Journal of Obstetrics and Gynecology of India最新文献

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Management of Isolated Umbilical Endometriosis in a Resource Limited Country: Two Cases and Review of the Literature. 在资源有限的国家治疗孤立性脐带子宫内膜异位症:两例并文献复习。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-05-04 DOI: 10.1007/s13224-023-01742-2
Dehi Boston Mian, Vedi Loue, Alexis Yao, N'guessan Koffi, Boni Serge
{"title":"Management of Isolated Umbilical Endometriosis in a Resource Limited Country: Two Cases and Review of the Literature.","authors":"Dehi Boston Mian, Vedi Loue, Alexis Yao, N'guessan Koffi, Boni Serge","doi":"10.1007/s13224-023-01742-2","DOIUrl":"10.1007/s13224-023-01742-2","url":null,"abstract":"","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 5","pages":"451-454"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of HDP-Gestosis Score and Ophthalmic Artery Doppler in Prediction of Pre-eclampsia. HDP手势评分和眼动脉多普勒在先兆子痫预测中的作用。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-07-21 DOI: 10.1007/s13224-023-01799-z
Pooja Shah, Nandita Maitra, Palak Vaishnav, Jinal Dhruv, Twinkle Sara Shyam, Priyam Pandya
{"title":"Performance of HDP-Gestosis Score and Ophthalmic Artery Doppler in Prediction of Pre-eclampsia.","authors":"Pooja Shah, Nandita Maitra, Palak Vaishnav, Jinal Dhruv, Twinkle Sara Shyam, Priyam Pandya","doi":"10.1007/s13224-023-01799-z","DOIUrl":"10.1007/s13224-023-01799-z","url":null,"abstract":"<p><strong>Purpose of study: </strong>To study the predictive accuracy of maternal characteristics, mean arterial pressure, uterine artery doppler and maternal ophthalmic artery doppler in second trimester for subsequent development of pre-eclampsia.</p><p><strong>Methods: </strong>A prospective cohort study of 440 women at 19-24 weeks' gestation. It included recording of maternal demographic characteristics and calculation of HDP Gestosis Score, measurement of MAP and ultrasound evaluation for fetal anatomy, Uterine artery doppler and maternal ophthalmic artery doppler. The mean Peak Systolic Velocity ratio was obtained by taking two sets of reading from both eyes. The statistical analysis was done using independent t-test for quantitative variables and chi-square test, Fisher's exact test for qualitative variables and Area Under Curve was obtained at 10% False Positive Rate.</p><p><strong>Results: </strong>Among 440 pregnant women, 43(10.8%) developed Hypertensive Disorder of Pregnancy (8 early onset PE, 16 late onset PE and 19 GHTN) and 42 were lost to follow up, with an incidence rate of 10.8%. Combination of Gestosis Score + OAD PSV Ratio had highest AUC of 0.73. Whereas combination of Gestosis Score + MAP + UtAPI + OAD-PSV Ratio had highest sensitivity of 97.67%. The OAD PSV ratio improved detection rate of Gestosis Score (from 90 to 100%) for prediction of development of PE, especially Preterm PE at 10% FPR.</p><p><strong>Conclusion: </strong>Maternal Ophthalmic artery doppler study significantly improved prediction of development of PE at 19-24 weeks' gestation, both independently as well as in combination with HDP-Gestosis Score, MAP and uterine artery doppler.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 1","pages":"43-50"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Analysis of Hyperemesis Gravidarum and Its Psychological Impact during Hospital Admission. 妊娠呕吐的回顾性分析及其住院期间的心理影响。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-06-30 DOI: 10.1007/s13224-023-01787-3
Rania Gamal Anwar El-Skaan, Rehab Mohamed Abdelrahman, Ahmed Mohamed Abdelhamed Hassan
