Journal of Obstetrics and Gynecology of India最新文献

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A Comparative Study Between Continuous and Interrupted Suturing of Rectus Sheath Closure in Caesarean Section Patients at a Tertiary care Teaching Hospital. 某三级教学医院剖宫产术中连续缝合与间断缝合直肌鞘闭合的比较研究。
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-05-21 DOI: 10.1007/s13224-025-02126-4
Sumita Saroj, Hemraj R Narkhede, Rahul Chavan, Anand Karale, Nutan Wanjare
{"title":"A Comparative Study Between Continuous and Interrupted Suturing of Rectus Sheath Closure in Caesarean Section Patients at a Tertiary care Teaching Hospital.","authors":"Sumita Saroj, Hemraj R Narkhede, Rahul Chavan, Anand Karale, Nutan Wanjare","doi":"10.1007/s13224-025-02126-4","DOIUrl":"10.1007/s13224-025-02126-4","url":null,"abstract":"<p><strong>Background: </strong>Caesarean delivery may be followed by several complications, surgical site infection (SSI) being one of them. The rate of SSI ranges from 3 to 15% worldwide (1-6). SSI is associated with a maternal mortality rate of up to 1.33%. (3) It places physical and emotional burdens on the mother and her family.</p><p><strong>Aim: </strong>Study aimed to compare incidence of incisional SSI in two techniques of rectus sheath closure: the conventional continuous method and intermittent in patients undergoing caesarean section.</p><p><strong>Methods: </strong>Comparative observational study of total 578 patients who underwent caesarean sections was enrolled in the study. These were divided into two equal groups of 289 each and assigned as either continuous or intermittent rectus sheath closure group. Standard surgical steps and post-operative care given to all. Wound complications were analysed in both groups.</p><p><strong>Results: </strong>Out of total 578 LSCS studied, we have found 47 SSI (8.1%); 10 (3.4%) SSI found in intermittent rectus sheath closure group which is less than in continuous group, 37 (12.8%). Intermittent closure group is associated with less induration, pain at the wound site, serous discharge, and spontaneous superficial dehiscence. Resuturing need was less in intermitant group but significant difference not noted between the two groups (p = 0.651).</p><p><strong>Conclusion: </strong>Intermittent suturing of rectus sheath is associated with a lower incidence of SSI and fewer clinical manifestations compared to continuous suturing in caesarean section. Adopting the intermittent suturing technique for rectus sheath closure would significantly reduce post-operative complications like wound discharge, wound dehiscence, and improve patient outcomes.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"311-317"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triptorelin 0.1 mg as a Luteal Phase Support in Antagonist Intracytoplasmic Sperm Injection Cycles. 雷公藤雷素0.1 mg作为拮抗剂胞浆内精子注射周期的黄体期支持剂。
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-05-30 DOI: 10.1007/s13224-025-02121-9
Kamal M Zahran, Moustafa M A Ahmed, Tarek A Farghaly, Azza A Elsayed, Ihab M El-Nashar
{"title":"Triptorelin 0.1 mg as a Luteal Phase Support in Antagonist Intracytoplasmic Sperm Injection Cycles.","authors":"Kamal M Zahran, Moustafa M A Ahmed, Tarek A Farghaly, Azza A Elsayed, Ihab M El-Nashar","doi":"10.1007/s13224-025-02121-9","DOIUrl":"10.1007/s13224-025-02121-9","url":null,"abstract":"<p><strong>Background: </strong>Transvaginal progesterone is used to aid throughout the luteal phase. Administering a dose of gonadotrophin-releasing-hormone analogues (GnRHa) six days following OPU in GnRH antagonist cycles might cause rise in pituitary gonadotropins (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)), leading to rise in steroid synthesis (estradiol (E2) and progesterone (P)) by the corpora lutea (CL). This work aimed to contrast the effect of lipopolysaccharides (LPS) with adding GnRHa to progesterone P, at day six after ovum pickup versus P alone, on the clinical pregnancy rate.</p><p><strong>Methods: </strong>This open labeled randomized controlled trial study was carried out at women health hospital (WHH), Assiut University on 150 women with antagonist controlled ovarian hyperstimulation protocol (COH). Individuals had been categorized into two groups: Study group: include women who obtained 0.1 mg of GnRH agonist \"triptorelin\" at day 6 after OPU in addition to (P) since day of oocyte pickup (OPU) compared with the control group: administration of P only since (OPU) as LP support.