Respiratory Medicine Case Reports最新文献_第2页

Psoriasis flare confused with drug allergy: A collaborative effort is required to treat tuberculosis in the setting of severe psoriasis 牛皮癣耀斑与药物过敏混淆：在严重牛皮癣的情况下，需要合作治疗结核病

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI: 10.1016/j.rmcr.2026.102378

Quratulain Kizilbash , Adriana Vasquez , Barbara Seaworth , Lynn Horvath

{"title":"Psoriasis flare confused with drug allergy: A collaborative effort is required to treat tuberculosis in the setting of severe psoriasis","authors":"Quratulain Kizilbash , Adriana Vasquez , Barbara Seaworth , Lynn Horvath","doi":"10.1016/j.rmcr.2026.102378","DOIUrl":"10.1016/j.rmcr.2026.102378","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is a chronic autoimmune disorder. Severe psoriasis is treated with systemic immunosuppressive agents. Systemic immunosuppression increases the risk of tuberculosis (TB) disease. Sudden cessation of immunosuppression seems logical in a TB patient but can lead to psoriasis flares. And when a new rash occurs during TB therapy, drug reaction is usually suspected. This can result in untreated TB disease or intermittent therapy, thus increasing the risk for acquired drug resistance.</div></div><div><h3>Methods</h3><div>We describe two patients who developed TB disease during immunosuppressive therapy for psoriasis. When the immunosuppressive therapy was stopped, due to TB disease, both patients experienced significant worsening of psoriasis. The skin changes were confused with drug reaction to TB medications. Significant treatment interruptions resulted. A single team of TB physicians and one dermatologist, worked in conjunction to formulate a psoriasis and TB treatment plan. The patients were treated with acitretin and cyclosporine systemically along with topical agents to achieve psoriasis control. Then both were sequentially challenged with one TB medication at a time to ensure no drug reaction occurred while monitored at Texas Center for Infectious Disease. Cyclosporine was then tapered off.</div></div><div><h3>Results</h3><div>Both patients tolerated the alternative psoriasis regimen and TB therapy well. Both demonstrated clinical, bacteriologic, and radiographic improvement.</div></div><div><h3>Conclusion</h3><div>Treatment of TB disease in patients with severe psoriasis requires a collaborative effort between the TB treatment team and dermatology. A balanced approach, including treatment of both diseases, is necessary to avoid confusion of psoriasis flare versus drug induced skin reactions from TB medications.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"59 ","pages":"Article 102378"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Massive bilateral pulmonary hydatid disease in a seronegative child: Thoracoscopic management of an unusual presentation 血清阴性儿童大量双侧肺包虫病：一个不寻常表现的胸腔镜处理

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-06-02 DOI: 10.1016/j.rmcr.2026.102441

Raed Al-Taher , Abdallah Alabadla , Salameh Al-Halaseh , Leen AlZghoul , Yara Abu Salah , Salsabil Fakih

引用次数: 0

Internal auditory canal metastasis as the only brain lesion in progressive lung adenocarcinoma: Case report and literature review 进展性肺腺癌中唯一的脑损害为内听道转移：病例报告及文献复习。

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-06-16 DOI: 10.1016/j.rmcr.2026.102452

Mohamed Yassine Boujnah, Mouna Ben Rejeb, Molka Mezghani, Ghada Abdessatar, Lotfi Kochbati

{"title":"Internal auditory canal metastasis as the only brain lesion in progressive lung adenocarcinoma: Case report and literature review","authors":"Mohamed Yassine Boujnah, Mouna Ben Rejeb, Molka Mezghani, Ghada Abdessatar, Lotfi Kochbati","doi":"10.1016/j.rmcr.2026.102452","DOIUrl":"10.1016/j.rmcr.2026.102452","url":null,"abstract":"<div><h3>Background</h3><div>Metastases to the internal auditory canal (IAC) are exceptionally rare, especially as a solitary lesion without associated parenchymal brain or leptomeningeal involvement. Lung adenocarcinomas with a signet-ring cell component are aggressive and prone to early dissemination.</div></div><div><h3>Case presentation</h3><div>We report a 64-year-old man with stage IV lung adenocarcinoma with a signet-ring cell component who developed rapidly progressive left-sided facial palsy, vertigo, and hearing loss. Brain MRI revealed a solitary enhancing lesion in the left IAC. Considering the clinical context and rapid symptom progression, a metastatic lesion was suspected. The patient was treated with corticosteroids and radiotherapy. At three-week follow-up, he showed marked improvement in vertigo and hearing, with partial recovery of facial nerve function (House–Brackmann grade III).</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of recognizing rare sites of metastasis in patients with known malignancy. Early diagnosis and prompt treatment with a multidisciplinary approach can lead to meaningful neurological improvement and symptom relief, even in the context of ongoing systemic disease. Clinicians should be alert for IAC metastases when acute cochleovestibular or facial nerve symptoms occur.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"62 ","pages":"Article 102452"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13293743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late presentation of alveolar capillary dysplasia with misalignment of pulmonary veins presenting as refractory pulmonary hypertension in infancy 晚期肺泡毛细血管发育不良伴肺静脉错位表现为婴儿期难治性肺动脉高压。