{"title":"Retrospective Analysis of Hyperemesis Gravidarum and Its Psychological Impact during Hospital Admission.","authors":"Rania Gamal Anwar El-Skaan, Rehab Mohamed Abdelrahman, Ahmed Mohamed Abdelhamed Hassan","doi":"10.1007/s13224-023-01787-3","DOIUrl":"10.1007/s13224-023-01787-3","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate hyperemesis gravidarum in pregnant women and its psychological impact.</p><p><strong>Methods: </strong>This retrospective study included 109 pregnant females suffering from hyperemesis gravidarum admitted during 2019-2020 at Maternity Ain shams university hospital.</p><p><strong>Results: </strong>Disease severity and laboratory investigations such as Na and K levels (<i>P</i> = 0.007 and < 0.001, respectively) and serum creatinine level (<i>P</i> < 0.001) were significantly positively correlated. Depressive symptoms included guilt feeling for leaving family (49.5% patients), suicidal thoughts (9.2%), crying (56.9%) and lost concentration (33.9%).</p><p><strong>Conclusions: </strong>Medical staff should be aware of psychological impact of the disease and refer to specialists if needed.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 1","pages":"19-24"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sheehan's Syndrome in India: Clinical Characteristics and Laboratory Evaluation. 印度的希恩综合征:临床特征和实验室评估。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-08-23 DOI: 10.1007/s13224-023-01801-8
Prabhat Agrawal, Ruchika Garg, Mohita Agrawal, Manish Kumar Singh, Urvashi Verma, Richa Chauhan
{"title":"Sheehan's Syndrome in India: Clinical Characteristics and Laboratory Evaluation.","authors":"Prabhat Agrawal, Ruchika Garg, Mohita Agrawal, Manish Kumar Singh, Urvashi Verma, Richa Chauhan","doi":"10.1007/s13224-023-01801-8","DOIUrl":"10.1007/s13224-023-01801-8","url":null,"abstract":"<p><strong>Background: </strong>Sheehan's Syndrome (SS) is an important cause of hypopituitarism especially in developing countries though it remains underdiagnosed to a great extent. Torrential bleeding after delivery followed by lactation failure and amenorrhoea gives a clue to the diagnosis which is usually made after several years of delivery.</p><p><strong>Materials and methods: </strong>It was a retrospective observational study conducted by reviewing the case records of 38 cases of SS. The age, anthropometric measurements, signs and symptoms, biochemical parameters, hormone levels and imaging reports were examined and analyzed.</p><p><strong>Results: </strong>The mean age at presentation was 36.5 years because there was a delay of 8.4 years from last delivery before diagnosis could be made. Ninety percent patients presented with lactation failure. Anaemia, hypotension, hypogonadism, hypothyroidism, and altered lipid profile were the most common findings. The mean systolic blood pressure (BP) was 80.95 mm and diastolic BP was 51.6 mm of Hg at the time of presentation. Hyponatremia was the most common electrolyte abnormality noted and low HDL was the commonest lipid abnormality.</p><p><strong>Conclusion: </strong>A large percentage of patients presented with amenorrhea, lactation failure, and decreased or absent axillary/pubic hair. Shock, anemia, and hyponatremia were also common symptoms among the patients studied. The diagnosis of SS rests upon a thorough history taking of the postpartum events in cases presenting with hypopituitarism irrespective of the age at presentation. Proper antenatal care with exclusive institutional deliveries can reduce the prevalence of SS in developing countries.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 1","pages":"51-55"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obstructive Sleep Apnoea: A Shrouded High-Risk Association for Development of Hypertensive Disorders of Pregnancy. 阻塞性睡眠呼吸暂停:妊娠期高血压疾病发展的高风险关联。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-09-26 DOI: 10.1007/s13224-023-01835-y
Vinita Sarbhai, Pooja Paswan, Vikram Sarbhai