</p><p><strong>Results: </strong>Women who received GnRHa 0.1 mg & P as LPS were reported significant higher progesterone level, beta human chorionic gonadotropins (BHCG) level, fetal pulsation, implantation rate, clinical pregnancy rate, biochemical pregnancy rate, ongoing pregnancy and live birth rates contrasted to control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Adding GnRHa to P as LPS is associated with significant higher progesterone level at day 7 after OPU BHCG day 14 of embryo transfer, clinical pregnancy rate, biochemical pregnancy rate, implantation rate, ongoing pregnancy rate, and live birth rate.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"290-296"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changing Dynamics of Management in Fetus Near Viability at 23 Weeks to a Successful Outcome. 23周接近生存能力的胎儿到成功结局的管理动态变化。
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-06-30 DOI: 10.1007/s13224-025-02125-5
Venus Bansal, Vikas Bansal
{"title":"Changing Dynamics of Management in Fetus Near Viability at 23 Weeks to a Successful Outcome.","authors":"Venus Bansal, Vikas Bansal","doi":"10.1007/s13224-025-02125-5","DOIUrl":"10.1007/s13224-025-02125-5","url":null,"abstract":"<p><p>Fetus near viability approaching hospitals for care is increasing in number in India. However, the lack of evidence and experience may make an obstetrician reluctant to treat fetuses of 22-26 weeks gestation. The present case demonstrates the intact survival of a 23.5-week-old baby with a multidisciplinary approach. Moreover, we have tried to summarize our hospital protocol for obstetrics and neonatal management to optimize the outcome.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"353-355"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Sub-foveal Choroidal Thickness in Patients with Hypertensive Disorders of Pregnancy Versus Normotensive Pregnant Women in Third Trimester. 妊娠晚期高血压疾病与正常妊娠患者中央凹下脉络膜厚度的比较。
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-06-05 DOI: 10.1007/s13224-025-02122-8
M Sanjana, K B Suma, H V Soumya
{"title":"Comparison of Sub-foveal Choroidal Thickness in Patients with Hypertensive Disorders of Pregnancy Versus Normotensive Pregnant Women in Third Trimester.","authors":"M Sanjana, K B Suma, H V Soumya","doi":"10.1007/s13224-025-02122-8","DOIUrl":"10.1007/s13224-025-02122-8","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive disorders of pregnancy (HDP), is a leading cause of morbidity and mortality in both the mother and the fetus. These disorders often lead to significant systemic and ocular changes, particularly in the choroidal vasculature. The sub-foveal choroidal thickness (SFCT) may provide critical insights into these changes and serve as a non-invasive marker for assessing the severity of HDP.</p><p><strong>Objective: </strong>The study aimed to compare the SFCT in patients with HDP versus normotensive pregnant women in their third trimester and to correlate SFCT with the severity of hypertension.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at JSS Hospital, Mysuru, involving 100 pregnant women in their third trimester, divided into 51 cases (HDP group) and 49 controls (normotensive group). SFCT was measured using spectral domain optical coherence tomography (SD-OCT). Data was analyzed and SFCT values compared between the two groups using mean arterial pressure (MAP).</p><p><strong>Results: </strong>Results showed significantly higher SFCT in the HDP group (229.76 μm) compared to controls (173.45 μm), with a <i>p</i>-value < 0.001. The HDP group also had a notably higher MAP (115.07 mmHg vs. 87.63 mmHg), and a positive correlation (<i>r</i> = 0.541, <i>p</i> < 0.001) was found between MAP and SFCT.</p><p><strong>Conclusion: </strong>The study demonstrates that SFCT is significantly increased in patients with HDP, correlating positively with MAP. Further studies are recommended to explore the broader clinical applications of SFCT in HDP.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"297-303"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal Anomalies: An Obstetrician's Overview. 胎儿畸形:产科医生的概述。
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-08-14 DOI: 10.1007/s13224-025-02211-8
Sujata Dalvi