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-06-17 DOI: 10.1016/j.rmcr.2026.102456

Tamer Abusido, Saleh Alshaibi, Abdullah Aldraihem, Abdulmajeed Alfadhel

{"title":"Late presentation of alveolar capillary dysplasia with misalignment of pulmonary veins presenting as refractory pulmonary hypertension in infancy","authors":"Tamer Abusido, Saleh Alshaibi, Abdullah Aldraihem, Abdulmajeed Alfadhel","doi":"10.1016/j.rmcr.2026.102456","DOIUrl":"10.1016/j.rmcr.2026.102456","url":null,"abstract":"<div><h3>Background</h3><div>Alveolar capillary dysplasia with misalignment of the pulmonary veins (ACD-MPV) is a rare congenital lung disorder characterized by abnormal pulmonary vascular and alveolar–capillary development, resulting in severe pulmonary hypertension (PH) that is typically refractory to therapy. Most affected infants present within the first days of life; however, delayed presentations can occur and are frequently misdiagnosed, leading to late recognition and rapid clinical deterioration.</div></div><div><h3>Case presentation</h3><div>We report a 7-month-old girl who presented with progressive respiratory distress and severe pulmonary hypertension without an immediately identifiable cause. Initial evaluation including cardiac imaging and laboratory investigations did not reveal a clear etiology. Despite supportive management and pulmonary vasodilator therapy, the patient demonstrated persistent pulmonary hypertension with clinical deterioration. Due to the unexplained and refractory nature of the disease, lung biopsy was performed and confirmed the diagnosis of alveolar capillary dysplasia with misalignment of pulmonary veins.</div></div><div><h3>Conclusion</h3><div>This case highlights the diagnostic challenges associated with atypical presentations of ACD-MPV beyond the neonatal period. Clinicians should consider this rare condition in infants with severe pulmonary hypertension that is disproportionate to initial findings and poorly responsive to therapy. Early recognition is essential for appropriate counselling and management planning.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"62 ","pages":"Article 102456"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13315117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary pulmonary leiomyosarcoma in a patient with disseminated pulmonary tuberculosis and constrictive pericarditis 播散性肺结核合并缩窄性心包炎患者的原发性肺平滑肌肉瘤

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-08-27 DOI: 10.1016/j.rmcr.2026.102490

Stefan Van Der Westhuizen, Allison Jane Arendse, Zane Ismail, Danie Krynauw, Dan Zaharie, Brian W. Allwood

{"title":"Primary pulmonary leiomyosarcoma in a patient with disseminated pulmonary tuberculosis and constrictive pericarditis","authors":"Stefan Van Der Westhuizen, Allison Jane Arendse, Zane Ismail, Danie Krynauw, Dan Zaharie, Brian W. Allwood","doi":"10.1016/j.rmcr.2026.102490","DOIUrl":"10.1016/j.rmcr.2026.102490","url":null,"abstract":"<div><div>Primary pulmonary leiomyosarcoma (PPL) is an exceedingly rare malignancy, accounting for fewer than 0.5% of all lung tumours. Its occurrence alongside disseminated tuberculosis (TB) complicated by constrictive pericarditis has not previously been described. We report a 66-year-old HIV-negative male from rural South Africa presenting with progressive dyspnoea, found to have a right upper lobe nodule that enlarged despite adequate anti-TB therapy. Computed tomography (CT)-guided biopsy demonstrated spindle cell morphology. Cardiac MRI and right and left heart catheterisation confirmed constrictive pericarditis with severely impaired right ventricular function, precluding immediate lobectomy. A staged surgical approach was employed: anterior pericardiectomy via median sternotomy was performed first in attempt to optimise right ventricular function, followed by open right upper lobectomy. Histopathological analysis and immunohistochemistry confirmed PPL (FNLCC Grade 3, pT3N0M0) with R0 resection margins. All sampled nodal stations were free of malignancy, and whole-body positron emission tomography-CT (PET-CT) excluded nodal involvement and distant metastatic disease. The patient was discharged on postoperative day six and remained ECOG performance status 1 at 10-month follow up. This case illustrates that in TB-endemic regions, a lung nodule enlarging on adequate anti-TB therapy should prompt tissue diagnosis irrespective of an established alternative diagnosis. It further highlights the importance of a staged surgical approach when concomitant cardiac pathology compromises right ventricular function, acknowledging rapid tumour growth progression during the inter-procedural recovery interval.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"63 ","pages":"Article 102490"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sevoflurane-associated diffuse alveolar hemorrhage: A rare cause of postoperative dyspnea. Case report and literature review 七氟醚相关弥漫性肺泡出血：术后呼吸困难的罕见原因。病例报告及文献复习