{"title":"Obstructive Sleep Apnoea: A Shrouded High-Risk Association for Development of Hypertensive Disorders of Pregnancy.","authors":"Vinita Sarbhai, Pooja Paswan, Vikram Sarbhai","doi":"10.1007/s13224-023-01835-y","DOIUrl":"10.1007/s13224-023-01835-y","url":null,"abstract":"<p><strong>Background: </strong>This objective of this study was to diagnose Obstructive Sleep Apnoea (OSA) in pregnant women using Questionnaire-based methods and to determine any association of Sleep-Disordered Breathing (SDB) with Hypertensive Disorder of Pregnancy (HDP). Additionally, the study aimed to identify factors associated with OSA.</p><p><strong>Methods: </strong>This case-control study was conducted in department of Obstetrics in tertiary care hospital in Delhi. We Identified SDB using Berlin Questionnaire and Modified Stop-Bang Questionnaire in 100 pregnant women with Hypertension and 100 normotensive controls. We compared the groups using appropriate statistical analysis.</p><p><strong>Results: </strong>The mean age of women with HDP (25.46 ± 4.38) was found to be slightly higher than controls (24.13 ± 3.89) (<i>p</i> value-0.02). Sleep apnoea as depicted by the presence of either high-risk STOP Bang or Berlin score was seen more often in hypertensive women in 45% as compared to controls in 8% (<i>p</i> value < 0.001). Higher pre-pregnancy weight (58.58 ± 9.77 vs. 53.0 ± 6.59), higher BMI (24.03 ± 5.89 vs. 20.68 ± 1.49), higher mean neck circumference (14.97 vs. 14.27 inches) weight gain more than 11 kg during pregnancy (55.6% vs. 38.2%) were the high-risk factors more commonly associated with SDB as seen in women with OSA in hypertensive women. On logistic regression analysis, the presence of OSA was singularly responsible for development of Hypertension (Odds Ratio-13.014, 95% CI 5.237-32.337) (<i>p</i> value < 0.001).</p><p><strong>Conclusion: </strong>Gestational hypertension appears to be strongly associated with the presence of obstructive sleep apnoea. The recognition and treatment of OSA during pregnancy may lead to improved outcomes.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 5","pages":"391-396"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomised Control Study of Misoprostol and Mifepristone versus Misoprostol Alone in Second Trimester Termination of Pregnancy. 米索前列醇和米非司酮与单独米索前列终止妊娠中期的随机对照研究。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-07-18 DOI: 10.1007/s13224-023-01800-9
Ajit Kumar Nayak, Swetalin Mishra, Subhasri Mishra, Ranjita Patnaik, Ipsita Mohapatra
{"title":"Randomised Control Study of Misoprostol and Mifepristone versus Misoprostol Alone in Second Trimester Termination of Pregnancy.","authors":"Ajit Kumar Nayak, Swetalin Mishra, Subhasri Mishra, Ranjita Patnaik, Ipsita Mohapatra","doi":"10.1007/s13224-023-01800-9","DOIUrl":"10.1007/s13224-023-01800-9","url":null,"abstract":"<p><strong>Introduction: </strong>This study was done to assess and compare the efficacy and safety of mifepristone and misoprostol combination versus misoprostol alone for second trimester termination of pregnancy in relation to induction abortion interval, average amount of misoprostol required in each group, success rate and side effects.</p><p><strong>Materials and methods: </strong>This randomised control study was conducted on 100 women admitted in the Department of Obstetrics & Gynaecology, S.C.B. Medical College & Hospital, Cuttack, for second trimester termination of pregnancy, divided into two groups, Group A and Group B of 50 patients each. Group A patients received 200 mg of oral mifepristone followed by 400 mcg of vaginal misoprostol after 48 h, and then 400 mcg of vaginal misoprostol every 3 hourly until complete expulsion or up to a maximum of 6 doses. Group B patients received 400 mcg of vaginal misoprostol every 3 hourly until complete expulsion or up to maximum 6 doses.</p><p><strong>Results: </strong>Complete abortion was seen in 92% and 72% cases in Group A and Group B, respectively. Mean induction abortion interval was 11.59 ± 2.71 h in Group A and 15.57 ± 2.27 h in Group B (<i>p</i> value < 0.001). The average dose of misoprostol required was less in combination regimen, i.e. 1128 ± 384 mcg compared to 1680 ± 302 mcg in misoprostol alone group (<i>p</i> value < 0.001). Side effects like nausea, vomiting and diarrhoea were less in combination regimen than misoprostol alone group.</p><p><strong>Conclusion: </strong>Mifepristone and misoprostol combination is more effective and safer alternative than misoprostol alone in second trimester termination of pregnancy.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 5","pages":"428-433"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Central Fat Accumulation Indices with Body Mass Index in Women with Polycystic Ovary Syndrome. 多囊卵巢综合征妇女中心脂肪堆积指数与体重指数的比较。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-09-20 DOI: 10.1007/s13224-023-01834-z
