Neural Plasticity最新文献

{"title":"Acupuncture Alleviates CUMS-Induced Depression-Like Behaviors by Restoring Prefrontal Cortex Neuroplasticity.","authors":"Peng Li,&nbsp;Wenya Huang,&nbsp;Yiping Chen,&nbsp;Muhammad Shahzad Aslam,&nbsp;Wenjing Cheng,&nbsp;Yang Huang,&nbsp;Wenjie Chen,&nbsp;Yanxun Huang,&nbsp;Xinnan Wu,&nbsp;Yining Yan,&nbsp;Junliang Shen,&nbsp;Tao Tong,&nbsp;Shuqiong Huang,&nbsp;Xianjun Meng","doi":"10.1155/2023/1474841","DOIUrl":"10.1155/2023/1474841","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the therapeutic efficiency of acupuncture and the related molecular mechanism of neural plasticity in depression.</p><p><strong>Methods: </strong>Chronic unpredictable mild stress- (CUMS-) induced rats were established for the depression animal model. There were a total of four rat groups, including the control group, the CUMS group, the CUMS+acupuncture group, and the CUMS+fluoxetine group. The acupuncture group and the fluoxetine group were given a 3-week treatment after the modeling intervention. The researcher performed the open-field, elevated plus maze, and sucrose preference tests to evaluate depressive behaviors. The number of nerve cells, dendrites' length, and the prefrontal cortex's spine density were detected using Golgi staining. The prefrontal cortex expression, such as BDNF, PSD95, SYN, and PKMZ protein, was detected using the western blot and RT-PCR.</p><p><strong>Results: </strong>Acupuncture could alleviate depressive-like behaviors and promote the recovery of the neural plasticity functions in the prefrontal cortex, showing the increasing cell numbers, prolonging the length of the dendrites, and enhancing the spine density. The neural plasticity-related proteins in the prefrontal cortex, including BDNF, PSD95, SYN, and PKMZ, were all downregulated in the CUMS-induced group; however, these effects could be partly reversed after being treated by acupuncture and fluoxetine (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Acupuncture can ameliorate depressive-like behaviors by promoting the recovery of neural plasticity functions and neural plasticity-related protein upregulation in the prefrontal cortex of CUMS-induced depressed rats. Our study provides new insights into the antidepressant approach, and further studies are warranted to elucidate the mechanisms of acupuncture involved in depression treatment.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"1474841"},"PeriodicalIF":3.1,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment.","authors":"Ting Long, Haijun Li, Yongqiang Shu, Kunyao Li, Wei Xie, Yaping Zeng, Ling Huang, Li Zeng, Xiang Liu, Dechang Peng","doi":"10.1155/2023/5598047","DOIUrl":"10.1155/2023/5598047","url":null,"abstract":"<p><p>This study was aimed at investigating the functional connectivity (FC) changes between the insular subregions and whole brain in patients with obstructive sleep apnea (OSA) after 6 months of continuous positive airway pressure (CPAP) treatment and at exploring the relationship between resting-state FC changes and cognitive impairment in OSA patients. Data from 15 patients with OSA before and after 6 months of CPAP treatment were included in this study. The FC between the insular subregions and whole brain was compared between baseline and after 6 months of CPAP treatment in OSA. After 6 months of treatment, OSA patients had increased FC from the right ventral anterior insula to the bilateral superior frontal gyrus and bilateral middle frontal gyrus and increased FC from the left posterior insula to the left middle temporal gyrus and left inferior temporal gyrus. Hyperconnectivity was found from the right posterior insula to the right middle temporal gyrus, bilateral precuneus, and bilateral posterior cingulate cortex, which mainly involved the default mode network. There are changes in functional connectivity patterns between the insular subregions and whole brain in OSA patients after 6 months of CPAP treatment. These changes provide a better understanding of the neuroimaging mechanisms underlying the improvement in cognitive function and emotional impairment in OSA patients and can be used as potential biomarkers for clinical CPAP treatment.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"5598047"},"PeriodicalIF":3.