Respiratory Medicine Case Reports最新文献

Successful Early Regression of Giant Pulmonary Artery Aneurysms in Behçet’s Disease Treated with Mycophenolate Mofetil: A Case Report 霉酚酸酯治疗behaperet病巨肺动脉动脉瘤早期消退成功1例

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-03-20 DOI: 10.1016/j.rmcr.2026.102415

abdalrhman alras , Khalid khattab , Abdullah Alfandi , Ali Jumaa , Mohammad Adi , Samar Almoazen , Tasneem Alras , Yaman Alsharef , Aiman Abo Al Shamat

{"title":"Successful Early Regression of Giant Pulmonary Artery Aneurysms in Behçet’s Disease Treated with Mycophenolate Mofetil: A Case Report","authors":"abdalrhman alras , Khalid khattab , Abdullah Alfandi , Ali Jumaa , Mohammad Adi , Samar Almoazen , Tasneem Alras , Yaman Alsharef , Aiman Abo Al Shamat","doi":"10.1016/j.rmcr.2026.102415","DOIUrl":"10.1016/j.rmcr.2026.102415","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary artery aneurysms are a rare but life-threatening manifestation of Behçet’s disease and are associated with a high risk of fatal hemoptysis. Standard treatment typically involves high-dose corticosteroids combined with cyclophosphamide; however, concerns regarding long-term toxicity and fertility preservation have prompted interest in alternative immunosuppressive strategies.</div></div><div><h3>Case Description</h3><div>We report the case of a 20-year-old male who presented with recurrent hemoptysis and systemic inflammatory features and was diagnosed with Behçet’s disease complicated by multiple pulmonary artery aneurysms. Computed tomography pulmonary angiography demonstrated several saccular aneurysms, the largest measuring 52 mm in the right lower-lobe pulmonary artery with partial mural thrombosis. The patient was treated with high-dose corticosteroids followed by oral prednisone in combination with mycophenolate mofetil. At four-week follow-up, inflammatory markers had normalized, and repeat imaging demonstrated regression of the aneurysm sizes without new vascular complications.The patient remained clinically stable and was scheduled for further imaging and rheumatology evaluation at two months.</div></div><div><h3>Conclusions</h3><div>This case highlights mycophenolate mofetil as a potential steroid-sparing immunosuppressive option for pulmonary artery aneurysms in Behçet’s disease.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"61 ","pages":"Article 102415"},"PeriodicalIF":0.7,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147554100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible bronchoscopic cryoablation as definitive treatment for endobronchial hamartoma: A case report 柔性支气管镜冷冻消融术治疗支气管内错构瘤1例

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2025-12-24 DOI: 10.1016/j.rmcr.2025.102350

Akihiko Amano , Takashi Niwa , Masamitsu Hamakawa , Yasushi Fukuda , Toshihide Yokoyama , Tadashi Ishida

{"title":"Flexible bronchoscopic cryoablation as definitive treatment for endobronchial hamartoma: A case report","authors":"Akihiko Amano , Takashi Niwa , Masamitsu Hamakawa , Yasushi Fukuda , Toshihide Yokoyama , Tadashi Ishida","doi":"10.1016/j.rmcr.2025.102350","DOIUrl":"10.1016/j.rmcr.2025.102350","url":null,"abstract":"<div><div>Endobronchial hamartoma is a rare benign tumor that, when located in the central airway, can lead to airway obstruction, hemoptysis, and recurrent respiratory infections. Although various bronchoscopic treatment modalities have been reported, the application of transbronchial cryoablation has rarely been described. We report the case of a 78-year-old man with squamous cell carcinoma in the left lower lobe, in whom a pedunculated tumor was incidentally identified in the left B6 bronchus during video-assisted thoracoscopic surgery. Postoperatively, the patient's performance status declined and additional surgical resection was deemed unfeasible. Transbronchial cryoablation using a flexible cryoprobe was therefore selected as the treatment strategy. The procedure involved resection by cryo-debulking, followed by three cycles of 30-s freezing and thawing applied to each site across the entire resection margin. This intervention was safely completed under sedation without severe complications. Histopathological examination of the resected specimen confirmed the diagnosis of endobronchial hamartoma. Follow-up bronchoscopy at 6 months revealed no evidence of recurrence. This case demonstrates the potential utility of flexible cryoprobe-based cryoablation as a minimally invasive, curative approach for patients who are unsuitable candidates for surgery.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"59 ","pages":"Article 102350"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synchronous occurrence of interstitial lung disease and ICANS after tarlatamab initiation in recurrent small-cell lung cancer 复发性小细胞肺癌塔拉他单抗起始后间质性肺疾病和ICANS的同步发生

