Journal of Obstetrics and Gynecology of India最新文献_第3页

Vaginal Dose Reduction by Changing the Ovoid Loading Pattern in Image Guided Intracavitary Brachytherapy of Cervix. 通过改变图像引导下宫颈腔内近距离放射治疗中的卵圆形装载模式减少阴道剂量

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI: 10.1007/s13224-023-01868-3

Ramya Rangarajan

{"title":"Vaginal Dose Reduction by Changing the Ovoid Loading Pattern in Image Guided Intracavitary Brachytherapy of Cervix.","authors":"Ramya Rangarajan","doi":"10.1007/s13224-023-01868-3","DOIUrl":"https://doi.org/10.1007/s13224-023-01868-3","url":null,"abstract":"Aim: Locally advanced cervical cancer is frequently treated using a combination of external beam radiotherapy and brachytherapy. Radiotherapy often leads to vaginal morbidity, which poses a significant problem. This study aims to analyze the impact of reducing ovoid loading on dosimetry.Materials and methods: We analyzed forty-five CT-based intracavitary brachytherapy plans from fifteen patients. Three plan sets were created for the 45 applications: a standard loading plan (A), a plan with reduced ovoid loading (B), and a tandem-only loading plan (C). We generated Dose-Volume Histograms and recorded dose volume parameters for the three plan sets.Results: The D90 for the Clinical Target Volume (CTV) did not show significant differences among the three plan sets (p = 0.20). The average D90 values for plans A, B, and C were 8.15 Gy, 8.16 Gy, and 7.4 Gy, respectively. No statistically significant differences were observed in D2cc bladder (p = 0.09) (average values: 6.8 Gy, 6.5 Gy, and 5.9 Gy for plans A, B, and C, respectively) and D2cc sigmoid (p = 0.43) (average values: 2.8 Gy, 2.6 Gy, and 2.4 Gy, respectively) among the three plan sets. However, there was a statistically significant difference in D2cc rectum (p < 0.001) (average values: 4 Gy, 3.3 Gy, and 1.8 Gy, respectively), as well as in vaginal dose points (p < 0.001).Conclusion: Reducing ovoid loading significantly decreased the doses to vaginal dose points and the rectum without compromising the dose to the Clinical Target Volume (CTV). Therefore, in carefully selected cases, the adoption of tandem-only loading or reduced ovoid loading could be considered to minimize vaginal morbidity following high dose rate intracavitary brachytherapy.","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 2","pages":"179-184"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MPNST of Uterine Round Ligament: A Report of a Surgically Challenging Aggressive Rare Case and Literature Review. 子宫圆韧带 MPNST：一例极具手术挑战性的罕见病例报告及文献综述

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-12-01 Epub Date: 2023-11-21 DOI: 10.1007/s13224-023-01874-5

Deepak Bose, P Rema, J Sivaranjith, S Suchetha

{"title":"MPNST of Uterine Round Ligament: A Report of a Surgically Challenging Aggressive Rare Case and Literature Review.","authors":"Deepak Bose, P Rema, J Sivaranjith, S Suchetha","doi":"10.1007/s13224-023-01874-5","DOIUrl":"https://doi.org/10.1007/s13224-023-01874-5","url":null,"abstract":"MPNSTs (malignant peripheral nerve sheath tumours) arise rarely from the female genital tract, even more rarely from the uterus. A literature review showed 18 cases affecting the uterine cervix, but only four affecting the uterus per se, making our present case the fifth to be involving the uterus, specifically round ligament. It was the first time a uterine lesion (not uterine cervix) was defined in a neurofibromatosis patient. This was a young patient who initially underwent a uterus-sparing surgery for a round ligament tumour which was finally diagnosed to be MPNST. She received adjuvant chemotherapy but recurred with pelvic vascular involvement. A challenging surgery was performed, and the tumour was resected without morbidity. She was followed up with radiotherapy; however, she quickly developed extensive peritoneal disease and succumbed to the disease. High-grade nature of MPNST along with the background of NF could have made the tumour more aggressive, highlighting the importance of suspecting MPNST in spindle cell tumours of pelvis and performing total resection in the first setting.","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 2","pages":"315-318"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Our Experience of Distal and Total Urethrectomies in Post Irradiated Vulvar Malignancies in Low Resource Settings: A Single Centre Study. 我们在资源匮乏地区对外阴恶性肿瘤辐照后进行远端和全尿道切除术的经验：单中心研究

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-12-01 Epub Date: 2023-11-16 DOI: 10.1007/s13224-023-01854-9