Neha Singh, Nupur Hooja
{"title":"Comparison of Central Fat Accumulation Indices with Body Mass Index in Women with Polycystic Ovary Syndrome.","authors":"Neha Singh, Nupur Hooja","doi":"10.1007/s13224-023-01834-z","DOIUrl":"10.1007/s13224-023-01834-z","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is an endocrinopathic disorder commonly affecting women in the reproductive age group, predisposing them to risk of metabolic syndrome. Currently, body mass index (BMI) is used as a marker to assess obesity. However, it is the central obesity which is a prevalent characteristic of PCOS which goes undetected in many women who exhibit an apparently lean PCOS. Recently, indices, such as body fat percentage (BFP), visceral adiposity index (VAI) and lipid accumulation product (LAP), have been deemed more effective, as they present formulas, anthropometric indices and biochemical measures. The aim of this study was to compare the other central fat accumulation indices-VAI, LAP and BFP with BMI in women with PCOS.</p><p><strong>Methods: </strong>The descriptive type of cross-sectional study was conducted in a tertiary care hospital which included 110 women, aged 18-40 year fulfilling the Rotterdam criteria for diagnosis of polycystic ovary syndrome. Height, weight and lipid profile were measured, and BMI, LAP and VAI were calculated. Body fat percentage was measured by the body fat analyser using the bioelectrical impedance method. All indices were then compared.</p><p><strong>Results: </strong>BMI showed a significant positive correlation with BFP (<i>r</i> = 0.68). VAI and LAP showed significant correlation with each other (<i>p</i> < 0.05). LAP and VAI were found to weakly correlate with BFP. However, lean PCOS also had higher values of visceral adiposity indices and hence did not show strong correlation.</p><p><strong>Conclusion: </strong>Central fat accumulation indices should be integral in assessing body fat distribution. BFP, VAI and LAP assess fat distribution and function both and, hence, present complete information at low cost.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 1","pages":"156-160"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Placental Histopathology and It's Co-relation with Pregnancy Complications and Neonatal Outcome. 胎盘组织病理学评估及其与妊娠并发症和新生儿结局的关系。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-08-04 DOI: 10.1007/s13224-023-01806-3
B V Induja, Vasudha Sawant, Archana Kumbhar, Addanki Rohith, Cherabudla Mouna
{"title":"Evaluation of Placental Histopathology and It's Co-relation with Pregnancy Complications and Neonatal Outcome.","authors":"B V Induja, Vasudha Sawant, Archana Kumbhar, Addanki Rohith, Cherabudla Mouna","doi":"10.1007/s13224-023-01806-3","DOIUrl":"10.1007/s13224-023-01806-3","url":null,"abstract":"<p><strong>Introduction: </strong>The placental examination provides important information about the effect of maternal abnormalities on the placenta or the cause of preterm delivery, fetal growth restriction, or fetal neurodevelopmental damage. Placental anatomical and pathologic lesions are usually associated with pregnancy complications and neonatal impaired outcome.</p><p><strong>Patients and methods: </strong>We included in our study 100 patients with gestational age of 37-40 weeks. These cases have been then subdivided into the following study groups: Group A: 50 placentas from pathological pregnancies; and, Group B: a control group of 50 physiological or normal pregnancies due to the absence of maternal, fetal, and early neonatal pathologies.