevention is a critical public health issue. While social media use is increasing among older adults, its impact on well-being is complex and not fully understood beyond a simple active-passive dichotomy. This study aims to explore the relationship between specific social media usage patterns, users' psychosocial backgrounds, and frailty risk.</p><p><strong>Methods: </strong>We conducted a cross-sectional online survey of 950 community-dwelling older adults in Japan. Frailty was assessed using the Kihon Checklist. A two-stage analysis was performed: 1) K-means cluster analysis was used to classify participants based on eight SOCIAL MEDIA use behavior variables, followed by a Kruskal-Wallis test to compare psychosocial characteristics across clusters; 2) Ordinal logistic regression analysis was used to identify specific behaviors associated with frailty after adjusting for covariates.</p><p><strong>Results: </strong>Three distinct user clusters were identified: \"Balanced, reality-oriented communicators\" (n = 333), \"Low-engagement, passive users\" (n = 419), and \"Active, multi-purpose users\" (n = 198). The \"Low-engagement\" group reported the highest levels of loneliness and unhappiness, despite high real-world social participation. Regression analysis revealed that the specific behavior of \"using social media to keep a record of my own activities\" (self-documentation) was independently associated with an increased risk of frailty (β = 0.105, p < .05). Conversely, high exercise self-efficacy (p < .001), sleep satisfaction (p < .01), and satisfaction with face-to-face communication (p < .001) were protective factors.</p><p><strong>Conclusion: </strong>Social media usage patterns reflect underlying psychosocial states, but are not direct predictors of frailty. The motivation-driven behavior of self-documentation, rather than general activity, is a risk factor. These findings suggest that interventions should focus on the quality and function of social media use, promoting digital literacy that enhances well-being in older adults.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 6","pages":"100091"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of sarcopenia and resistance exercise training on mitochondrial quality control proteins.","authors":"Catherine B Springer-Sapp, Olayinka O Ogbara, Odessa Addison, Sarah Kuzmiak-Glancy, Steven J Prior","doi":"10.1016/j.tjfa.2025.100090","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100090","url":null,"abstract":"<p><strong>Background: </strong>The progression of sarcopenia with aging may be related to mitochondrial dysfunction due in part to altered mitochondrial dynamics (fusion, fission, mitophagy, and biogenesis). Previous work has identified altered expression of proteins associated with these processes in with aging, but whether further changes occur in sarcopenia remains unclear.</p><p><strong>Objectives: </strong>The purpose of this study was to assess protein expression of markers of mitochondrial fusion (Mfn2, Opa1), fission (Drp1, Fis1), mitophagy (Parkin), biogenesis (PGC-1α), and content (Complex IV: CIV) in sarcopenic and non-sarcopenic older adults. We also determined whether resistance training affected skeletal muscle mitochondrial content and expression of mitochondrial quality control proteins in sarcopenic older adults.</p><p><strong>Design: </strong>Longitudinal exercise training study, with cross-sectional baseline comparison.</p><p><strong>Setting and participants: </strong>Ten older adults with mild-moderate sarcopenia, plus ten non-sarcopenic, matched older adults from Maryland, USA.</p><p><strong>Intervention: </strong>Twelve-week resistance training.</p><p><strong>Measurements: </strong>Strength, sarcopenic index (ALM/BMI: appendicular lean mass divided by body mass index), body composition, and mitochondrial morphology and protein expression in vastus lateralis muscle.</p><p><strong>Results: </strong>No differences in protein expression were observed between sarcopenic and non-sarcopenic participants at baseline; however, ALM/BMI was inversely related to CIV expression (r = -0.55, P = 0.013) across all subjects. Similarly, lean body mass and ALM correlated inversely with expression of the fusion protein Opa1-S (r = -0.55 - -0.51, P ≤ 0.022). Resistance training increased strength in sarcopenic older adults by 13 % (P = 0.02), but this group's expression of mitochondrial quality control proteins was mostly unaltered.</p><p><strong>Conclusions: </strong>The presence of sarcopenia identified by ALM/BMI was not associated with changes in protein expression that are consistent with impaired mitochondrial dynamics beyond those changes that might occur with aging alone. While short-term resistance training increased strength in older adults with sarcopenia, this was not accompanied by changes in protein expression, with the possible exception of fusion protein Mfn2.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 6","pages":"100090"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of sarcopenia and sarcopenic obesity in a German geriatric day clinic.","authors":"Basel Habboub, Emmanuel Oludowole, Robert Speer, Johanna Masuch, Ursula Berger, Markus Gosch, Katrin Singler","doi":"10.1016/j.tjfa.2025.100072","DOIUrl":"10.1016/j.tjfa.2025.100072","url":null,"abstract":"<p><strong>Purpose: </strong>Sarcopenia and sarcopenic obesity are defined by the loss of muscle strength and mass. Both diseases pose a growing global challenge. Their prevalences vary between studied populations. The aim of this study is to estimate the prevalences of sarcopenia and sarcopenic obesity in sample of community-dwelling older adults attending a geriatric day clinic.