Upasana Baruah, Apoorva Tak, Debabrata Barmon, Dimpy Begum

{"title":"Our Experience of Distal and Total Urethrectomies in Post Irradiated Vulvar Malignancies in Low Resource Settings: A Single Centre Study.","authors":"Upasana Baruah, Apoorva Tak, Debabrata Barmon, Dimpy Begum","doi":"10.1007/s13224-023-01854-9","DOIUrl":"https://doi.org/10.1007/s13224-023-01854-9","url":null,"abstract":"Introduction: At diagnosis, women with vulvar cancer often present in locally advanced stage especially in developing countries, owing to the associated ignorance and social stigma. Generally tumour is seen involving adjacent organs, like the vagina, anus, and urethra. Damage to the sphincter system leads to urinary incontinence. Available evidence regarding urethral resections, subsequent lower urinary tract dysfunction and neo-meatus reconstruction in radical vulvar surgeries is scarce and conflicting.Methodology: Considering, the lack of literature on outcomes of partial and total urethrectomies post chemoradiation in advanced vulvar malignancies from India, in the current study, we analysed our experience of such cases that have been operated post chemoradiation over a span of 2 years (from January 2019 to January 2021).Results: DFS ( disease free survival) of more than 6 months was seen in 5 of our patients, however in view of local wound complications after primary closure, we recommend reconstruction with myocutaneous flaps. Also in view of incontinence observed in two of our patients who had undergone more than 1⁄2 of urethral resection, as a result of failed suprapubic catheterisation, further plan of urethral reconstruction should be considered especially in patients who have received prior radiation.Conclusion: Our small group of patients represents a unique cohort of patients in whom surgery was attempted after radiation therapy. We have seen that surgery is a feasible option after radiotherapy in patients with advanced disease.","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 2","pages":"173-178"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Efficacy of Cervical Ripening and Induction of Labor Using Prostaglandin E1 in Primiparas, Multiparas and Grand Multiparas. 在初产妇、多产妇和大龄多产妇中使用前列腺素 E1 进行宫颈成熟和引产的安全性和有效性。

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-12-01 Epub Date: 2023-11-15 DOI: 10.1007/s13224-023-01847-8

Lior Kashani-Ligumsky, Asaf Bilgory, Ran Neiger

{"title":"Safety and Efficacy of Cervical Ripening and Induction of Labor Using Prostaglandin E1 in Primiparas, Multiparas and Grand Multiparas.","authors":"Lior Kashani-Ligumsky, Asaf Bilgory, Ran Neiger","doi":"10.1007/s13224-023-01847-8","DOIUrl":"https://doi.org/10.1007/s13224-023-01847-8","url":null,"abstract":"Objective: To compare the efficacy and safety of cervical ripening and induction of labor with prostaglandin E1 among primiparas, multiparas and grand multiparas.Study design: This was a retrospective cohort study.Results: Between January and December 2017, 1713 women underwent cervical ripening and induction of labor with prostaglandin E1: 523 were primiparas, 656 were multiparas, and 534 were grand multiparas. Four hundred and seventy-nine (91.6%) primiparas delivered vaginally as did 640 (97.6%) multiparas and 521 (97.6%) grand multiparas. Forty-four (8.4%) primiparas underwent cesarean delivery compared to 16 (2.4%) multiparas and 13(2.4%) grand multiparas. Induction to delivery interval was significantly longer in primiparas (29.7 ± 22.8 h). There were no cases of uterine rupture, and the rates of postpartum hemorrhage and endometritis were similar among the three groups. Neonatal outcomes including Apgar score < 7 and umbilical artery pH < 7.1 were not significantly different between the groups.Conclusion: Using prostaglandin E1 for cervical ripening and labor induction is efficient and safe in primiparas, multiparas and grand multiparas.","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 2","pages":"222-226"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Furcate and Velamentous Cord Insertion: Prenatal Ultrasound. 分叉和Velamentus脐带插入术：产前超声检查。

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-06-08 DOI: 10.1007/s13224-023-01760-0

Nupur Shah

引用次数: 0

Novel Hystero-laparoscopic Technique for LNG-IUD Fixation in Women with High Risk of Expulsion and Desiring to Save the Uterus. 新型宫腔镜-腹腔镜技术用于LNG-IUD固定术，适用于驱逐和渴望挽救子宫的高危女性。

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-06-19 DOI: 10.1007/s13224-023-01788-2

B Ramesh, M S Madhuri, Kiran R Konda, Prajwala S Aradhya, B Jalajakshi

引用次数: 0

Pregnancy Outcome in Bernard-Soulier Syndrome. Bernard-Soulier综合征的妊娠结局。

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-03-17 DOI: 10.1007/s13224-023-01745-z

Vignesh Durai, Sathiyapriya Subburaj, Murali Subbaiah

引用次数: 0

Association of Cerebroplacental Ratio by Colour Doppler with Perinatal Outcome in Near Term and Term Foetuses. 彩色多普勒检测的脑胎盘比率与近期和足月胎儿围产期结局的关系。

