Joseph J Gallo, Timothy C Guetterman, Janiece L Taylor, Emerald Jenkins, Sarah M Murray
{"title":"Applying Mixed Methods to Enhance Health Equity in Research on Dementia and Cognitive Impairment.","authors":"Joseph J Gallo, Timothy C Guetterman, Janiece L Taylor, Emerald Jenkins, Sarah M Murray","doi":"10.1177/08982643241308933","DOIUrl":"10.1177/08982643241308933","url":null,"abstract":"<p><p>ObjectivesThe NIA health disparities research framework details a life course approach that considers multilevel environmental, sociocultural, behavioral, and biological factors. Mixed methods are well-suited to study complex problems like structural racism, combining the benefits of generalizability with contextualization.MethodsWe draw on experience as faculty in the Mixed Methods Research Training Program for the Health Sciences to introduce mixed methods research on health equity and disparities in dementia and cognitive impairment.ResultsWe describe common reasons why health science investigators may use mixed methods, provide examples of mixed methods designs, and discuss challenges and practicalities of mixed methods research.DiscussionMany risk factors for dementia are modifiable, so the emphasis of research turns from description to intervention studies that enhance health equity. The information and insights acquired from the use of mixed methods are central in tailoring interventions to populations most affected by Alzheimer's disease and related dementias.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":"37 3-4_suppl","pages":"104S-113S"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah N Forrester, Joseph J Gallo, Jeannie-Marie Leoutsakos, Roland J Thorpe, Timothy M Hughes, Annette L Fitzpatrick, Stephen R Rapp, Teresa E Seeman
{"title":"Measuring the Interrelationships Between Cognitive Performance, Race/Ethnicity, Discrimination, Health Behaviors, and Physiological Dysregulation: A Path Analysis of the Multi-Ethnic Study of Atherosclerosis.","authors":"Sarah N Forrester, Joseph J Gallo, Jeannie-Marie Leoutsakos, Roland J Thorpe, Timothy M Hughes, Annette L Fitzpatrick, Stephen R Rapp, Teresa E Seeman","doi":"10.1177/08982643241309457","DOIUrl":"10.1177/08982643241309457","url":null,"abstract":"<p><p>ObjectiveThe objective of this study was to examine the interrelationships between cognitive performance, race/ethnicity, discrimination, health behaviors, and physiological dysregulation.MethodsWe used data from the Multi-Ethnic Study of Atherosclerosis (MESA) (<i>N</i> = 1667). We used path analyses to examine the association between discrimination, physiological dysregulation, health behaviors, and cognitive performance using the Cognitive Ability Screening Instrument (CASI) at Exam 5 (2010-12) and Exam 6 (2016-18). We examined the relationship between discrimination at Exam 1 (2000-02) and physiological dysregulation at Exam 5. We used overall and ethnoracial-stratified path analysis. All models were adjusted for age, sex, site, depression, stress, socioeconomic status, and <i>APOE</i>-e4.ResultsPhysiological dysregulation was associated with worse cognitive performance in the full sample and among the White ethnoracial subgroup. Everyday discrimination was associated with better cognitive performance among Black participants.DiscussionAssociations between discrimination, physiological dysregulation, and cognitive performance vary and should be examined longitudinally.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":"37 3-4_suppl","pages":"40S-52S"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roshanak Mehdipanah, Emily M Briceño, Madelyn Malvitz, Wen Chang, Lisa Lewandowski-Romps, Steven G Heeringa, Deborah A Levine, Darin B Zahuranec, Kenneth M Langa, Xavier F Gonzales, Nelda Garcia, Lewis B Morgenstern
{"title":"Exploring Pathways to Caregiver Health: The Roles of Caregiver Burden, Familism, and Ethnicity.","authors":"Roshanak Mehdipanah, Emily M Briceño, Madelyn Malvitz, Wen Chang, Lisa Lewandowski-Romps, Steven G Heeringa, Deborah A Levine, Darin B Zahuranec, Kenneth M Langa, Xavier F Gonzales, Nelda Garcia, Lewis B Morgenstern","doi":"10.1177/08982643241235970","DOIUrl":"10.1177/08982643241235970","url":null,"abstract":"<p><strong>Objectives: </strong>This study examines the associations of ethnicity, caregiver burden, familism, and physical and mental health among Mexican Americans (MAs) and non-Hispanic Whites (NHWs).</p><p><strong>Methods: </strong>We recruited adults 65+ years with possible cognitive impairment (using the Montreal Cognitive Assessment score<26), and their caregivers living in Nueces County, Texas. We used weighted path analysis to test effects of ethnicity, familism, and caregiver burden on caregiver's mental and physical health.</p><p><strong>Results: </strong>516 caregivers and care-receivers participated. MA caregivers were younger, more likely female, and less educated compared to NHWs. Increased caregiver burden was associated with worse mental (B = -0.53; <i>p</i> < .001) and physical health (B = -0.15; <i>p</i> = .002). Familism was associated with lower burden (B = -0.14; <i>p</i> = .001). MA caregivers had stronger familism scores (B = 0.49; <i>p</i> < .001).</p><p><strong>Discussion: </strong>Increased burden is associated with worse caregiver mental and physical health. MA caregivers had stronger familism resulting in better health. Findings can contribute to early identification, intervention, and coordination of services to help reduce caregiver burden.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":" ","pages":"148-155"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11339238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna-Maria Lahti, Tuija M Mikkola, Niko S Wasenius, Timo Törmäkangas, Jenni N Ikonen, Sini Siltanen, Johan G Eriksson, Mikaela B von Bonsdorff