</p><p><strong>Results: </strong>In group of complicated pregnancies (Group A), most common complication was severe pre-eclampsia (20%) followed by Gestational hypertension (18%) and Anaemia (16%). Abnormal placental findings were seen in 42% in Group A and in 24% patients in group B. C. Over all neonatal complications were significant significantly high in group A compared to Group B (60% and 36%). LBW (40% and 22%), Need for NICU admission (52% and 32%) and APGAR Score < 7, (8% and 2%) were significantly high in group A compared to Group B. One neonate was expired in Group A and in Group B, no mortality seen.</p><p><strong>Conclusions: </strong>Present study shows that identification of placental histology can be associated with pregnancy outcomes and complications. Understanding Placental histology could help in association with biological markers or more sophisticated instruments for early diagnosis.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 1","pages":"56-60"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrauterine Administration of Autologous Platelet-Derived Growth Factor Concentrate (aka Autologous Blood Cell Derivative) Improves the Endometrial Thickness in 'Thin' Endometrium in the Frozen Embryo Transfer Cycle. 在冷冻胚胎移植周期中,宫内给予自体血小板衍生生长因子浓缩物(又名自体血细胞衍生物)可改善“薄”子宫内膜的子宫内膜厚度。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-04-22 DOI: 10.1007/s13224-022-01735-7
Pratap Kumar, Anjali Mundkur, D Sai Bhavna, Vasanthi Palanivel, Prashanth Adiga, Vidyashree G Poojari, Shubha Rao, Rashmi Ullagaddi
{"title":"Intrauterine Administration of Autologous Platelet-Derived Growth Factor Concentrate (aka Autologous Blood Cell Derivative) Improves the Endometrial Thickness in 'Thin' Endometrium in the Frozen Embryo Transfer Cycle.","authors":"Pratap Kumar,&nbsp;Anjali Mundkur,&nbsp;D Sai Bhavna,&nbsp;Vasanthi Palanivel,&nbsp;Prashanth Adiga,&nbsp;Vidyashree G Poojari,&nbsp;Shubha Rao,&nbsp;Rashmi Ullagaddi","doi":"10.1007/s13224-022-01735-7","DOIUrl":"https://doi.org/10.1007/s13224-022-01735-7","url":null,"abstract":"<p><strong>Context: </strong>Thin endometrium during the frozen embryo transfer cycles leads to cycle cancellation. The embryo transfer cycle getting deferred is an unpleasant experience for the patients and the fertility specialist.</p><p><strong>Aims: </strong>The purpose of this study is to evaluate the effectiveness of Autologous Blood Cell Derivative (ABCD) growth factor concentrate to obtain an optimal thickness of endometrium for embryo transfer during IVF treatments, where rapid regeneration is crucial for the expected therapeutic outcome.</p><p><strong>Settings and design: </strong>A retrospective cohort study was conducted in Manipal Assisted Reproduction Center, a referral center in Southern India.</p><p><strong>Methods and material: </strong>Fifty-six patients with thin endometrium were administered three doses of ABCD growth factor concentrate as per the protocol after informed consent. All of them had a history of embryo transfer (ET) cancellation in frozen-thawed embryo cycles due to inadequate growth of the endometrium despite therapy with estrogens and drugs for improving uterine blood circulation.</p><p><strong>Results: </strong>The endometrium thickness during the implantation window in the patients included in the study averaged 6.48 ± 1.19 mm. After the intervention, 55 out of 56 patients (98.2%) showed a considerable change in the thickness of the endometrium layer with an average thickness of 8.48 ± 1.32 mm (< 0.0001, SE 0.233, 95% CI 1.58-2.5). Out of the 55 patients, 20 got pregnant, i.e., 36.4% pregnancy rate. Till date, thirteen pregnancies had live births (65%), three pregnancies (15%) were biochemical pregnancies, 1 (5%) was ectopic, and three pregnancies (15%) had spontaneous miscarriage before eight weeks. When we compared the endometrial thickness (EMT) in the pregnant and non-pregnant groups pre- and post-ABCD instillation, (6.47 ± 1.31 mm vs 6.48 ± 1.4 mm, <i>p</i> = 0.98 and 8.68 ± 1.32 mm vs 8.48 ± 1.32 mm, <i>p</i> value 0.59) the <i>p</i> value was not statistically significant.