Respiratory Medicine Case Reports最新文献

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Traumatic tumor hemorrhage of inflammatory myofibroblastic tumor of the lung 肺部炎性肌纤维母细胞瘤创伤性肿瘤出血
IF 1.1
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.101981
Takashi Yamashita, Yuta Matsubayashi, Takahiro Mochizuki
{"title":"Traumatic tumor hemorrhage of inflammatory myofibroblastic tumor of the lung","authors":"Takashi Yamashita,&nbsp;Yuta Matsubayashi,&nbsp;Takahiro Mochizuki","doi":"10.1016/j.rmcr.2024.101981","DOIUrl":"https://doi.org/10.1016/j.rmcr.2024.101981","url":null,"abstract":"<div><p>A 23-year-old female with a history of idiopathic epilepsy was found to have a right chest cavity shadow in a school health checkup 5 years before. CT revealed a thin-walled cavity lesion in the right middle lobe containing a ball-like mass, showing air crescent sign. After falling due to a seizure, she was transported by ambulance and admitted. CT revealed diffuse ground-glass opacities throughout the right lung field. Bronchoscopy revealed bloody bronchial alveolar lavage fluid. Due to the tumor hemorrhage, an elective simple right middle lobe resection was performed without complications. The initial immunohistochemical staining was negative for ALK using ALK1 clone; however, subsequent staining of ALK by D5F3 and 5A4 clone was positive. Immunostaining findings led to a diagnosis of inflammatory myofibroblastic tumor. The patient remains under regular observation and has experienced no recurrence over the 6-year postoperative period. This case contains two different points: the first is that a cavity lesion of inflammatory myofibroblastic tumor may cause traumatic bleeding and should be treated with caution; the second is that attention should be paid to differences in stainability among clones when diagnosing inflammatory myofibroblastic tumor.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"47 ","pages":"Article 101981"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000042/pdfft?md5=bb40f93f935458442a4bcfc72af8b939&pid=1-s2.0-S2213007124000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139473185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare case of straight-back syndrome causing airway obstruction 直背综合征导致气道阻塞的罕见病例
IF 1.1
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.102024
Aham Okorozo , Vicky Chiang , Hyun S. Kim , Marc Vimolratana , Ali Sadoughi
{"title":"A rare case of straight-back syndrome causing airway obstruction","authors":"Aham Okorozo ,&nbsp;Vicky Chiang ,&nbsp;Hyun S. Kim ,&nbsp;Marc Vimolratana ,&nbsp;Ali Sadoughi","doi":"10.1016/j.rmcr.2024.102024","DOIUrl":"https://doi.org/10.1016/j.rmcr.2024.102024","url":null,"abstract":"<div><h3>Background</h3><p>Straight-back syndrome is a rare congenital condition involving the loss of the normal dorsal curvature of the upper thoracic spine. This leads to flattening of the upper thoracic cavity, resulting in compression of the underlying vasculature and airways. In this case report, we discuss the management of an 18-year-old male with straight-back syndrome who was referred to our interventional pulmonary clinic for further management of his stridor and apneic events. A trial of airway stenting was done which resolved the patient's respiratory symptoms. Definitive surgical correction was not applicable due to other significant medical conditions, but tracheostomy provided a sustainable alternative treatment. Tracheostomy tube placement and airway stenting are reasonable alternatives to surgery for patients who experience airway obstruction due to straight-back syndrome. Stent placement may also relieve respiratory symptoms but is associated with a higher rate of complications.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"50 ","pages":"Article 102024"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000479/pdfft?md5=d3253ec9cc22a46242a0ead2604ac637&pid=1-s2.0-S2213007124000479-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140825888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detecting early signs of deterioration and preventing hospitalizations in skilled nursing facilities using remote respiratory monitoring 利用远程呼吸监测仪检测病情恶化的早期征兆并预防老年护理机构的住院治疗
IF 1.1
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.102044
Timo Lauteslager , Vahe Dishakjian , Lauren Watson , Jacqueline Savarese , Adrian J. Williams , Guy D. Leschziner