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-02-27 DOI: 10.1016/j.rmcr.2026.102395

Masakazu Takahara, Atsuto Mouri, Ou Yamaguchi, Tatsuhiko Uno, Kosuke Hashimoto, Hisao Imai, Hiroshi Kagamu, Kyoichi Kaira

引用次数: 0

Out of the fire into the frying pan: Everolimus-induced organizing pneumonia in a patient with pancreatic neuroendocrine tumor 出了火又进了煎锅：依维莫司致胰腺神经内分泌肿瘤患者组织性肺炎1例。

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-02-17 DOI: 10.1016/j.rmcr.2026.102380

Rabia Riasat, Shirley Felipe, Akshay Avula

{"title":"Out of the fire into the frying pan: Everolimus-induced organizing pneumonia in a patient with pancreatic neuroendocrine tumor","authors":"Rabia Riasat, Shirley Felipe, Akshay Avula","doi":"10.1016/j.rmcr.2026.102380","DOIUrl":"10.1016/j.rmcr.2026.102380","url":null,"abstract":"<div><h3>Background</h3><div>Recently, mTOR inhibitors have emerged as key agents in the treatment of neuroendocrine tumors. Drug-induced pneumonitis is one of the most common causes of adverse drug events, unfortunately leading to treatment cessation.</div></div><div><h3>Case report</h3><div>We report a case of an 81-female with a history of hypertension, CKD, aortic stenosis, and pancreatic neuroendocrine tumor with metastatic liver disease who presented to the ED with persistent fatigue associated with exertional dyspnea, cough, and intermittent chest pain occurring after everolimus dose increase from 5mg to 7.5mg. She was placed on 1L of oxygen to relieve her dyspnea. Pulmonology team was consulted given CT findings concerning for bilateral lower lung multifocal opacities and left lower lobe consolidation, different compared to a recent PET scan. Dedicated CT scan showed organizing pneumonia pattern. She was empirically treated with IV azithromycin and ceftriaxone then discharged on PO amoxicillin-clavulanate with new requirement of 1L of oxygen at rest and 2L on exertion. Everolimus was held until outpatient bronchoscopy. BAL was negative for infectious workup. Cytology showed 10% eosinophil, with pathology confirming focal organizing pneumonia. Her respiratory symptoms and oxygen requirements improved after cessation of everolimus. She was eventually transitioned to cabozantinib instead.</div></div><div><h3>Conclusion</h3><div>Low-threshold for suspicion of everolimus-induced pneumonitis in patients who present with respiratory symptoms after initiation or dose adjustment. Prompt diagnosis leads to avoidance of unnecessary antibiotics and immediate discontinuation and substitution of offending drug. Further research on adjunct therapy is recommended to avoid development of EIP in patients who urgently need therapy.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"60 ","pages":"Article 102380"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tepotinib-induced interstitial lung disease in a patient with adenosquamous lung carcinoma 替波替尼诱发肺腺鳞癌间质性肺疾病1例

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2025-12-30 DOI: 10.1016/j.rmcr.2025.102355

Takeshi Imakura, Soji Kakiuchi, Ikumi Nishimura, Naoya Murakami, Hiroki Yamamoto, Hitomi Kagawa, Mami Inayama, Takashi Haku

引用次数: 0

Psoriasis flare confused with drug allergy: A collaborative effort is required to treat tuberculosis in the setting of severe psoriasis 牛皮癣耀斑与药物过敏混淆：在严重牛皮癣的情况下，需要合作治疗结核病

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI: 10.1016/j.rmcr.2026.102378

