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Safety of brigatinib following alectinib-induced-pneumonitis: Case report 阿勒替尼致肺炎后布加替尼的安全性：病例报告
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2024.102160
Blerina Resuli , Heidi Galarza , Laura Elsner , Diego Kauffmann-Guerrero , Jürgen Behr , Amanda Tufman
{"title":"Safety of brigatinib following alectinib-induced-pneumonitis: Case report","authors":"Blerina Resuli ,&nbsp;Heidi Galarza ,&nbsp;Laura Elsner ,&nbsp;Diego Kauffmann-Guerrero ,&nbsp;Jürgen Behr ,&nbsp;Amanda Tufman","doi":"10.1016/j.rmcr.2024.102160","DOIUrl":"10.1016/j.rmcr.2024.102160","url":null,"abstract":"<div><div>Anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK TKIs) show robust efficacy and has revolutionized the treatment of NSCLC patients harboring an ALK-rearrangement. Side effects, sometimes even serious such as pneumonitis, can occur with ALK TKIs.</div><div>We report a case of a patient with ALK positive advanced NSCLC who developed pneumonitis during treatment with first-line alectinib. With no alternative etiology of pneumonitis identified, the patient was treated with corticosteroids and discontinuation of alectinib. Following rapid clinical recovery and radiographic resolution of the opacities, the patient was started with brigatinib, with no recurrence of the clinical symptoms or radiographic findings of pneumonitis. While further descriptions are needed, our experience suggests that switching to a second ALK-TKI may be a safe therapeutic option in some patients who develop drug-induced pneumonitis on ALK TKIs.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"53 ","pages":"Article 102160"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solitary metastasis in the internal auditory canal from non-small cell lung carcinoma: A case report
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102175
Julie De Boos , Marie Bruyneel , Ionela Bold
{"title":"Solitary metastasis in the internal auditory canal from non-small cell lung carcinoma: A case report","authors":"Julie De Boos ,&nbsp;Marie Bruyneel ,&nbsp;Ionela Bold","doi":"10.1016/j.rmcr.2025.102175","DOIUrl":"10.1016/j.rmcr.2025.102175","url":null,"abstract":"<div><h3>Background</h3><div>Metastases to the internal auditory canal (IAC) are exceedingly rare. This case report details the case of a patient with a history of locally advanced non-small cell lung carcinoma (NSCLC) who developed a solitary IAC metastasis.</div></div><div><h3>Case presentation</h3><div>A 59-year-old active smoker was initially diagnosed with a locally advanced, unresectable stage IIIA Pancoast tumor (NSCLC, cT4N1M0) and treated with concurrent chemoradiation (cisplatin-pemetrexed) followed by immunotherapy (durvalumab). A subsequent PET CT scan indicated a complete metabolic response. Eighteen months later, the patient presented with rapidly progressing vertigo, left-sided facial palsy, and hearing loss. MRI revealed enhancement on nerves VII and VIII, with no intracranial metastasis or leptomeningeal enhancement. A biopsy via an endoscope-assisted retrosigmoid approach confirmed that it was an NSCLC metastasis. Gamma knife radiosurgery was initiated, resulting in a favorable clinical and radiological response.</div></div><div><h3>Discussion</h3><div>IAC metastases are rare, representing only 0.3%–0.7 % of all lesions in this anatomical space. Lung cancer is a common primary source. Clinically, IAC metastases manifest with acute onset and rapid symptom progression, often mimicking benign conditions. MRI with gadolinium contrast is the imaging modality of choice. Biopsy, though challenging, is sometimes crucial for definitive diagnosis. Gamma knife radiosurgery is a promising treatment, offering potential preservation of hearing and tumor control.</div></div><div><h3>Conclusion</h3><div>This rare case underscores the importance of considering metastatic IAC lesions in patients with a history of malignancy, highlights the feasibility of a biopsy via retrosigmoid approach for diagnosis, and demonstrates the effectiveness of gamma knife radiosurgery.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"53 ","pages":"Article 102175"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary artery aneurysm as a rare manifestation of Alpha-1 antitrypsin deficiency
