Journal of Frailty & Aging最新文献

{"title":"Nationwide insights into frailty: Systematic review and meta-analysis of community-based prevalence studies from India.","authors":"Sunanda Gupta, Aninda Debnath, Ankit Yadav, Anubhav Mondal, Shweta Charag, Jugal Kishore","doi":"10.1016/j.tjfa.2025.100032","DOIUrl":"10.1016/j.tjfa.2025.100032","url":null,"abstract":"<p><p>Frailty, a biologic syndrome of decreased reserve and resistance to stressors, affects 5 % to 17 % of older adults and is linked to factors like low BMI, female sex, and low exercise levels. With India's older population expected to double by 2050, frailty presents major public health and economic challenges. This study summarizes the prevalence of frailty among community-dwelling Indians. This systematic review and meta-analysis followed PRISMA guidelines to determine the prevalence of frailty among adults in India. We conducted a comprehensive search across multiple databases, including PubMed, Scopus, EMBASE, and Web of Science, up to January 16, 2024, excluding hospital-based studies and reviews. Data were analyzed using STATA software with a random-effects model, and quality was assessed using the JBI Critical Appraisal Checklist. The meta-analysis revealed a pooled frailty prevalence of 36 % (95 % CI: 29 % to 44 %) among 330,007 community-dwelling adults in India, with significant heterogeneity across studies (I² = 99.95 %). Frailty prevalence varied by assessment method, with 48 % using the frailty index and 31 % using the Fried phenotype. Subgroup analyses indicated significant variability in frailty prevalence by gender, data source, and assessment tool, with no significant publication bias detected. This meta-analysis found a pooled frailty prevalence of 36 % and pre-frailty prevalence of 48 % among adults in India, with higher frailty in women (45 %) than men (35 %) and variation across assessment tools. Future research should focus on longitudinal studies and developing tailored frailty assessment tools.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 2","pages":"100032"},"PeriodicalIF":3.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of frailty in people experiencing homelessness: A systematic review and meta-analysis.","authors":"Thomas Cronin, David Healy, Noel McCarthy, Susan M Smith, John Travers","doi":"10.1016/j.tjfa.2025.100029","DOIUrl":"10.1016/j.tjfa.2025.100029","url":null,"abstract":"<p><strong>Background: </strong>The experience of homelessness has been associated with premature ageing and an earlier onset of geriatric syndromes. Identification of frailty and appropriate intervention, may help improve health outcomes for people experiencing homelessness (PEH). This review aimed to identify prevalence, use of screening tools and risk factors for frailty in PEH.</p><p><strong>Method: </strong>A systematic review, conducted and reported following the PRISMA checklist, was undertaken investigating the prevalence and risk factors of frailty among PEH. Searches were conducted in Ovid MEDLINE, PsycInfo, Web of Science and CINAHL from inception to July 2024. A meta-analysis examining prevalence of frailty and pre-frailty was completed with a narrative synthesis of related risk factors.</p><p><strong>Results: </strong>A total of 1672 articles were screened for eligibility and 11 studies were included, containing 1017 participants from seven countries. Six different screening tools were employed to detect frailty in the included studies. The range of frailty prevalence was 16-70 % and pre-frailty prevalence was 18-60 %. The pooled frailty prevalence from studies employing the Fried Criteria was 39 % (95 % CI 15-66); the Clinical Frailty Scale: 37 % (95 % CI 24-51); the Edmonton Frailty Scale: 53 % (95 % CI 44-63); and the Tilburg Fraily Indicator: 31 % (95 % CI 8-60). High heterogeneity was observed between the studies. Identified risk factors for developing frailty in PEH included being female, increased years spent homeless, and drug addiction.</p><p><strong>Conclusion: </strong>This study highlights a high prevalence of frailty and pre-frailty in PEH. The identified risk factors illustrate potential areas to target interventions to reverse frailty. Future research should focus on the role of screening for frailty in PEH and developing appropriate frailty detection tools in this group.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 2","pages":"100029"},"PeriodicalIF":3.