Quratulain Kizilbash , Adriana Vasquez , Barbara Seaworth , Lynn Horvath

{"title":"Psoriasis flare confused with drug allergy: A collaborative effort is required to treat tuberculosis in the setting of severe psoriasis","authors":"Quratulain Kizilbash , Adriana Vasquez , Barbara Seaworth , Lynn Horvath","doi":"10.1016/j.rmcr.2026.102378","DOIUrl":"10.1016/j.rmcr.2026.102378","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is a chronic autoimmune disorder. Severe psoriasis is treated with systemic immunosuppressive agents. Systemic immunosuppression increases the risk of tuberculosis (TB) disease. Sudden cessation of immunosuppression seems logical in a TB patient but can lead to psoriasis flares. And when a new rash occurs during TB therapy, drug reaction is usually suspected. This can result in untreated TB disease or intermittent therapy, thus increasing the risk for acquired drug resistance.</div></div><div><h3>Methods</h3><div>We describe two patients who developed TB disease during immunosuppressive therapy for psoriasis. When the immunosuppressive therapy was stopped, due to TB disease, both patients experienced significant worsening of psoriasis. The skin changes were confused with drug reaction to TB medications. Significant treatment interruptions resulted. A single team of TB physicians and one dermatologist, worked in conjunction to formulate a psoriasis and TB treatment plan. The patients were treated with acitretin and cyclosporine systemically along with topical agents to achieve psoriasis control. Then both were sequentially challenged with one TB medication at a time to ensure no drug reaction occurred while monitored at Texas Center for Infectious Disease. Cyclosporine was then tapered off.</div></div><div><h3>Results</h3><div>Both patients tolerated the alternative psoriasis regimen and TB therapy well. Both demonstrated clinical, bacteriologic, and radiographic improvement.</div></div><div><h3>Conclusion</h3><div>Treatment of TB disease in patients with severe psoriasis requires a collaborative effort between the TB treatment team and dermatology. A balanced approach, including treatment of both diseases, is necessary to avoid confusion of psoriasis flare versus drug induced skin reactions from TB medications.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"59 ","pages":"Article 102378"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracheal schwannoma presenting as pneumonia: A rare case report in an adolescent 气管神经鞘瘤表现为肺炎：一例罕见的青少年病例报告。

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-03-12 DOI: 10.1016/j.rmcr.2026.102398

Wanyan Xiong , Zhixuan Deng

{"title":"Tracheal schwannoma presenting as pneumonia: A rare case report in an adolescent","authors":"Wanyan Xiong , Zhixuan Deng","doi":"10.1016/j.rmcr.2026.102398","DOIUrl":"10.1016/j.rmcr.2026.102398","url":null,"abstract":"<div><h3>Background</h3><div>Tracheal schwannoma is a rare benign tumor originating from Schwann cells, and it is even less common in adolescents. The clinical manifestations are usually nonspecific respiratory symptoms such as cough and sputum production, which can easily be mistaken for infectious diseases. Imaging findings often suggest an inflammatory mass, making early diagnosis challenging.</div></div><div><h3>Case presentation</h3><div>A 15-year-old female was admitted with a 3-day history of cough and sputum production and was initially diagnosed with community-acquired pneumonia. High-resolution chest CT and 3D reconstruction revealed a well-defined, mildly to moderately enhanced round nodule (approximately 1.1 × 0.7 cm) in the lower trachea, accompanied by bronchopneumonia. Imaging findings suggested an inflammatory myofibroblastic tumor or inflammatory granuloma. The lesion was completely resected under painless bronchoscopy. Histopathology showed spindle cells arranged in bundles, with strong positive staining for S-100 and SOX-10 and a Ki-67 proliferation index of about 5%, confirming the diagnosis of benign tracheal schwannoma. After postoperative anti-infective therapy, the patient's symptoms rapidly resolved.</div></div><div><h3>Conclusion</h3><div>Although tracheal schwannoma is benign, it may initially present as pneumonia and mimic an inflammatory tumor on imaging, leading to diagnostic confusion. For adolescent patients with recurrent respiratory symptoms and poor response to conventional therapy, early chest CT and bronchoscopy should be considered. Bronchoscopic resection combined with anti-infective therapy can achieve excellent outcomes.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"60 ","pages":"Article 102398"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial pericarditis after endobronchial ultrasound-guided transbronchial needle aspiration 超声引导下经支气管针吸后细菌性心包炎

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-03-23 DOI: 10.1016/j.rmcr.2026.102411

Rachna S. Gulati , Håkon Kravdal , Heidi Hoven , Erlend Eriksen , Hans Kristian Haugland , Tehmina Mustafa

