Immunity & Ageing最新文献

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Early-life thymectomy results in visceral adipose tissue inflammation and glucose intolerance. 早期胸腺切除术导致内脏脂肪组织炎症和葡萄糖耐受不良。
IF 5.6 2区 医学
Immunity & Ageing Pub Date : 2025-10-01 DOI: 10.1186/s12979-025-00531-x
David J Buckley, Sogol Zahedi, Prema Velusamy, Sunita Sharma, Manoj Sabnani, Lisa C Flores, Ganga Tandukar, Yuji Ikeno, Paul J Fadel, Lisa A Lesniewski, Daniel W Trott
{"title":"Early-life thymectomy results in visceral adipose tissue inflammation and glucose intolerance.","authors":"David J Buckley, Sogol Zahedi, Prema Velusamy, Sunita Sharma, Manoj Sabnani, Lisa C Flores, Ganga Tandukar, Yuji Ikeno, Paul J Fadel, Lisa A Lesniewski, Daniel W Trott","doi":"10.1186/s12979-025-00531-x","DOIUrl":"https://doi.org/10.1186/s12979-025-00531-x","url":null,"abstract":"<p><p>We have previously demonstrated that proinflammatory T cells in adipose tissue and the liver play a mechanistic role in glucose intolerance in old mice. Further, we and others have demonstrated that early life thymectomy results in a T cell phenotype that shares many features of classical T cell aging in an otherwise young healthy mouse. In this investigation, we sought to test the hypothesis that inducing premature T cell aging via early life thymectomy results in T cell mediated inflammation of the liver and visceral adipose tissue, as well as glucose intolerance in otherwise young mice. Mice were thymectomized at three weeks of age. At 9 months of age, thymectomized mice exhibited glucose intolerance that was independent of body mass along with greater frailty. Thymectomized mice exhibited blunted proportions of naïve and greater proportions of memory cells in the spleen, liver and perigonadal adipose tissue (pgWAT). Bulk RNAseq of the pgWAT revealed that thymectomized mice exhibited an upregulation of genes responsible for immune activation, chemokine signaling, and inflammation along with a downregulation of genes responsible for metabolic function. We also found that T cells in the pgWAT of thymectomized mice exhibited greater chemokine receptor expression as well as increased markers of histopathological inflammation that were independent of greater adipose tissue expansion. These results suggest that early life thymectomy results in T cell mediated pgWAT inflammation, systemic glucose intolerance and frailty in adult mice.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"36"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting immunosenesence promotes clearance of senescent cells. 靶向免疫衰老促进衰老细胞的清除。
IF 5.6 2区 医学
Immunity & Ageing Pub Date : 2025-09-30 DOI: 10.1186/s12979-025-00518-8
Anteneh Mehari Tizazu, Eyerusalem Amossa Tessema, Olivier Nf Cexus
{"title":"Targeting immunosenesence promotes clearance of senescent cells.","authors":"Anteneh Mehari Tizazu, Eyerusalem Amossa Tessema, Olivier Nf Cexus","doi":"10.1186/s12979-025-00518-8","DOIUrl":"10.1186/s12979-025-00518-8","url":null,"abstract":"<p><p>Known as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated with age. Cellular senescence is a crucial process that puts cells in an irreversible cell-cycle arrest which prevents damaged or stressed cells from uncontrolled propagation and eventually potential malignancy. Paradoxically, senescence also contributes to the occurrence of cancer and increases the risk of metastasis through different secretory mediators. Altogether, the recent use of senotherapy to eliminate senescent cells has been shown to delay tumorigenesis, attenuate age-related deterioration of organs, and promote healthy aging. Interestingly, immune cells have been shown to specifically interact with, and kill senescent cells, thus opening new opportunities for the development of specific therapeutic strategies similar to immunotherapy in cancer. Through its detrimental impact on the immune system, immunosenescence is also leading to the accumulation of senescent cells with age thus further contributing to the occurrence and worsening of multiple age-related pathologies such as cancer. Understanding the molecular and cellular events occurring during the aging process, and triggering immunosenescence as well as the mechanisms by which senescent cells escape immune surveillance would help to improve immune responses to senescent cells and their clearance. In this review, we highlight how senescent cells interact with immune cells, and how immunosenescence-associated phenotypical and functional deregulation hinder the ability of immune cells to clear senescent cells. We further characterize strategies aimed at promoting the clearance of senescent cells by the immune system.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"35"},"PeriodicalIF":5.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport. 三个队列研究中的极端代谢健康评分与炎症和胆固醇转运的血浆蛋白标志物有关。
