Respiratory Medicine Case Reports最新文献_第8页

Bronchoscopic lung volume reduction complicated by ipsilateral pleural effusion 支气管镜下肺体积缩小合并同侧胸腔积液。

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2024.102151

Marc Assaad, Wasif Shamsi, Anthony Loschner, Maria del Mar Cirino-Marcano

引用次数: 0

Extensively drug-resistant Acinetobacter baumannii lung abscess and empyema in a patient with fulminant mycoplasma pneumoniae pneumonia 暴发性肺炎支原体肺炎患者的广泛耐药鲍曼不动杆菌肺脓肿和脓肿。

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2024.102150

Siyu Yang, Chaojie Wei

引用次数: 0

Acute eosinophilic pneumonia caused by an exploding mobile battery: A case report 由手机电池爆炸引起的急性嗜酸性肺炎1例

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102196

Hiroe Aramaki , Masafumi Shimoda , Kozo Morimoto , Kozo Yoshimori , Ken Ohta , Yoshiaki Tanaka

引用次数: 0

Nocardia empyema in an immunocompromised host: A case report 免疫功能低下宿主的脓胸诺卡菌1例报告

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102199

Carlos Ignacio Rodríguez Reyna , Erick Torres Luna , Ajay Sheshadri , Saadia Faiz , Lara Bashoura , Nathan Box

引用次数: 0

Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature tezepelumab在近致死性哮喘中的同情使用：一个病例报告和文献回顾

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102223

Mako Nakajima , Masashi Matsuyama , Yuki Yamazaki , Hiroya Sunabe , Yuta Takahashi , Keishun Boku , Takeshi Miura , Tomohiro Tamura , Yoshiaki Inoue , Nobuyuki Hizawa

引用次数: 0

Diffuse necrotizing pneumonia, cavitations and hemoptysis: A case of sweet syndrome 弥漫性坏死性肺炎、空化和咯血：甜证1例

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102225

Felicia Montero-Arias , Randall Rojas-Varela , Abril Rodriguez-Loria , Ricardo Ramos-Castro , Simon Belilty-Montvelisky , Rodrigo Cartin-Ceba

引用次数: 0

Case of a rare EGFR mutation L747P identified using the lung cancer compact Panel™ leading to successful Afatinib treatment 使用肺癌紧凑面板™发现罕见的EGFR突变L747P病例，导致成功的阿法替尼治疗

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Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102255

Hitoshi Sumitani , Akihiro Tamiya , Yuki Iwahashi , Daisuke Sekinada , Akihiro Tsukaguchi , Yuya Tanaka , Takafumi Iguchi , Yuji Inagaki , Yoshihiko Taniguchi , Tomoko Kagawa , Yoshinobu Matsuda , Kyoichi Okishio

{"title":"Case of a rare EGFR mutation L747P identified using the lung cancer compact Panel™ leading to successful Afatinib treatment","authors":"Hitoshi Sumitani , Akihiro Tamiya , Yuki Iwahashi , Daisuke Sekinada , Akihiro Tsukaguchi , Yuya Tanaka , Takafumi Iguchi , Yuji Inagaki , Yoshihiko Taniguchi , Tomoko Kagawa , Yoshinobu Matsuda , Kyoichi Okishio","doi":"10.1016/j.rmcr.2025.102255","DOIUrl":"10.1016/j.rmcr.2025.102255","url":null,"abstract":"<div><div>This report describes the case of a 44-year-old Japanese female diagnosed with Stage IA lung adenocarcinoma harboring a rare epidermal growth factor receptor (<em>EGFR</em>) <em>L747P</em> mutation. Conventional polymerase chain reaction (PCR)-based assays did not identify the mutation. Despite undergoing surgery and subsequent chemoradiotherapy, disease recurrence occurred. A computed tomography (CT)-guided lung biopsy revealed the presence of the <em>L747P</em> mutation using the Lung Cancer Compact Panel™. Afatinib therapy was initiated, leading to a significant clinical response and size reduction of metastatic lung lesions. A literature review was conducted to assess the efficacy of afatinib in patients with the <em>L747P</em> mutation and explore the methods available for its detection. This case highlights the utility of the Lung Cancer Compact Panel™ in detecting this unique mutation for targeted therapy.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"57 ","pages":"Article 102255"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From diagnostic biopsy to bullectomy: A case of progressive complications in pulmonary langerhans cell histiocytosis 从诊断活检到大泡切除术：肺朗格汉斯细胞组织细胞增多症的进行性并发症1例

