Neural Plasticity最新文献

{"title":"Functional Changes in the Glymphatic System in Children With Sensorineural Hearing Loss: A Study of Diffusion Tensor Imaging.","authors":"Jin Wang, Jiayan Zhuang, Kongqing Li, Gengbiao Zhang, Hongyi Zheng, Wenbin Zheng","doi":"10.1155/np/4484163","DOIUrl":"10.1155/np/4484163","url":null,"abstract":"<p><strong>Aim: </strong>Diffusion tensor imaging-analysis along the perivascular space (DTI-ALPS) indicators and free-water (FW) mapping derived from diffusion tensor imaging (DTI) data have been proposed as noninvasive markers of glymphatic system (GS) function. This study aimed to investigate GS function in children with sensorineural hearing loss (SNHL) with particular focus on the sensitive period of auditory development.</p><p><strong>Methods: </strong>This study enrolled 53 children with SNHL (SNHL group) and 42 age- and sex-matched healthy children (healthy control [HC] group). Based on the age of 36 months, we separated the study participants into two groups: Group A (0-36 months; A-SNHL group, <i>n</i> = 32; A-HC group, <i>n</i> = 21) and group B (36-180 months; B-SNHL group, <i>n</i> = 21; B-HC group, <i>n</i> = 21). We collected their DTI image data and calculated the ALPS index for the left and right hemispheres and the fractional volume of free water in white matter (FW-WM) and analyzed the differences between the groups. The DTI-ALPS has several limitations, the most prominent one being the influence of microstructure. However, it has many advantages and high clinical value.</p><p><strong>Results: </strong>Compared to the HC group, the ALPS index for both hemispheres in the SNHL group was significantly lower (L: <i>p</i> < 0.001; R: <i>p</i> < 0.001), and group B exhibited the same results (L: <i>p</i> < 0.001; R: <i>p</i> < 0.001). In group A, the left-hemisphere ALPS index of the A-SNHL group was significantly lower than that of the A-HC group (L: <i>p</i> = 0.002; R: <i>p</i> = 0.067). The FW imaging analysis indicated that the FW-WM in the B-SNHL group was significantly higher than that of the B-HC group, and it exhibited a negative correlation with the left-hemisphere ALPS index (<i>r</i> = -0.515, <i>p</i> = 0.017).</p><p><strong>Conclusion: </strong>Children with SNHL (especially those over 3 years old) might exhibit compromised cerebral glymphatic function, possibly attributable to clearance dysfunction and interstitial fluid (ISF) retention. Despite the recognized limitation of DTI-ALPS, its integration with FW mapping may enhance the noninvasive indirect evaluation of glymphatic function.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2026 ","pages":"4484163"},"PeriodicalIF":3.7,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connectomic Mapping of Chronic Musculoskeletal Pain: Neural Circuitries Identified Through a Systematic Review and ALE Meta-Analysis.","authors":"Jeffeson Hildo Medeiros de Queiroz, Gabriel Mesquita da Conceição Bahia, Marcio Gonçalves Corrêa, Rebeca da Costa Gomes, Thais Alves Lobão, Erica Miranda Sanches Aires, Evander de Jesus Oliveira Batista, Gláucia Mota Bragança, Marta Chagas Monteiro, Carlomagno Pacheco Bahia","doi":"10.1155/np/5301861","DOIUrl":"https://doi.org/10.1155/np/5301861","url":null,"abstract":"<p><p>Functional neuroimaging of the encephalon of humans with chronic musculoskeletal pain (CMP) has consistently demonstrated functional alterations in the neurophysiological properties of cortical and subcortical circuits. Nevertheless, the current knowledge on specific neural circuitries that may occur in different CMP subgroups is limited, which in turn limits the understanding of the encephalon mechanisms associated with persistent pain and clinical heterogeneity. This systematic review (CRD42022382309) and activation likelihood estimation (ALE) meta-analysis of observational functional magnetic resonance imaging (fMRI) studies on human encephalon aimed to characterize specific patterns of connectomic reorganization in different CMP subgroups. PubMed, Web of Science, and Scopus databases were searched. Two independent reviewers read titles and abstracts, full texts, assessed methodological quality using the Newcastle-Ottawa scale, and extracted X, Y, and Z coordinates. The data analyses were conducted using the GingerALE 3.0.2 software and complemented by frequency analyses. All neuroanatomical coordinates used in the ALE meta-analyses were standardized to the Montreal Neurological Institute 152 space. A 95% confidence interval (CI) for the family-wise error (FWE) rate was applied using an initial uncorrected voxel-level threshold of p  < 0.001, together with 1000 permutation tests and a minimum cluster volume of ≥200 mm³. In total, 43 