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2024.102164
Mark A. Colantonio , Sanjana Aggarwal , Himanshu Deshwal
{"title":"Pulmonary artery aneurysm as a rare manifestation of Alpha-1 antitrypsin deficiency","authors":"Mark A. Colantonio ,&nbsp;Sanjana Aggarwal ,&nbsp;Himanshu Deshwal","doi":"10.1016/j.rmcr.2024.102164","DOIUrl":"10.1016/j.rmcr.2024.102164","url":null,"abstract":"<div><div>Alpha-1 antitrypsin is a relatively well-known genetic disease known to primarily affect the lungs and liver. Extrapulmonary manifestations of this disease have been reported, including vascular aneurysms. To date, few cases have reported vascular manifestations of this disease affecting the pulmonary vasculature. Here, we present a rare manifestation of alpha-1 antitrypsin deficiency leading to a saccular pulmonary artery aneurysm.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"53 ","pages":"Article 102164"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New onset bronchial asthma following oral propranolol for infantile hemangioma
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102187
Yuki Yamaguchi, Satoshi Horino, Hiroki Miyabayashi, Haruka Aki, Katsushi Miura
{"title":"New onset bronchial asthma following oral propranolol for infantile hemangioma","authors":"Yuki Yamaguchi,&nbsp;Satoshi Horino,&nbsp;Hiroki Miyabayashi,&nbsp;Haruka Aki,&nbsp;Katsushi Miura","doi":"10.1016/j.rmcr.2025.102187","DOIUrl":"10.1016/j.rmcr.2025.102187","url":null,"abstract":"<div><div>Propranolol, a nonselective adrenergic beta-receptor blocker, is the first-line drug used for the treatment of infantile hemangiomas (IH). However, its use is contraindicated in patients with bronchial asthma. Nevertheless, studies assessing whether propranolol triggers asthma in infants and affects asthma control are limited. Here, we report the case of an infant with IH who developed asthma after starting propranolol. Asthma control was refractory to inhaled corticosteroids and leukotriene receptor antagonists, although it improved remarkably with discontinuation of propranolol. This report suggests that infants with a family history of allergic disorders should be monitored for asthma after propranolol administration.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"54 ","pages":"Article 102187"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary metastasis originating from colonic mucinous adenocarcinoma with a tree-in-bud pattern on computed tomography: A case report
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102192
Kensuke Takei , Hiroki Mori , Katsuyuki Asai
{"title":"Pulmonary metastasis originating from colonic mucinous adenocarcinoma with a tree-in-bud pattern on computed tomography: A case report","authors":"Kensuke Takei ,&nbsp;Hiroki Mori ,&nbsp;Katsuyuki Asai","doi":"10.1016/j.rmcr.2025.102192","DOIUrl":"10.1016/j.rmcr.2025.102192","url":null,"abstract":"<div><div>The tree-in-bud pattern, a chest computed tomography (CT) finding, is occasionally associated with malignant tumors. We report a surgical case of pulmonary metastasis from colonic mucinous adenocarcinoma presenting with a tree-in-bud pattern on chest CT. A 50-year-old man underwent surgery for descending colon cancer, which was histopathologically diagnosed as well-differentiated mucinous adenocarcinoma. During follow-up after adjuvant chemotherapy, chest CT revealed nodules with linear branching patterns in the left lung segments S9 and S10, consistent with a tree-in-bud pattern. Diagnostic thoracoscopic wedge resection of the left S9 was performed to exclude inflammatory disease, confirming metastatic colonic adenocarcinoma. Subsequently, 1 month later, left S10 segmentectomy was conducted. Histopathological examination revealed mucus filling the bronchioles in the affected area. This finding indicates that pulmonary metastases from colonic mucinous adenocarcinomas may present as a tree-in-bud pattern. CT findings of this pattern in patients with a history of colon cancer with extracellular mucus require thorough evaluation.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"54 ","pages":"Article 102192"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endobronchial tuberculosis mimicking malignancy: Lessons from a case report
