Respiratory Medicine Case Reports最新文献_第10页

Case report: Severe asthma exacerbation with steroid-induced anaphylaxis in a 30-year-old female 病例报告：严重哮喘加重伴类固醇过敏性反应1例30岁女性

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102197

Fatema Alkhan , Hatem Qutub , Faisal AlShahrani , Abdullah AlKhudair , Mohammed Al-Hariri

引用次数: 0

Pathologic complete response to pralsetinib in stage IV RET-positive non-small cell lung cancer: A case report 4期ret阳性非小细胞肺癌患者对普拉塞替尼的病理完全缓解1例报告

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102186

Xinxin Chen , Guoxin Wang , Jianfeng Zhang , Wei Bao , Jun Cai , Jing Guo , Tangfeng Lv , Mingxiang Ye

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Severe denosumab-induced hypocalcemia requiring long-term intensified medication in a patient with EGFR-mutant lung cancer and diffuse osteoblastic bone metastases egfr突变肺癌和弥漫性成骨细胞骨转移患者需要长期强化治疗的严重地地单抗诱导的低钙血症

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102183

Masayuki Mori , Masayuki Shirasawa , Akihito Oguri , Hiroki Yamamoto , Hideaki Manabe , Yoshiro Nakahara , Takashi Sato , Katsuhiko Naoki

{"title":"Severe denosumab-induced hypocalcemia requiring long-term intensified medication in a patient with EGFR-mutant lung cancer and diffuse osteoblastic bone metastases","authors":"Masayuki Mori , Masayuki Shirasawa , Akihito Oguri , Hiroki Yamamoto , Hideaki Manabe , Yoshiro Nakahara , Takashi Sato , Katsuhiko Naoki","doi":"10.1016/j.rmcr.2025.102183","DOIUrl":"10.1016/j.rmcr.2025.102183","url":null,"abstract":"<div><div>Lung cancer often causes bone metastasis, and denosumab is administered to bone metastases to prevent bone-related adverse events. One of the important side effects of denosumab is hypocalcemia, but this is generally not a problem, as it is used with calcium supplementation. A 48-year-old non-smoker male was diagnosed with lung adenocarcinoma with EGFR L858R mutation with diffuse bone metastases. Three days after receiving denosumab, the patient developed weakness and numbness in his limbs and was diagnosed with drug-induced hypocalcemia due to denosumab. It takes more than 4 months for treating the hypocalcemia in this case with continuous intravenous infusion of calcium gluconate with oral calcium supplementation for 2 months of hospitalization and subsequent 2 months of outpatient treatment with intermittent intravenous infusion of calcium gluconate three times a week along with oral supplementation. Tartrate-resistant acid phosphatase-5b (TRACP-5b), a marker of bone resorption, was a biomarker for the required amount of calcium in this case. Patients with lung cancer with diffuse osteoblastic bone metastases could develop severe hypocalcemia and require long-term calcium supplementation.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"54 ","pages":"Article 102183"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Isolated unilateral absence of pulmonary artery presenting as hemoptysis: A case report 孤立的单侧肺动脉缺失表现为咯血1例

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102228

Pauline Chale , Sibtain M. Moledina , Sylvia B. Nsato , Hery O. Kimwela , Damas Wilson , Hedwiga F. Swai

引用次数: 0

A case of primary pulmonary synovial sarcoma 原发性肺滑膜肉瘤1例

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102236

Keigo Ozono , Keita Sakanashi , Naoya Iwamoto , Yoshiyuki Nakanishi , Yoshinao Oda , Masafumi Nakamura

引用次数: 0

Clinical characterization of immunocompetent patients with Scedosporium detected in respiratory samples: A case series 呼吸样本中检测到的免疫功能正常患者的临床特征：一个病例系列