studies out of 5543 records met the inclusion criteria and none presented a very high risk of bias. The seven encephalon regions comprising the basic neural circuitry of CMP (somatosensory cortex, motor cortex, anterior cingulate cortex, insula, prefrontal cortex, thalamus, and cerebellum) correspond to an integrated connectomic hub that coordinates sensory-motor discriminative, affective-emotional, and cognitive-motivational processing. Additionally, 13 other regions are specifically recruited in distinct conditions of CMP. These parallel connections expand the processing network and add dimensions related to reward, memory, descending pain modulation, and attention. This dynamic reorganization reflects a pattern of cross-modal plasticity with maladaptive mechanisms.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e5301861"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A JNK-Regulated and IL-1β-Dependent Astrocyte-Neuron Signaling Pathway in the Spinal Dorsal Horn is Essential for Stress-Induced Hyperalgesia.","authors":"Jian Qi, Chen Chen, Qian Gao","doi":"10.1155/np/2791699","DOIUrl":"10.1155/np/2791699","url":null,"abstract":"<p><p>Various forms of mild stress may exacerbate pain in patients with chronic pain disorders, though the underlying mechanism remains unclear. Astrocyte activation in the spinal dorsal horn plays a predominant role in stress and pain. The present study investigated the neuron-astrocyte interactions in the spinal dorsal horn in post-traumatic stress disorder (PTSD)-induced hyperalgesia using a single-prolonged stress (SPS) model, a Complete Freund's Adjuvant (CFA) model and an SPS + CFA model. Animals were tested for mechanical withdrawal threshold (MWT) of the paw after SPS, CFA and SPS + CFA. SPS + CFA group induced significantly increased mechanical allodynia compared with the SPS or CFA group. We tested the hypothesis that IL-1β contributes to signaling between astrocytes and neurons in stress-induced hyperalgesia (SIH). Immunohistochemical data showed that there was an upregulation of glial fibrillary acidic proteins (GFAPs, a marker of astrocyte) and Fos (a marker of neuron) in SIH. Immunohistochemical data showed specific localization of IL-1β to astrocyte, but not to microglia and neurons and a neuronal localization of the IL-1β receptor (IL-1RI) with NMDAR2B (NR2B). Enzyme immunoassay analysis showed that IL-1β release was dependent on c-Jun N-terminal kinase (JNK) activation in astrocyte. The JNK inhibitor SP600125 suppressed IL-1β release. SP600125 and IL-1RI blockade with IL-1ra resulted in a restoration of behavioral nociceptive thresholds. Our results showed that the IL-1β-dependent, JNK-regulated astrocyte-neuron signaling pathway mediated the astroglia component of pain maintenance in SIH.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e2791699"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular-Visual Reweighting in Persistent Postural-Perceptual Dizziness: A Multilevel Resting-State fMRI Study.","authors":"Jin-Ju Kang, Yongseon Yoo, Sang-Yeon Kim, Sohui Kim, Jong-Min Lee, Sun-Young Oh","doi":"10.1155/np/9968808","DOIUrl":"10.1155/np/9968808","url":null,"abstract":"<p><p>Persistent postural-perceptual dizziness (PPPD) is a disabling functional vestibular disorder characterized by chronic dizziness and visually and motion-induced unsteadiness that markedly impairs daily activities, yet it lacks objective neurobiological markers. We acquired resting-state functional MRI (rs-fMRI) in 52 patients with PPPD and 50 age- and sex-matched healthy controls (HCs) and analyzed the data using a three-tier approach: (i) functional network connectivity (FNC) of independent component analysis (ICA-FNC), (ii) voxel-wise measures of spontaneous amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF), and (iii) seed-based connectivity using a priori vestibular and subcortical regions of interest (ROIs; e.g., cerebellar (CB) nodulus, parafascicular thalamus, and caudate). Integrating these analytic tiers, we observed a coherent pattern: broadly increased connectivity of CB and primary visual (VIS) networks together with selective hypoconnectivity between a brainstem-cerebellar (BSC) component and the multimodal vestibular cortex (MVC), oculomotor (frontal eye field [FEF]), and default-mode networks (DMN). Voxel metrics revealed decreased ALFF in parietal and frontal opercular cortices-key vestibular integration regions-contrasting with increased fALFF in mid-cingulate, lateral occipital, and premotor areas. Seed-based mapping identified strengthened thalamo-VIS, striato-limbic, and nodulus-hippocampal connectivity. Importantly, increased BSC-to-VIS coupling correlated positively with depressive symptom severity and state anxiety, but negatively with balance confidence and psychological resilience, linking network imbalance to the biopsychosocial phenotype of PPPD. These findings support a multiscale signature of vestibular cortical disengagement accompanied by maladaptive VIS-CB reinforcement and motivate multicenter validation of network-level markers as adjuncts to symptom-based diagnosis.