</p><p><strong>Conclusions: </strong>The implantation, clinical pregnancy and live birth rates were 36.4, 30 and 65%, respectively. This result is a significant improvement for patients with thin endometrium for whom we would otherwise cancel the frozen transfer. An autologous resource is a safe, readily available and inexpensive treatment modality.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 1","pages":"108-114"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis Resection Using Nerve Sparing Versus Non-nerve Sparing Surgical Techniques. 保留神经与非保留神经的子宫内膜异位症切除术。
IF 0.7
Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-09-05 DOI: 10.1007/s13224-023-01794-4
Shailesh P Puntambekar, Sneha Venkateswaran, Saranya Naidu, Maitreyee Parulekar, Madhavi Patil, Sravya Inampudi, Mihir Chitale, Suyog Bharambe, Aishwarya Puntambekar, Kshitij Manerikar, Seema Puntambekar
{"title":"Endometriosis Resection Using Nerve Sparing Versus Non-nerve Sparing Surgical Techniques.","authors":"Shailesh P Puntambekar, Sneha Venkateswaran, Saranya Naidu, Maitreyee Parulekar, Madhavi Patil, Sravya Inampudi, Mihir Chitale, Suyog Bharambe, Aishwarya Puntambekar, Kshitij Manerikar, Seema Puntambekar","doi":"10.1007/s13224-023-01794-4","DOIUrl":"10.1007/s13224-023-01794-4","url":null,"abstract":"<p><strong>Introduction: </strong>Endometriosis is the condition in which there are ectopic endometrial tissues outside the uterine cavity. The use of nerve sparing technique has been well established in the field of oncology, leading to better quality of life following radical oncologic procedures without compromising on the long-term survival. The objective of this study is to compare the quality of life in terms of sexual function and urinary function in women undergoing nerve sparing surgeries for endometriosis and those undergoing non-nerve sparing surgeries.</p><p><strong>Material and methods: </strong>Data of 51 patients operated for endometriosis at Galaxy Care Laparoscopic Institute, Pune, India between 1st January 2020 till 31st December 2020 were collected and analysed. We included patients in age group between 38 and 44 years in monogamous relationship, with moderate to severe endometriosis (Revised American Society of Reproductive Medicine r-ASRM score of 16 and above 5), being operated for hysterectomy along with ureterolysis and/or bowel resection (including shaving of rectal endometriosis, discoid resection, segmental resection), and excision of large ovarian endometriomas (> 3 cm size) with cul-de-sac obliteration.</p><p><strong>Results: </strong>The patients were evaluated for the following factors: age, parity, nature of surgery done, immediate intraoperative complications (bowel injury, bladder injury, ureteric injury), operative time in minutes, average blood loss, length of hospital stay, days to removal of foley's catheter and postoperative urinary and sexual function which were assessed on follow up visit and a 1-year follow up interview. We found that the urinary and sexual function in the group undergoing nerve sparing surgeries was significantly better than the patients undergoing non-nerve sparing surgeries.</p><p><strong>Conclusion: </strong>Laparoscopic nerve sparing approach for clearance of endometriosis has allowed better quality of life post surgery. Proper understanding and demonstration of pelvic neuroanatomy has made this approach feasible and achievable in carefully selected patients.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 5","pages":"421-427"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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