{"title":"Analysis of three cases with false positive PCR results of non tuberculosis mycobacterium","authors":"Wenwen Jin , Jing Wang , Xin Yang","doi":"10.1016/j.rmcr.2023.101973","DOIUrl":"https://doi.org/10.1016/j.rmcr.2023.101973","url":null,"abstract":"<div><h3>Background</h3><p>Real-time fluorescent quantitative PCR (RT-PCR) can effectively distinguish between <em>Mycobacterium tuberculosis</em> (MTB) and Non-tuberculosis mycobacterium (NTM), but when there are overlapping sequences between other pathogens (such as Nocardia otidiscaviarum, Mycobacterium parantracellulare, Mycolicibacterium fluoranthenivorans) and NTM, abnormal amplification curves may appear.</p></div><div><h3>Case presentation</h3><p>The clinical manifestations of the three patients were fever and respiratory symptoms. Chest CT showed “multiple lung infections”. The acid-fast bacilli were negative by microscopic examination. The results of RT-PCR detection of <em>Mycobacterium tuberculosis</em> DNA showed that they are all NTM, while the results of DNA microarray method showed that there were no non-Mycobacterium tuberculosis. Identified by MALDI-TOF mass spectrometry, they are Nocardia otidiscaviarum, Mycobacterium parantracellale, Mycolicibacterium fluoranthenivorans. We found that the sequences of the above three bacteria can be combined with the primers and probes used for NTM PCR detection, resulting in false positive.</p></div><div><h3>Conclusions</h3><p>In the RT-PCR detection of mycobacteria, if there's abnormal amplification, and the mycobacterial species cannot be identified, the amplified products sequencing or MALDI- TOF mass spectrometry identification will help avoid the omission of rare pathogens.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"47 ","pages":"Article 101973"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007123001685/pdfft?md5=d5cd3feadae2e73ac7bebe1605e4caa1&pid=1-s2.0-S2213007123001685-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Never too old: A case of fatal epstein barr virus pneumonia in an immunocompetent adult","authors":"Carl Tanba, Omar Almaadawy, Nahar Saleh","doi":"10.1016/j.rmcr.2023.101970","DOIUrl":"https://doi.org/10.1016/j.rmcr.2023.101970","url":null,"abstract":"<div><p>A 67-year-old immunocompetent male with COPD on supplemental oxygen presented with shortness of breath and was initially treated for bronchitis exacerbation with initial suspicion of bacterial pneumonia. He was later found to have EBV pneumonia diagnosed via positive EBV on bronchoalveolar lavage PCR. Severe lung involvement has been rarely reported in context of acute EBV infection. Treatment for this entity has not yet been established, with few reports of acyclovir and steroid use. This report describes the presentation, diagnosis, and treatment of acute EBV pneumonia.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"47 ","pages":"Article 101970"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221300712300165X/pdfft?md5=60a50bb171eb59ce6634e7b20410eb42&pid=1-s2.0-S221300712300165X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth Espinosa Vega , Alfredo Fonseca Negrín , Luis Ángel Iglesias Sánchez
{"title":"Pneumonia due to Pasteurella multocida, case report and considerations","authors":"Elizabeth Espinosa Vega , Alfredo Fonseca Negrín , Luis Ángel Iglesias Sánchez","doi":"10.1016/j.rmcr.2023.101971","DOIUrl":"https://doi.org/10.1016/j.rmcr.2023.101971","url":null,"abstract":"<div><p>Community acquired pneumonia is frequent in the elderly but a pathogen is identified in less than fifty per cent of the cases. It is rarely produced by <em>Pasteurella multocida</em>, a Gram-negative oral commensal of many dogs and cats. We report the case of an elderly man with chronic obstructive respiratory disease who owned a dog and developed severe pneumonia due to <em>P. multocida.</em></p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"47 ","pages":"Article 101971"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007123001661/pdfft?md5=e011f7c2e0aa2fb1242438d37c24ebcf&pid=1-s2.0-S2213007123001661-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathryn M. Pendleton , Jacob Fiocchi , Julia Meyer , Alexandra Fuher , Sarah Green , William M. LeTourneau , Ronald A. Reilkoff