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102201
Tomohito Okano , Hajime Fujimoto , Toshiyuki Ito , Atsushi Tomaru , Haruko Saiki , Tatsuki Tsuruga , Taro Yasuma , Corina N. D'Alessandro-Gabazza , Esteban C. Gabazza , Tetsu Kobayashi
{"title":"Endobronchial tuberculosis mimicking malignancy: Lessons from a case report","authors":"Tomohito Okano ,&nbsp;Hajime Fujimoto ,&nbsp;Toshiyuki Ito ,&nbsp;Atsushi Tomaru ,&nbsp;Haruko Saiki ,&nbsp;Tatsuki Tsuruga ,&nbsp;Taro Yasuma ,&nbsp;Corina N. D'Alessandro-Gabazza ,&nbsp;Esteban C. Gabazza ,&nbsp;Tetsu Kobayashi","doi":"10.1016/j.rmcr.2025.102201","DOIUrl":"10.1016/j.rmcr.2025.102201","url":null,"abstract":"<div><div>Endobronchial tuberculosis is characterized by the presence of tuberculous lesions within the bronchi, irrespective of the formation of pulmonary lesions. When these lesions are visible, their morphology often raises the differential diagnosis of malignancy. Diagnostic challenges arise as sputum smear tests—crucial for mycobacterial identification—may yield negative results in up to half of the cases. Here, we present a 66-year-old male who exhibited clinical and radiological findings suggestive of malignancy but was ultimately diagnosed with endobronchial tuberculosis through a combination of bronchoscopy, histopathology, and polymerase chain reaction testing. The patient responded favorably to anti-tuberculosis therapy. This case underscores the importance of comprehensive diagnostic strategies for endobronchial tuberculosis, particularly in distinguishing it from tracheal malignancies.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"55 ","pages":"Article 102201"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case study of airway management using laryngeal mask airway combined with Bronchial blocker for surgical treatment of tracheal tumors with pulmonary nodules
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102208
Tingting Hu, Jun Yang, Min Xia
{"title":"A case study of airway management using laryngeal mask airway combined with Bronchial blocker for surgical treatment of tracheal tumors with pulmonary nodules","authors":"Tingting Hu,&nbsp;Jun Yang,&nbsp;Min Xia","doi":"10.1016/j.rmcr.2025.102208","DOIUrl":"10.1016/j.rmcr.2025.102208","url":null,"abstract":"<div><div>A 60-year-old female with a tracheal tumor near the glottis and a lung nodule underwent surgery for resection. The tumor's proximity to the glottis prevented the safe use of a tracheal tube, as it risked crossing the tumor and causing injury. Given this challenge, a 4<sup>#</sup> single-lumen laryngeal mask airway (LMA) was used in combination with a 9<sup>#</sup> bronchial blocker to achieve one-lung ventilation. This approach minimized the risk of tracheal injury, bleeding, and tumor dissemination. The procedure, including the resection of the lung nodule and tracheal tumor, was completed successfully, with stable postoperative recovery. This case demonstrates the efficacy of LMA and bronchial blocker in complex airway management.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"55 ","pages":"Article 102208"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis 突破霉菌：高ige综合征作为侵袭性曲霉病的载体。
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2024.102149
Joseph Nordin , Stephen Smetana , Rachel Johnson , Angela Bartosiak , Nicholas Nassif