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e9968808"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of White Matter Structural Brain Network in Children With Sensorineural Hearing Loss: A Graph Theory Analysis for Auditory Sensitivity Period.","authors":"Jiayan Zhuang, Jin Wang, Gengbiao Zhang, Hongyi Zheng, Lingmei Kong, Lexing Huang, Juyue Hong, Wenbin Zheng","doi":"10.1155/np/4263849","DOIUrl":"10.1155/np/4263849","url":null,"abstract":"<p><strong>Objective: </strong>The central auditory system has greater plasticity when children are 2-4 years old, called the auditory sensitive period, during which cochlear implantation (CI) can give a good prognosis to children with congenital sensorineural hearing loss (CSNHL), but some will have a poor prognosis. This experiment aims to construct a structural brain network by using diffusion tensor imaging (DTI) and analyze alterations of the topological properties of structural brain networks by graph theory method, provide an imaging basis for the pathophysiological mechanism of white matter network changes with age in SNHL children.</p><p><strong>Materials and methods: </strong>A total of 109 children with SNHL and 61 normal control groups were included. According to the auditory sensitivity period, children were divided into a group within the auditory sensitivity period (group A, 12-47 months) and a group beyond the auditory sensitivity period (group B, 48-120 months). DTI data were collected to construct the structural brain network for graph theory analysis, identify the network changes of the topological properties of the SNHL, as well as the differences before and after the auditory sensitivity period.</p><p><strong>Results: </strong>Compared with the control group, both groups of SNHL had network topological changes. Group A showed a decrease in nodal parameters in higher-order cognitive-related brain regions but no difference in global topology parameters and network connection strength. However, group B showed a decrease in the nodal parameters of multiple contact cortical brain regions and the global efficiency (Eglob) of structural networks. Besides, subnetwork analysis showed weakened connection strength between key brain regions related to higher-order cognition.</p><p><strong>Conclusion: </strong>The structural brain network of SNHL children before the auditory sensitive period has not undergone extensive changes, and once the auditory sensitive period of development is exceeded, the formation of deaf brain features will be more obvious, with greater impact on higher-order cognitive regions. Before the auditory sensitivity period, hearing stimulation should be introduced to SNHL children as soon as possible to reduce extensive damage to the white matter network.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e4263849"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimmune Clearance and EEG Biomarkers: A Unified Model of ASD and Dyslexia.","authors":"Günet Eroğlu","doi":"10.1155/np/6347511","DOIUrl":"10.1155/np/6347511","url":null,"abstract":"<p><p>Recent advances in neuroimmunology and cerebrovascular biology have highlighted the important roles of microglial synaptic pruning and the brain's meningeal lymphatic system in shaping neural circuits during development. Disruptions in one or both of these systems have been reported in neurodevelopmental conditions such as autism spectrum disorder (ASD) and developmental dyslexia. This review synthesizes existing evidence suggesting that impaired meningeal lymphatic clearance may be associated with sustained neuroinflammatory states, which in turn could alter microglial homeostasis and contribute to dysregulated synaptic pruning. We propose a testable theoretical framework linking these cellular and vascular processes to electrophysiological signatures measured by electroencephalography (EEG), while explicitly acknowledging that the majority of available evidence is correlational rather than causal. Reported alterations in EEG frequency bands-such as increased slow-wave power or disrupted oscillatory coordination-are discussed as potential circuit-level correlates of underlying neuroimmune dysregulation, rather than definitive mechanistic outcomes. Drawing on findings from both human and animal studies, we outline an integrative conceptual model describing how clearance dysfunction and microglial abnormalities may be associated with patterns of cortical underconnectivity or hyperconnectivity observed in ASD and dyslexia. Rather than establishing causality, this framework aims to generate hypotheses and guide future multimodal investigations combining neuroimmune markers, lymphatic imaging, and electrophysiological measures to evaluate the translational potential of EEG-informed biomarkers in developmental disorders.