Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache.

IF 3 4区医学 Q2 NEUROSCIENCES

Neural Plasticity Pub Date : 2023-01-01 DOI:10.1155/2023/6560298

Xiu Yang, DianXuan Guo, Wei Huang, Bing Chen

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引用次数: 1

Abstract

Objective: The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. The aim of the present study was to explore intrinsic brain functional activity alterations in ETTH.

Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 32 patients with ETTH and 32 age- and gender-matched healthy controls (HCs). Differences in intrinsic brain functional activity between patients with ETTH and HCs were analyzed utilizing the fractional amplitude of low-frequency fluctuation (fALFF) approach. Correlation analyses were performed to examine the relationship between fALFF alterations and clinical characteristics.

Results: Compared to HCs, patients with ETTH exhibited increased fALFF in the right posterior insula and anterior insula and decreased fALFF in the posterior cingulate cortex. Moreover, the fALFF in the right anterior insula was negatively correlated with attack frequency in ETTH.

Conclusions: This study highlights alterations in the intrinsic brain functional activity in the insula and posterior cingulate cortex in ETTH that can help us understand its neurobiological underpinnings.

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发作性紧张性头痛的内在脑功能活动异常。

目的:发作性紧张性头痛(ETTH)的神经生物学基础仍不清楚。本研究的目的是探讨ETTH的内在脑功能活动改变。方法:收集32例ETTH患者和32例年龄和性别匹配的健康对照(hc)的静息状态功能磁共振成像(rs-fMRI)数据。利用低频波动分数振幅(fALFF)方法分析ETTH和hc患者内在脑功能活动的差异。进行相关分析以检验fALFF改变与临床特征之间的关系。结果:与hc相比，ETTH患者右侧后岛和前岛的fALFF增加，后扣带皮层的fALFF减少。此外，右脑岛前部的fALFF与ETTH发作频率呈负相关。结论:本研究强调了ETTH患者脑岛和后扣带皮层内在脑功能活动的变化，可以帮助我们了解其神经生物学基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neural Plasticity NEUROSCIENCES-

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.

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