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102256

Yasuhiro Ito , Seiichi Miwa , Akira Watanabe , Masahiro Shirai

{"title":"Clinical characterization of immunocompetent patients with Scedosporium detected in respiratory samples: A case series","authors":"Yasuhiro Ito , Seiichi Miwa , Akira Watanabe , Masahiro Shirai","doi":"10.1016/j.rmcr.2025.102256","DOIUrl":"10.1016/j.rmcr.2025.102256","url":null,"abstract":"<div><div>Although <em>Scedosporium</em> is increasingly recognized in pulmonary infections, the optimal management of immunocompetent patients with <em>Scedosporium</em> detected in respiratory samples is poorly understood. This study aimed to characterize the clinical features of immunocompetent patients with <em>Scedosporium</em> detected in respiratory specimens. We retrospectively reviewed cases from 2014 to 2022 at our hospital. Eight elderly, immunocompetent female patients were identified, all presenting with bronchiectasis on chest imaging. Notably, seven (87.5 %) had a history of pulmonary <em>Mycobacterium avium</em> complex (MAC) disease. Based on their clinical courses, seven patients were classified as having colonization. One patient, diagnosed with infection, was treated with voriconazole, and her clinical symptoms stabilized without negative conversion of sputum cultures. Our findings suggest that bronchiectasis, particularly when linked with pulmonary MAC disease, may serve as an important underlying condition for <em>Scedosporium</em> colonization or infection in immunocompetent individuals. In the majority of cases, <em>Scedosporium</em> is indicative of colonization. However, distinguishing between colonization and infection remains a critical challenge for respiratory physicians.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"57 ","pages":"Article 102256"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic pulmonary hemosiderosis: A pediatric case report 特发性肺含铁血黄素沉着症：一个儿科病例报告

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102257

Zaina A. Khaled , Anas K. Assi , Habeeb H. Awwad , Riman A. Sultan , Marah Salameh , Mohand Abulilhya , Khalil Karim

{"title":"Idiopathic pulmonary hemosiderosis: A pediatric case report","authors":"Zaina A. Khaled , Anas K. Assi , Habeeb H. Awwad , Riman A. Sultan , Marah Salameh , Mohand Abulilhya , Khalil Karim","doi":"10.1016/j.rmcr.2025.102257","DOIUrl":"10.1016/j.rmcr.2025.102257","url":null,"abstract":"<div><h3>Background</h3><div>Idiopathic pulmonary hemosiderosis (IPH) is a rare entity, which needs exclusion of all other possible etiologies. It mainly affects children and young adolescents, but still can come at any age. Despite its rarity, it has many consequences which can lead to significant morbidity if not diagnosed and managed. This report presents the first documented case of IPH in Palestine, highlighting the need for increased awareness and timely recognition of this condition in clinical practice, even in regions where it has not been previously reported.</div></div><div><h3>Case presentation</h3><div>We report the case of a 14-year-old female diagnosed with IPH at the age of 5. She has a history of recurrent hemoptysis and two intensive care unit (ICU) admissions for diffuse alveolar hemorrhage and acute respiratory distress syndrome (ARDS). Investigations including a high-resolution computed tomography (HRCT) scan of the chest, revealed ground-glass opacities and nodularity. Bronchoalveolar lavage (BAL) and transbronchial biopsy (TBB) confirmed the diagnosis of IPH complicated by interstitial lung disease. Management included corticosteroid therapy at first; however, due to suboptimal response, a steroid-sparing immunosuppressive agent was added.</div></div><div><h3>Conclusion</h3><div>This case is the first reported case of IPH in Palestine, it underscores the importance of recognizing rare diseases in underreported regions. IPH suspicion and diagnosis are challenging. Despite its rarity, it remains one of the causes of diffuse alveolar hemorrhage (DAH). This case highlightes the importance of early recognition and diagnosis of IPH, in order to start an appropriate management strategy and improve outcomes and emphasizes the need for further research into the epidemiology, optimal therapeutic approaches, and long-term outcomes of IPH in diverse populations.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"57 ","pages":"Article 102257"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary fibrosis as the sole manifestation of anti-Ku antibody positivity in the absence of myositis: A case report 无肌炎时，肺纤维化为抗ku抗体阳性的唯一表现：1例报告。

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102165

Angelo Nigro Dr.

{"title":"Pulmonary fibrosis as the sole manifestation of anti-Ku antibody positivity in the absence of myositis: A case report","authors":"Angelo Nigro Dr.","doi":"10.1016/j.rmcr.2025.102165","DOIUrl":"10.1016/j.rmcr.2025.102165","url":null,"abstract":"<div><h3>Background</h3><div>Anti-Ku antibodies are autoantibodies directed against the Ku protein complex involved in DNA repair. They are typically associated with overlap syndromes featuring polymyositis and systemic sclerosis. Isolated pulmonary involvement without myositis is exceedingly rare.</div></div><div><h3>Case presentation</h3><div>We report the case of a 70-year-old male, a former smoker with an 18-year smoking history who quit 20 years ago, presenting with a one-year history of progressive dyspnea and dry cough. High-resolution computed tomography (HRCT) revealed pulmonary fibrosis with areas of ground-glass opacities. Laboratory tests showed antinuclear antibodies at a titer of 1:2560 with a speckled pattern and positivity for anti-Ku antibodies. Creatine phosphokinase levels were within normal limits. There were no clinical signs of myositis, myalgia, skin manifestations, or Raynaud's phenomenon.</div></div><div><h3>Conclusion</h3><div>This case underscores the rarity of pulmonary fibrosis as the sole clinical manifestation associated with anti-Ku antibody positivity in the absence of myositis. Clinicians should consider testing for anti-Ku antibodies in patients with idiopathic interstitial lung disease, even when muscular and cutaneous symptoms are absent.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"53 ","pages":"Article 102165"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic multicentric Castleman disease developing after a diagnosis of sarcoidosis: A case report and literature review 结节病诊断后发展为特发性多中心Castleman病：1例报告及文献复习