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic disease among frailty phenotype clusters in adults aging with HIV.","authors":"Raymond Jones, Ene M Enogela, Stephanie A Ruderman, Mari M Kitahata, Richard Moore, Jeffrey M Jacobson, Maile Karris, Meredith Greene, Julia Fleming, Sonia Napravnik, Greer Burkholder, Joseph A C Delaney, Heidi M Crane, Amanda L Willig, Thomas W Buford","doi":"10.1016/j.tjfa.2025.100011","DOIUrl":"10.1016/j.tjfa.2025.100011","url":null,"abstract":"<p><strong>Background: </strong>Age-related morbidity, including frailty and cardiometabolic disease has become increasingly prevalent among people living with HIV (PWH), and each frailty characteristic may, independently and synergistically, play a role in cardiometabolic disease.</p><p><strong>Objective: </strong>To evaluate the prevalence of unique frailty clusters and the prevalence ratios of cardiometabolic diseases within frailty clusters among a large diverse cohort of PWH in clinical care.</p><p><strong>Design: </strong>Cross-sectional analyses within longitudinal clinical cohort.</p><p><strong>Setting: </strong>The Center for AIDS Research Network of Integrated Clinical Systems (CNICS) from 8 Clinics PARTICIPANTS: 4,856 PWH, mean age 61 years. 16 % frail, 45 % pre-frail, 40 % robust.</p><p><strong>Measurements: </strong>The validated, modified Fried Phenotype from patient-reported outcomes and clustering (15 clusters) of the frailty characteristics and cardiometabolic diseases (7 diseases and multimorbidity) within each cluster.</p><p><strong>Results: </strong>Among 4856 PWH (age: 61 ± 6 years), the prevalence of frail, pre-frail, and robust was 16 %, 45 %, and 40 %, respectively. The most prevalent cardiometabolic disease among frail PWH was hypertension (62.6 %), followed by dyslipidemia (58.8 %) and diabetes (31.4 %). Among pre-frail PWH, the most prevalent cardiometabolic diseases were dyslipidemia (65.8 %), hypertension (61.8 %), and obesity (30.5 %). The prevalence of cardiometabolic disease among frailty clusters varied. For example, PWH in the \"fatigue + poor mobility\" cluster had a greater prevalence of cerebrovascular disease (PR: 2.23; 95 % CI: 1.01-4.91), diabetes (1.76; 95 % CI: 1.41-2.21), and obesity (1.66; 95 % CI: 1.35-2.05) when compared with robust PWH. Individuals in the \"poor mobility\" cluster had a higher prevalence of diabetes (1.37; 95 % CI: 1.15-1.64), hypertension (1.12; 95 % CI: 1.04 - 1.22), and obesity (1.38; 95 % CI: 1.17-1.61) compared with robust PWH.</p><p><strong>Conclusions: </strong>The frailty components, independently and synergistically, were associated with an increased prevalence of cardiometabolic disease. This study identified distinct frailty clusters that may be associated with increased prevalence of cardiometabolic disease among PWH.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 2","pages":"100011"},"PeriodicalIF":3.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitating oral and dental care in older people in low- and middle-income countries: The role of teledentistry.","authors":"Sedighe Sadat Hashemikamangar, Behnaz Behniafar","doi":"10.1016/j.tjfa.2025.100035","DOIUrl":"10.1016/j.tjfa.2025.100035","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 2","pages":"100035"},"PeriodicalIF":3.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic determinants of muscle health: A population-based study.","authors":"Sylvia Maria Affonso da Silva, Priscila Farias Tempaku, Ronaldo D Piovezan, Monica Levy Andersen, Sergio Tufik, Vânia D'Almeida","doi":"10.1016/j.tjfa.2025.100013","DOIUrl":"10.1016/j.tjfa.2025.100013","url":null,"abstract":"<p><strong>Background: </strong>Muscle mass is associated with physical and functional performance across adulthood. Its reduction plays a crucial role in the development of age-related conditions such as frailty and sarcopenia. Genetic variations potentially impact muscle health, particularly in an aged population.</p><p><strong>Objectives: </strong>For this reason, we aimed to evaluate the association between genetic biomarkers and appendicular lean mass index (ALMI), a marker of muscle health, to identify possible risk factors for age-related sarcopenia in a population-based study.</p><p><strong>Materials and methods: </strong>We cross-sectionally analyzed data collected in 2015 from the São Paulo Epidemiologic Sleep Study (EPISONO). Participants underwent bioelectrical impedance and genetic evaluations.