{"title":"Social Mobility and Health-Related Quality of Life Trajectory Classes Among Older Women and Men.","authors":"Anna-Maria Lahti, Tuija M Mikkola, Niko S Wasenius, Timo Törmäkangas, Jenni N Ikonen, Sini Siltanen, Johan G Eriksson, Mikaela B von Bonsdorff","doi":"10.1177/08982643241242513","DOIUrl":"10.1177/08982643241242513","url":null,"abstract":"<p><strong>Objectives: </strong>Changes in socioeconomic status (SES) during life may impact health in old age. We investigated whether social mobility and childhood and adulthood SES are associated with trajectories of health-related quality of life (HrQoL) over a 17-year period.</p><p><strong>Methods: </strong>We used data from the Helsinki Birth Cohort Study (<i>n</i> = 2003, 46% men, mean age 61.5 years). Social mobility was derived from childhood SES, obtained from healthcare records, and register-based adulthood SES.</p><p><strong>Results: </strong>Logistic regression models showed that lower adulthood SES was associated with lower physical HrQoL trajectories. Among men low (OR 3.95, <i>p</i> < .001), middle (OR 2.20, <i>p</i> = .006), and declining lifetime SES (OR 2.41, <i>p</i> = .001) were associated with lower physical HrQoL trajectories compared to men with high SES. Socioeconomic status was not associated with mental HrQoL trajectories.</p><p><strong>Discussion: </strong>Declining SES during life course may have negative health consequences, while improving SES is potentially as beneficial as high SES to later-life health among men.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":" ","pages":"220-232"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amanda Emerson, Xinyang Li, Nick Zaller, Megha Ramaswamy
{"title":"Characterizing Aging-Related Health in Older Women with a History of Incarceration: Multimorbidity, Polypharmacy, Mortality, Frailty, and Depression.","authors":"Amanda Emerson, Xinyang Li, Nick Zaller, Megha Ramaswamy","doi":"10.1177/08982643241233322","DOIUrl":"10.1177/08982643241233322","url":null,"abstract":"<p><strong>Objective: </strong>To characterize aging-related health in women with past CLSI and compare with women with no-CLSI.</p><p><strong>Method: </strong>Health and Retirement Study Wave 11 and 12 data from women age >50 with CLSI were compared with data from women age >50 with no-CLSI. Generalized linear models were estimated for aging-related health outcomes.</p><p><strong>Results: </strong>The group with CLSI (<i>n</i> = 230) was significantly younger than the no-CLSI group (<i>n</i> = 8035) yet had more physical, functional, and mental health challenges and fewer resources. Incarceration significantly predicted aging-related outcomes of multimorbidity, polypharmacy, mortality, frailty, and depression.</p><p><strong>Discussion: </strong>Earlier onset of physical and functional health conditions in women with past CLSI has implications for health education and promotion, clinical practice, and intervention design.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":" ","pages":"135-147"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Learning Barriers, Engagement, and Interests Among Low-Income Latino Older Adults: Highlighting the Privilege of Learning and Retirement.","authors":"Tania M Rodriguez, Xitlaly Neri, Rachel Wu","doi":"10.1177/08982643241309135","DOIUrl":"10.1177/08982643241309135","url":null,"abstract":"<p><p>ObjectivesEngagement in learning new skills can potentially foster cognitive and functional growth among low-income Latinos, a population at high risk for developing Alzheimer's disease and related dementias. However, they may face unique barriers to learning. The present qualitative study identified learning barriers, learning engagement, and learning interests among low-income Latino older adults.MethodsTwenty Spanish-speaking participants were interviewed utilizing a semi-structured interview protocol. The data were analyzed using a thematic analysis approach.ResultsSome of the identified barriers include lacking good health, finances, learning opportunities, technology, proficiency in English, transportation, and motivation. Participants were most interested in learning technology, English, sewing skills, and culinary arts to primarily improve their financial situation.DiscussionThese findings highlight the privilege of prioritizing leisure activities for novel skill learning in old age for those with more financial resources. Our findings promote the need to provide tailored novel skill learning opportunities for underserved populations.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":"37 3-4_suppl","pages":"53S-65S"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing Alzheimer's Disease and Related Dementias Research: The Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research.","authors":"George W Rebok, Joseph J Gallo, Roland J Thorpe","doi":"10.1177/08982643241308448","DOIUrl":"10.1177/08982643241308448","url":null,"abstract":"<p><p>ObjectiveThis article introduces a special issue on advancing Alzheimer's disease (AD) and AD-related dementias (ADRD) research drawing from research conducted by the Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research (JHAD-RCMAR).MethodWe describe the JHAD-RCMAR, highlighting work of early career investigators in the JHAD-RCMAR, summarize key accomplishments, and propose recommendations for next steps in ameliorating disparities in cognitive decline and AD/ADRD risk.ResultsArticles in this special issue report on innovative research focused on basic, clinical, psychosocial, or health services aspects of minority aging, AD/ADRD, and health disparities. In addition, we include a paper on how mixed methods can be used to enhance health equity in research on AD/ADRD and cognitive impairment.DiscussionThe Supplement helps fill a critical knowledge gap regarding drivers of disparities in cognitive decline or risk in AD/ADRD, thereby informing future work as it relates to AD/ADRD and health equity.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":"37 3-4_suppl","pages":"3S-8S"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia L Sheffler, Zhuo Meng, Natalie Sachs-Ericsson, Viviana G Caimary, Juhi Patel, Scott Pickett