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9273912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex.","authors":"Amielle Moreno, Swetha Rajagopalan, Matthew J Tucker, Parker Lunsford, Robert C Liu","doi":"10.1155/2023/5225952","DOIUrl":"10.1155/2023/5225952","url":null,"abstract":"<p><p>While infant cues are often assumed to innately motivate maternal response, recent research highlights how the neural coding of infant cues is altered through maternal care. Infant vocalizations are important social signals for caregivers, and evidence from mice suggests that experience caring for mouse pups induces inhibitory plasticity in the auditory cortex (AC), though the molecular mediators for such AC plasticity during the initial pup experience are not well delineated. Here, we used the maternal mouse communication model to explore whether transcription in AC of a specific, inhibition-linked, memory-associated gene, brain-derived neurotrophic factor (<i>Bdnf</i>) changes due to the very first pup caring experience hearing vocalizations, while controlling for the systemic influence of the hormone estrogen. Ovariectomized and estradiol or blank-implanted virgin female mice hearing pup calls with pups present had significantly higher AC exon IV <i>Bdnf</i> mRNA compared to females without pups present, suggesting that the social context of vocalizations induces immediate molecular changes at the site of auditory cortical processing. E2 influenced the rate of maternal behavior but did not significantly affect <i>Bdnf</i> mRNA transcription in the AC. To our knowledge, this is the first time <i>Bdnf</i> has been associated with processing social vocalizations in the AC, and our results suggest that it is a potential molecular component responsible for enhancing future recognition of infant cues by contributing to AC plasticity.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"5225952"},"PeriodicalIF":3.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9356987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache.","authors":"Xiu Yang,&nbsp;DianXuan Guo,&nbsp;Wei Huang,&nbsp;Bing Chen","doi":"10.1155/2023/6560298","DOIUrl":"https://doi.org/10.1155/2023/6560298","url":null,"abstract":"<p><strong>Objective: </strong>The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. The aim of the present study was to explore intrinsic brain functional activity alterations in ETTH.</p><p><strong>Methods: </strong>Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 32 patients with ETTH and 32 age- and gender-matched healthy controls (HCs). Differences in intrinsic brain functional activity between patients with ETTH and HCs were analyzed utilizing the fractional amplitude of low-frequency fluctuation (fALFF) approach. Correlation analyses were performed to examine the relationship between fALFF alterations and clinical characteristics.</p><p><strong>Results: </strong>Compared to HCs, patients with ETTH exhibited increased fALFF in the right posterior insula and anterior insula and decreased fALFF in the posterior cingulate cortex. Moreover, the fALFF in the right anterior insula was negatively correlated with attack frequency in ETTH.</p><p><strong>Conclusions: </strong>This study highlights alterations in the intrinsic brain functional activity in the insula and posterior cingulate cortex in ETTH that can help us understand its neurobiological underpinnings.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"6560298"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9928985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Sustained Auditory Attentional Load Decreases Audiovisual Integration in Older and Younger Adults.","authors":"Neural Plasticity","doi":"10.1155/2023/9795436","DOIUrl":"https://doi.org/10.1155/2023/9795436","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2021/4516133.].</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"9795436"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10559769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Molecule to Patient Rehabilitation: The Impact of Transcranial Direct Current Stimulation and Magnetic Stimulation on Stroke-A Narrative Review.","authors":"Anca Badoiu,&nbsp;Smaranda Ioana Mitran,&nbsp;Bogdan Catalin,&nbsp;Tudor Adrian Balseanu,&nbsp;Aurel Popa-Wagner,&nbsp;Florin Liviu Gherghina,&nbsp;Carmen Valeria Albu,&nbsp;Raluca Elena Sandu","doi":"10.1155/2023/5044065","DOIUrl":"https://doi.org/10.1155/2023/5044065","url":null,"abstract":"<p><p>Stroke is a major health problem worldwide, with numerous health, social, and economic implications for survivors and their families. One simple answer to this problem would be to ensure the best rehabilitation with full social reintegration. As such, a plethora of rehabilitation programs was developed and used by healthcare professionals. Among them, modern techniques such as transcranial magnetic stimulation and transcranial direct current stimulation