Journal of Frailty & Aging最新文献

{"title":"Phase angle is related to physical function in high-risk Dutch older adults: implications for sarcopenia screening.","authors":"Pol Grootswagers, Alice Ricco, Paul Hulshof, Lisette de Groot","doi":"10.1016/j.tjfa.2025.100071","DOIUrl":"10.1016/j.tjfa.2025.100071","url":null,"abstract":"<p><strong>Introduction: </strong>Sarcopenia, a progressive age-related loss of skeletal muscle mass and function, poses significant health risks in older adults. Phase angle (PhA), derived from bioimpedance analysis, has been proposed as an indicator of muscle quality and physical functioning. This study investigates the association between PhA and physical function, and its potential utility in case-finding phase of sarcopenia assessment based on EWGSOP2 functional cut-offs.</p><p><strong>Methods: </strong>This cross-sectional observational study used baseline data from two clinical trials involving Dutch older adults (≥65 years, n=228) at risk of malnutrition or frailty. PhA was measured using multi-frequency bioimpedance vector analysis. Physical functioning was assessed through handgrip strength, knee extension strength, chair rise test, and gait speed (4m and 400-m/6-min walk tests). Associations were evaluated using linear mixed models adjusted for age, gender, height, and lean body mass. Receiver-operating characteristic (ROC) analyses identified PhA thresholds for low performance based on EWGSOP2 cut-offs.</p><p><strong>Results: </strong>PhA was significantly associated with all performance outcomes in crude models. After adjustment, each unit increase in PhA was associated with a 43.5 ± 8.4 N increase in knee extension strength (P < 0.0001), a 1.5 ± 0.4 s reduction in chair rise time (P = 0.0004), and a 0.14 ± 0.02 m/s increase in gait speed (P < 0.0001). Associations with handgrip strength became non-significant after full adjustment. A PhA threshold of 5.4° showed high sensitivity (0.96) for detecting low physical performance via the chair rise test. However, misclassification rates exceeded 25 %.</p><p><strong>Conclusions: </strong>PhA is associated with physical function, particularly lower-body performance measures, but without muscle mass assessment, it cannot support a complete diagnosis of sarcopenia. It may be valuable as a case-finding tool in older adults at risk.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100071"},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"15^th International Conference on Frailty & Sarcopenia Research (ICFSR) March 12-14, 2025 Toulouse, France Conference proceedings.","authors":"","doi":"10.1016/j.tjfa.2025.100095","DOIUrl":"10.1016/j.tjfa.2025.100095","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 1S","pages":"100095"},"PeriodicalIF":3.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"15^th International Conference on Frailty & Sarcopenia Research (ICFSR) March 12-14, 2025 Toulouse, France Conference proceedings.","authors":"","doi":"10.1016/j.tjfa.2025.100096","DOIUrl":"10.1016/j.tjfa.2025.100096","url":null,"abstract":"","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 1S","pages":"100096"},"PeriodicalIF":3.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bidirectional relationship between knee osteoarthritis and frailty in China: A longitudinal study.","authors":"Ziwei Tian, Huimin Zhao, Yanping Zhai, Zhilan Yang","doi":"10.1016/j.tjfa.2025.100087","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100087","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis is a common disease that causes disability and loss of independence in middle-aged and older adults, and may interact with frailty through shared pathways. Understanding their bidirectional relationship is clinically meaningful for early intervention. This study aimed to investigate the associations between knee osteoarthritis and frailty among middle-aged and older adults in China.</p><p><strong>Methods: </strong>The data for this study came from three waves (baseline 2011, follow-up 2013 and 2015) of the China Health and Retirement Longitudinal Study (CHARLS). A total of 3560 participants were included. Frailty was assessed with the Frailty Index. Knee osteoarthritis was defined as physician-diagnosed arthritis with self-reported knee pain. Longitudinal bidirectional relationships were found using cross-lagged panel models and random-intercept cross-lagged panel models.</p><p><strong>Results: </strong>A longitudinal bidirectional relationship between knee osteoarthritis and frailty was observed, with a stronger effect of frailty on subsequent knee osteoarthritis (Wald χ² = 11.416, P < 0.001). At the between-person level, individuals with knee osteoarthritis also tend to have a higher risk of frailty (β= 0.454, P < 0.001). At the within-person level, the predictive effect of knee osteoarthritis on frailty was significant only in the long term (β=0.055, P < 0.05). Subgroup analyses showed that this longitudinal bidirectional relationship was particularly strong among females as well as those with low education levels.