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e6347511"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive Dysfunction in Autism Spectrum Disorder Is Associated With Increased Cerebro-Cerebellar Resting-State Functional Connectivity.","authors":"Xiaotong Zhang, Guorong Qiu, Zhiwei Mou, Changfu Chen, Jianliang Lu, Zhiming Tang, Zhaowen Zhou","doi":"10.1155/np/7449692","DOIUrl":"10.1155/np/7449692","url":null,"abstract":"<p><p>This study examined the correlation between the cerebellar functional status and the executive function (EF) scores and explored alterations of functional connectivity (FC) among autism spectrum disorder (ASD) individuals compared to typically developing (TD) subjects. Individuals from the Autism Brain Imaging Data Exchange II dataset (ABIDE II) with complete cerebellum scanning coverage and available Behavior Rating Inventory of EF (BRIEF) t-scores were included, yielding a final sample of 71 ASD (age: 11.50 ± 2.77) and 149 TD (age:11.48 ± 1.60) individuals. Four cerebellar ROIs (left Lobule VI, left Crus I, right Crus I, and left VIIB) were defined from a meta-analysis. We quantified cerebellar intrinsic activity using percent amplitude of fluctuation (PerAF) and assessed seed-based FC within cerebro-cerebellar circuits. We found no between-group differences in PerAF across the four ROIs, and PerAF showed no significant association with global executive composite (GEC) scores within the ASD group. In contrast, FC analyses revealed predominantly increased cerebro-cerebellar connectivity in ASD. Notably, stronger FC between left Lobule VI and right inferior frontal gyrus, pars opercularis (IFGoper), as well as between left Crus I and left IFGoper were positively correlated with BRIEF Shift scores, indicating that greater coupling within these loops was associated with poorer cognitive flexibility. These results suggest that EF impairment among ASD individuals might be reflected in part by alterations in functional interconnections within the cerebro-cerebellar system. These findings help to understand the potential role of the cerebellum in EF among ASD individuals and might provide ideas for therapeutic interventions.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e7449692"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Consequences of a Spinal Cord Injury During Development: Unique Insights From Ex Vivo Models.","authors":"Mariia E Ermolaeva, Atiyeh Mohammadshirazi, Dimitry Sayenko, Giuliano Taccola","doi":"10.1155/np/7460038","DOIUrl":"10.1155/np/7460038","url":null,"abstract":"<p><p>Over the past 40 years, increasing demand for spinal cord injury (SCI) repair strategies has driven extensive research, yet critical recovery mechanisms remain poorly understood. Key gaps include the temporary loss of spinal reflexes during spinal shock and the dynamics of \"injury potentials,\" which spread rapidly from the impact site, similar to cortical spreading depression (CSD). While traditionally spinal shock has been viewed as unavoidable, targeted interventions could potentially mitigate SCI pathology and improve recovery. Additionally, immediate changes in brain circuitry post-SCI remain debated, with limited markers for assessing early neuronal and glial damage. Early supraspinal biomarkers, including neuron-specific enolase (NSE), S-100β, and microRNAs, may further refine injury severity assessments. The potential for spontaneous spinal circuit repair is often underestimated, yet molecular evidence suggests preserved interneuronal networks may support functional reconnections. Pediatric SCIs show superior self-repair, highlighting unique plasticity mechanisms that could be leveraged for therapeutic benefit. While in vivo models mimic human pathology, ex vivo neonatal rodent models allow continuous electrophysiological recordings of spontaneous and evoked neuronal activity during SCI, revealing how lumbar locomotor circuits integrate afferent input post-injury. Using an ex vivo neonatal SCI model, we demonstrate real-time network changes in the brain and spinal cord. Our model enables modulation of the extracellular ionic environment and afferent stimulation. By integrating ex vivo models, molecular biomarkers, and insights from early developmental stages, we can uncover novel mechanisms of an acute SCI or refine neuromodulatory strategies to promote recovery of functions.