Journal of Advanced Prosthodontics最新文献

{"title":"Palatal vault configuration and its influence on intraoral scan time and accuracy in completely edentulous arches: a prospective clinical study.","authors":"Dina Mohamed Ahmed Elawady, Wafaa Ibrahim Ibrahim, Radwa Gamal Ghanem, Reham Bassuni Osman","doi":"10.4047/jap.2024.16.4.201","DOIUrl":"10.4047/jap.2024.16.4.201","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this prospective clinical study was to compare the influence of palatal vault forms on accuracy and speed of intraoral (IO) scans in completely edentulous cases.</p><p><strong>Materials and methods: </strong>Based on the palatal vault form, participants were divided into three equal groups (n = 10 each); Class I: moderate; Class II: deep; Class III: flat palatal vault. A reference model was created for each patient using polyvinylsiloxane impression material. The poured models were digitized using an extraoral scanner. The resultant data were imported as a solid CAD file into 3D analysis software (GOM Inspect 2018; Gom GmbH, Braunschweig, Germany) and aligned using the software's coordinate system to determine its X, Y, and Z axes. Five digital impressions (DIs) of maxilla were captured for each patient using an intraoral scanner (TRIOS; 3Shape A/S, Copenhagen, Denmark) and the resultant Standard Tessellation Language (STL) scan files served as test models. Trueness was evaluated by calculating arithmetic mean deviation (AMD) of the vault area between reference and test files while precision was evaluated by calculating AMD between captured scans to measure repeatability of scan acquisition. The scan time taken for each participant was also recorded.</p><p><strong>Results: </strong>There was no significant difference in trueness and precision among the groups (<i>P</i> = .806 and .950, respectively). Average scan time for Class I and III palatal vaults was 1 min 13 seconds and 1 min 37 seconds, respectively, while class II deep palatal vaults showed the highest scan time of 5 mins.</p><p><strong>Conclusion: </strong>Palatal vault form in edentulous cases has an influence on scan time. However, it does not have a substantial impact on the accuracy of the acquired scans.</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 4","pages":"201-211"},"PeriodicalIF":2.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recording maximal intercuspation and border positions of the mandible with intraoral scanner using the acquisition software's multi-occlusion function.","authors":"Noha Morsy, Ihab Hammad","doi":"10.4047/jap.2024.16.4.221","DOIUrl":"10.4047/jap.2024.16.4.221","url":null,"abstract":"<p><strong>Purpose: </strong>This <i>in vitro</i> study was conducted to investigate the accuracy of intraoral scanner (IOS) for recording maximal intercuspal position (MIP) and border positions of the mandible.</p><p><strong>Materials and methods: </strong>Maxillary and mandibular master casts were articulated in MIP, protrusive, and lateral interocclusal position sequentially on a semi-adjustable articulator. For each articulation relation, sites of occlusal contacts (SOCs) and sites of clearance (SCs) were identified on the master casts with articulating paper (reference sites). IOS was used to take full arch scans and nine virtual interocclusal records (VIRs) for virtual articulation of models. Virtual SOCs and SCs were detected with 3D processing software and compared to those identified with the articulating paper. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each articulation relation.</p><p><strong>Results: </strong>For MIP, IOS showed adequate sensitivity and NPV of 100%, and specificity and a PPV of 99%. For protrusive position, the IOS showed a sensitivity and a NPV of 100%, a high PPV of 86%, and a specificity of 83%. For lateral positions, the specificity and the PPV were high (93% and 79%, respectively), but the sensitivity and the NPV were below the clinically acceptable limits (28% and 56%, respectively).</p><p><strong>Conclusion: </strong>IOS displayed clinically acceptable accuracy for recording MIP and protrusive border mandibular position. However, IOS had less accuracy for lateral border mandibular position.</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 4","pages":"221-230"},"PeriodicalIF":2.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum - Standardized multi-institutional data analysis of fixed and removable prosthesis: estimation of life expectancy with regards to variable risk factors.","authors":"","doi":"10.4047/jap.2024.16.3.200","DOIUrl":"https://doi.org/10.4047/jap.2024.16.3.200","url":null,"abstract":"<p><p>[This corrects the article on p. 67 in vol. 16, PMID: 38694192.].