are being used and seem to bring improvements to poststroke rehabilitation. This success is attributed to their capacity to enhance cellular neuromodulation. This modulation includes the reduction of the inflammatory response, autophagy suppression, antiapoptotic effects, angiogenesis enhancement, alterations in the blood-brain barrier permeability, attenuation of oxidative stress, influence on neurotransmitter metabolism, neurogenesis, and enhanced structural neuroplasticity. The favorable effects have been demonstrated at the cellular level in animal models and are supported by clinical studies. Thus, these methods proved to reduce infarct volumes and to improve motor performance, deglutition, functional independence, and high-order cerebral functions (i.e., aphasia and heminegligence). However, as with every therapeutic method, these techniques can also have limitations. Their regimen of administration, the phase of the stroke at which they are applied, and the patients' characteristics (i.e., genotype and corticospinal integrity) seem to influence the outcome. Thus, no response or even worsening effects were obtained under certain circumstances both in animal stroke model studies and in clinical trials. Overall, weighing up risks and benefits, the new transcranial electrical and magnetic stimulation techniques can represent effective tools with which to improve the patients' recovery after stroke, with minimal to no adverse effects. Here, we discuss their effects and the molecular and cellular events underlying their effects as well as their clinical implications.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"5044065"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9273936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leonurine Regulates Hippocampal Nerve Regeneration in Rats with Chronic and Unpredictable Mild Stress by Activating SHH/GLI Signaling Pathway and Restoring Gut Microbiota and Microbial Metabolic Homeostasis.","authors":"Pan Meng,&nbsp;Xi Zhang,&nbsp;Dandan Li,&nbsp;Hui Yang,&nbsp;Xiaoyuan Lin,&nbsp;Hongqing Zhao,&nbsp;Ping Li,&nbsp;Yuhong Wang,&nbsp;Xiaoye Wang,&nbsp;Jinwen Ge","doi":"10.1155/2023/1455634","DOIUrl":"https://doi.org/10.1155/2023/1455634","url":null,"abstract":"<p><p>Depression is a highly prevalent and heterogeneous disorder that requires new strategies to overcome depression. In this study, we aimed to investigate whether leonurine modulated hippocampal nerve regeneration in chronic and unpredictable mild stress (CUMS) rats through the SHH/GLI signaling pathway and restoring gut microbiota and microbial metabolic homeostasis. The CUMS rat model was constructed and treated with leonurine. The body weight of rats was recorded, and a series of tests were performed. Western blot was utilized to measure the expression of BDNF and 5-HT in the hippocampus. Then the expression of SHH, GLI, PTCH, and SMO were measured by qRT-PCR and western blot. The colocalization of BrdU+DCX and BrdU+NeuN was evaluated by IF. 16S rDNA high-throughput sequencing was applied to detect the composition and distribution of gut microbiota. The differential metabolites were analyzed by untargeted metabolomics. The correlation between gut microbiota and microbial metabolites was analyzed by Pearson correlation coefficient. After CUMS modeling, the body weight of rats was decreased, and the expression of BDNF and 5-HT were decreased, while the body weight was recovered, and the expression of BDNF and 5-HT were increased after leonurine treatment. Leonurine reversed the reduction in the colocalization of BrdU+DCX and BrdU+NeuN and the reduction in the levels of SHH, GLI, PTCH, and SMO induced by CUMS modeling. Leonurine also restored gut microbiota and microbial metabolites homeostasis in CUMS rats. Furthermore, <i>Prevotellaceae_Ga6A1_group</i> was negatively correlated with 3-Oxocholic acid, nutriacholic acid, and cholic acid. Collectively, leonurine regulated hippocampal nerve regeneration in CUMS rats by activating the SHH/GLI signaling pathway and restoring gut microbiota and microbial metabolic homeostasis.