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e7460038"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Investigation of Exercise Interventions in Rodent Models of Alzheimer's Disease and Prospects for Clinical Translation.","authors":"Tianhang Peng, Zike Zhang, Ni Ding, Jiayi Zhang","doi":"10.1155/np/6718671","DOIUrl":"10.1155/np/6718671","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a progressive and debilitating neurodegenerative disorder for which existing pharmacotherapies are inadequate to arrest pathological progression, highlighting the imperative to identify safe and effective nonpharmacological interventions. Exercise, as a multi-target therapeutic modality, has been shown to reverse multiple facets of AD-related neuropathology through diverse mechanisms. In this systematic review, we synthesize evidence on the effects of voluntary running, structured swimming, and modulation of the gut microbiota in transgenic murine models of AD. Exercise was found to ameliorate AD pathology by modulating amyloid precursor protein (APP) processing and β-amyloid (Aβ) production/clearance, restoring mitochondrial integrity and function, attenuating neuroinflammatory responses, enhancing synaptic plasticity, and upregulating neurotrophic factors. Moreover, exercise reshapes the intestinal microbiome and thereby modulates the gut-brain axis, further promoting neuroimmune homeostasis and cognitive resilience. Through RNA sequencing data analysis, key genes such as Tlr4, Cdc42, and F13a1 were identified, which may play significant roles in neuroimmune regulation and cognitive protection. By integrating multi-omics evidence, we propose a coordinated \"exercise-microbiota-brain\" mechanistic framework that offers theoretical support for personalized, exercise-based therapeutic strategies and translational applications in AD. We also emphasize the necessity of future studies combining exercise with complementary interventions to accelerate the clinical translation of multimodal therapeutic approaches.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2026 1","pages":"e6718671"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Neural Activity in Adolescent Major Depressive Disorder With Nonsuicidal Self-Injury: A Resting-State Functional Magnetic Resonance Imaging Meta-Analysis.","authors":"Yanping Shu, Qin Zhang, Zuli Zheng, Yongzhe Hou","doi":"10.1155/np/7885279","DOIUrl":"10.1155/np/7885279","url":null,"abstract":"<p><strong>Background: </strong>Resting-state functional magnetic resonance imaging (rs-fMRI) reveals diverse neural activity patterns in adolescent major depressive disorder (MDD) with nonsuicidal self-injury (NSSI; nsMDD). However, the reported results are inconsistent. The aim of this study was to conduct a meta-analysis to identify consistent patterns of brain activity alterations in adolescent nsMDD.</p><p><strong>Methods: </strong>A systematic search was conducted across PubMed, Web of Science, Embase, Google Scholar, Wanfang, and CNKI for rs-fMRI studies that compared nsMDD patients with healthy controls (HCs), up to June 30, 2025. Significant cluster coordinates were extracted for comprehensive analysis. We utilized regional homogeneity (ReHo) and amplitude of low-frequency fluctuations (ALFFs) analyses. Activation likelihood estimation (ALE) was used to identify regions of aberrant spontaneous neural activity in adolescent nsMDD compared to HCs.</p><p><strong>Results: </strong>Eight studies (249 adolescent nsMDD and 278 HCs) were included. The ALE meta-analysis revealed increased activity in the left lingual gyrus (LING; Brodmann area [BA] 18) in adolescent nsMDD compared to HCs (voxel size = 200 mm³; <i>p</i> < 0.05). Decreased activity was observed in the right posterior cingulate cortex (PCC; BA 29) in adolescent nsMDD compared to HCs (voxel size = 360 mm³; <i>p</i> < 0.05). Jackknife sensitivity analyses demonstrated robust reproducibility in five of eight tests for the left LING and in six of eight tests for the right PCC.</p><p><strong>Conclusions: </strong>This meta-analysis confirms consistent alterations in specific brain regions in adolescent nsMDD, highlighting the potential of rs-fMRI to refine diagnostic and therapeutic strategies.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2025 ","pages":"7885279"},"PeriodicalIF":3.7,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12638161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145589680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}