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-10-01 DOI: 10.1016/j.rmcr.2026.102513

Amir Ashiq, Rabia Ahmed, Muhammad Waqas, Fatima Anwar

{"title":"Sevoflurane-associated diffuse alveolar hemorrhage: A rare cause of postoperative dyspnea. Case report and literature review","authors":"Amir Ashiq, Rabia Ahmed, Muhammad Waqas, Fatima Anwar","doi":"10.1016/j.rmcr.2026.102513","DOIUrl":"10.1016/j.rmcr.2026.102513","url":null,"abstract":"<div><div>Diffuse alveolar hemorrhage (DAH) is a rare, life threatening, early post-operative pulmonary complication of inhaled anesthetics, which are used for induction and maintenance of general anesthesia. It refers to hemorrhage originating from pulmonary microcirculation. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. Common causes are systemic vasculitis, Collagen vascular disease, Bone marrow transplantation, Drugs, and idiopathic conditions. Treatment ranges from supportive care and withdrawal of offending drugs to high-dose steroids, immunosuppressants, and plasmapheresis. Sevoflurane induced diffuse alveolar hemorrhage is a rarely reported entity in the literature that clinicians should be aware of and consider among the post-operative causes of dyspnea while ruling out other etiologies. We present a literature review over sevoflurane induced diffuse alveolar hemorrhage and a case involving a young otherwise healthy patient who underwent surgery for metatarsal fractures under general anesthesia, but diffuse alveolar hemorrhage developed after sevoflurane inhalation in the postoperative period.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"64 ","pages":"Article 102513"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149161310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly growing pulmonary inflammatory myofibroblastic tumor: a case report 快速生长的肺炎性肌成纤维细胞瘤1例

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-09-26 DOI: 10.1016/j.rmcr.2026.102515

Hiroaki Komatsu, Nao Furukawa, Izaya Arashiro, Kazunori Okabe

{"title":"Rapidly growing pulmonary inflammatory myofibroblastic tumor: a case report","authors":"Hiroaki Komatsu, Nao Furukawa, Izaya Arashiro, Kazunori Okabe","doi":"10.1016/j.rmcr.2026.102515","DOIUrl":"10.1016/j.rmcr.2026.102515","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory myofibroblastic tumor (IMT) of the lung is a rare mesenchymal tumor. Rapid growth of IMT is rare.</div></div><div><h3>Case presentation</h3><div>A 73-year-old woman was referred to our hospital because of a mediastinal tumor. Chest computed tomography (CT) showed a 13 mm anterior mediastinal tumor that was cystic on magnetic resonance imaging. A 6 month-follow-up chest CT revealed an 11 mm nodule in the left upper lobe of the lung. One month later, chest CT showed rapid growth of the lung nodule (diameter, 16 mm). The doubling time of the tumor was calculated as 19 days. Positron emission tomography revealed high accumulation of fluorodeoxyglucose in the nodule, which was suspected to be malignant. Robot-assisted thoracoscopic surgery was then performed. Intraoperative pathology of the left pulmonary tumor was poorly differentiated non-small cell carcinoma. Therefore, left upper lobectomy and resection of the anterior mediastinal tumor were performed. The final pathological diagnosis of the left pulmonary tumor was inflammatory myofibroblastic tumor; the mediastinal tumor was a thymic cyst. The patient's postoperative course was uneventful and she was discharged on postoperative day 4. She was recurrence-free at the 1-year follow-up.</div></div><div><h3>Conclusion</h3><div>IMT rarely presents with rapid growth and should be considered in the differential diagnosis of tumors with a doubling time <20 days.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"64 ","pages":"Article 102515"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149161380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New therapies, new challenges: Cystic lung disease after cancer immunotherapy 新疗法，新挑战：癌症免疫治疗后的囊性肺疾病