{"title":"Detecting early signs of deterioration and preventing hospitalizations in skilled nursing facilities using remote respiratory monitoring","authors":"Timo Lauteslager ,&nbsp;Vahe Dishakjian ,&nbsp;Lauren Watson ,&nbsp;Jacqueline Savarese ,&nbsp;Adrian J. Williams ,&nbsp;Guy D. Leschziner","doi":"10.1016/j.rmcr.2024.102044","DOIUrl":"10.1016/j.rmcr.2024.102044","url":null,"abstract":"<div><p>An increase in respiratory rate (RR) can be an early indicator of clinical deterioration, yet it remains an often-neglected vital sign. The most common way of measuring RR is by manually counting chest-wall movements, a time-consuming and error-prone process. Staffing and funding shortages, particularly in post-acute and long-term care, mean these RR measurements are often infrequent, potentially leading to missed diagnoses and preventable readmissions. Here we present a case series from skilled nursing facilities, highlighting how continuous respiratory monitoring using a contactless remote patient monitoring (RPM) system can support clinicians in initiating timely interventions, potentially reducing preventable hospitalizations, mortality, and associated financial implications.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"50 ","pages":"Article 102044"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000674/pdfft?md5=8a218b1d6a1e73d3d43f98e0fa7c0ca7&pid=1-s2.0-S2213007124000674-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141130441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inspiratory muscle training for diaphragmatic dysfunction: A case series 治疗膈肌功能障碍的吸气肌肉训练:病例系列
IF 1.1
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.102066
Grant Turner , Surendran Sabapathy , Myles Moore , Sylvio Provenzano , Andrie Stroebel , Lawrence P. Cahalin
{"title":"Inspiratory muscle training for diaphragmatic dysfunction: A case series","authors":"Grant Turner ,&nbsp;Surendran Sabapathy ,&nbsp;Myles Moore ,&nbsp;Sylvio Provenzano ,&nbsp;Andrie Stroebel ,&nbsp;Lawrence P. Cahalin","doi":"10.1016/j.rmcr.2024.102066","DOIUrl":"10.1016/j.rmcr.2024.102066","url":null,"abstract":"<div><p>Inspiratory muscle training (IMT) is used across various pathology domains to improve respiratory function. Limited literature exists which demonstrates IMT benefit among patients with Diaphragmatic dysfunction. 7 individuals with a mean age of 59.6yrs had unilateral diaphragmatic dysfunction (UDD) post cardiac surgery and were referred to a cardiac rehab program where an IMT strength based protocol was prescribed. IMT implementation over an average of 13 weeks yielded an average improvement in maximum inspiratory pressure (MIP) of 48 % (p value 0.018), peak inspiratory flow rate (PIFR) of 45 % (p value 0.018), forced expired volume in 1 sec (FEV1) of 15 % (p value 0.028) and forced vital capacity (FVC) of 15 % (p value 0.018). This case series of data adds to the limited evidence that exists currently and outlines the benefits of IMT application within unilateral diaphragmatic dysfunction.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"51 ","pages":"Article 102066"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000893/pdfft?md5=e6f74968c14d7cc402cfa768bda86ac8&pid=1-s2.0-S2213007124000893-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141409057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of cavitated non-small cell lung cancer presenting as “Halloween pumpkin” following the consecutive NEOADAURA and ADAURA2 strategy: A case report 采用连续 NEOADAURA 和 ADAURA2 策略治疗表现为 "万圣节南瓜 "的空洞化非小细胞肺癌:病例报告
IF 0.8
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.102089
Lingyun Wei , Nan Yang , Chuan Gao , Weinan Li , Mingxiang Ye
{"title":"Treatment of cavitated non-small cell lung cancer presenting as “Halloween pumpkin” following the consecutive NEOADAURA and ADAURA2 strategy: A case report","authors":"Lingyun Wei ,&nbsp;Nan Yang ,&nbsp;Chuan Gao ,&nbsp;Weinan Li ,&nbsp;Mingxiang Ye","doi":"10.1016/j.rmcr.2024.102089","DOIUrl":"10.1016/j.rmcr.2024.102089","url":null,"abstract":"<div><p>Osimertinib is a third-generation tyrosine kinase inhibitor that targets mutant epidermal growth factor receptor (EGFR). The success of FLAURA and ADAURA trials prompted the license of Osimertinib for the treatment of EGFR mutant non-small cell lung cancer (NSCLC) at advanced stage and for patients with stages IB to IIIA disease in post-operative setting. In the present study, we described neoadjuvant use of Osimertinib in an EGFR mutant NSCLC patient with locally metastatic disease (T2aN2M0). Intriguingly, the cavitated NSCLC resembled an impressive“Halloween pumpkin” appearance that dramatically responded to Osimertinib treatment. Downstaging of N2 metastatic disease was reached and surgical resection was scheduled. The post-operative clinical stage was IA3. The patient was recommended to continue Osimertinib adjuvant treatment and our follow-ups showed no signs of disease recurrence. Our case study underscored the feasibility of Osimertinib as a neoadjuvant and adjuvant therapy for patients with locally advanced EGFR mutant NSCLC.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"51 ","pages":"Article 102089"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124001126/pdfft?md5=4d79435f9362bab37e38d3a8ead74d7a&pid=1-s2.0-S2213007124001126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In emergency situations, tracheal intubation replaces fiberoptic bronchoscopy to extract foreign bodies from the airway, a case report 在紧急情况下,气管插管取代纤维支气管镜从气道中取出异物的病例报告