</p><p><strong>Methods: </strong>A secondary analysis of the Paint-II Data (single-center randomized controlled trial on the effects of art therapy) was used to estimate the prevalence of sarcopenia and sarcopenic obesity. Furthermore, a machine learning model predicted factors associated with both diseases.</p><p><strong>Results: </strong>We had body composition information on 255 of the 409 Paint-II participants. Their mean age was 81 ± 5 years and 78 % were female. Depending on the appendicular skeletal muscle mass (ASM) definition, the prevalence of sarcopenia ranged between 10 % and 24 % using ASM/height² or absolute ASM respectively. The prevalence of sarcopenic obesity was 15 %. Weight was the most influential predictor, with higher weight being linked to sarcopenic obesity and lower weight associated with sarcopenia.</p><p><strong>Conclusions: </strong>The prevalence of sarcopenia and sarcopenic obesity among community-dwelling older adults attending geriatric day clinics is higher than among the general geriatric population. There is a significant discrepancy in sarcopenia prevalence depending on whether muscle mass is measured absolutely or adjusted for body size. Diagnosis is further complicated by varying recommended cut-offs. We support efforts to simplify and standardize the diagnostic criteria.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100072"},"PeriodicalIF":3.3,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of physical activity on cognitive function in patients with neurocognitive disorders: A systematic review.","authors":"Théodore Decaix, Claire Bonnin, Karl Götze, Véronique François, Camille Petit, Clémentine Rivière, Sandrine Greffard, Emmanuel Cognat, Jacques Hugon, Claire Paquet, Louise Sindzingre, Matthieu Lilamand","doi":"10.1016/j.tjfa.2025.100069","DOIUrl":"10.1016/j.tjfa.2025.100069","url":null,"abstract":"<p><p>Neurocognitive disorders, particularly in older adults, significantly affect functional abilities and global health. Physical activity has emerged as a potential non-pharmacological intervention to improve cognitive performance in patients with neurodegenerative diseases. This review specifically addressed the issue of tailored physical activity interventions for individuals with various neurocognitive disorders. This literature review analyzed studies investigating the effects of physical activity on cognitive function in patients with Alzheimer's disease (AD), vascular cognitive impairment, Parkinson's disease, and Lewy body dementia. The studies were evaluated for methodological rigor, participant characteristics, types of physical activities, and cognitive outcomes. Of the 21 studies reviewed, 14 reported beneficial effects of physical exercise on cognitive function, particularly with aerobic activities. While most studies observed improvements in cognitive performance and physical functional capacity, results were inconsistent, and effect sizes were modest. Mechanisms proposed for cognitive improvement in AD included reductions in β-amyloid and tau protein burdens, improved glucose metabolism, and enhanced brain-derived neurotrophic factor levels. Specific improvements were noted in Parkinson's disease, with evidence suggesting mediation through dopamine pathways. Despite evidence of short-term benefits, significant variability exists among studies, highlighting the need for individualized exercise programs tailored to specific neurocognitive conditions. Physical activity stands as a cornerstone non-pharmacological intervention, essential for supporting cognitive health in individuals with neurodegenerative diseases. Further research is necessary to establish long-term effects and optimal exercise modalities, along with standardized evaluation criteria to assess the cognitive impacts of physical activity reliably.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100069"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the frequency of going outdoors by life space and incident disability among older adults.","authors":"Takehiko Doi, Sho Nakakubo, Fumio Sakimoto, Soichiro Matsuda, Hiroyuki Shimada","doi":"10.1016/j.tjfa.2025.100070","DOIUrl":"10.1016/j.tjfa.2025.100070","url":null,"abstract":"<p><strong>Background: </strong>Going outdoors is crucial in promoting older adults' health. This study examined the association between incident disability and the frequency of going outdoors in certain life spaces.</p><p><strong>Methods: </strong>This prospective study included 19,822 older adults (mean age ± standard deviation: 73.5 ± 5.8 years; 53.6 % women). The frequency of going outdoors within the past month was collected based on life space, categorized by distance from home (up to 1 km; 1-10 km; and >10 km). Participants were classified into three groups (called \"Rarely\": less than 1 day, \"Sometimes\": 1 to 3 days, and \"Often\": 4 days or more) for each life space. Incident disability was defined using the Long-Term Care Insurance system data (mean follow-up: 23.3 months). A Cox proportional hazards model was used to examine the association between incident disability and the frequency of going outdoors for each life space, adjusted for covariates.</p><p><strong>Results: </strong>A total of 1038 (5.2 %) participants had an incident disability. Within the \"up to 1 km\" category, no frequency group was associated with disability; within \"1-10 km,\" two frequency groups were associated with disability (\"Sometimes\" group: hazard ratio [HR] 0.85, [95 % confidence interval [CI]: 0.73-0.99]; \"Often\" group: HR 0.68, [95 % CI: 0.57-0.81]); within \">10 km,\" similar results were observed (\"Sometimes\" group: HR 0.84, [95 % CI: 0.72-0.98]; \"Often\" group: HR 0.75, [95 % CI: 0.53-1.07]).