{"title":"Fetal Anomalies: An Obstetrician's Overview.","authors":"Sujata Dalvi","doi":"10.1007/s13224-025-02211-8","DOIUrl":"10.1007/s13224-025-02211-8","url":null,"abstract":"<p><p>Fetal anomalies-also known as congenital anomalies or birth defects-are unusual conditions that affect fetus during pregnancy. It can affect one or multiple organs, can be structural or functional and range from mild, moderate to severe. Fetal anomalies are present in 3-5% of live births. Congenital anomalies are usually detected in prenatal period during anomaly scan around 18-20 weeks. Some may be detected during NT-NB scan (11-14 weeks) or in third trimester. The risk factors could be genetic, environmental or both, and sometimes, no cause is detected. Some anomalies can resolve after birth, or some may need corrective therapy with special monitoring during antenatal period at specialized center. Patients with fetal anomaly incompatible with life, detected before 24 weeks of gestation, are advised to undergo termination, and those beyond 24 weeks, special permission is needed for termination. Early detection and timely intervention are helpful to improve outcome. Children with fetal anomalies are likely to have physical, intellectual, cognitive impairment leading to emotional stress in family. Awareness with regard to nutritional supplements and folic acid needs to be created, and high-risk factors like diabetes, obesity and certain medications need to be taken care of. Those with genetic predisposition needs thorough counseling, detailed investigations and possibility of treatment with pre-genetic diagnosis (PGD) for next pregnancy.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"275-281"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetoscopic Reduction and Closure for Complex Gastroschisis: A Novel Minimally Invasive Prenatal Approach. 复杂胃裂的胎儿镜复位和闭合:一种新的微创产前方法。
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI: 10.1007/s13224-025-02187-5
Gustavo Yano Callado, Edward Araujo Júnior, Adriane Sakae Tsujita, Wilson Tadashi Tomimatsu, Alexandre Silva E Silva, Rubia Melissa Ferreira Pereira, Maitê Cervantes Chagas, Camila Lopes Ianni, Gustavo Giraldi Silva, Mauricio Saito
{"title":"Fetoscopic Reduction and Closure for Complex Gastroschisis: A Novel Minimally Invasive Prenatal Approach.","authors":"Gustavo Yano Callado, Edward Araujo Júnior, Adriane Sakae Tsujita, Wilson Tadashi Tomimatsu, Alexandre Silva E Silva, Rubia Melissa Ferreira Pereira, Maitê Cervantes Chagas, Camila Lopes Ianni, Gustavo Giraldi Silva, Mauricio Saito","doi":"10.1007/s13224-025-02187-5","DOIUrl":"10.1007/s13224-025-02187-5","url":null,"abstract":"<p><p>Gastroschisis is a congenital defect where fetal intestines herniate through an abdominal wall opening. Although postnatal surgical repair is standard, fetal surgery via fetoscopic techniques is emerging as a potential intervention, particularly for complex cases. This case report documents a fetoscopic technique for in utero gastroschisis correction with favorable outcomes. A fetoscopic surgery for gastroschisis was performed at 29 weeks of gestation. Using ultrasound guidance, a fetoscope and two trocars were introduced into the amniotic cavity to reposition the herniated intestines into the fetal abdomen and close the abdominal wall defect with a continuous suture. The procedure was completed in 80 min, with fetal vitality monitored during surgery. A live female newborn was delivered by cesarean section at 32 weeks of gestation for premature rupture of ovular membranes, weighing 1620 g. The newborn demonstrated appropriate gastrointestinal function and was discharged at 14 days without the need for further surgical interventions. This case report demonstrates the feasibility and safety of fetoscopic repair of gastroschisis, resulting in favorable neonatal outcomes, including early discharge without additional surgery. The approach warrants further investigation by randomized clinical trial to evaluate its benefits compared to standard postnatal treatment for gastroschisis, especially in complex suspect cases.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13224-025-02187-5.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"356-359"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Spatial Hot spots Clustering and Geographically Weighted Regression Analysis to Assess Predictors of Cesarean Section Delivery in Northeastern States, India. 印度东北部剖宫产的空间热点聚类及地理加权回归分析
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-06-28 DOI: 10.1007/s13224-025-02150-4
Kh Jitenkumar Singh, Md Asif Khan, Krishna Kumar, Nongzaimayum Tawfeeq Alee, Saurabh Sharma, Jeetendra Yadav, Ravleen Kaur Bakshi, Reema Mukherjee