</p><p><strong>Results: </strong>After adjusting the data for age and sex, 12 single nucleotide polymorphisms (SNP) were significantly associated with ALMI. Among them, rs9928094 (beta = -0.031 p = 0.029) and rs9930333 (beta = -0.030 p = 0.035) are located in the FTO gene, which is related to obesity and fat gain and, rs16839632 (beta = 0.038 p = 0.029) located in the FMN2 gene, responsible for actin cytoskeleton and cell polarity.</p><p><strong>Conclusions: </strong>Poor muscle health is a multifactorial condition and genetic biomarkers can support the stratification of the risk for adverse body composition states affecting muscle and physical performance across adulthood.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 2","pages":"100013"},"PeriodicalIF":3.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoas muscle density predicts elective colorectal surgical outcomes more accurately than psoas muscle area or indexed area.","authors":"Louis Scarrold, Douglas Stupart, David Watters","doi":"10.1016/j.tjfa.2025.100037","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100037","url":null,"abstract":"<p><strong>Background: </strong>CT measurements of psoas muscle density (PMD) and area (PMA) (with or without indexing to height-squared or body-surface-area) are used interchangeably as sarcopenia measures - it is unknown which best correlates with surgical risk.</p><p><strong>Objectives: </strong>1.Determine the correlation between psoas muscle density, area, and indexed area; 2.Identify which psoas measures most strongly associated with surgical outcomes DESIGN: The University Hospital Geelong Colorectal database included all patients who underwent elective colorectal surgery from 2007 to 2014 (minimum five-years follow-up). Pre-operative CT scans were reviewed, psoas measures correlated with each other and with outcomes.</p><p><strong>Setting: </strong>University Hospital Geelong is a regional referral hospital in Victoria, Australia.</p><p><strong>Participants: </strong>This database listed 552 patients, 120 were excluded as pre-operative CT-films were not accessible, leaving 432 patients included.</p><p><strong>Exposure: </strong>Psoas muscle density, area, and area indexed by height-squared and body-surface-area.</p><p><strong>Measurements: </strong>Pearson correlations investigated correlations between psoas muscle measures. Logistic regression and ROC-analysis investigated each psoas measures association with peri‑operative morbidity. Kaplan-Meier survival-analysis investigated the association of each psoas measure with long-term survival.</p><p><strong>Results: </strong>Mean age was 70.4 years, 41 % were female. Psoas muscle density correlated poorly with area (R²=0.15). Unindexed psoas muscle area correlated well with area indexed by height-squared (R²=0.950) and body-surface-area (R²=0.938). Long-term survival was associated with psoas muscle density (HR1.515(95 %CI 1.062-2.161)) and area (HR1.886(95 %CI 1.322-2.692)). Increasing psoas muscle density (reduced sarcopenia) was associated with decreased major-complications (OR0.963(95 %CI 0.938-0.989)) and peri‑operative mortality (OR0.903(95 %CI 0.847-0.962)), with ROC-curve AUC=0.829 indicating an accurate test. There was no association between psoas muscle area and major-complications (OR1.000(95 %CI 1.000-1.000)), nor peri‑operative mortality (OR1.000(95 %CI 0.999-1.001)), with ROC-curves AUC=0.507-0.521. Indexed area measures were not associated with outcomes.</p><p><strong>Conclusions: </strong>Psoas muscle density and area did not correlate. Both were associated with long-term survival, but only density was associated major-complications and mortality. Indexing removed the correlation of area with long-term survival.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 3","pages":"100037"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate admission to the surgery hospital significantly optimises quality indicators in older patients with hip fractures: A before-and-after study.","authors":"José Luis Dinamarca-Montecinos, Alejandra Leiva Vásquez, Carmelinda Ruggiero, Yasna Barrera Fernández, Rayén Delgado Gac, Ada Carrillo, Gedeón Lazcano Améstica, Daniel Ulloa Vásquez, Fernando Aranda, Andrés Canales Pizarro, Graciela Mardones, Constanza Morales Gherardelli, Victoria Assael Novik, Osvaldo Sepúlveda, Jossie Acuña, Carola Arancibia Aravena, Julio Ibarra, Jack Bell, Emma Sutton","doi":"10.1016/j.tjfa.2025.100014","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100014","url":null,"abstract":"<p><strong>Background: </strong>Hip fractures generate high biomedical, social, functional, organisational, and economic costs. There are various quality indicators to guide its management. One of them is surgery within 48-72 h. In Chilean public health system, this indicator has out-of-standard results. This situation could have organizational causes: after hip fracture diagnosis, many older patients are first referred to general hospitals, whilst waiting an orthopedic surgical bed.