Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study.

IF 3.3 Q2 GERIATRICS & GERONTOLOGY

Journal of Frailty & Aging Pub Date : 2025-07-01 DOI:10.1016/j.tjfa.2025.100064

Kelly Virecoulon Giudici, Philipe de Souto Barreto, Christelle Cantet, Henrik Zetterberg, Kaj Blennow, Bruno Vellas

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引用次数: 0

Abstract

Background: Intrinsic capacity (IC) is a recent key concept proposed by the World Health Organization (WHO) based on aspects of functional ability (both physical and mental) rather than the presence or absence of diseases, with a potential to predict several health outcomes.

Objective: To explore associations between IC and cognitive function (prospectively), and between IC and plasma p-tau181 (cross-sectionally and prospectively) among community-dwelling older adults.

Methods: Observational study with 491 subjects ≥70 years (67.4 % female, mean 75.3 years, SD=4.4), participants from the Multidomain Alzheimer Preventive Trial (MAPT). IC domains (locomotion, cognition, psychological, vitality) were combined into a 0-100 score. Alternative classification was based on the number of domains' abnormalities. Plasma p-tau181 was measured at baseline and 36 months of follow-up. A composite cognitive score (CCS) based on four tests was determined at baseline, 6, 12, 24, 36, 48 and 60 months.

Results: Inverse cross-sectional associations were observed between baseline IC score and p-tau181 (unadjusted model: β=-0.08, 95 %CI -0.13 to -0.03; p = 0.0025). A significant mean difference in p-tau181 3-year changes was observed between participants with low and normal IC (based on IC score) (adjusted model: 1.71, 95 %CI 0.01 to 3.40; p = 0.0483). Prospective 5-year associations between IC and CCS were only observed in unadjusted analysis according to the alternative IC classification (-0.21, 95 %CI -0.38 to -0.04; p = 0.0156).

Conclusion: IC was associated with plasma p-tau181 and cognitive function, but findings varied according to the method of IC classification. Further research may help settle the role of IC as a predictor of neurodegenerative diseases such as AD. In this regard, multidomain interventions have potential to protect IC over the aging process and prevent cognitive impairment, and should also be encouraged.

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内在容量、血浆p-tau181与社区老年人认知功能之间的关系：MAPT研究的二次分析

背景：内在能力（IC）是世界卫生组织（世卫组织）最近提出的一个关键概念，基于功能能力（身体和精神）的各个方面，而不是存在或不存在疾病，具有预测几种健康结果的潜力。目的：探讨社区老年人IC与认知功能之间的关系（前瞻性），IC与血浆p-tau181之间的关系（横断面和前瞻性）。方法：观察性研究，491名年龄≥70岁的受试者（67.4%为女性，平均75.3岁，SD=4.4），来自多域阿尔茨海默病预防试验（MAPT）。IC领域（运动、认知、心理、活力）综合成0-100分。另一种分类是基于区域异常的数量。在基线和随访36个月时测量血浆p-tau181。在基线、6个月、12个月、24个月、36个月、48个月和60个月测定基于四项测试的复合认知评分（CCS）。结果：基线IC评分与p-tau181呈负相关(未调整模型：β=-0.08, 95% CI -0.13至-0.03；P = 0.0025)。在低IC和正常IC的参与者之间观察到p-tau181 3年变化的显著平均差异（基于IC评分）(调整模型：1.71,95% CI 0.01至3.40；P = 0.0483)。仅在未调整的分析中，根据可选的IC分类，观察到IC和CCS之间的前瞻性5年相关性(-0.21,95% CI -0.38至-0.04；P = 0.0156)。结论：IC与血浆p-tau181和认知功能相关，但IC分类方法不同，结果不同。进一步的研究可能有助于确定IC作为神经退行性疾病（如AD）的预测因子的作用。在这方面，多领域干预有可能在衰老过程中保护IC并预防认知障碍，也应该得到鼓励。

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来源期刊

Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-

CiteScore

5.90

自引率

7.70%

发文量

期刊介绍： The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons. The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).