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-09-21 DOI: 10.1007/s13224-023-01823-2

Vishakha Dhurvey, Purnima R Satoskar

引用次数: 0

Circulatory Maternal Endothelin 1 and Matrix Metalloproteinase-9 Gene Expression in PREECLAMPSIA: A Study in Western Uttar Pradesh, India. 循环母体内皮素1和基质金属蛋白酶-9基因在先兆子痫中的表达：印度北方邦西部的一项研究。

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2022-11-28 DOI: 10.1007/s13224-022-01720-0

Ravoori Saideswar Rao, Preeti Sharma, Mamta Padhy, Ritu Sharma, Rakesh Gupta, Jayashree Bhatacharjee, Manisha Singh

{"title":"Circulatory Maternal Endothelin 1 and Matrix Metalloproteinase-9 Gene Expression in PREECLAMPSIA: A Study in Western Uttar Pradesh, India.","authors":"Ravoori Saideswar Rao, Preeti Sharma, Mamta Padhy, Ritu Sharma, Rakesh Gupta, Jayashree Bhatacharjee, Manisha Singh","doi":"10.1007/s13224-022-01720-0","DOIUrl":"10.1007/s13224-022-01720-0","url":null,"abstract":"Introduction: Preeclampsia (PE) is a multiorgan disease of pregnant women. The main pathophysiology of PE is a trophoblastic invasion into maternal circulation leading to alterations in circulatory levels of matrix metalloproteinases (MMPs), inflammatory markers, and endothelin 1(ET1) levels. Therefore, the present study has explored the role of MMP-9 and ET1 and their association in PE. The advantage of the study is to provide insight into the pathology of PE. These markers may help in the early diagnosis and prognosis of PE.Objective: To investigate MMP-9 gene expression, ET1 level in PE cases and their correlation with blood pressure (BP), gestational age, weight, and height.Methods: The study design was a case-control observational study, which included 70 subjects in each case (PE) and controls (normal pregnant women (NPW)). Whole blood (250 ul) was utilized for RNA extraction (Trizol method) and synthesized cDNA as per manufacturer protocol. MMP-9 gene expression was analyzed by real-time PCR. Serum was utilized for ET1 estimation by sandwich ELISA.Results: The ET1 levels and MMP-9 gene expression were significantly increased in preeclamptic women as compared to controls. There was no significant correlation between MMP-9 gene expression and serum ET1 levels. However, a significant moderate association between systolic BP and diastolic BP with ET1 levels and MMP9 gene expression was seen in both PE and NPW.Conclusion: A significantly increased circulatory concentration of ET1 and MMP-9 gene expression in PE might be used as an early diagnostic as well as a prognostic marker of PE.","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 1","pages":"97-102"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mode of Delivery and Postpartum Depression: A Cohort Study. 分娩方式与产后抑郁：一项队列研究。

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Journal of Obstetrics and Gynecology of India Pub Date : 2023-10-01 Epub Date: 2023-08-16 DOI: 10.1007/s13224-023-01810-7

Pratima Agarwal, Papa Dasari, Sonali Sarkar

{"title":"Mode of Delivery and Postpartum Depression: A Cohort Study.","authors":"Pratima Agarwal, Papa Dasari, Sonali Sarkar","doi":"10.1007/s13224-023-01810-7","DOIUrl":"10.1007/s13224-023-01810-7","url":null,"abstract":"Background: There are many established risk factors for postpartum depression (PPD). It is controversial whether the mode of delivery is associated with PPD. This prospective study assessed the prevalence of PPD among women who delivered normally versus cesarean section and the association between sociodemographic factors and clinical factors with PPD.Materials and methods: This prospective cohort study was conducted in the Department of Obstetrics and Gynecology, JIPMER Hospital Puducherry, from July 2019 to June 2020. Women without high risk factors for PPD were included. The sample size was 121 in the normal delivery (ND) group and 121 in the cesarean section (CS) group. PPD screening was conducted within one week of delivery and again after six weeks of delivery using a validated Tamil or English version of the Edinburgh Postnatal Depression Scale (EPDS). A score of EPDS score ≥ 13 was considered positive for PPD. Univariate and multivariable analysis was done to find out the association.Results: The overall prevalence of PPD was 27.27%. The prevalence of PPD was higher in the CS (34.71%) than in the ND group (19.83%). PPD was found 2.1 times (OR-2.1, CI 1.2-3.8) in the CS group within one week and 2.5 times (RR-2.5, CI 1.5-3.9) at six weeks of delivery, respectively. Among the social factors, a history of domestic abuse or violence was found to be significantly associated with PPD by both univariate and multivariable analysis.Conclusion: PPD was twice higher among women in the CS than in the ND group. Domestic abuse or violence was very highly significantly associated with PPD.","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"73 Suppl 1","pages":"88-96"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0