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"1455634"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9285151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic Inflammation.","authors":"Yi-Li Wang,&nbsp;Hai-Yan Zhu,&nbsp;Xi-Qian Lv,&nbsp;Xing-Ying Ren,&nbsp;Ying-Chun Peng,&nbsp;Jin-Yu Qu,&nbsp;Xue-Fang Shen,&nbsp;Ran Sun,&nbsp;Meng-Lu Xiao,&nbsp;Hong Zhang,&nbsp;Zhao-Hui Chen,&nbsp;Peng Cong","doi":"10.1155/2023/9303419","DOIUrl":"https://doi.org/10.1155/2023/9303419","url":null,"abstract":"<p><p>Referred somatic pain triggered by hyperalgesia is common in patients with inflammatory bowel disease (IBD). It was reported that sprouting of sympathetic nerve fibers into the dorsal root ganglion (DGR) and neurogenic inflammation were related to neuropathic pain, the excitability of neurons, and afferents. The purpose of the study was to explore the potential and mechanism of electroacupuncture (EA) at Zusanli (ST36) for the intervention of colon inflammation and hyperalgesia. Sprague-Dawley (SD) was randomly divided into four groups, including control, model, EA, and sham-EA. Our results showed EA treatment significantly attenuated dextran sulfate sodium- (DSS-) induced colorectal lesions and inflammatory cytokine secretion, such as TNF-<i>α</i>, IL-1<i>β</i>, PGE2, and IL-6. EA also inhibited mechanical and thermal pain hypersensitivities of colitis rats. Importantly, EA effectively abrogated the promotion effect of DSS on ipsilateral lumbar 6 (L6) DRG sympathetic-sensory coupling, manifested as the sprouting of tyrosine hydroxylase- (TH-) positive sympathetic fibers into sensory neurons and colocalization of and calcitonin gene-related peptide (CGRP). Furthermore, EA at Zusanli (ST36) activated neurogenic inflammation, characterized by decreased expression of substance P (SP), hyaluronic acid (HA), bradykinin (BK), and prostacyclin (PGI2) in colitis rat skin tissues corresponding to the L6 DRG. Mechanically, EA treatment reduced the activation of the TRPV1/CGRP, ERK, and TLR4 signaling pathways in L6 DRG of colitis rats. Taken together, we presumed that EA treatment improved colon inflammation and hyperalgesia, potentially by suppressing the sprouting of sympathetic nerve fibers into the L6 DGR and neurogenic inflammation via deactivating the TRPV1/CGRP, ERK, and TLR4 signaling pathways.</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"9303419"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9650081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imbalance of Microbacterial Diversity Is Associated with Functional Prognosis of Stroke.","authors":"Xintong Zhang,&nbsp;Xiangyu Wang,&nbsp;Hong Zhao,&nbsp;Risheng Cao,&nbsp;Yini Dang,&nbsp;Binbin Yu","doi":"10.1155/2023/6297653","DOIUrl":"https://doi.org/10.1155/2023/6297653","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;There is mounting evidence to suggest that the pathophysiology of stroke is greatly influenced by the microbiota of the gut and its metabolites, in particular short-chain fatty acids (SCFAs). The primary purpose of the study was to evaluate whether the levels of SCFAs and the gut microbiota are altered in poststroke patients and to examine the relationship between these alterations and the physical condition, intestinal health, pain, or nutritional status of patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Twenty stroke patients and twenty healthy controls were enrolled in the current study, and their demographics were matched. Gas chromatography was used to determine the fecal SCFAs, and 16S rRNA gene sequencing was used to evaluate their fecal microbiota. Microbial diversity and richness were examined using the diversity indices alpha and beta, and taxonomic analysis was utilized to determine group differences. The relationships between the gut microbiome and fecal SCFAs, discriminant bacteria, and poststroke clinical outcomes were analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Less community richness (ACE and Chao) was observed in the poststroke patients (&lt;i&gt;P&lt;/i&gt; &lt; 0.05), but the differences between the poststroke group and the healthy control group in terms of species diversity (Shannon and Simpson) were not statistically significant. The makeup of the poststroke gut microbiota was distinct from that of the control group, as evidenced by beta diversity. Then, the relative abundances of the taxa in the poststroke and control groups were compared in order to identify the specific microbiota changes. At the level of phylum, the poststroke subjects showed a significant increase in the relative abundances of &lt;i&gt;Akkermansiaceae&lt;/i&gt;, &lt;i&gt;Fusobacteriota&lt;/i&gt;, &lt;i&gt;Desulfobacterota, Ruminococcaceae&lt;/i&gt;, and &lt;i&gt;Oscillospirales&lt;/i&gt; and a particularly noticeable decrease in the relative abundance of &lt;i&gt;Acidobacteriota&lt;/i&gt; compared to the control subjects (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). In regard to SCFA concentrations, lower levels of fecal acetic acid (&lt;i&gt;P&lt;/i&gt; = 0.001) and propionic acid (&lt;i&gt;P&lt;/i&gt; = 0.049) were found