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.rmcr.2025.102356

Ananya Venkatesh , David Camacho , Ross Summer , Michael Dong

{"title":"New therapies, new challenges: Cystic lung disease after cancer immunotherapy","authors":"Ananya Venkatesh , David Camacho , Ross Summer , Michael Dong","doi":"10.1016/j.rmcr.2025.102356","DOIUrl":"10.1016/j.rmcr.2025.102356","url":null,"abstract":"<div><div>Immunotherapies have reduced reliance on cytotoxic strategies with their associated high toxicity levels, revolutionizing cancer care. However, these targeted therapies have also increased prevalence of previously rare sequelae, impacting patients experiencing longer survival. We describe a case of endometrial adenocarcinoma with lung metastases, in which tumor resolution following immunotherapy created cystic airspaces, leading to a pneumothorax complication. A 49-year-old female with advanced stage endometrial adenocarcinoma and lung metastasis developed cystic lung lesions in areas of previous metastatic lesions after treatment with Pembrolizumab and Bevacizumab. She developed a pneumothorax secondary to the rupture of one of the large lung cysts, leading to a bronchopleural fistula and required surgical intervention. Structural lung changes, such as cystic lung disease following immunotherapy are emerging complications. As immunotherapy continues to reshape cancer treatment, the emergence of associated complications highlights the need for optimized screening and management strategies for these newly recognized manifestations of cancer therapy.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"59 ","pages":"Article 102356"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung transplantation in a patient with SARS-CoV-2 infection: a case report SARS-CoV-2感染患者肺移植1例报告

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1016/j.rmcr.2026.102365

Elena Seminari , Paola Giordani , Patrizia Cambieri , Stefano Pelenghi , Mirko Belliato , Raffaele Bruno

{"title":"Lung transplantation in a patient with SARS-CoV-2 infection: a case report","authors":"Elena Seminari , Paola Giordani , Patrizia Cambieri , Stefano Pelenghi , Mirko Belliato , Raffaele Bruno","doi":"10.1016/j.rmcr.2026.102365","DOIUrl":"10.1016/j.rmcr.2026.102365","url":null,"abstract":"<div><div>The COVID19 pandemic had a major impact on solid organ transplantation, causing concerns about the possibility of donor-derived infection and the risk of severe infection in positive recipients resulting from immunosuppression. Since transplant recipients are known to be at an increased risk of severe SARS-CoV-2 infection, transplantation societies recommend deferring transplantation in recipients with active SARS-CoV-2 infection. Several centers however perform transplants also in SARS-CoV-2 positive recipients, although the available data in literature remain limited, and mostly restricted to kidney and liver transplants, to provide clear data on the safety of transplantation in recipients with ongoing SARS-CoV-2 infection. Only two cases of lung transplants in patients with a positive SARS-CoV-2 nasal swab at the time of transplantation were reported in the literature. Unlike our case, the positivity was limited to the molecular test, which showed high cycle-threshold (CT) value (30.9 and 39.2, respectively). Here, we present a case of a successful double-lung transplant performed in a patient with ongoing SARS-CoV-2 infection, evidenced by a positive molecular swab with a low CT value on the day of transplantation. The post-transplant course was regular with good lung function and the patient was extubated on post-operative day 3. The patient was treated with remdesivir and rapidly cleared SARS-CoV2 RNA from nasal swab without COVID-related complications. Despite immunosuppression the patient did not develop SARS-CoV2 pneumonia.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"59 ","pages":"Article 102365"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papillary thyroid cancer with endobronchial metastasis managed with Aragon plasma coagulation: A case report 阿拉贡血浆凝固治疗甲状腺乳头状癌支气管内转移1例

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Respiratory Medicine Case Reports Pub Date : 2026-01-01 Epub Date: 2025-12-02 DOI: 10.1016/j.rmcr.2025.102338

Amjad Altalla, Muhannad Hawari, Abdulaziz Almogbil

引用次数: 0