{"title":"High PEEP extubation as guided by esophageal manometry","authors":"Kathryn M. Pendleton , Jacob Fiocchi , Julia Meyer , Alexandra Fuher , Sarah Green , William M. LeTourneau , Ronald A. Reilkoff","doi":"10.1016/j.rmcr.2024.101985","DOIUrl":"10.1016/j.rmcr.2024.101985","url":null,"abstract":"<div><p>The ventilatory management of morbidly obese patients presents an ongoing challenge in the Intensive Care Unit (ICU) as multiple physiologic changes in the respiratory system complicate weaning efforts and make extubation more difficult, often leading to increased time on the ventilator. We report the case of a young adult male who presented to our ICU on two separate occasions with hypoxemic respiratory failure requiring intubation. Esophageal manometry (EM) guided positive end expiratory pressure (PEEP) titration was utilized during both ICU admissions to improve oxygenation and aid in extubation with spontaneous breathing trials performed on higher-than-normal PEEP settings and successful liberation on both occasions.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"48 ","pages":"Article 101985"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221300712400008X/pdfft?md5=d5632fce0b856c64900321afb334b89d&pid=1-s2.0-S221300712400008X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139638124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naoto Arai , Toshikazu Takasaki , Masashi Bando , Kei Yaoita , Yutaro Ueki , Shu Hisata , Makoto Maemondo
{"title":"A case of microscopic polyangiitis with interstitial pneumonia after coronavirus disease-2019 infection, evidenced by positivity for multiple autoantibodies","authors":"Naoto Arai , Toshikazu Takasaki , Masashi Bando , Kei Yaoita , Yutaro Ueki , Shu Hisata , Makoto Maemondo","doi":"10.1016/j.rmcr.2024.102103","DOIUrl":"10.1016/j.rmcr.2024.102103","url":null,"abstract":"<div><p>Anti-neutrophil cytoplasmic antibody-associated vasculitis is triggered by infection, dust exposure, and drugs. A 73-year-old male presented with dyspnea. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection was confirmed upon admission. Exacerbation of interstitial pneumonia and renal dysfunction were observed. Analysis revealed positivity for myeloperoxidase-anti-neutrophil cytoplasmic antibody, other anti-aminoacyl transfer RNA synthetase antibodies, and anti-melanoma differentiation-associated gene 5. Renal biopsy confirmed crescentic glomerulonephritis, leading to the diagnosis of microscopic polyangiitis. Combination therapy with prednisolone and cyclophosphamide was initiated, resulting in improved respiratory and renal failure. There is a potential association between SARS-CoV-2 infection and the onset of autoimmune diseases.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"51 ","pages":"Article 102103"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124001266/pdfft?md5=2d6251fafb48a1dad840ae459aa88f84&pid=1-s2.0-S2213007124001266-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Betul Kinik , Seda Tural Onur , Asli Bicen , Kaan Kara , Cemal Aker
{"title":"Inflammatory myofibroblastic tumors: Diagnostic challenges and treatment strategies - A case report and literature review","authors":"Betul Kinik , Seda Tural Onur , Asli Bicen , Kaan Kara , Cemal Aker","doi":"10.1016/j.rmcr.2024.102117","DOIUrl":"10.1016/j.rmcr.2024.102117","url":null,"abstract":"<div><div>Inflammatory myofibroblastic tumors (IMTs) are rare benign mesenchymal tumors that present diagnostic challenges due to their diverse clinical and radiological manifestations. We present a case of a 19-year-old female with a history of intermittent hemoptysis. Imaging studies suggested a mediobasal lung lesion, prompting further evaluation. Bronchoscopy revealed vascular changes, and PET imaging indicated high metabolic activity. A left lower lobectomy was performed for diagnostic and therapeutic purposes, confirming the diagnosis of IMT characterized by spindle cell proliferation and inflammatory infiltrates. Surgical resection remains the cornerstone treatment, offering favorable outcomes with rare recurrence. Follow-up underscores the importance of monitoring and assessing prognostic factors to optimize patient management.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"52 ","pages":"Article 102117"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tuberous sclerosis-associated pulmonary lymphangioleiomyomatosis: The role of pulmonary rehabilitation - A case report","authors":"Flor Castro-Rodriguez , Yakdiel Rodriguez-Gallo","doi":"10.1016/j.rmcr.2024.102128","DOIUrl":"10.1016/j.rmcr.2024.102128","url":null,"abstract":"<div><div>Lymphangioleiomyomatosis (LAM) is a rare lung disease that primarily affects women. A patient with a medical history of Tuberous Sclerosis-Associated Lymphangioleiomyomatosis (TSC-LAM), a prior thyroidectomy for thyroid cancer, chronic hypertension, and a previous pulmonary thromboembolism was admitted to the hospital. Following the stabilization of her clinical condition, diaphragmatic exercises and incentive spirometers were implemented. This intervention significantly enhanced her respiratory status, prevented the need for invasive mechanical ventilation, and expediting pulmonary functional recovery. While further studies are needed, pulmonary rehabilitation has the potential to influence the clinical course of TSC-LAM patients in the ICU by improving respiratory capacity and reducing hospitalization time.