Applied Neuropsychology-Adult最新文献_第5页

Demographically unadjusted cognitive test scores may enhance the validity of mild cognitive impairment as a dementia prodrome. 人口统计学上未调整的认知测试分数可能会提高轻度认知障碍作为痴呆前驱症状的有效性。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-14 DOI: 10.1080/23279095.2025.2518576

Mathilde Suhr Hemminghyth, Monica Haraldseid Breitve, Luiza Jadwiga Chwiszczuk, Berglind Gísladóttir, Erik Hessen, Nikias Siafarikas, Ragnhild Eide Skogseth, Gøril Rolfseng Grøntvedt, Henrik Karlsen, Arvid Rongve, Tormod Fladby, Bjørn-Eivind Kirsebom

{"title":"Demographically unadjusted cognitive test scores may enhance the validity of mild cognitive impairment as a dementia prodrome.","authors":"Mathilde Suhr Hemminghyth, Monica Haraldseid Breitve, Luiza Jadwiga Chwiszczuk, Berglind Gísladóttir, Erik Hessen, Nikias Siafarikas, Ragnhild Eide Skogseth, Gøril Rolfseng Grøntvedt, Henrik Karlsen, Arvid Rongve, Tormod Fladby, Bjørn-Eivind Kirsebom","doi":"10.1080/23279095.2025.2518576","DOIUrl":"https://doi.org/10.1080/23279095.2025.2518576","url":null,"abstract":"Mild cognitive impairment (MCI) precedes most forms of neurodegenerative dementias and is considered an important time window for treatment initiation. It is however unclear whether the widespread use of demographically adjusted norms improve detection of dementia-related impairment and identification of individuals at risk for dementia. In the current multicenter study (n = 561), we compared three Petersen/Winblad criteria-based MCI diagnoses with varying levels of demographic adjustments, in relation to their associations with biomarkers for Alzheimer's disease and neurodegeneration, as well as risk of conversion to future dementia. Our MCI diagnoses were (1) demographically unadjusted; (2) adjusted for sex and education; or (3) adjusted for age, sex, and education. In our cohort, we found the differences between the models to be small, albeit consistent, and our results show a tendency for an unadjusted MCI diagnosis to be more strongly associated to dementia biomarkers and conversion to dementia. Our results thus suggest that an MCI diagnosis based on unadjusted test scores may provide a more valid diagnosis of prodromal dementia, while no evidence is provided to support this in other contexts. This goes against the recommendations from the major diagnostic classification systems, indicating the need for further research to explore these relationships.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing stroke detection with genetic algorithm-based feature selection in deep learning models. 深度学习模型中基于遗传算法的特征选择优化脑卒中检测。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-14 DOI: 10.1080/23279095.2025.2516259

Gouri Sankar Nayak, Pradeep Kumar Mallick, Dhaneshwar Prasad Sahu, Avinash Kathi, Rewat Reddy, Jahnavi Viyyapu, Nithina Pabbisetti, Sai Parvathi Udayana, Harika Sanapathi

{"title":"Optimizing stroke detection with genetic algorithm-based feature selection in deep learning models.","authors":"Gouri Sankar Nayak, Pradeep Kumar Mallick, Dhaneshwar Prasad Sahu, Avinash Kathi, Rewat Reddy, Jahnavi Viyyapu, Nithina Pabbisetti, Sai Parvathi Udayana, Harika Sanapathi","doi":"10.1080/23279095.2025.2516259","DOIUrl":"https://doi.org/10.1080/23279095.2025.2516259","url":null,"abstract":"Brain stroke is a leading cause of disability and mortality worldwide, necessitating the development of accurate and efficient diagnostic models. In this study, we explore the integration of Genetic Algorithm (GA)-based feature selection with three state-of-the-art deep learning architectures InceptionV3, VGG19, and MobileNetV2 to enhance stroke detection from neuroimaging data. GA is employed to optimize feature selection, reducing redundancy and improving model performance. The selected features are subsequently fed into the respective deep-learning models for classification. The dataset used in this study comprises neuroimages categorized into \"Normal\" and \"Stroke\" classes. Experimental results demonstrate that incorporating GA improves classification accuracy while reducing computational complexity. A comparative analysis of the three architectures reveals their effectiveness in stroke detection, with MobileNetV2 achieving the highest accuracy of 97.21%. Notably, the integration of Genetic Algorithms with MobileNetV2 for feature selection represents a novel contribution, setting this study apart from prior approaches that rely solely on traditional CNN pipelines. Owing to its lightweight design and low computational demands, MobileNetV2 also offers significant advantages for real-time clinical deployment, making it highly applicable for use in emergency care settings where rapid diagnosis is critical. Additionally, performance metrics such as precision, recall, F1-score, and Receiver Operating Characteristic (ROC) curves are evaluated to provide comprehensive insights into model efficacy. This research underscores the potential of genetic algorithm-driven optimization in enhancing deep learning-based medical image classification, paving the way for more efficient and reliable stroke diagnosis.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ecological validity of two novel non-immersive virtual reality tests of attention and executive functions in an mTBI population. 两种新颖的非沉浸式虚拟现实测试在mTBI人群中的注意力和执行功能的生态有效性。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-14 DOI: 10.1080/23279095.2025.2518575