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102188

Takumi Muramatsu , Masato Kono , Masaki Ishige , Takahiko Saito , Misato Higasa , Fumiya Nihashi , Yuya Aono , Mineo Katsumata , Hideki Miwa , Yoshihiro Miki , Taro Misaki , Yoshiro Otsuki , Dai Hashimoto , Noriyuki Enomoto , Takafumi Suda , Hidenori Nakamura

{"title":"Idiopathic multicentric Castleman disease developing after a diagnosis of sarcoidosis: A case report and literature review","authors":"Takumi Muramatsu , Masato Kono , Masaki Ishige , Takahiko Saito , Misato Higasa , Fumiya Nihashi , Yuya Aono , Mineo Katsumata , Hideki Miwa , Yoshihiro Miki , Taro Misaki , Yoshiro Otsuki , Dai Hashimoto , Noriyuki Enomoto , Takafumi Suda , Hidenori Nakamura","doi":"10.1016/j.rmcr.2025.102188","DOIUrl":"10.1016/j.rmcr.2025.102188","url":null,"abstract":"<div><div>A 72-year-old woman presented with an abnormal shadow on chest radiograph. She was histologically diagnosed with sarcoidosis 20 years previously, and prednisolone was initiated 8 years previously. Computed tomography revealed centrilobular micronodules and bronchovascular bundle thickening in both lungs with multicentric lymphadenopathies; multiple pulmonary nodular lesions appeared during prednisolone tapering. Laboratory findings included polyclonal hypergammaglobulinemia and elevated interleukin-6 levels. Surgical lung biopsy revealed marked lymphoplasmacytic infiltration with lymphoid aggregates. The patient tested negative for human herpesvirus-8 and clinically diagnosed with idiopathic multicentric Castleman disease. The coexistence of sarcoidosis and Castleman disease is rare; this case improved with additional tocilizumab treatment.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"54 ","pages":"Article 102188"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute fibrinous and organizing pneumonia after lung transplantation: A case report of treatment with infliximab and tocilizumab and literature review 肺移植术后急性纤维性和组织性肺炎：英夫利昔单抗与托珠单抗联合治疗1例并文献复习。

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2024.102159

Christophe Abellan , Foteini Ioakeim , Alessio Casutt , Benoit Lechartier , Zisis Balmpouzis , Samuel Rotman , Leslie Noirez , Isabelle Rochat , John-David Aubert , Angela Koutsokera

{"title":"Acute fibrinous and organizing pneumonia after lung transplantation: A case report of treatment with infliximab and tocilizumab and literature review","authors":"Christophe Abellan , Foteini Ioakeim , Alessio Casutt , Benoit Lechartier , Zisis Balmpouzis , Samuel Rotman , Leslie Noirez , Isabelle Rochat , John-David Aubert , Angela Koutsokera","doi":"10.1016/j.rmcr.2024.102159","DOIUrl":"10.1016/j.rmcr.2024.102159","url":null,"abstract":"<div><h3>Introduction</h3><div>Acute fibrinous and organizing pneumonia (AFOP) is a severe form of acute lung injury which can occur after lung transplantation. Treatment is empiric, based on immunosuppressive regimens and the mortality rate is very high.</div></div><div><h3>Case presentation</h3><div>We report the case of a young lung transplant (LT) recipient who developed AFOP following a respiratory viral infection while on suboptimal maintenance immunosuppression due to adherence issues. Diagnosis was confirmed by cryobiopsies showing intra-alveolar fibrin balls. Despite high dose systemic corticosteroids, the patient developed severe respiratory failure requiring mechanical ventilation. IV infliximab and tocilizumab were administered. The patient was extubated 11 days later and discharged to home 42 days after intubation with 1L/min O2. She developed severe pleuritic pain needing opioid treatment and died 4 months later.</div></div><div><h3>Conclusion</h3><div>While high-dose systemic corticosteroids remain the first line of treatment, the use of anti TNF-α has shown promising results in case reports. Furthermore, we propose prompt realization of a cytokine panel analysis in both blood and bronchoalveolar lavage to better guide the adjuvant administration of a targeted anti-inflammatory therapy.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"53 ","pages":"Article 102159"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0