</p><p><strong>Conclusions: </strong>This study reveals a longitudinal bidirectional relationship between knee osteoarthritis and frailty in middle-aged and older adults. In particular, the dominant role of frailty in the development of knee osteoarthritis was found, as well as the negative impact of knee osteoarthritis accumulation on frailty over time. This result suggests that targeting frailty early interventions in an ageing society may help to interrupt the vicious cycle of knee osteoarthritis and reduce the risk of disability. It provides a scientific basis for public health strategies.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100087"},"PeriodicalIF":3.3,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty Nexus: Community of practice for frailty researchers and healthcare professionals.","authors":"Benignus Logan, Adrienne Young, Kristiana Ludlow, David Ward, Leila Shafiee Hanjani, Natasha Reid, Ruth E Hubbard","doi":"10.1016/j.tjfa.2025.100074","DOIUrl":"10.1016/j.tjfa.2025.100074","url":null,"abstract":"<p><strong>Background: </strong>There has been success in implementing frailty education for healthcare professionals, but there remains a need to improve the knowledge and skills of researchers and healthcare professionals to develop, implement and evaluate frailty-focused research.</p><p><strong>Objectives: </strong>This paper describes how the Australian Frailty Network developed and evaluated a virtual community of practice (VCOP), a proven model for fostering knowledge mobilisation, to support researchers and healthcare professionals in advancing frailty research and practice in Australia.</p><p><strong>Design: </strong>Mixed methods.</p><p><strong>Setting: </strong>Australian research and healthcare workplaces.</p><p><strong>Participants: </strong>Researchers and healthcare professionals.</p><p><strong>Measurements: </strong>A survey of prospective members sought to define the VCOP's purpose, membership and structure. An evaluation was undertaken 18 months post-commencement, guided by the RE-AIM framework to assess reach, effectiveness, adoption, implementation and maintenance.</p><p><strong>Results: </strong>Fifty-five prospective members completed the initial survey. There was wide agreement from respondents to be inclusive in defining membership. The preferred purposes of the group included networking, opportunities to gain feedback, review frailty research, and knowledge and skill acquisition. In response, Frailty Nexus was launched, with three core components ('Learning Link-Up', online learning events; 'Nexus News', newsletter sharing learning and research opportunities; 'Nexus Nook', a library of shared resources). Membership totalled 618 from 81 organisations. Ninety-six percent of surveyed members expressed satisfaction with Frailty Nexus.</p><p><strong>Conclusions: </strong>Frailty Nexus is contributing to capacity building in multidisciplinary and translational frailty research. This VCOP could serve as a model that can be adapted by others to improve research outcomes and policy implementation.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100074"},"PeriodicalIF":3.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Built-in healthcare applications reveal step changes associated with temperature, transportation, and marital status among urban cities in Japan.","authors":"Nobuhiko Wakai, Taiga Yamada, Hiroyuki Tomoyama, Shigehiro Iida","doi":"10.1016/j.tjfa.2025.100059","DOIUrl":"10.1016/j.tjfa.2025.100059","url":null,"abstract":"<p><strong>Background: </strong>Walking is a fundamental daily activity representing health status and physical condition. The number of steps taken in a given time period is widely used in research areas such as aging, geriatrics, gerontology, public health, and preventive medicine. However, the underlying mechanisms of step counts are not well understood.</p><p><strong>Objectives: </strong>To investigate daily step counts associated with temperature, transportation, and marital status.</p><p><strong>Design: </strong>Time series analysis of daily steps using built-in healthcare applications on smartphones.</p><p><strong>Setting: </strong>Government-designated, well-developed urban cities in Japan: Fukuoka, Kawasaki, Kobe, Kyoto, and Saitama.</p><p><strong>Participants: </strong>Respondents totaled 622 40- to 79-year-olds, comprising 370 males and 252 females.</p><p><strong>Measurements: </strong>The mean period of our retrospective data was 2,344 days.</p><p><strong>Results: </strong>Seasonal-trend decomposition using loess was applied to time series steps. With the high coefficient of determination R²: 0.798, an absolute value function was fitted between temperature and the mean daily steps of the seasonal component. Furthermore, ordinary train usage in Saitama, Kawasaki, and Fukuoka was significantly greater than that in Kobe and Kyoto by 14.1 points (p=0.001). Moreover, married and divorced or bereaved males' mean daily step counts were significantly larger than those of females' by 1,832 (p=0.001) and 2,480 (p=0.001), respectively. By contrast, the difference in the mean daily step counts for unmarried males and females was only 100.