</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 3","pages":"200"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and time efficiency of conventional and digital outlining of extensions of denture foundation on preliminary casts.","authors":"Anne Kaline Claudino Ribeiro, Aretha Heitor Veríssimo, Rodrigo Falcão Carvalho Porto de Freitas, Rayanna Thayse Florêncio Costa, Burak Yilmaz, Sandra Lúcia Dantas de Moraes, Adriana da Fonte Porto Carreiro","doi":"10.4047/jap.2024.16.3.139","DOIUrl":"10.4047/jap.2024.16.3.139","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this diagnostic study was to assess the accuracy and time efficiency of a digital method to draw the denture foundation extension outline on preliminary casts compared with the conventional technique.</p><p><strong>Materials and methods: </strong>A total of 28 preliminary edentulous casts with no anatomical landmarks were digitized using a laboratory scanner. The outlining of the entire basal seat of the denture was performed on preliminary casts and digitized. Casts with no extension outline were digitized and outlines were drawn using software (DWOS, Straumann). The accuracy of the extension outlined between both techniques was evaluated in the software (GOM Inspect; GOM GmbH) by file superimposition. Specificity and sensitivity tests were applied to measure accuracy. The paired t-test (95% CI) was used to compare the mean total area and the working time.</p><p><strong>Results: </strong>The accuracy ranged from 0.57 to 0.92. The buccal and labial frenulum showed a lower value in the maxilla (0.57); while the area between the retromolar pad and buccal frenulum (0.64) showed a lower score in the mandible. The maxillary denture foundation and the working time for both arches were significantly longer for the digital method (<i>P</i> < .001).</p><p><strong>Conclusion: </strong>The denture foundation extension outline exhibited a sufficiently excellent accuracy for the digital method, except for the maxillary anterior region. However, the digital method required a longer working time.</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 3","pages":"139-150"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of storage time on chemical structure of a single-bottle and a two-bottle experimental ceramic primer and micro-shear bond strength of composite to ceramic.","authors":"Armaghan Naghili, Amirparsa Ghasemi, Amir Ghasemi, Narges Panahandeh","doi":"10.4047/jap.2024.16.3.163","DOIUrl":"10.4047/jap.2024.16.3.163","url":null,"abstract":"<p><strong>Purpose: </strong>This study assessed the effect of storage time on chemical structure of a single-bottle and a two-bottle experimental ceramic primer and micro-shear bond strength (µSBS) of composite to ceramic.</p><p><strong>Materials and methods: </strong>This study was conducted on 60 sintered zirconia and 60 feldspathic porcelain blocks. Half of the specimens (n = 30) were subjected to surface treatment with the single-bottle Clearfil ceramic primer (n = 15) and two-bottle experimental primer (n = 15) after 24 hours. The remaining half received the same surface treatments after 6 months storage in distilled water. Composite cylinders were bonded to the ceramics, and they were then subjected to µSBS test. Also, the primers underwent Fourier-transform infrared spectroscopy (FTIR) after 24 hours and 6 months to assess their chemical structure. Data were analyzed with 3-way ANOVA and adjusted Bonferroni test (alpha = 0.05).</p><p><strong>Results: </strong>The µSBS of both ceramics significantly decreased at 6 months in one-bottle ceramic primer group (<i>P</i> = .001), but it was not significantly different from the two-bottle experimental primer group (<i>P</i> = .635). FTIR showed hydrolysis of single-bottle primer, cleavage of silane and 10-MDP bonds, and formation of siloxane bonds after 6 months.</p><p><strong>Conclusion: </strong>Six months of storage caused significant degradation of single-bottle ceramic primer, and consequently had an adverse effect on µSBS.</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 3","pages":"163-173"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of plasma treatment for surface cleansing and osseointegration of sandblasted and acid-etched titanium implants.","authors":"Gang-Ho Bae, Won-Tak Cho, Jong-Ho Lee, Jung-Bo Huh","doi":"10.4047/jap.2024.16.3.189","DOIUrl":"10.4047/jap.2024.16.3.189","url":null,"abstract":"<p><strong>Purpose: </strong>This study was conducted to evaluate the effects of plasma treatment of sandblasted and acid-etched (SLA) titanium implants on surface cleansing and osseointegration in a beagle model.</p><p><strong>Materials and methods: </strong>For morphological analysis and XPS analysis, scanning electron microscope and x-ray photoelectron spectroscopy were used to analyze the surface topography and chemical compositions of implant before and after plasma treatment. For this animal experiment, twelve SLA titanium implants were divided into two groups: a control group (untreated implants) and a plasma group (implants treated with plasma). Each group was randomly located in the mandibular bone of the beagle dog (n = 6). After 8 weeks, the beagle dogs were sacrificed, and volumetric analysis and histometric analysis were performed within the region of interest.