Eliyas Jeffay, Sanghamithra Ramani, Konstantine K Zakzanis

{"title":"The ecological validity of two novel non-immersive virtual reality tests of attention and executive functions in an mTBI population.","authors":"Eliyas Jeffay, Sanghamithra Ramani, Konstantine K Zakzanis","doi":"10.1080/23279095.2025.2518575","DOIUrl":"https://doi.org/10.1080/23279095.2025.2518575","url":null,"abstract":"Introduction: Within the realm of mild traumatic brain injury (mTBI) research, it has been argued that current test measures of attention are not sufficiently sensitive to assess the various aspects of attention involved in everyday life. The literature indicates that virtual reality (VR) test measures that resemble real-life situations have good ecological validity. Novel VR assessment tools were developed and their predictive ability investigated as it pertains to return to work (RTW) in a sample of patients in the post-acute recovery period of mTBI.Methods: 50 participants who had sustained an mild traumatic brain injury (mTBI) were recruited. Their clinical evaluation included an intake interview, standardized neuropsychological battery, psychological questionnaires. Two virtual reality tests (VRTs) were developed and also given to the participants.Results: Tests of attention (VR and traditional tests) significantly predicted group membership at 82% accuracy, with 82.6% sensitivity and 81.5% specificity. The second difficulty level attention shift trial of the VRT and to a lesser degree the total speed score of the Ruff 2 & 7 were predictive of employment status.Discussion: These findings provide a starting point for future studies to determine which particular parameters and combination of tests would comprise an 'ecological battery' in an effort to place clinical neuropsychological diagnostic decision making as it pertains to employability on firmer scientific grounds.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-20"},"PeriodicalIF":1.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-cultural adaptation, reliability, and validity of the rehabilitation activities profile (RAP) in stroke patients. 脑卒中患者康复活动档案（RAP）的跨文化适应、可靠性和有效性。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-11 DOI: 10.1080/23279095.2025.2517761

Leyla Kaya Ozturk, Sedef Sahin, Orkun Tahir Aran, Meral Huri

{"title":"Cross-cultural adaptation, reliability, and validity of the rehabilitation activities profile (RAP) in stroke patients.","authors":"Leyla Kaya Ozturk, Sedef Sahin, Orkun Tahir Aran, Meral Huri","doi":"10.1080/23279095.2025.2517761","DOIUrl":"https://doi.org/10.1080/23279095.2025.2517761","url":null,"abstract":"Objective: The Rehabilitation Activities Profile (RAP) is an interview-based scale designed to assess both performance and self-perceived problem severity in activities of daily living (ADL). The aim of this study was to provide cultural adaptation of the RAP and to examine the reliability and validity of this adaptation individuals with stroke.Methods: The translation and cross-cultural adaptation process followed Beaton's guidelines. A total of 81 individuals with stroke (36 female, 45 male) were included. Test-retest reliability was evaluated using the intra-class correlation coefficient (ICC), internal consistency was assessed using Cronbach's alpha, and construct validity was examined by analyzing the correlation between RAP scores and the Barthel Index (BI), a measure of ADL performance.Results: Following the cross-cultural adaptation, minor modifications were made to enhance cultural relevance. Test-retest reliability was excellent, with ICC values of 0.976 for RAP disability and 0.986 for RAP self-perceived problem severity. Internal consistency was high, with Cronbach's alpha values of 0.953 for RAP disability and 0.911 for self-perceived problem severity. Construct validity analysis revealed a strong negative correlation between RAP scores and BI (r = -0.856, p < 0.001), supporting the validity of the scale.Conclusion: This study provides preliminary evidence supporting the use of the Turkish RAP in clinical and research settings for comprehensive assessment of ADL-related disability and self-perceived problem severity in stroke patients.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative analysis of executive functions in Broca's aphasia and healthy adults. 布洛卡失语症与健康成人执行功能的比较分析。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-10 DOI: 10.1080/23279095.2025.2515127