{"title":"Identification of Spatial Hot spots Clustering and Geographically Weighted Regression Analysis to Assess Predictors of Cesarean Section Delivery in Northeastern States, India.","authors":"Kh Jitenkumar Singh, Md Asif Khan, Krishna Kumar, Nongzaimayum Tawfeeq Alee, Saurabh Sharma, Jeetendra Yadav, Ravleen Kaur Bakshi, Reema Mukherjee","doi":"10.1007/s13224-025-02150-4","DOIUrl":"10.1007/s13224-025-02150-4","url":null,"abstract":"<p><strong>Background: </strong>It is difficult to achieve health related Sustainable Development Goals when a higher proportion of birth delivery occurs through cesarean section (CS) than vaginal delivery without considerable medical benefits. This study aims to identify the spatial hot spot clustering and determinants of cesarean section in northeastern states, India.</p><p><strong>Methods: </strong>The study utilized data from the fifth round of the National Family Health Survey (NFHS-5, 2019-2021), which included responses from 34,222 mothers who delivered live births in the five years preceding the survey. The study investigated spatial hot spot clustering of CS prevalence using Getis-Ord Gi* statistics and applied multiscale geographically weighted regression (MGWR) to identify spatial clusters in the relationships between predictor variables and CS delivery.</p><p><strong>Results: </strong>The study identified spatial hot spot clustering of CS rates in districts of Sikkim, western and southern Tripura, eastern and western Assam, and central Manipur. MGWR results indicated that significant determinants of CS include maternal age (30-49 years), first birth order, highest educational level, high body mass index, and highest wealth quintile, with regression coefficients varying significantly by district in this region.</p><p><strong>Conclusion: </strong>The study found that CS rates vary by clusters in the districts of northeastern states of India. It suggests that piloting educational interventions for pregnant women and regularly monitoring CS facilities could be initial strategies to better understand and address the higher CS trends in these regions.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"324-330"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Vein PI, Cardiac Function and Remodeling in SGA Fetuses`. SGA胎儿肺静脉PI、心功能及重构。
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-06-28 DOI: 10.1007/s13224-025-02162-0
Vandana Swami, Vatsla Dadhwal, K Aparna Sharma, Vanamail Perumal, Anubhuti Rana, Neha Sahay, Jyoti Meena, Vidushi Kulshrestha
{"title":"Pulmonary Vein PI, Cardiac Function and Remodeling in SGA Fetuses`.","authors":"Vandana Swami, Vatsla Dadhwal, K Aparna Sharma, Vanamail Perumal, Anubhuti Rana, Neha Sahay, Jyoti Meena, Vidushi Kulshrestha","doi":"10.1007/s13224-025-02162-0","DOIUrl":"10.1007/s13224-025-02162-0","url":null,"abstract":"<p><strong>Background: </strong>To investigate the myocardial performance index (MPI), global sphericity index (GSI) and pulmonary vein pulsatility index (PVPI) changes in FGR fetuses in an Indian population.</p><p><strong>Method: </strong>In this prospective observational study, 70 fetuses from 26 weeks to term were recruited into two groups: 35 fetuses with appropriate growth (controls) and 35 with EFW < 10th centile, which were further classified into SGA (<i>n</i> = 14) and FGR (<i>n</i> = 21) based on vessel Doppler parameter (umbilical artery PI > 95th centile, CPR < 5th centile). PVPI, MPI and GSI were measured and compared among groups.</p><p><strong>Result: </strong>Mean PVPI was increased in FGR 0.91 ± 0.23 compared to controls 0.79 ± 0.19 (<i>p</i> = 0.021) and showed an increasing trend across groups-controls, SGA and FGR. The mean GSI was decreased in FGR 1.16 ± 0.12 compared to controls 1.33 ± 0.33 (<i>p</i> = 0.047), indicating a more globular heart. Though the mean MPI did not show a statistically significant difference between the groups, its component ET (ejection time) was shorter in FGR 158.28 ± 17.81 compared to controls 165.54 ± 13.78 (<i>p</i> = 0.047).</p><p><strong>Conclusion: </strong>Growth-restricted fetuses undergo cardiac remodeling due to hemodynamic redistribution and show a decreased global sphericity index, indicating a more globular heart. Additionally pulmonary vein Doppler changes like increased PVPI reflect atrial dynamic changes which can be used as an early predictor of compromise as these occur before DV changes.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"337-342"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal and Fetal Outcomes in Gestational Diabetes Mellitus Treated with Metformin with or Without Insulin. 二甲双胍联合或不联合胰岛素治疗妊娠期糖尿病的母婴结局。
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-06-07 DOI: 10.1007/s13224-025-02124-6
Abhinav Kumar, J Muthukrishnan, Ankita Patel, Burle Chaitanya Kiran