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"52 ","pages":"Article 102128"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interstitial lung disease in a patient with anti-eIF2B antibodies-positive systemic sclerosis: A case report and literature review","authors":"Naoya Aoshiba , Kazutoshi Toriyama , Shohei Yamashita , Nao Shioiri , Yuko Iwata , Tomonori Uruma , Shinji Abe , Kenji Tsushima","doi":"10.1016/j.rmcr.2024.102141","DOIUrl":"10.1016/j.rmcr.2024.102141","url":null,"abstract":"<div><div>We report the case of a 76-year-old male patient with systemic sclerosis positive for anti-eukaryotic initiation factor 2B (eIF2B) antibodies. He presented to our hospital with dyspnea on exertion and, following a comprehensive physical examination, was diagnosed with interstitial lung disease associated with systemic sclerosis. Furthermore, systemic sclerosis was positive for the anti-eIF2B antibody. The presence of anti-eIF2B antibodies in systemic sclerosis is very rare, occurring in only 1–2.5 % of cases and seldom reported. Similar to our case, systemic sclerosis with positive anti-eIF2B antibodies has been reported to be more likely to be complicated by interstitial lung disease. Herein, we discuss our case in detail and summarize the previous findings.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"52 ","pages":"Article 102141"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of community-acquired Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus (MRSA) necrotizing pneumonia successfully treated with two anti-MRSA drugs","authors":"Ritsuya Shiiba, Masahiro Sano, Yoshihito Kogure, Hiroto Murao, Yuki Takigawa, Atsushi Torii, Arisa Yamada, Yuka Shinohara, Hideyuki Niwa, Chiyoe Kitagawa, Masahide Oki","doi":"10.1016/j.rmcr.2024.102023","DOIUrl":"https://doi.org/10.1016/j.rmcr.2024.102023","url":null,"abstract":"<div><p>A 22-year-old Vietnamese man was referred to our hospital owing to cough, dyspnea, and difficulty moving. The patient was diagnosed with community-acquired Panton-Valentine leukocidin-positive methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) bacteremia and necrotizing pneumonia. Treatment involved vancomycin (VCM) and meropenem, and the MRSA bacteremia improved. However, lung tissue destruction progressed. Therefore, linezolid was added to the VCM regimen, and this intervention led to the patient's recovery, and he was discharged from the hospital. Here, we report a case in which the patient was treated with a combination of two anti-MRSA drugs and was cured.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"49 ","pages":"Article 102023"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213007124000467/pdfft?md5=99dc383a6eccbc9bf2db027b6a0f5968&pid=1-s2.0-S2213007124000467-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Su Ji Oh , Jun Hyeok Lim , Lucia Kim , Young Sam Kim
{"title":"Diffuse pulmonary meningotheliomatosis: A case report","authors":"Su Ji Oh , Jun Hyeok Lim , Lucia Kim , Young Sam Kim","doi":"10.1016/j.rmcr.2024.102105","DOIUrl":"10.1016/j.rmcr.2024.102105","url":null,"abstract":"<div><p>A 57-year-old female presented with chest discomfort and exertional dyspnea but no other respiratory symptoms or history of malignancy. Chest CT revealed multifocal centrilobular nodules with ground-glass opacity in both lungs. Thoracoscopic wedge resection was done, and histological examination confirmed interstitial meningothelial-like nodules, consistent with diffuse meningotheliomatosis. The patient was discharged without complications and showed no disease progression on follow-up CT at 3 months, maintaining stability during 6 months of outpatient observation. Diffuse pulmonary meningotheliomatosis is an exceedingly rare condition, but this may be one of the causative etiologies in patients with diffuse bilateral pulmonary nodules.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"52 ","pages":"Article 102105"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221300712400128X/pdfft?md5=0a2181699384126586012d9c676cde1a&pid=1-s2.0-S221300712400128X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}