Dana Irani, Mehdi Purmohammad, Shabnam Abbasian

{"title":"A comparative analysis of executive functions in Broca's aphasia and healthy adults.","authors":"Dana Irani, Mehdi Purmohammad, Shabnam Abbasian","doi":"10.1080/23279095.2025.2515127","DOIUrl":"https://doi.org/10.1080/23279095.2025.2515127","url":null,"abstract":"Cognitive deficits can be present in people with aphasia and may affect their language abilities. Neuroimaging research suggests a correlation between the activation of brain regions responsible for executive functions and language recovery in aphasia. Considering the critical role of executive functions in language rehabilitation and the inconsistencies reported in previous findings, the present study aimed to characterize the executive function profiles of individuals with Broca's aphasia. Thirty individuals with Broca's aphasia and 30 healthy controls were examined using the Western Aphasia Battery (WAB) and the Delis-Kaplan Executive Function System (D-KEFS). D-KEFS subtests, including Trail Making, Design Fluency, Sorting, Tower, and Proverb, were used were used to assess problem-solving, creativity, inhibition, concept formation, cognitive shifting, spatial planning, rule learning, and cognitive set maintenance. Individuals with Broca's aphasia performed significantly lower than healthy controls on all tests, demonstrating greater difficulty in specific executive function domains. These results indicate a strong correlation between Broca's aphasia and executive functions.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the recovery process of post-traumatic amnesia: A single-center retrospective study. 创伤后遗忘症的恢复过程分析：单中心回顾性研究。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-07 DOI: 10.1080/23279095.2025.2515605

Èlia Vilageliu-Jordà, Antonia Enseñat-Cantallops, Alberto García-Molina

{"title":"Analysis of the recovery process of post-traumatic amnesia: A single-center retrospective study.","authors":"Èlia Vilageliu-Jordà, Antonia Enseñat-Cantallops, Alberto García-Molina","doi":"10.1080/23279095.2025.2515605","DOIUrl":"https://doi.org/10.1080/23279095.2025.2515605","url":null,"abstract":"This study aimed to investigate the orientation recovery process in patients with post-traumatic amnesia (PTA) following a traumatic brain injury (TBI). A retrospective observational study was carried out with 55 patients with PTA admitted to the Institut Guttmann Neurorehabilitation Hospital between 2019 and 2023. PTA was assessed using the Galveston Orientation and Amnesia Test (GOAT). Changes in the orientation recovery process were evaluated through an ad hoc questionnaire administered at four different time points. Statistically significant differences were found between the different administrations of the PTA questionnaire for the following variables: date of birth (p = 0.014), age (p = 0.014), current location (p < 0.001), hospital name (p < 0.001), year (p < 0.001), month (p < 0.001), and day of the month (p = 0.002). Our results show marked variability in patient responses, making it difficult to establish a single prototypical pattern of orientation recovery in cases of PTA. Beyond the dimensional view of orientation recovery, attention to individual elements is necessary to understand the process of orientation recovery in patients with PTA, as well as to determine the nature of early neurorehabilitation interventions.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impairments in executive functions four years after a stroke. 中风后四年的执行功能受损。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-04 DOI: 10.1080/23279095.2025.2512784

Marte C Ørbo, Marianne Berg Halvorsen, Synne Garder Pedersen, Mari Thoresen Løkholm, Audny Anke