IF 1.1
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.102045
Yingying Wang , Liqun Zhu , Hairong Yong , Xiaohong Lv , Binbin Qian , Zihan Wang
{"title":"In emergency situations, tracheal intubation replaces fiberoptic bronchoscopy to extract foreign bodies from the airway, a case report","authors":"Yingying Wang ,&nbsp;Liqun Zhu ,&nbsp;Hairong Yong ,&nbsp;Xiaohong Lv ,&nbsp;Binbin Qian ,&nbsp;Zihan Wang","doi":"10.1016/j.rmcr.2024.102045","DOIUrl":"https://doi.org/10.1016/j.rmcr.2024.102045","url":null,"abstract":"<div><h3>Introduction</h3><p>Foreign bodies in the airways can cause significant morbidity and mortality. If emergency personnel are unable to clear an airway obstruction frequently results in cardiac arrest.</p></div><div><h3>Patient concerns</h3><p>A 78-year-old man developed a persistent cough and dyspnoea after consuming alcohol. Fiberoptic bronchoscopy was performed, revealing complete blockage of the main airways on both sides by fish.</p></div><div><h3>Diagnosis</h3><p>Endotracheal foreign body.</p></div><div><h3>Interventions</h3><p>The foreign body was removed with an endotracheal tube under the guidance of a fiberoptic bronchoscope.</p></div><div><h3>Outcomes</h3><p>The airway foreign body had been successfully removed and the man recovered uneventfully.</p></div><div><h3>Conclusion</h3><p>When repeated attempts to extract airway foreign bodies under the guidance of bronchoscopy have failed, endotracheal intubation can be considered as a viable alternative in emergency situations.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"50 ","pages":"Article 102045"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000686/pdfft?md5=e3fbdc53f93b69f70d1897a3ba220e1d&pid=1-s2.0-S2213007124000686-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141164172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case of stage 0 pulmonary sarcoidosis pathologically diagnosed via transbronchial lung cryobiopsy 经支气管肺冷冻活检病理诊断的肺肉样瘤病 0 期病例
IF 1.1
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.102047
Hikari Ishii , Nobuyasu Awano , Minoru Inomata , Yuan Bae , Takehiro Izumo
{"title":"Case of stage 0 pulmonary sarcoidosis pathologically diagnosed via transbronchial lung cryobiopsy","authors":"Hikari Ishii ,&nbsp;Nobuyasu Awano ,&nbsp;Minoru Inomata ,&nbsp;Yuan Bae ,&nbsp;Takehiro Izumo","doi":"10.1016/j.rmcr.2024.102047","DOIUrl":"https://doi.org/10.1016/j.rmcr.2024.102047","url":null,"abstract":"<div><p>A 45-year-old male was diagnosed with arrhythmia during a routine health examination. Findings from different modalities, such as echocardiography and radiography, were consistent with cardiac involvement in sarcoidosis. There was no ocular involvement or superficial lymph node enlargement. A chest computed tomography scan did not reveal any pulmonary lesions or bilateral hilar lymphadenopathy. To pathologically diagnose systemic sarcoidosis, transbronchial lung cryobiopsy was performed. Results showed pathological evidence of noncaseating epithelioid granulomas. Herein, we present a case in which sarcoidosis diagnosis was confirmed via transbronchial lung cryobiopsy despite the absence of respiratory lesions on computed tomography scan.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"50 ","pages":"Article 102047"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000704/pdfft?md5=d2847453c8c319bfd068fcc358d1ac6d&pid=1-s2.0-S2213007124000704-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare pulmonary manifestation of Crohn's disease: Acute fibrinous and organizing pneumonia presenting as multifocal nodules 克罗恩病罕见的肺部表现:表现为多灶性结节的急性纤维组织性肺炎
IF 1.1
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.101993
Sohi Mistry , Asangi R. Kumarapeli , Harsha V. Mudrakola
{"title":"A rare pulmonary manifestation of Crohn's disease: Acute fibrinous and organizing pneumonia presenting as multifocal nodules","authors":"Sohi Mistry ,&nbsp;Asangi R. Kumarapeli ,&nbsp;Harsha V. Mudrakola","doi":"10.1016/j.rmcr.2024.101993","DOIUrl":"https://doi.org/10.1016/j.rmcr.2024.101993","url":null,"abstract":"<div><p>Acute Fibrinous and Organizing Pneumonia (AFOP) is a rare pulmonary disease, and it has not been recorded in literature as a pulmonary manifestation of Crohn's disease. A 22-year-old individual with an extensive history of Crohn's disease presented to the hospital initially for hematochezia and diarrhea. Computed tomography of her abdomen and pelvis showed multiple pulmonary nodules bilaterally. The patient did not report cough, sputum production, or dyspnea. Autoimmune and infectious workup were overall unremarkable. A CT-guided percutaneous biopsy of a peripheral lung nodule was performed showing features consistent with AFOP. The patient was ultimately treated with a long taper of prednisone and Ustekinumab for Crohn's disease. Follow-up CT-chest showed interval reduction and improvement in lung nodules, which correlated with better control of the patient's Crohn's disease. Pulmonary manifestations of IBD are varied, including pleural disease, bronchiectasis, and organizing pneumonia. Bronchiolitis obliterans organizing pneumonia has been described more frequently in patients with ulcerative colitis compared to Crohn's. Pulmonary nodules are a rare manifestation of IBD and often tend to be granulomatous or necrobiotic. AFOP is a rare entity with no previously reported association with IBD. Secondary AFOP can be caused by autoimmune diseases, drug reactions, infections, or radiation. Treatment of AFOP is usually immunosuppression by glucocorticoids.