</p><p><strong>Conclusions: </strong>The frequency of going outdoors at specific distances from home is associated with disability.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100070"},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of hand grip strength in a cohort of older Nigerian Africans: Findings from the population-based VALIANT project.","authors":"Rufus O Akinyemi, Oladotun V Olalusi, Gabriel O Ogunde, Tolulope O Akinyemi, Joseph O Yaria, Olabode Oguntiloye, Ayotomiwa Fagbemi, Eniola O Cadmus, Femi O Popoola, Mayowa Ogunronbi, Dorcas Olujobi, Olaoluwa Famuyiwa, Joshua O Akinyemi, Mayowa O Owolabi, Roman Romero-Ortuno, Adesola Ogunniyi, Raj Kalaria, Brian Lawlor","doi":"10.1016/j.tjfa.2025.100068","DOIUrl":"10.1016/j.tjfa.2025.100068","url":null,"abstract":"<p><p>Previous evidence suggests there are racial, genetic, and geographic differences in hand grip strength (HGS) underlying the need to define population-specific normative values and their determinants. We determined the normative values of HGS and investigated its correlates in an urban community sample in Nigeria. We assessed 607 participants from the Vascular heAlth, fraiLty, and cognItion in Ageing Nigerians sTudy [VALIANT] - a population-based cohort of 1031 older persons in Ibadan, a city in Southwestern Nigeria. They were recruited through a multi-stage, stratified cluster random sampling method. HGS was defined as the highest recorded/maximum HGS (max. HGS) of both hands. The determinants (β coefficient, p values) of HGS were identified using linear regression model. The mean (SD) age of the participants was 64.6 (11.5) with 67.8 % females. The mean (SD) max. HGS (in kg) of the study population was 19.65±10.16 overall; 24.51(14.01) among males and 17.31(6.51) among females (p < 0.001). Overall, female sex (β=-6.38, p < 0.001), clinical frailty (β=-1.35, p < 0.001), and baseline MoCA scores (β=0.37, p 0.001) were independently associated with max. HGS. In the subgroup analysis, presence of hypertension (β=2.64, p < 0.001) and diabetes mellitus (β=-2.61, p 0.05) were independently associated with max. HGS among females, but not males. Our findings buttress the intricate link between overall physical, cardiometabolic as well as cognitive health in this unique West African population.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100068"},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of ethnicity on frailty in a United Kingdom (UK) population.","authors":"A H Heald, W Lu, R Williams, K Mccay, A Clegg, C Todd, A Maharani, M J Cook, T W O'Neill","doi":"10.1016/j.tjfa.2025.100089","DOIUrl":"10.1016/j.tjfa.2025.100089","url":null,"abstract":"<p><strong>Background: </strong>Frailty is an important and increasing clinical and public health problem. Within the United Kingdom (UK). Most data relating to the occurrence of frailty is derived from Caucasian groups. This study aimed to determine the influence of ethnicity on the occurrence of frailty in a large UK urban conurbation. We also looked at frailty-related risk of severe illness related to COVID-19 infection.</p><p><strong>Methods: </strong>Using data from the Greater Manchester Health Record (GMCR), we analysed primary care electronic medical records of 534,367 men and women aged 60 years and over who were alive on 1st January 2020. We assessed frailty using an electronic frailty index (eFI) and categorised subjects as fit, mild, moderate, and severe frailty. We used logistic regressions to examine the association between moderate and severe frailty (eFI ≥ 0.25) and ethnicity adjusted with age, sex and area deprivation (as measured using Townsend Index). We also looked among those with a first positive COVID test, the influence of frailty on subsequent admission to the hospital within 28 days.</p><p><strong>Results: </strong>The majority of subjects were White (84 %), with 4.7 % describing themselves as Asian or Asian British, and 1.3 % Black or Black British. The unadjusted prevalence of moderate to severe frailty (eFI ≥ 0.25) was 22.1 %. Compared to the prevalence of frailty in Whites (22.5 %), the prevalence was higher in those of Asian or Asian British ethnicity (28.1 %) and lower in those of Black/Black British descent (18.7 %). After adjustment for age, gender, and deprivation, the risk of frailty remained higher in Asians (Odds Ratio = 1.61; 95 % Confidence Intervals = 1.56-1.66) and lower in Black British (OR = 0.73; 95 % CI 0.68-0.78) compared to White British. Among those with a positive COVID-19 test, those with frailty were more likely to require admission to the hospital within 28 days (OR = 1.61; 95 % CI = 1.53, 1.69).</p><p><strong>Conclusion: </strong>There is variation in the occurrence of frailty across Greater Manchester across ethnic groups, with higher frequency among those of Asian or Asian British descent and lower frequency among those of Black or Black British descent. This study has added to our understanding of the way that frailty prevalence maps across communities, in this case in a large European conurbation. Further research is required to understand the causes of ethnic variation in frailty and whether ethnicity influences frailty outcomes.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 6","pages":"100089"},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}