</p><p><strong>Objective: </strong>To evaluate the effects of a protocol of immediate-admission to the surgery hospital on organisational and economic indicators of hip-fractured older patients.</p><p><strong>Design: </strong>Before-and-after study, between 01/01/2017-09/30/2019; 12 months before and 21 months after implementation.</p><p><strong>Setting: </strong>Regional surgical hospital responsible for 87 % of the older population in its assigned territory, in the more aged region of Chile.</p><p><strong>Participants: </strong>Anonymised data of 902 hip-fractured older adults (≥ 60 years).</p><p><strong>Intervention: </strong>Implementation of a protocol that requires immediate admission to the surgical hospital of all older hip-fractured patients at the time of diagnosis.</p><p><strong>Measurements: </strong>Number of hip-fractured patients with no immediate admission, time to surgery, total in-hospital time, and economic costs. Normality tests (Kolmogorov-Smirnov), non-parametric tests (Chi-squared), Mann-Whitney and Kruskal-Wallis tests were performed. Measures of central tendency (medians and percentiles) were used.</p><p><strong>Results: </strong>After protocol there was a significant reduction in the proportion of patients referred to general hospitals in both, first and second year (pre=37,8 %; post 1 = 27,3 %; post 2 = 23,3 %, p = 0,000). Time to surgery was also significantly reduced (medians bed days pre=15, post 1 = 11, post 2 = 10, p = 0,000). Total in-hospital time decreased 21 % (3395 bed days), and there was also a significant decrease in costs from USD130,000 to USD35,000 (p = 0,000).</p><p><strong>Conclusion: </strong>Immediate admission to orthopedic surgical hospital of older adults with hip fractures significantly decreases inter-hospital transfers, time to surgery, total in-hospital time, and direct hospital costs.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 3","pages":"100014"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported outcomes in sarcopenia: An ICFSR task force report.","authors":"Charlotte Beaudart, David Cella, Roger A Fielding, Yves Rolland, Bruno Vellas, Marco Canevelli","doi":"10.1016/j.tjfa.2024.100010","DOIUrl":"https://doi.org/10.1016/j.tjfa.2024.100010","url":null,"abstract":"<p><p>The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force convened in March 2024 to address patient-reported outcomes measures (PROMs) in the field of sarcopenia. PROMs are crucial to enhance healthcare services at both individual and societal levels. PROMs complement objective outcome measures by capturing insights that patients are best suited to judge. In recent years, there has been an increase in the recognition of PROMs' importance within clinical trials by pharmaceutical industries and regulatory agencies. Consequently, it has become imperative to develop valid and reliable tools tailored to capture various aspects of patient's experience and health status. This report aims to present the state-of-the-art available and validated PROMs for sarcopenia that can be used within clinical settings by various stakeholders, and to highlight several research gaps and barriers that need to be addressed to expedite and improve the use of these outcome measures within the context of clinical trials.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 1","pages":"100010"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin tactile perception is associated with longitudinal gait performance in middle-aged and older Japanese community dwellers.","authors":"Rei Otsuka, Shu Zhang, Rumi Kozakai, Chikako Tange, Sayaka Kubota, Kanae Furuya, Fujiko Ando, Hiroshi Shimokata, Yukiko Nishita, Hidenori Arai","doi":"10.1016/j.tjfa.2024.100006","DOIUrl":"https://doi.org/10.1016/j.tjfa.2024.100006","url":null,"abstract":"<p><strong>Background: </strong>Skin tactile perception may indicate frailty in older adults. Although gait performance is crucial for diagnosing frailty, its association with skin tactile perception has not yet been explored.</p><p><strong>Objectives: </strong>To examine the association between skin tactile perception and changes in step length, cadence, and gait speed in middle-aged and older adults.