in poststroke subjects. &lt;i&gt;Agathobacter&lt;/i&gt; was highly correlated with acetic acid level (&lt;i&gt;r&lt;/i&gt; = 0.473, &lt;i&gt;P&lt;/i&gt; = 0.002), whereas &lt;i&gt;Fusobacteria&lt;/i&gt; (&lt;i&gt;r&lt;/i&gt; = -0.371, &lt;i&gt;P&lt;/i&gt; = 0.018), &lt;i&gt;Flavonifractor&lt;/i&gt; (&lt;i&gt;r&lt;/i&gt; = -0.334, &lt;i&gt;P&lt;/i&gt; = 0.034), &lt;i&gt;Desulfovibrio&lt;/i&gt; (&lt;i&gt;r&lt;/i&gt; = -0.362, &lt;i&gt;P&lt;/i&gt; = 0.018), and &lt;i&gt;Akkermansia&lt;/i&gt; (&lt;i&gt;r&lt;/i&gt; = -0.321, &lt;i&gt;P&lt;/i&gt; = 0.043) were negatively related to acetic acid levels. Additionally, the findings of the correlation analysis revealed that &lt;i&gt;Akkermansia&lt;/i&gt; (&lt;i&gt;r&lt;/i&gt; = -0.356, &lt;i&gt;P&lt;/i&gt; = 0.024), &lt;i&gt;Desulfovibrio&lt;/i&gt; (&lt;i&gt;r&lt;/i&gt; = -0.316, P = 0.047), and &lt;i&gt;Alloprevotella&lt;/i&gt; (&lt;i&gt;r&lt;/i&gt; = -0.366, &lt;i&gt;P&lt;/i&gt; = 0.020) were significantly negatively correlated with high-density lipoprotein cholesterol. In addition, the Neurogenic Bowel Dysfunction score (&lt;i&gt;r&lt;/i&gt; = 0.495, &lt;i&gt;P&lt;/i&gt; = 0.026), Barthe","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"6297653"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9572233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture Alters Brain's Dynamic Functional Network Connectivity in Stroke Patients with Motor Dysfunction: A Randomised Controlled Neuroimaging Trial.","authors":"Yahui Wang,&nbsp;Mengxin Lu,&nbsp;Ruoyi Liu,&nbsp;Liping Wang,&nbsp;Yue Wang,&nbsp;Lingling Xu,&nbsp;Kang Wu,&nbsp;Chen Chen,&nbsp;Tianzhu Chen,&nbsp;Xinyue Shi,&nbsp;Kuangshi Li,&nbsp;Yihuai Zou","doi":"10.1155/2023/8510213","DOIUrl":"https://doi.org/10.1155/2023/8510213","url":null,"abstract":"<p><strong>Objectives: </strong>Neuroimaging studies have confirmed that acupuncture can promote static functional reorganization in poststroke patients with motor dysfunction. But its effect on dynamic brain networks remains unclear. This study is aimed at investigating how acupuncture affected the brain's dynamic functional network connectivity (dFNC) after ischemic stroke.</p><p><strong>Methods: </strong>We conducted a single-center, randomised controlled neuroimaging study in ischemic stroke patients. A total of 53 patients were randomly divided into the true acupoint treatment group (TATG) and the sham acupoint treatment group (SATG) at a ratio of 2 : 1. Clinical assessments and magnetic resonance imaging (MRI) scans were performed on subjects before and after treatment. We used dFNC analysis to estimate distinct dynamic connectivity states. Then, the temporal properties and strength of functional connectivity (FC) matrix were compared within and between the two groups. The correlation analysis between dynamic characteristics and clinical scales was also calculated.</p><p><strong>Results: </strong>All functional network connectivity (FNC) matrices were clustered into 3 connectivity states. After treatment, the TATG group showed a reduced mean dwell time and found attenuated FC between the sensorimotor network (SMN) and the frontoparietal network (FPN) in state 3, which was a sparsely connected state. The FC between the dorsal attention network (DAN) and the default mode network (DMN) was higher after treatment in the TATG group in state 1, which was a relative segregated state. The SATG group preferred to increase the mean dwell time and FC within FPN in state 2, which displayed a local tightly connected state. In addition, we found that the FC value increased between DAN and right frontoparietal network (RFPN) in state 1 in the TATG group after treatment compared to the SATG group. Correlation analyses before treatment showed that the Fugl-Meyer Assessment (FMA) lower score was negatively correlated with the mean dwell time in state 3. FMA score showed positive correlation with FC in RFPN-SMN in state 3. FMA-lower score was positively correlated with FC in DAN-DMN and DAN-RFPN in state 1.</p><p><strong>Conclusions: </strong>Acupuncture has the potential to modulate abnormal temporal properties and promote the balance of separation and integration of brain function. True acupoint stimulation may have a more positive effect on regulating the brain's dynamic function. <i>Clinical Trial Registration</i>. This trial is registered with Chinese Clinical Trials Registry (ChiCTR1800016263).</p>","PeriodicalId":51299,"journal":{"name":"Neural Plasticity","volume":"2023 ","pages":"8510213"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9735910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}