</p><p><strong>Results: </strong>In morphological analysis, plasma treatment did not alter the implant surface topography or cause any physical damage. In XPS analysis, the atomic percentage of carbon at the inspection point before the plasma treatment was 34.09%. After the plasma treatment, it was reduced to 18.74%, indicating a 45% reduction in carbon. In volumetric analysis and histometric analysis, the plasma group exhibited relatively higher mean values for new bone volume (NBV), bone to implant contact (BIC), and inter-thread bone density (ITBD) compared to the control group. However, there was no significant difference between the two groups (<i>P</i> > .05).</p><p><strong>Conclusion: </strong>Within the limits of this study, plasma treatment effectively eliminated hydrocarbons without changing the implant surface.</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 3","pages":"189-199"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface treatment, liquid, and aging effects on color and surface properties of monolithic ceramics.","authors":"Sertaç Sarıyer, Meryem Gülce Subaşı","doi":"10.4047/jap.2024.16.3.174","DOIUrl":"10.4047/jap.2024.16.3.174","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to investigate the effects of surface treatments, liquids, and aging on color, translucency, and surface properties of monolithic ceramics.</p><p><strong>Materials and methods: </strong>Lithium disilicate (LDS) and zirconia-reinforced lithium silicate (ZLS) ceramics (n = 135 each) were cut and divided into three groups [crystallization+glaze (single stage), crystallization-glaze (two stages), and crystallization-polish (two stages)]. One sample from each group was examined using scanning electron microscopy (SEM). Remaining samples were divided into four subgroups (distilled water, coffee, grape juice, and smoothie) (n = 11 each), stored for 12 d in the respective liquids, and thermally aged. One sample from each subgroup was analyzed using SEM. The color, gloss, and roughness values of the samples were analyzed after surface treatment (initial) and storage under different liquids+aging conditions. The initial data and both the aged data and data change values were analyzed using robust two- and three-way analyses of variance.</p><p><strong>Results: </strong>The glazed groups exhibited smoother surfaces. Ceramic type and ceramic-surface treatment interactions affected the initial translucency parameter (TP) (<i>P</i> < .001) and the initial and aged roughness values (<i>P</i> ≤ .001). Surface treatment type affected the color change (<i>P</i> < .001), and ceramic type affected the aged TP values (<i>P</i> < .001). Type of ceramic, surface treatment, and their interactions affected both the initial and aged gloss (<i>P</i> ≤ .001) and TP change values (<i>P</i> ≤ .015). Surface treatment type and ceramic-surface treatment interactions affected the gloss change values (<i>P</i> ≤ .001).</p><p><strong>Conclusion: </strong>Although both ceramics and all surface treatments are clinically applicable, crystallization-glaze is recommended. When gloss and smoothness are important or when translucency is important, ZLS or LDS may be preferred, respectively.</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 3","pages":"174-188"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of lifespan and assessing risk factors of large-sample implant prostheses: a multicenter study.","authors":"Jeong Hoon Kim, Joon-Ho Yoon, Hae-In Jeon, Dong-Wook Kim, Young-Bum Park, Namsik Oh","doi":"10.4047/jap.2024.16.3.151","DOIUrl":"10.4047/jap.2024.16.3.151","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze factors influencing the success and failure of implant prostheses and to estimate the lifespan of prostheses using standardized evaluation criteria. An online survey platform was utilized to efficiently gather large samples from multiple institutions.</p><p><strong>Materials and methods: </strong>During the one-year period, patients visiting 16 institutions were assessed using standardized evaluation criteria (KAP criteria). Data from these institutions were collected through an online platform, and various statistical analyses were conducted. Risk factors were assessed using both the Cox proportional hazard model and Cox regression analysis. Survival analysis was conducted using Kaplan-Meier analysis and nomogram, and lifespan prediction was performed using principal component analysis.