IF 0.8

Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102263

Yuan-Chia Hsin , Yung-Chia Huang , Yen-Lin Wu , Shih-Wei Lee , Po-Chun Lo

{"title":"From diagnostic biopsy to bullectomy: A case of progressive complications in pulmonary langerhans cell histiocytosis","authors":"Yuan-Chia Hsin , Yung-Chia Huang , Yen-Lin Wu , Shih-Wei Lee , Po-Chun Lo","doi":"10.1016/j.rmcr.2025.102263","DOIUrl":"10.1016/j.rmcr.2025.102263","url":null,"abstract":"<div><div>A 38-year-old male smoker presented with a persistent dry cough lasting several weeks. Chest radiography showed bilateral reticulonodular opacities predominantly in the upper lung fields. Subsequent chest computed tomography revealed diffuse, thick-walled, irregular cystic lesions mainly involving the mid and upper lung zones with a centrilobular distribution. Histopathological examination obtained through video-assisted thoracoscopic surgery demonstrated bronchiolocentric nodules and cysts containing Langerhans cells with convoluted nuclei, confirmed by positive immunohistochemical staining for CD1a, S-100, and Langerin. These findings confirmed the diagnosis of pulmonary Langerhans Cell Histiocytosis (PLCH). The patient's symptoms improved initially following smoking cessation but were complicated by recurrent pneumothorax and the formation of giant bullae, ultimately requiring surgical intervention. This case emphasizes the association between PLCH and smoking, highlights potential complications following surgical biopsy, and underscores smoking cessation as a critical therapeutic measure, with targeted therapies reserved for refractory or mutation-specific cases.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"57 ","pages":"Article 102263"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tropheryma whipplei in interstitial lung disease: A case series 肺间质性疾病中的惠氏滋养瘤：一个病例系列

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102279

Juan Li , Bingpeng Guo , Gui Zhao, Rui Wei, Qun Luo, Chao Zhuo, Qian Han

{"title":"Tropheryma whipplei in interstitial lung disease: A case series","authors":"Juan Li , Bingpeng Guo , Gui Zhao, Rui Wei, Qun Luo, Chao Zhuo, Qian Han","doi":"10.1016/j.rmcr.2025.102279","DOIUrl":"10.1016/j.rmcr.2025.102279","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Tropheryma whipplei</em> (TW) is a bacterium associated with Whipple's disease (WD). It primarily affects the small intestine, heart and eyes, but some studies have explored its relationship with parenchymal disease. With technological advances, next-generation technology has enabled detection of TW in bronchoalveolar lavage (BALF),especially in patients with interstitial lung disease (ILD).</div></div><div><h3>Case series</h3><div>We describe three patients with ILD that was progressive, despite aggressive treatment. Next generation sequecning of BALF revealed the presence of TW, confirmed by polymerase chain reaction (PCR). Periodic acid-Schiff (PAS)-positive macrophages were identified in duodenal biopsy specimens from one patient. All three patients were prescribed doxycycline and hydroxychloroquine, as well as <strong>pharmacotherapy for</strong> ILD. During 3–6 months follow-up, TW was not detected in BALF and ILD was stable.</div></div><div><h3>Conclusion</h3><div>We report TW detection in BALF of 3 ILD patients, indicating its potential role as a disease-modifying pathogen in ILD progression. These cases underscore the impact of lung microbiome disturbances on ILD pathophysiology and highlight therapeutic implications.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"57 ","pages":"Article 102279"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel cystic fibrosis mutation “delS1255” in a male diagnosed at birth 一名男性在出生时诊断出一种新的囊性纤维化突变“delS1255”

IF 0.7

Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI: 10.1016/j.rmcr.2025.102286

Mirna Gerges , Sarah Sutherland , Meredith Chiasson

{"title":"A novel cystic fibrosis mutation “delS1255” in a male diagnosed at birth","authors":"Mirna Gerges , Sarah Sutherland , Meredith Chiasson","doi":"10.1016/j.rmcr.2025.102286","DOIUrl":"10.1016/j.rmcr.2025.102286","url":null,"abstract":"<div><div>Cystic fibrosis (CF) is an autosomal recessive disorder caused by pathogenic variants in the <em>CFTR</em> gene. Over 2000 CFTR variants have been identified, and ongoing genetic characterization remains critical for guiding eligibility for CFTR modulator therapies and contributing to variant databases that support diagnosis and research. We describe a 20-year-old Caucasian male who is a compound heterozygous for the common F508del mutation and a novel variant, p.Ser1255del (c.3763_3765delTCA; delS1255). He was diagnosed with CF in the neonatal period following meconium ileus, confirmed by elevated sweat chloride testing. His clinical course included pancreatic insufficiency, chronic <em>Staphylococcus aureus</em> colonization, and sinus disease with nasal polyps, but no evidence of CF-related diabetes or liver disease. Molecular diagnostic testing conducted at Stanford Clinical Laboratory using PCR and bidirectional Sanger sequencing confirmed the F508del mutation and identified the previously unreported delS1255 variant, an in-frame deletion of a serine residue at position 1255. This variant is absent from population databases and a missense mutation at the same codon has previously been associated with severe CF phenotypes, supporting its likely pathogenicity. The patient was initiated on elexacaftor-tezacaftor-ivacaftor (ETI) therapy in 2021, based on the presence of the F508del allele. Since starting ETI, he has experienced substantial clinical improvement, including improved spirometry, radiology, and a marked reduction in sweat chloride concentration. The response is presumed to be driven by the F508del variant, while the effect of delS1255 on modulator responsiveness remains unknown. This case adds to the growing spectrum of <em>CFTR</em> variants with clinical relevance.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"58 ","pages":"Article 102286"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0