虚弱调节中度至剧烈体力活动和静止时间与膝关节骨关节炎症状的关系。

IF 3.3 Q2 GERIATRICS & GERONTOLOGY

Journal of Frailty & Aging Pub Date : 2025-08-01 DOI:10.1016/j.tjfa.2025.100077

Sophie E Rayner, Selena P Maxwell, Jocelyn Waghorn, Rebecca Moyer, Kenneth Rockwood, Olga Theou, Myles W O'Brien

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引用次数: 0

摘要

身体活动可以防止骨关节炎的发展，是管理虚弱的最佳方法之一，虚弱可以被描述为存在健康缺陷。目前还不清楚一个人的整体健康状况是否会影响体力活动与膝关节健康之间的关系。目的：检验体力活动与膝骨关节炎症状相关的假设，并探讨虚弱作为调节因素的作用。设计：本队列观察性研究纳入受试者(n = 1351；728名女性)，年龄45-79（60±9）岁。使用穿戴在臀部的加速度计来量化自由生活的静止时间、轻度（LPA）和中度至剧烈的身体活动（MVPA）。西安大略和麦克马斯特大学骨关节炎指数（WOMAC）定义了症状进展。基线虚弱是通过31项虚弱指数来确定的，参与者分为非虚弱（0-0.09），非常轻微虚弱（0.1-0.19）和轻度虚弱+(>0.2)。在72个月的随访中测定加速度计和WOMAC。结果：MVPA（18±19min /day）与WOMAC结果呈负相关（β 0.3061）。静止时间（606±88min /day）与WOMAC刚度呈正相关（β=0.0009, p = 0.0147）。虚弱（0.134±0.077）没有调节LPA和WOMAC的关系（p < 0.308）。与极轻度虚弱组和非虚弱组相比，轻度虚弱+组的MVPA与WOMAC疼痛呈较强的负相关（β=-0.0092, p = 0.041）。与极轻度虚弱组和非虚弱组相比，在轻度虚弱+组中，静止时间与WOMAC刚度之间存在更强的正相关（β=0.0013, p = 0.012）。结论：参与MVPA和限制静止时间可能对虚弱的老年人膝关节骨关节炎疼痛和僵硬更有益。

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Frailty moderates the relation between moderate-to-vigorous physical activity & stationary time with knee osteoarthritis symptoms.

Physical activity is protective against osteoarthritic development and is among the best approaches to manage frailty, which can be characterized as the presence of health deficits. It is unclear whether overall health of a person influences the relation between physical activity and knee-joint health.

Objective: Test the hypothesis that physical activity is associated with knee osteoarthritis symptoms and investigate frailty as a moderator.

Design: This cohort observational study included participants (n = 1351; 728 females) from the Osteoarthritis Initiative, aged 45-79 (60±9) years. Hip-worn accelerometers were used to quantify free-living stationary time, light (LPA) and moderate-to-vigorous-physical-activity (MVPA). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) defined symptom progression. Baseline frailty was determined via a 31-item Frailty Index and participants grouped into Non-Frail (0-0.09), Very-Mild Frailty (0.1-0.19), and Mild Frailty+ (>0.2). Accelerometry and WOMAC were determined at 72-month follow-up.

Results: MVPA (18±19mins/day) was negatively related to WOMAC outcomes (β<-0.0155, p < 0.0022), while LPA (274±79mins/day) was not (β<0.0005, p > 0.3061). Stationary time (606±88mins/day) was positively associated with WOMAC stiffness (β=0.0009, p = 0.0147). Frailty (0.134±0.077) did not moderate LPA and WOMAC relations (p > 0.308). A stronger negative relation between MVPA and WOMAC pain (β=-0.0092, p = 0.041) was observed in the Mild Frailty+ group compared to the Very-Mild Frailty and Non-Frail groups. A stronger positive relation between Stationary time and WOMAC stiffness (β=0.0013, p = 0.012) was observed in the Mild Frailty+ groups compared to the Very-Mild Frailty and Non-Frail groups.

Conclusion: Engaging in MVPA and limiting stationary time may be more beneficial on knee osteoarthritis pain and stiffness among frailer older adults.

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来源期刊

Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-

CiteScore

5.90

自引率

7.70%

发文量

期刊介绍： The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons. The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).