</p><p><strong>Conclusions: </strong>This study presents significant associations between mean daily steps and the factors of temperature, transportation, and marital status. These associations can alleviate biases in step research by area and season to facilitate better step count comparisons in many research fields.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100059"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sarcopenia operationalized using muscle strength or power and health-related parameters.","authors":"Hélio José Coelho Júnior, Alejandro Álvarez-Bustos, Riccardo Calvani, Stefano Cacciatore, Anna Picca, Matteo Tosato, Francesco Landi, Emanuele Marzetti","doi":"10.1016/j.tjfa.2025.100062","DOIUrl":"10.1016/j.tjfa.2025.100062","url":null,"abstract":"<p><strong>Background and objectives: </strong>The present study examined the associations between sarcopenia, operationalized through muscle strength or muscle power, and health parameters in Italian community-dwelling older adults.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Unconventional settings across Italy.</p><p><strong>Participants: </strong>Italian older adults (65+ years) who provided a written informed consent.</p><p><strong>Measurements: </strong>Physical function was evaluated according to isometric handgrip strength (IHG) and 5-time sit-to-stand (5STS) performances. Muscle power parameters were estimated based on 5STS values. Sarcopenia was operationalized according to the presence of low physical function (i.e., IHG or 5STS), or low muscle power, plus low appendicular skeletal muscle mass. Health parameters included the capacity to perform the 400 m test, adherence to the Mediterranean (MED) diet, practice of physical activity (PA), blood pressure (BP) values, blood concentration of total cholesterol and glucose, verbal fluency, sleep quality, and self-reported health status.</p><p><strong>Results: </strong>Results indicated that sarcopenic indexes had a poor-to-moderate level of agreement. Moreover, results indicated that operationalizing sarcopenia using muscle power measures provided exclusive or stronger associations with health parameters. Specifically, older adults classified as sarcopenic based on muscle power values were less likely to complete the 400-meter walk test, more likely to engage in PA, reported poorer self-rated health, and showed lower adherence to the MED diet.</p><p><strong>Conclusions: </strong>Findings of the present study indicated that sarcopenia indexes based on muscle strength or muscle power capture different aspects of older adults' health. Specifically, operationalizing sarcopenia using muscle power measures provided exclusive or stronger associations with health parameters.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100062"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain as a mediator in the falls-frailty association: Evidence from middle-aged and older ethnic minorities in Yunnan, China.","authors":"Xuan Wen, Rui Deng, Xinping Wang, Chunyan Deng, Xiaoju Li, Yafang Zhang, Ying Chen, Yuan Huang","doi":"10.1016/j.tjfa.2025.100050","DOIUrl":"10.1016/j.tjfa.2025.100050","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Falls are associated with an increased risk of frailty in middle-aged and older adults; however, the mediating role between falls and frailty remains underexplored, particularly among ethnic minority groups with distinct sociocultural and environmental exposures. Ethnic minority populations exhibit significant disparities in the prevalence of falls, frailty, and chronic pain compared to the majority. The primary objective of this study is to examine the relationship between falls and frailty in middle-aged and elderly individuals residing in Yunnan Province, China, with a specific emphasis on exploring the potential mediating effect of chronic pain across different ethnic groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Employing a cross-sectional design, data were collected from July to December 2022 from adults aged ≥45 years in five ethnically diverse counties of Yunnan Province, China. Structured face-to-face interviews and stratified multistage cluster sampling were used for data collection. Baron and Kenny's causal steps method was used to explore the mediating effect of chronic pain on the relationship between falls and frailty. Spearman correlation analysis, multiple linear regression models, and bootstrap method were used for data analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 2710 respondents participated in this study. The age distribution was as follows: 1161 (42.84 %) aged 45-59 years, 863 (31.85 %) aged 60-69 years, and 686 (25.31 %) aged 70 years or older. The sample comprised 1218 males (44.94 %) and 1492 females (55.06 %). The prevalence of falls among middle-aged and older individuals was 12.77 %, while the prevalence of frailty in the same population was observed to be 21.62 %. Spearman correlation analysis revealed significant positive association between chronic pain and both falls (r = 0.135, P &lt; 0.05) as well as frailty (r = 0.383, P &lt; 