{"title":"Sleep Quality as a Critical Pathway Between Adverse Childhood Experiences and Multimorbidity and the Impact of Lifestyle.","authors":"Julia L Sheffler, Zhuo Meng, Natalie Sachs-Ericsson, Viviana G Caimary, Juhi Patel, Scott Pickett","doi":"10.1177/08982643241237832","DOIUrl":"10.1177/08982643241237832","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to establish the effects of ACEs on multimorbidity through sleep quality and investigate whether lifestyle factors (e.g., eating habits and exercise) may influence this relationship among middle-aged and older adults.</p><p><strong>Methods: </strong>Participants were drawn from a cross-sectional sample of community dwelling older adults (<i>N</i> = 276, 55+) and three waves of data from the Midlife in the United States study (MIDUS, <i>N</i> = 843). We examined the direct and indirect effects of ACEs, sleep quality, and health conditions, as well as the conditional effects of physical activity and eating habits.</p><p><strong>Results: </strong>Across both samples, sleep quality mediated the relationship between ACEs and chronic health conditions. Moderating effects of unhealthy eating and physical activity differed between samples.</p><p><strong>Discussion: </strong>Sleep quality is an important pathway connecting ACEs and adult multimorbidity, and health behaviors may provide targets for intervention particularly in older adults.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":" ","pages":"167-181"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mallory J Bell, Madison R Sauerteig-Rolston, Kenneth F Ferraro
{"title":"Is Early-Life Enrichment Associated With Better Cognitive Function Among Older Adults? Examining Home and School Environments.","authors":"Mallory J Bell, Madison R Sauerteig-Rolston, Kenneth F Ferraro","doi":"10.1177/08982643241232718","DOIUrl":"10.1177/08982643241232718","url":null,"abstract":"<p><p><b>Objectives:</b> We examine whether early-life enrichment, involving varied and stimulating activities to enhance cognitive function during childhood and adolescence, is associated with cognitive function in later life and whether the benefits persist over time. <b>Methods:</b> Growth curve models were used to examine up to five waves of data from the Health and Retirement Study-a nationally representative survey of adults 50 years and older (<i>N</i> = 10,070). We constructed separate measures of early-life enrichment to distinguish sources of influence (i.e., enriched home environment and enriched school environment). Global cognitive function was assessed with a modified version of the Telephone Interview for Cognitive Status. <b>Results:</b> Greater enrichment in each environment was incrementally associated with better cognitive function at baseline, but enrichment was not associated with change in cognitive function over time. <b>Discussion:</b> Receiving enrichment from multiple environments during sensitive periods of cognitive development may be advantageous for cognitive functioning in later life.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":" ","pages":"156-166"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Resigned but Resilient: Caregiver Perceptions of Role Ambiguity and Quality of Care During Hospital-to-Home Transitions of Older Latinos Living With Dementia.","authors":"Sylvan Greyson, Maningbe Keita, Rhea Sharma, Sevil Yasar, Cynthia Boyd, Sarah Keller, Ayse Gurses, Quincy Samus, Alicia Arbaje","doi":"10.1177/08982643241309443","DOIUrl":"10.1177/08982643241309443","url":null,"abstract":"<p><p>ObjectivesHospital-to-home transitions are high-risk periods, especially for Latinos living with dementia. Cultural differences may exacerbate role ambiguity-unclear patient/caregiver/provider roles. The objective was to elicit views on role ambiguity and care quality during hospital-to-home transitions of older Latinos with dementia and categorize factors shaping healthcare-related task distribution.MethodsQualitative study using semi-structured interviews with caregivers of older Latinos with dementia.ResultsInterviews with 21 caregivers indicated 1) concern about over-medication, 2) resignation over limited medication effectiveness, 3) scarcity of culturally specific resources, 4) wariness to trust medical institutions, and 5) aversion to institutional care. Factors shaping healthcare-related tasks were geographic proximity, gender roles, relationship to patient, English fluency, and work schedules.DiscussionCaregivers felt disillusioned and unsupported during care transitions. Findings suggest healthcare professionals and advocacy organizations should carefully consider efforts to connect caregivers to sources of culturally tailored, home-based support, and they could engage in concerted efforts to earn trust.</p>","PeriodicalId":51385,"journal":{"name":"Journal of Aging and Health","volume":"37 3-4_suppl","pages":"66S-75S"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}