{"title":"Bacterial pericarditis after endobronchial ultrasound-guided transbronchial needle aspiration","authors":"Rachna S. Gulati , Håkon Kravdal , Heidi Hoven , Erlend Eriksen , Hans Kristian Haugland , Tehmina Mustafa","doi":"10.1016/j.rmcr.2026.102411","DOIUrl":"10.1016/j.rmcr.2026.102411","url":null,"abstract":"<div><h3>Background</h3><div>Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a valuable diagnostic and staging tool for lung cancer and is generally considered a safe procedure with very low complication rates. Bacterial pericarditis is a rare but serious complication following EBUS-TBNA. Here we describe a case of bacterial pericarditis that developed after an EBUS-TBNA procedure.</div></div><div><h3>Case summary</h3><div>A 61-year-old woman underwent EBUS-TBNA to investigate a tumor in her right lung. Two weeks after the procedure she presented to the emergency department due to dizziness, nausea and chest pain. Her condition rapidly deteriorated, leading to hypotension and cardiogenic shock. She was diagnosed with bacterial pericarditis resulting in cardiac tamponade. Emergency pericardial drainage was performed and treatment with antibiotics was started along with adjunctive corticosteroids. Although she initially responded well to treatment, she later developed constrictive pericarditis, which caused a slight reduction in cardiac output. She also responded well to treatment with Osimertinib for non-small-cell lung cancer.</div></div><div><h3>Conclusion</h3><div>Bacterial pericarditis following EBUS-TBNA is a rare but severe complication. It has been associated with certain risk factors, particularly sampling necrotic lesions near the pericardium.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"61 ","pages":"Article 102411"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147554012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent catamenial pneumothorax in an adolescent: A case report with review of diagnostic and therapeutic challenges 青少年复发性肠膜性气胸：一个病例报告，回顾诊断和治疗的挑战

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-03-21 DOI: 10.1016/j.rmcr.2026.102401

Alberto Pedraza, Qian Yang, Nicholas Clayton, Oleg Opsha

引用次数: 0

A case of malignant lymphoma with a peripheral pulmonary lesion diagnosed by endobronchial ultrasound-guided needle aspiration using a thin convex-probe endobronchial ultrasound bronchoscope 薄凸探头支气管超声支气管镜下超声引导下针吸诊断恶性淋巴瘤伴肺外周病变1例

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-04-22 DOI: 10.1016/j.rmcr.2026.102428

Atsushi Torii, Tomoya Baba, Toshihiro Ohama, Hiroto Watanabe, Yo Imaeda, Masahide Oki

{"title":"A case of malignant lymphoma with a peripheral pulmonary lesion diagnosed by endobronchial ultrasound-guided needle aspiration using a thin convex-probe endobronchial ultrasound bronchoscope","authors":"Atsushi Torii, Tomoya Baba, Toshihiro Ohama, Hiroto Watanabe, Yo Imaeda, Masahide Oki","doi":"10.1016/j.rmcr.2026.102428","DOIUrl":"10.1016/j.rmcr.2026.102428","url":null,"abstract":"<div><h3>Background</h3><div>Performing biopsies of peripheral lesions adjacent to the bronchus is challenging. Conventionally, transbronchial needle aspiration of peripheral pulmonary nodules is performed using a radial echo probe; however, the diagnostic yield remains controversial. More recently, transbronchial needle aspiration of peripheral pulmonary lesions has been attempted using endobronchial ultrasound guidance (EBUS-TBNA); however, reaching the target is often difficult due to limitations in outer diameter and flexibility.</div></div><div><h3>Case presentation</h3><div>A 39-year-old male, previously diagnosed with diffuse large B-cell lymphoma, underwent chemotherapy and achieved complete remission. However, 8 months after the final chemotherapy session, computed tomography revealed a right peripheral lung lesion and lymphadenopathy. Although the lymphadenopathy suggested recurrence of malignant lymphoma, the lesion in the right lower lobe did not appear to have the same pathology. Therefore, EBUS-TBNA was first performed at stations 13L and 4R using a thin convex-probe endobronchial ultrasound bronchoscope. The procedure was also performed on the right peripheral lesion at B10iβy 3 days later. Although obtaining an adequate specimen from station 13L was challenging, all lesions were ultimately diagnosed as malignant lymphoma, and heterogeneity in pathological characteristics was identified.</div></div><div><h3>Conclusions</h3><div>EBUS-TBNA for peripheral pulmonary lesions using a thin convex-probe bronchoscope appears to be an effective diagnostic technique for such lesions.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"61 ","pages":"Article 102428"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147803239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0