{"title":"Maternal and Fetal Outcomes in Gestational Diabetes Mellitus Treated with Metformin with or Without Insulin.","authors":"Abhinav Kumar, J Muthukrishnan, Ankita Patel, Burle Chaitanya Kiran","doi":"10.1007/s13224-025-02124-6","DOIUrl":"10.1007/s13224-025-02124-6","url":null,"abstract":"<p><strong>Background: </strong>Gestational Diabetes Mellitus (GDM) is linked with a multitude of adverse perinatal outcomes. There is a want for standard guidelines regarding the usage of Metformin in GDM. We aimed to study the perinatal outcomes in women diagnosed with GDM treated primarily with Metformin with or without Insulin.</p><p><strong>Methods: </strong>We conducted a randomized controlled pilot study. with a total of 75 women, divided into three groups: GDM treated with Metformin with or without Insulin (Group M), GDM on Insulin alone (Group I), and healthy pregnant women as controls (Group H), with 25 subjects in each group. At delivery, fetal and maternal outcomes were documented.</p><p><strong>Results: </strong>The mean age in groups M, I and H were 27.4, 26.2, and 27.3 years respectively. The baseline mean HOMA-IR were 3.9 and 4.1 for Group M and Group I, respectively (<i>p</i>-0.560). The mean fetal birth weight was 2.95 ± 0.54 kg, 2.8 ± 0.41 kg, and 2.97 ± 0.65 kg in Groups M, H, and I, respectively (<i>p</i> = 0.527). The mean newborn HOMA-IR in Groups M and I was 1.8 ± 0.4 and 1.7 ± 0.5, respectively (<i>p</i> = 0.185). The adverse events in newborns were 20% (<i>n</i> = 5), 16% (<i>n</i> = 4) and 16% (<i>n</i> = 4) in Groups M, H, and I respectively (<i>p</i> = 0.403). The incidence of caesarean deliveries was 40% (<i>n</i> = 10), 48% (<i>n</i> = 12) and 24% (<i>n</i> = 6) in Groups M, H, and I respectively (<i>p</i>-0.253).</p><p><strong>Conclusion: </strong>The study revealed identical maternal and fetal outcomes in women treated with Metformin as the primary drug compared to conventional treatment with Insulin in GDM.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"304-310"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factor Analysis of Gestational Diabetes Mellitus Across Urban India: Findings from the Pregnancy Study Group. 印度城市妊娠期糖尿病的危险因素分析:来自妊娠研究组的发现。
IF 0.6
Journal of Obstetrics and Gynecology of India Pub Date : 2025-08-01 Epub Date: 2025-06-28 DOI: 10.1007/s13224-025-02178-6
Rutul Gokalani, Ami Sanghvi, Shefali Karlhanis, Prashanth Sankar, Dharmendra Panchal, Ashish Dengra, Bharat Saboo, Sunil Kota, Mahira Saiyed, Banshi Saboo, Shalini Jaggi, Rajeev Chawla
{"title":"Risk Factor Analysis of Gestational Diabetes Mellitus Across Urban India: Findings from the Pregnancy Study Group.","authors":"Rutul Gokalani, Ami Sanghvi, Shefali Karlhanis, Prashanth Sankar, Dharmendra Panchal, Ashish Dengra, Bharat Saboo, Sunil Kota, Mahira Saiyed, Banshi Saboo, Shalini Jaggi, Rajeev Chawla","doi":"10.1007/s13224-025-02178-6","DOIUrl":"10.1007/s13224-025-02178-6","url":null,"abstract":"<p><strong>Background: </strong>GDM is an intermediate phase in a woman's life that certainly poses a high risk of type 2 diabetes. Maternal health affects the health of offspring, a precursor of the vicious cycle of diabetes that continues through generations. Knowing the causative factors of GDM is important to breaking this cycle.</p><p><strong>Objective: </strong>To study the risk factors of GDM in Indian women.</p><p><strong>Method: </strong>The observational study database records from 2022 to 2023 from 11 different centres across India. We included pregnant women diagnosed with GDM with any OGTT criteria and excluded women with pre-existing diabetes.</p><p><strong>Results: </strong>A total of 431 women with GDM were included in the study. 166 women were diagnosed with GDM in the 3rd trimester, followed by 235 women in the 2nd trimester, and 30 women in the 1st trimester of pregnancy. Those detected with GDM during the 1st trimester had a BMI of 27.9 kg/m2, followed by 28.3 and 29.3 kg/m2 in 3rd trimester. Multigravida showed a positive correlation with a family history of T2D (0.04), previous history of GDM (<i>p</i>-value < 0.001), history of stillbirth (<i>p</i>-value < 0.001) and hypertension (<i>p</i>-value 0.03).</p><p><strong>Conclusion: </strong>Pre-pregnancy BMI and women's age at family planning are two important risk factors for the prevention of gestational diabetes.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 4","pages":"343-347"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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