0.05). Frailty also exhibited a significant positive correlation with falls (r = 0.162, P &lt; 0.05). After adjusting for all covariates, the total effect of falls on frailty was estimated to be 1.065 (95 % bootstrap CI: 0.804∼1.326), with a direct effect estimate of 0.797 (95 % bootstrap CI: 0.511∼1.083). The indirect effect of chronic pain on this association was found to be approximately one-quarter at 0.268 (95 % bootstrap CI: 0.170∼0.366). The subgroup analysis discovered differences in the mediating effects across different ethnic groups; specifically, the proportions mediated by chronic pain were found to be 28.2 %, 18.4 %, and 21.5 % for Han majority group, Zhiguo ethnic minorities, and other ethnic minority groups, respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study provides valuable insights into the intricate association between frailty, falls, and chronic pain among middle-aged and older adults from diverse ethnic backgrounds in a western province of China. Effective management strategies targeting chronic pain and falls prevention could serve as ","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 4","pages":"100050"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty moderates the relation between moderate-to-vigorous physical activity & stationary time with knee osteoarthritis symptoms.","authors":"Sophie E Rayner, Selena P Maxwell, Jocelyn Waghorn, Rebecca Moyer, Kenneth Rockwood, Olga Theou, Myles W O'Brien","doi":"10.1016/j.tjfa.2025.100077","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100077","url":null,"abstract":"<p><p>Physical activity is protective against osteoarthritic development and is among the best approaches to manage frailty, which can be characterized as the presence of health deficits. It is unclear whether overall health of a person influences the relation between physical activity and knee-joint health.</p><p><strong>Objective: </strong>Test the hypothesis that physical activity is associated with knee osteoarthritis symptoms and investigate frailty as a moderator.</p><p><strong>Design: </strong>This cohort observational study included participants (n = 1351; 728 females) from the Osteoarthritis Initiative, aged 45-79 (60±9) years. Hip-worn accelerometers were used to quantify free-living stationary time, light (LPA) and moderate-to-vigorous-physical-activity (MVPA). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) defined symptom progression. Baseline frailty was determined via a 31-item Frailty Index and participants grouped into Non-Frail (0-0.09), Very-Mild Frailty (0.1-0.19), and Mild Frailty+ (>0.2). Accelerometry and WOMAC were determined at 72-month follow-up.</p><p><strong>Results: </strong>MVPA (18±19mins/day) was negatively related to WOMAC outcomes (β<-0.0155, p < 0.0022), while LPA (274±79mins/day) was not (β<0.0005, p > 0.3061). Stationary time (606±88mins/day) was positively associated with WOMAC stiffness (β=0.0009, p = 0.0147). Frailty (0.134±0.077) did not moderate LPA and WOMAC relations (p > 0.308). A stronger negative relation between MVPA and WOMAC pain (β=-0.0092, p = 0.041) was observed in the Mild Frailty+ group compared to the Very-Mild Frailty and Non-Frail groups. A stronger positive relation between Stationary time and WOMAC stiffness (β=0.0013, p = 0.012) was observed in the Mild Frailty+ groups compared to the Very-Mild Frailty and Non-Frail groups.</p><p><strong>Conclusion: </strong>Engaging in MVPA and limiting stationary time may be more beneficial on knee osteoarthritis pain and stiffness among frailer older adults.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100077"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive management of frailty. A broader perspective of implementation project \"Systemic Approach to Frailty with a Focus on Pre-Frailty for Healthy and High-Quality Aging\".","authors":"Branko Gabrovec, Nadja Cirar, Katarina Cesar, Rade Pribakovič Brinovec, Matej Vinko, Nina Pirnat, Urška Erklavec, Hajdi Kosednar, Jernej Bevk, Ivan Eržen, Tajda Golja, Anja Jutraž","doi":"10.1016/j.tjfa.2025.100075","DOIUrl":"https://doi.org/10.1016/j.tjfa.2025.100075","url":null,"abstract":"<p><p>Managing pre-frailty and frailty is crucial for maintaining the health and independence of older adults. Through \"Systemic Approach to Frailty with a Focus on Pre-Frailty for Healthy and High-Quality Aging\" project, Slovenia is establishing a systematic approach to identify and address frailty, while developing solutions to support preventive measures across healthcare and community levels. Key steps include integrating health and social care systems, strengthening health literacy, adapting and co-creating healthy living environments through a community-based approach and social participation, all essential for promoting healthier and higher-quality aging in the population. This paper outlines the innovative conceptual and methodological approach to project development and its anticipated outcomes.</p>","PeriodicalId":51629,"journal":{"name":"Journal of Frailty & Aging","volume":"14 5","pages":"100075"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}