</p><p><strong>Results: </strong>The number of patients involved in this study was 485, with a total of 841 prostheses evaluated. The median survival was estimated to be 16 years with a 95% confidence interval. Factors found to be significantly associated with implant prosthesis failure, characterized by higher hazard ratios, included the 'type of clinic', 'type of antagonist', and 'plaque index'. The lifespan of implant prostheses that did not fail was estimated to exceed the projected lifespan by approximately 1.34 years.</p><p><strong>Conclusion: </strong>To ensure the success of implant prostheses, maintaining good oral hygiene is crucial. The estimated lifespan of implant prostheses is often underestimated by approximately 1.34 years. Furthermore, standardized form, online platform, and visualization tool, such as nomogram, can be effectively utilized in future follow-up studies.</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 3","pages":"151-162"},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardized multi-institutional data analysis of fixed and removable prosthesis: estimation of life expectancy with regards to variable risk factors.","authors":"Hae-In Jeon, Joon-Ho Yoon, Jeong Hoon Kim, Dong-Wook Kim, Namsik Oh, Young-Bum Park","doi":"10.4047/jap.2024.16.2.67","DOIUrl":"10.4047/jap.2024.16.2.67","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess and predict lifespan of dental prostheses using newly developed Korean Association of Prosthodontics (KAP) criteria through a large-scale, multi-institutional survey.</p><p><strong>Materials and methods: </strong>Survey was conducted including 16 institutions. Cox proportional hazards model and principal component analysis (PCA) were used to find out relevant factors and predict life expectancy.</p><p><strong>Results: </strong>1,703 fixed and 815 removable prostheses data were collected and evaluated. Statistically significant factors in fixed prosthesis failure were plaque index and material type, with a median survival of 10 to 18 years and 14 to 20 years each. In removable prosthesis, factors were national health insurance coverage, antagonist type, and prosthesis type (complete or partial denture), with median survival of 10 to 13 years, 11 to 14 years, and 10 to 15 years each. For still-usable prostheses, PCA analysis predicted an additional 3 years in fixed and 4.8 years in removable prosthesis.</p><p><strong>Conclusion: </strong>Life expectancy of a prosthesis differed significantly by factors mostly controllable either by dentist or a patient. Overall life expectancy was shown to be longer than previous research.</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 2","pages":"67-76"},"PeriodicalIF":2.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular responses to 3D printed dental resins produced using a manufacturer recommended printer versus a third party printer.","authors":"Beatriz Sona Cardoso, Mariana Brito da Cruz, Joana Faria Marques, João Carlos Roque, João Paulo Martins, Rodrigo Cordeiro Malheiro, António Duarte da Mata","doi":"10.4047/jap.2024.16.2.126","DOIUrl":"https://doi.org/10.4047/jap.2024.16.2.126","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate the influence of different 3D dental resins, using a manufacturer recommended printer and a third-party printer, on cellular responses of human gingival cells.</p><p><strong>Materials and methods: </strong>Three NextDent resins (Denture 3D+, C&B MFH and Crowntec) were used to produce specimens on printers NextDent 5100 (groups ND, NC and NT, respectively) and Phrozen Sonic Mini 4K (groups PD, PC and PT, respectively). Human gingival fibroblasts were cultured and biocompatibility was evaluated on days 1, 3 and 7. IL-6 and IL-8 concentrations were evaluated at 3 days using ELISA. Surface roughness was evaluated by a contact profilometer. SEM and fluorescence micrographs were analyzed at days 1 and 7. Statistical analyses were performed using SPSS and mean differences were tested using ANOVA and post-hoc Tukey tests (<i>P</i> < .05).</p><p><strong>Results: </strong>There was an increase in cellular viability after 7 days in groups PC and PT, when compared to group PD. ND group resulted in higher concentration of IL-6 when compared to PT group. SEM and fluorescence micrographs showed less adhesion and thinner morphology of fibroblasts from group PD. No significant differences were found regarding surface roughness.</p><p><strong>Conclusion: </strong>The use of different printers or resins did not seem to influence surface roughness. NextDent 5100 and Phrozen Sonic Mini 4K produced resins with similar cellular responses in human gingival fibroblasts. However, Denture 3D+ resin resulted in significantly lower biocompatibility, when compared to C&B MFH and Crowntec resins. Further testing is required to support its long-term use, required for complete dentures.</p>","PeriodicalId":51291,"journal":{"name":"Journal of Advanced Prosthodontics","volume":"16 2","pages":"126-138"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}