tezepelumab在近致死性哮喘中的同情使用：一个病例报告和文献回顾

IF 0.7 Q4 RESPIRATORY SYSTEM

Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI:10.1016/j.rmcr.2025.102223

Mako Nakajima , Masashi Matsuyama , Yuki Yamazaki , Hiroya Sunabe , Yuta Takahashi , Keishun Boku , Takeshi Miura , Tomohiro Tamura , Yoshiaki Inoue , Nobuyuki Hizawa

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引用次数: 0

摘要

一位38岁的男性患者因哮喘接近致死性，需要插管和有创机械通气（IMV）被转至我院。静脉-静脉体外膜氧合（VV-ECMO）是由于低血压和纵隔肺气肿继发于气压创伤。由于大剂量全身皮质类固醇治疗未能缓解严重的支气管痉挛，因此在同情的基础上给予单剂量tezepelumab。这一干预措施在7天后成功拔管。这是一个罕见的情况下，生物制剂被用作抢救治疗几乎致命的哮喘。本病例与相关文献的回顾一起提出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Compassionate use of tezepelumab in near fatal asthma: A case report and review of the literature

A 38-year-old man with near fatal asthma requiring intubation and invasive mechanical ventilation (IMV) was transferred to our hospital. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) was initiated due to hypotension and mediastinal emphysema secondary to barotrauma. Since high-dose systemic corticosteroid therapy failed to relieve the severe bronchospasm, a single dose of tezepelumab was administered on a compassionate basis. This intervention resulted in successful extubation 7 days later. This is a rare case in which a biologic agent was used as a rescue therapy for near fatal asthma. This case is presented along with a review of the relevant literature.

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