</p><p><strong>Design: </strong>A longitudinal study (mean follow-up: 10.8 years) SETTING: Community-based survey PARTICIPANTS: A total of 1,403 middle-aged and older adults (aged 40-79 years, 53.6 % men) from the National Institute for Longevity Sciences-Longitudinal Study of Aging were included in this study. These participants completed the baseline survey (1997-2000) and at least two follow-up surveys (2000-2012), had no history of cerebrovascular disease, rheumatoid arthritis, or Parkinson's disease, and had complete data with no outliers in skin tactile perception measurements.</p><p><strong>Measurements: </strong>Skin tactile perception was assessed using a two-point discrimination test. Step length (cm), cadence (steps/min), and gait speed (m/min) were evaluated on an 11-m walkway at a usual speed.</p><p><strong>Results: </strong>The mean age of participants was 56.4 years. After full adjustment, mixed-effects models with splines revealed that the association between skin tactile perception and gait parameters varied with age. In adults aged 60 and above, we observed non-linear relationships between skin tactile perception and gait parameters. A consistent inflection point around 10 mm in tactile perception was identified across different age groups and gait parameters.</p><p><strong>Conclusions: </strong>Among community-dwelling middle-aged and older Japanese adults, skin tactile perception was associated with changes in gait parameters, particularly in those aged 60 and above. The 10-mm threshold in tactile perception may serve as a critical indicator for predicting changes in gait performance. Skin tactile perception tests may prove clinically useful for screening patients at elevated risk of impaired gait performance.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 1","pages":"100006"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age Self Care-Resilience, a medical group visit program targeting pre-frailty: A mixed methods pilot clinical trial.","authors":"Julia V Loewenthal, Wren Burton, Shaida Kamali, Subha Ramani, Peter M Wayne, Ariela R Orkaby, Louise Aronson","doi":"10.1016/j.tjfa.2024.100005","DOIUrl":"https://doi.org/10.1016/j.tjfa.2024.100005","url":null,"abstract":"<p><strong>Background: </strong>Pre-frailty is highly prevalent and multimodal lifestyle interventions are effective for preventing transition to frailty. However, little is known about the potential for medical group visits (MGV) to prevent frailty progression.</p><p><strong>Objectives: </strong>To assess the feasibility and acceptability of the MGV Age Self Care-Resilience.</p><p><strong>Design: </strong>Single-arm mixed methods pilot clinical trial.</p><p><strong>Setting: </strong>Virtual MGV delivered in an ambulatory setting at a U.S. academic medical center.</p><p><strong>Participants: </strong>Community-dwelling older adults (n = 11; age 65+) with pre- to mild frailty.</p><p><strong>Intervention: </strong>Age Self Care-Resilience, an 8-week virtual MGV (90-minute sessions once per week) with sessions focused on physical activity, nutrition, social engagement, mind-body practice, and home environment modification.</p><p><strong>Measurements: </strong>Primary outcomes were feasibility of recruitment, attendance, satisfaction, and feasibility of study measurements, collected via quantitative and qualitative approaches. Exploratory outcomes included frailty, psychosocial health, and physical function.</p><p><strong>Results: </strong>A priori feasibility criteria were met for recruitment, with 15 (48 %) of those screened (31) meeting eligibility criteria, 11 (35 %) enrolling (mean age 74.5 yrs), and recruitment completed in less than one month. The nine participants who completed the study attended a mean of 7.2 of 8 sessions and completed 100 % of baseline and follow-up study measures; participants completed 58 % of the home practice log. Themes from participant interviews included: (1) mixed reactions to the recruitment term \"pre-frailty;\" (2) finding group participation as meaningful and empowering; and (3) perception that the program positively changed attitudes and lifestyle behaviors.</p><p><strong>Conclusions: </strong>Age Self Care-Resilience is feasible and acceptable to pre- to mildly frail older adults. Next steps include evaluating the efficacy of Age Self Care-Resilience for preventing frailty progression with a fully powered randomized controlled trial.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 1","pages":"100005"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}