{"title":"Impairments in executive functions four years after a stroke.","authors":"Marte C Ørbo, Marianne Berg Halvorsen, Synne Garder Pedersen, Mari Thoresen Løkholm, Audny Anke","doi":"10.1080/23279095.2025.2512784","DOIUrl":"https://doi.org/10.1080/23279095.2025.2512784","url":null,"abstract":"Post-stroke executive functions (EF) are understudied, particularly in the chronic phase. This study assesses impairment rates in Working Memory, Inhibition, and Shifting, examines the correlations between domain-specific EF measured with performance tests and self-report, and explores whether vascular risk factors and initial stroke characteristics predict specific EF 4 years post-stroke. Sixty-five stroke survivors (48 men, mean age = 64 years), with mild (55%) or moderate (42%) strokes at onset performed subtests from the Delis-Kaplan Executive Function System, Wechsler Adult Intelligence Scale-IV, Conners Continuous Performance Test 3rd ed., and the self-reported Behavior Rating Inventory of Executive Functions. Subtests were combined into EF domain scores and global composite scores, calculated separately for self-reported and performance-based tests. Correlational analyses and multivariate models were employed to probe associations. Aside from the Digit Span Backwards, all test scores were below average. Impairment rates varied from 11 to 49% on individual tests but were reduced in domain and global composites. No significant correlations were found between self-reported and performance-based measures within an EF domain. Predictor analyses showed that atrial fibrillation was associated with poorer Shifting, diabetes with poorer Inhibition, and shorter education with poorer Working Memory, all with moderate effect sizes but only for performance EF. EF impairments were common, varying by domain and method of measurement. Performance-based EF domains, unlike the self-reported domains, were linked to vascular risk factors and education level. Further research is needed to identify optimal EF tests for stroke populations. In clinical practice, EF assessment remains paramount, even after mild strokes.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation impacts the relationship between gait speed and cognitive function in caregivers. 炎症影响看护者的步态速度和认知功能之间的关系。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-03 DOI: 10.1080/23279095.2025.2507846

Eliza Morgan, Adriana Savettiere, Jovian Lam, Rowena Gomez, Tilman Schulte, J Kaci Fairchild

{"title":"Inflammation impacts the relationship between gait speed and cognitive function in caregivers.","authors":"Eliza Morgan, Adriana Savettiere, Jovian Lam, Rowena Gomez, Tilman Schulte, J Kaci Fairchild","doi":"10.1080/23279095.2025.2507846","DOIUrl":"https://doi.org/10.1080/23279095.2025.2507846","url":null,"abstract":"Caregivers report significantly higher levels of stress than non-caregivers, which is related to increased burden associated with caregiving responsibilities. Chronic stress and caregiver burden are both associated with poorer health outcomes, slowed gait, and worse cognitive function. The positive relationship between gait speed and cognition, notably executive function and processing speed, is well-documented. However, less is understood about factors that influence this relationship. One important and yet unexplored factor is inflammation, as it holds a negative relationship to both gait speed and cognitive function. Thus, the current study explores the impact of inflammation on the relationship between gait speed and cognition in caregivers reporting subjective burden. The sample included 43 well-educated (i.e., 93% with some college education or more) caregivers aged 23 to 83 years (Mage = 58.35) who provided care for someone with traumatic brain injury or dementia. Participants completed a battery that included cognitive (e.g., Stroop Color and Word Test), functional (6-minute walk test), and biological (Interleukin-6 and C-reactive protein) measures. Utilizing a moderation analysis with age as a covariate, caregivers with below average (-1 SD from mean) and average (mean) levels of inflammation exhibited a positive, significant relationship between gait and cognition. However, gait was not associated with cognitive function in caregivers with above average (+1 SD from mean) levels of inflammation, indicating that elevated inflammation suppressed the positive relationship between gait speed and cognition. In both clinical and research settings, it is important to consider the influence of elevated inflammation when assessing gait speed or cognition.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global trends and psychosocial effects of traumatic brain injury: A bibliometric and machine learning analysis. 创伤性脑损伤的全球趋势和心理社会影响：文献计量学和机器学习分析。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-02 DOI: 10.1080/23279095.2025.2507845

