Immunity & Ageing最新文献

{"title":"Transient immunostimulation with LPS promotes tissue repair in aged skin.","authors":"Philipp Haas, Yongfang Wang, Albert Kallon Koroma, Jinnan Cheng, Mahyar Aghapour, Adelheid Hainzl, Linda Krug, Susanne Schatz, Meinhard Wlaschek, Pallab Maity, Karin Scharffetter-Kochanek, Karmveer Singh","doi":"10.1186/s12979-026-00570-y","DOIUrl":"https://doi.org/10.1186/s12979-026-00570-y","url":null,"abstract":"<p><p>Tissue repair is often hampered during aging. Worldwide, chronic wounds in elderly present a major challenge to the medical and socioeconomic infrastructure of societies. A comprehensive understanding of how the aging innate immune system impacts wound homeostasis is lacking. Here we employed the approach of immune modulation to restore disrupted wound repair in aged mice skin. We found that a short pulse of bacterial lipopolysaccharide (LPS) before wounding markedly accelerate tissue repair in aged mice, which - if non-primed - exhibit a defective epidermal wound closure. LPS priming induces rapid sealing of wounds, immune cell activity, keratinocyte responsiveness and their differentiation towards a newly reconstituted wound epithelium. Structural elements such as NETs composed of DNA and membrane protrusions derived from LPS-activated neutrophils and macrophages, respectively, reinforce physical skin barrier in aged wounds. The physical barrier established by LPS-primed innate immune cells subsequently facilitates epithelial tongue migration and adhesion of ECM-producing mesenchymal cells. Collectively, this not only prevents the invasion of pathogens into the restoring skin tissue after injury, but also averts the persistence of low-grade inflammation associated with aged wounds. These findings underscore the benefit of immune cell priming in promoting cellular interactions between innate immune cells and epithelial cells that consequently restores physical skin barrier and promote tissue repair.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"23 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammaging and the role of micronutrients as immunomodulators: a pathway to healthy aging.","authors":"Sheryl S L Tan, Vandana Garg, Abhijeet Dhiman, Nitu Bansal, Patricia Conway","doi":"10.1186/s12979-026-00569-5","DOIUrl":"https://doi.org/10.1186/s12979-026-00569-5","url":null,"abstract":"<p><strong>Background: </strong>Healthy aging is increasingly challenged by inflammaging, a chronic, low‑grade inflammatory state primarily exacerbated by gut microbiota dysbiosis and declining immune function. Persistent digestive and systemic inflammation, along with immunosenescence, contributes to multiple age‑related diseases. Micronutrients regulate key components of immune system and support the composition and function of the gut microbiota, underscoring their emerging role as modulators of inflammaging.</p><p><strong>Main body: </strong>This narrative review synthesizes current evidence insights on how micronutrients regulate cellular and molecular drivers of inflammaging, with emphasis on immune function and gut microbiota imbalance. Adequate intakes of vitamins A, B‑complex, C, D, E, and K, together with trace elements (zinc, selenium, magnesium, iron, and copper), supports both innate and adaptive immune response, genomic and epigenetic stability, mitochondrial efficiency, telomere integrity, and immune regulation. Importantly, micronutrients influence gut microbial composition and inflammatory signaling pathways, thereby mitigating dysbiosis-driven digestive inflammation, a major contributor to systemic inflammaging. The review also delineates the bidirectional micronutrient-microbiome relationship, whereby microbial composition shapes nutrient bioavailability, while micronutrients influence microbial diversity, short‑chain fatty acid production, and inflammatory signaling.</p><p><strong>Conclusion: </strong>Micronutrient sufficiency may help reduce digestive inflammation, restore microbial balance, and modulate immune pathways implicated in inflammaging. However, translating these benefits requires robust assessment of micronutrient status and gut microbiota. Developing standardized evaluation and microbiota‑informed nutrition strategies may enable more precise targeted interventions to support healthy aging.