{"title":"Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis","authors":"Joseph Nordin ,&nbsp;Stephen Smetana ,&nbsp;Rachel Johnson ,&nbsp;Angela Bartosiak ,&nbsp;Nicholas Nassif","doi":"10.1016/j.rmcr.2024.102149","DOIUrl":"10.1016/j.rmcr.2024.102149","url":null,"abstract":"<div><div>Hyperimmunoglobulin E syndrome (HIGES) is a rare immunodeficiency characterized by high levels of immunoglobulin E (IgE) in the setting of various clinical features such as cutaneous candidiasis, asthma, recurrent rashes, and fungal infections. This case describes a 70-year-old male with cachexia and dyspnea found to have a cavitary lesion and aspergilloma, with remarkably high IgE and positive 1,3-β-D-glucan and Aspergillus testing. Herein, we describe the aforementioned case, review the available literature, and hypothesize the connection between invasive fungal infections and HIGES. We hope this discussion helps highlight the importance of a broad differential in chronic dyspnea, including infectious etiologies, and allows for a better understanding of immunologic labs in the setting of fungal infections.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"53 ","pages":"Article 102149"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remarkable response to low dose of selpercatinib in a patient with RET-rearranged non-small cell lung cancer
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102176
Jun Sakakibara-Konishi , Hirofumi Takahashi , Kenichiro Ito , Tomoo Ikari , Yasuyuki Ikezawa , Hidenori Kitai , Megumi Furuta , Yuta Takashima , Tetsuaki Shoji , Masahide Fukudo , Satoshi Konno
{"title":"Remarkable response to low dose of selpercatinib in a patient with RET-rearranged non-small cell lung cancer","authors":"Jun Sakakibara-Konishi ,&nbsp;Hirofumi Takahashi ,&nbsp;Kenichiro Ito ,&nbsp;Tomoo Ikari ,&nbsp;Yasuyuki Ikezawa ,&nbsp;Hidenori Kitai ,&nbsp;Megumi Furuta ,&nbsp;Yuta Takashima ,&nbsp;Tetsuaki Shoji ,&nbsp;Masahide Fukudo ,&nbsp;Satoshi Konno","doi":"10.1016/j.rmcr.2025.102176","DOIUrl":"10.1016/j.rmcr.2025.102176","url":null,"abstract":"<div><div>Chromosomal rearrangements of the <em>RET</em> (rearranged during transfection) gene are detected in approximately 1–2% of non-small cell lung cancers (NSCLC) and have function as oncogenic driver genes. Selpercatinib is a highly effective RET inhibitor for <em>RET</em>-rearranged patients with NSCLC and shows mostly tolerable adverse events. However, hypertension, aspartate aminotransferase increase, and alanine aminotransferase increase are the most common adverse events, and dose modification or discontinuation is required occasionally. Here, we describe a case who has response to 40 mg of selpercatinib every other day because the dose had to be adjusted owing to adverse events such as liver dysfunction. Dose modification of selpercatinib, according to adverse event incidences, may be considered, as selpercatinib may be effective in some cases even at very low concentrations.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"53 ","pages":"Article 102176"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary vascular malformations in genetic epileptic encephalopathy: A rare, fatal case report
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2024.102155
N. Garancini , M. Ghezzi , A. Farolfi , V. Guaia , G. Canali , V. Fabiano , G.V. Zuccotti , E. D'Auria
{"title":"Pulmonary vascular malformations in genetic epileptic encephalopathy: A rare, fatal case report","authors":"N. Garancini ,&nbsp;M. Ghezzi ,&nbsp;A. Farolfi ,&nbsp;V. Guaia ,&nbsp;G. Canali ,&nbsp;V. Fabiano ,&nbsp;G.V. Zuccotti ,&nbsp;E. D'Auria","doi":"10.1016/j.rmcr.2024.102155","DOIUrl":"10.1016/j.rmcr.2024.102155","url":null,"abstract":"<div><div>Mutations of KCNT1 gene, encoding for a sodium-gated potassium channel, are causative of a wide spectrum of epilepsies and neurodevelopmental disorders; cardiovascular involvement also seems to be significant, with cardiac arrhythmia and, less frequently, the development of Systemic to Pulmonary Collateral Arteries (SPCAs) has been reported. We report the case of M., affected by a KCNT1-related drug-resistant epileptic encephalopathy, who presented fatal complications with massive hemoptysis due to SPCAs. We aim to increase the awareness regarding this infrequent but potentially severe clinical condition.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"53 ","pages":"Article 102155"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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