Najmeh Motaghi, Amin Saberinia, Hamideh Arvan, Mehdi Ahmadinejad, Hossein Ali Ebrahimi Meimand, Fatemeh Navadeh Khodadadi, Mahdiyeh Khazaneha

{"title":"Global trends and psychosocial effects of traumatic brain injury: A bibliometric and machine learning analysis.","authors":"Najmeh Motaghi, Amin Saberinia, Hamideh Arvan, Mehdi Ahmadinejad, Hossein Ali Ebrahimi Meimand, Fatemeh Navadeh Khodadadi, Mahdiyeh Khazaneha","doi":"10.1080/23279095.2025.2507845","DOIUrl":"https://doi.org/10.1080/23279095.2025.2507845","url":null,"abstract":"Aim: Traumatic brain injury (TBI) is particularly common in low- and middle-income countries, disproportionately affecting youth. While around 80% of TBI cases are classified as mild, even these can lead to disabling symptoms.Methodology: This study involved a comprehensive search for relevant articles published between 1934 and 2024 across multiple databases, utilizing specific keywords for data collection. Bibliometric analyses were conducted using R and VOSviewer tools to evaluate the literature.Results: The analysis included scientific and machine learning evaluations of TBI's pathophysiology, prognosis, and consequences, such as cognitive, behavioral, and physical outcomes, as well as therapeutic interventions and rehabilitation strategies. The findings underscore the need for increased attention to the psychosocial consequences of TBI. Evidence-based research can guide efforts to enhance the quality of life for both patients and caregivers.Conclusion: To improve therapeutic and rehabilitation options for TBI patients, collaborative efforts are essential to support ongoing research in this area. By focusing on the multidimensional effects of TBI, we can better address the needs of individuals living with the long-term consequences of this condition.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-15"},"PeriodicalIF":1.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Worry, gait speed, and inflammation as predictors of processing speed in older adults with amnestic mild cognitive impairments (aMCI). 焦虑、步态速度和炎症作为健忘轻度认知障碍（aMCI）老年人处理速度的预测因子。

IF 1.4 4区心理学

Applied Neuropsychology-Adult Pub Date : 2025-06-02 DOI: 10.1080/23279095.2025.2496748

Jovian C Lam, Lisa N Cruz, Mary Hong-Hoang T Nguyen, J Kaci Fairchild

{"title":"Worry, gait speed, and inflammation as predictors of processing speed in older adults with amnestic mild cognitive impairments (aMCI).","authors":"Jovian C Lam, Lisa N Cruz, Mary Hong-Hoang T Nguyen, J Kaci Fairchild","doi":"10.1080/23279095.2025.2496748","DOIUrl":"https://doi.org/10.1080/23279095.2025.2496748","url":null,"abstract":"Objectives: Efficient processing speed is important for quality of life and can buffer against further cognitive declines for older adults with amnestic mild cognitive impairment (aMCI). Etiologies of processing speed impairments are multifactorial. Slow gait and chronic worry have been suggested to be precursors to cognitive decline in older adults. Furthermore, both slow gait and worry involve inflammatory processes, which contribute to dementia conversion in those with MCI. Despite these links to cognitive decline, no study to date has examined the cumulative association of gait, worry, and inflammation on processing speed. Given the need to study processing speed through a multidisciplinary lens, the current study investigates the contributions of biological (inflammation), physiological (gait speed), and psychological (worry) factors to processing speed in older adults with aMCI.Methods: Participants include 65 community-dwelling older adults with aMCI. Linear regressions were used to (1) assess the contributions of each predictor (gait, inflammation, worry) and (2) compare each predictor versus their cumulative contribution to processing speed, controlling for age.Results: The cumulative contribution of gait, worry, and inflammation significantly predicted processing speed compared to just gait alone, with worry being a significant predictor. No significant difference was found when compared to separate models of worry and inflammation.Conclusions: Worry, even at a subclinical level, showed a significant negative association to processing speed. Interestingly, the contribution of worry on processing speed is more pronounced when considering other health factors, reinforcing the importance of a bio-physio-psychological perspective in cognitive aging.","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0