Sophie E Rayner, Selena P Maxwell, Jocelyn Waghorn, Rebecca Moyer, Kenneth Rockwood, Olga Theou, Myles W O'Brien
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引用次数: 0
Abstract
Physical activity is protective against osteoarthritic development and is among the best approaches to manage frailty, which can be characterized as the presence of health deficits. It is unclear whether overall health of a person influences the relation between physical activity and knee-joint health.
Objective: Test the hypothesis that physical activity is associated with knee osteoarthritis symptoms and investigate frailty as a moderator.
Design: This cohort observational study included participants (n = 1351; 728 females) from the Osteoarthritis Initiative, aged 45-79 (60±9) years. Hip-worn accelerometers were used to quantify free-living stationary time, light (LPA) and moderate-to-vigorous-physical-activity (MVPA). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) defined symptom progression. Baseline frailty was determined via a 31-item Frailty Index and participants grouped into Non-Frail (0-0.09), Very-Mild Frailty (0.1-0.19), and Mild Frailty+ (>0.2). Accelerometry and WOMAC were determined at 72-month follow-up.
Results: MVPA (18±19mins/day) was negatively related to WOMAC outcomes (β<-0.0155, p < 0.0022), while LPA (274±79mins/day) was not (β<0.0005, p > 0.3061). Stationary time (606±88mins/day) was positively associated with WOMAC stiffness (β=0.0009, p = 0.0147). Frailty (0.134±0.077) did not moderate LPA and WOMAC relations (p > 0.308). A stronger negative relation between MVPA and WOMAC pain (β=-0.0092, p = 0.041) was observed in the Mild Frailty+ group compared to the Very-Mild Frailty and Non-Frail groups. A stronger positive relation between Stationary time and WOMAC stiffness (β=0.0013, p = 0.012) was observed in the Mild Frailty+ groups compared to the Very-Mild Frailty and Non-Frail groups.
Conclusion: Engaging in MVPA and limiting stationary time may be more beneficial on knee osteoarthritis pain and stiffness among frailer older adults.
期刊介绍：
The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons. The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).
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