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"48 ","pages":"Article 101993"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000169/pdfft?md5=1a6403176044637178f2346349ea9f4a&pid=1-s2.0-S2213007124000169-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139699829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe pulmonary aspergillosis post viral illness in immunocompetent patients: A case series 免疫功能正常患者病毒性疾病后的严重肺曲霉菌病:病例系列
IF 1.1
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.101991
Moujaes Ghassan , Sleiman Wissam
{"title":"Severe pulmonary aspergillosis post viral illness in immunocompetent patients: A case series","authors":"Moujaes Ghassan ,&nbsp;Sleiman Wissam","doi":"10.1016/j.rmcr.2024.101991","DOIUrl":"https://doi.org/10.1016/j.rmcr.2024.101991","url":null,"abstract":"<div><p>Invasive pulmonary aspergillosis (IPA) is a life-threatening disease commonly affecting the lungs of immunosuppressed patients. Recently, Aspergillosis was diagnosed in immunocompetent patients with viral pneumonia due to influenza virus and coronavirus-19 infections. A series of four immunocompetent patients from different hospitals in Lebanon diagnosed with pulmonary aspergillosis post viral infection is reported. Aspergillosis is an important differential diagnosis in patients with viral infections and worsening infiltrates on chest x-ray, in addition to bacterial and mycobacterial infections with which they share common features. Fungal infections should be suspected early, and treatment should be considered knowing that these infections entail worse outcomes.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"48 ","pages":"Article 101991"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000145/pdfft?md5=4c43830ee73120135e02f1a3027ba9aa&pid=1-s2.0-S2213007124000145-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paclitaxel-induced acute fibrinous and organizing pneumonitis in early breast cancer: A case report 紫杉醇诱发的早期乳腺癌急性纤维组织性肺炎:病例报告
IF 1.1
Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI: 10.1016/j.rmcr.2024.102004
Piyarat Limpawittayakul , Supinda Petchjorm , Worawong Chueansuwan , Wanvisa Boonfueang
{"title":"Paclitaxel-induced acute fibrinous and organizing pneumonitis in early breast cancer: A case report","authors":"Piyarat Limpawittayakul ,&nbsp;Supinda Petchjorm ,&nbsp;Worawong Chueansuwan ,&nbsp;Wanvisa Boonfueang","doi":"10.1016/j.rmcr.2024.102004","DOIUrl":"https://doi.org/10.1016/j.rmcr.2024.102004","url":null,"abstract":"<div><h3>Background</h3><p>Paclitaxel is a chemotherapeutic drug widely used in breast cancer treatment. While common side effects are possible, paclitaxel-induced pneumonitis is rare, with an estimated incidence of 1%–5% and a high mortality rate.</p></div><div><h3>Case presentation</h3><p>A 57-year-old Thai woman diagnosed with stage II right breast cancer. She received adjuvant chemotherapy comprising doxorubicin and cyclophosphamide, followed by weekly paclitaxel. After the ninth paclitaxel cycle, she developed acute respiratory failure. Transbronchial biopsies revealed acute fibrinous and organizing pneumonitis. The patient was placed in prone position. Following the administration of dexamethasone, her symptoms improved. However, while reducing the dexamethasone dosage, she developed new-onset dyspnea as well as Takotsubo cardiomyopathy. Intravenous methylprednisolone 500 mg/day was administered for 3 days followed by transition to intravenous dexamethasone and slow tapering to prednisolone. Prednisolone was gradually tapered and eventually discontinued after 3 months.</p></div><div><h3>Conclusions</h3><p>Paclitaxel-induced pneumonitis is a rare complication. The diagnosis should be considered in any patient who develops respiratory symptoms while receiving paclitaxel. Acute fibrinous and organizing pneumonitis is a rare type of interstitial pneumonitis with high recurrence and mortality rates. High-dose steroids are needed to treat this type of pneumonitis.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"48 ","pages":"Article 102004"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000273/pdfft?md5=7f36798c47e8eb9a9394c07f7b33d6a4&pid=1-s2.0-S2213007124000273-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140103231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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