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-associated B cells, key players in autoimmune pathogenesis.","authors":"Seyede-Sara Hassani, Seyedeh Toktam Ekrani, Misagh Rajabinejad, Tola Abdulsattar Faraj, Alireza Rezaiemanesh, Seyed-Alireza Esmaeili","doi":"10.1186/s12979-026-00564-w","DOIUrl":"https://doi.org/10.1186/s12979-026-00564-w","url":null,"abstract":"","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-heart immuno-metabolic disruption associated with inflammaging and subclinical coronary artery disease in people with HIV on antiretroviral therapy.","authors":"Ana-Karla Diego-Matos, Kayluz Frias Boligan, Ralph-Sydney Mboumba Bouassa, Madeleine Durand, Cecile Tremblay, Carl Chartrand-Lefebvre, Mohamed El-Far, Marc Messier-Peet, Justine Giffard-Bouvier, Shari Margolese, Petronela Ancuta, Ido Kema, Cecilia T Costiniuk, Mohammad-Ali Jenabian","doi":"10.1186/s12979-026-00566-8","DOIUrl":"10.1186/s12979-026-00566-8","url":null,"abstract":"<p><strong>Background: </strong>Despite antiretroviral therapy (ART), people with HIV (PWH) face immunological ageing and accelerated comorbidities including coronary artery disease (CAD). Gut mucosal damage, chronic inflammation, and Tryptophan (Trp) catabolism into Kynurenine (Kyn) by indoleamine 2,3-dioxygenase (IDO), are associated with HIV disease progression and atherosclerosis. Thus, we comprehensively assessed the interplay between these perturbations in PWH with subclinical CAD under ART.</p><p><strong>Methods: </strong>Plasma levels of inflammatory mediators, Trp metabolites, and immune cell subset phenotyping were assessed on blood specimens from PWH and HIV seronegative participants with or without CAD diagnosed by cardiac computed tomography angiography from the Canadian HIV Aging Cohort Study.</p><p><strong>Results: </strong>Levels of gut damage markers regenerating islet-derived protein 3 alpha (REG3α), intestinal fatty-acid binding protein (I-FABP) and soluble CD14 (sCD14) were increased in PWH, but only I-FABP was associated with CAD. Among inflammatory soluble markers, soluble receptor type II for the tumor necrosis factor (sTNFRII) was elevated in PWH, while increased interferon-gamma (IFN-γ) and interleukin (IL)-17A levels were associated with CAD. Regardless of CAD, PWH were characterized by upregulated IDO/Kyn pathway and increased Trp metabolites Kyn, 3-hydroxykynurenine (3-H-Kyn), anthranilic acid, along with decreased xanthurenic acid (Xan acid). Accordingly, HIV+CAD+ participants exhibited highest Kyn/Trp and 3-H-Kyn/Xan acid ratios. CAD+ participants had increased classical CD14⁺ and decreased non-classical CD16⁺ monocyte frequencies, regardless of HIV status. HIV status was associated with increased frequencies of Ki67⁺ proliferating, CD28^-CD57⁺ senescent and CCR4⁺CXCR3⁺ CD4 and CD8 T-cells, while T-cell and regulatory T-cells (Treg) atheroprotective CD73-expressing subsets were decreased in PWH.</p><p><strong>Conclusions: </strong>In PWH, subclinical CAD is associated with a distinctive gut-heart immuno-metabolic feature and inflammaging characterized by elevated plasma markers of gut mucosal damage, increased IFN-γ levels and IDO pathway activity, and altered monocyte and T-cell subsets.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune cell signature in non-ischemic heart failure indicates chronic systemic immune activation with features of immunosenescence.","authors":"Lukas Baumhove, Gwenny M P J Verstappen, Frederik E Deiman, Just Dronkers, Wayel H Abdulahad, Kornelis van der Geest, Elisabeth Brouwer, Adriaan A Voors, Peter van der Meer, Nils Bomer","doi":"10.1186/s12979-026-00568-6","DOIUrl":"https://doi.org/10.1186/s12979-026-00568-6","url":null,"abstract":"","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis.","authors":"Renzhi Yang, Ying He, Youkai Pan, Aoyi Geng, Fang Huang, Kai Guo, Hongsheng Zhang","doi":"10.1186/s12979-026-00565-9","DOIUrl":"10.1186/s12979-026-00565-9","url":null,"abstract":"","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune reconstitution efficacy and the risk factors of immune non-responsiveness after combined antiretroviral therapy in HIV-1 positive MSM and heterosexual population - a prospective cohort study.","authors":"Jiangshan Wang, Wancha Huang, Ying Liu, Yanan Hou, Jinda He, Liuqin Chen, Haoge Lin, Hai Li, Zhaohua Lu, Jian Xiao, Zhigang Zheng","doi":"10.1186/s12979-026-00567-7","DOIUrl":"10.1186/s12979-026-00567-7","url":null,"abstract":"","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147534359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Klotho genotype on lactylation in Alzheimer's disease and mechanistic insights.","authors":"Yingying Cai, Ling Li, Zhuorong Li","doi":"10.1186/s12979-026-00563-x","DOIUrl":"10.1186/s12979-026-00563-x","url":null,"abstract":"","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complement regulatory proteins are associated with progression rate of geographic atrophy secondary to age-related macular degeneration.","authors":"Jenni Martinez Villarruel Hinnerskov, Marie Krogh Nielsen, Alexander Kai Thomsen, Maria Abildgaard Steffensen, Bent Honoré, Henrik Vorum, Mogens Holst Nissen, Torben Lykke Sørensen","doi":"10.1186/s12979-026-00562-y","DOIUrl":"10.1186/s12979-026-00562-y","url":null,"abstract":"","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12980988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging-induced decrease in progenitor B cells enhances the osteoclastogenesis of bone marrow macrophages via ROS-activated Fos/CCL3 signaling‌ pathway.","authors":"Ruiqing Sun, Lan Luo, Yang Chen, Liangjie Sun, Yuhao Huo, Chong Ding, Yixiang Wang","doi":"10.1186/s12979-026-00561-z","DOIUrl":"10.1186/s12979-026-00561-z","url":null,"abstract":"<p><strong>Background: </strong>Senile osteoporosis (SOP) is becoming a critical public health burden particularly in aging societies due to escalating fracture susceptibility among elderly populations. Despite advances in SOP research, the mechanistic role of immune cell alterations in senile osteoporosis remains unclear.</p><p><strong>Methods: </strong>As a validated SOP model, senescence-accelerated mouse prone 6 (SAMP6) mice were used for mechanistic studies, comparing with age- and gender-matched controls-senescence-accelerated mouse resistant 1 (SAMR1) mice. We combined micro-CT, molecular biology and histological techniques to assess the bone mineral density in femurs. To investigate dynamic interactions and differential pathways of immune cells within the bone marrow microenvironment, we employed a multi-omics integration strategy including single-cell RNA sequencing, transcriptome sequencing and flow cytometry. Furthermore, we conducted multicolor immunofluorescence and multiplex cytokine analysis to verify the above results. Moreover, we utilized BaF3 and RAW 264.7 cell lines to study the cell interactions during osteoclastogenesis and BX471(a CCR1 antagonist) was used to block this process.</p><p><strong>Results: </strong>SAMP6 mice showed a marked decline in bone mass accompanied by elevated reactive oxygen species (ROS) level in 3-month-old. The single-cell RNA sequencing of bone marrow revealed that a prominent depletion of B lymphocytes, with pro-B cells exhibiting the most pronounced reduction. Multi-omics integration analysis of pro-B cells suggested a significant activation of the Fos/Jun (AP-1) transcription complex accompanied by upregulation of chemokine CCL3 in the SAMP6 group. In vitro assays showed that H₂O₂-induced oxidative stress in BaF3 cells triggers Fos/Ccl3 axis activation and promoted osteoclastogenesis in RAW 264.7 cells. Moreover, blocking CCR1 with BX471 could suppress this effect.</p><p><strong>Conclusions: </strong>Our findings suggest that the elevation of ROS levels within bone marrow microenvironment accelerates immune-senescence of B lymphocytes, characterized by a significant reduction in progenitor B-cell populations, which subsequently activates the Fos/Jun-mediated stress signaling pathway. The cascade ultimately results in the overexpression of CCL3, further promoting osteoclastogenesis of macrophage through CCL3-CCR1 axis. CCR1 antagonist could alleviate pro-inflammatory osteoclast formation, revealing a potential therapeutic target for senile osteoporosis.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}