IF 5.6 2区 医学
Immunity & Ageing Pub Date : 2025-09-09 DOI: 10.1186/s12979-025-00527-7
Daniele Bizzarri, Erik B van den Akker, Marcel J T Reinders, René Pool, Marian Beekman, Nico Lakenberg, Nicolas Drouin, Kelly E Stecker, Albert J R Heck, Edward F Knol, Jeannette M Vergeer, M Arfan Ikram, Mohsen Ghanbari, Alain J van Gool, Joris Deelen, Bbmri-Nl, Dorret I Boomsma, P Eline Slagboom
{"title":"Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport.","authors":"Daniele Bizzarri, Erik B van den Akker, Marcel J T Reinders, René Pool, Marian Beekman, Nico Lakenberg, Nicolas Drouin, Kelly E Stecker, Albert J R Heck, Edward F Knol, Jeannette M Vergeer, M Arfan Ikram, Mohsen Ghanbari, Alain J van Gool, Joris Deelen, Bbmri-Nl, Dorret I Boomsma, P Eline Slagboom","doi":"10.1186/s12979-025-00527-7","DOIUrl":"10.1186/s12979-025-00527-7","url":null,"abstract":"<p><p>The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth score. Using a Luminex cytokine assay and liquid chromatography-mass spectrometry-based proteomics we explored the plasma proteins associating with the difference in 100 extreme scoring individuals selected from two large population cohorts, the Leiden Longevity Study (LLS) and the Rotterdam Study (RS), and discordant monozygotic twin pairs from the Netherlands Twin Register (NTR). In addition, we estimated the heritability of the score using 726 monozygotic (MZ) and 450 dizygotic (DZ) twin pairs. In the contrasting extreme scoring individuals from LLS and RS, we uncovered significant differences in 3 (out of 15) cytokines (GDF15, IL6, and MIG), and 106 (out of 289) plasma proteins. The high, poor health related, score associated with 42 increased inflammatory and immune related protein levels (CRP, LBP, HPT) and lowered levels of 71 HDL remodeling and cholesterol transport related proteins (e.g. APOA1, APOA2, APOA4, and TETN). Using the NTR twins, we subsequently showed that the MetaboHealth score is moderately heritable (h<sup>2</sup> = 0.4). In MZ twins selected for maximal discordance within a pair we found 68 serum proteins associated with the MetaboHealth score indicating that only a minor part of the associations observed in LLS and RS is likely explained by genetic influences. Taken together, our study sheds light on the intricate interplay between the MetaboHealth score, plasma proteins, cytokines, and genetic influences, paving the way for future investigations aimed at optimizing this mortality risk indicator.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"34"},"PeriodicalIF":5.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic inflammation as a central player in the initiation and development of Alzheimer's disease. 全身性炎症在阿尔茨海默病的发生和发展中起核心作用。
IF 5.6 2区 医学
Immunity & Ageing Pub Date : 2025-08-21 DOI: 10.1186/s12979-025-00529-5
Irem Bayraktaroglu, Natalia Ortí-Casañ, Debby Van Dam, Peter P De Deyn, Ulrich L M Eisel
{"title":"Systemic inflammation as a central player in the initiation and development of Alzheimer's disease.","authors":"Irem Bayraktaroglu, Natalia Ortí-Casañ, Debby Van Dam, Peter P De Deyn, Ulrich L M Eisel","doi":"10.1186/s12979-025-00529-5","DOIUrl":"10.1186/s12979-025-00529-5","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is an age-related neurodegenerative disorder and the most common cause of dementia. While the amyloid cascade hypothesis has long dominated AD research, emerging evidence suggests that neuroinflammation may play a more central role in disease onset and progression. Increasingly, AD is recognized as a multifactorial disorder influenced by systemic inflammation and immune dysregulation, shifting focus toward peripheral immune mechanisms as potential contributors to neurodegeneration. This review explores the hypothesis that inflammaging, the age-related increase in pro-inflammatory mediators, combined with lifelong exposure to infections, injuries, metabolic changes, and chronic diseases, among others, may prime the immune system, amplifying neuroinflammation and influencing the progression and exacerbation of AD pathology. To this end, we examined how systemic immune disturbances, including chronic pain, post-operative cognitive dysfunction, viral and bacterial infections, gut microbiome dysregulation, and cardiovascular disease, may act as risk factors for AD. Overall, evidence suggests that modulating peripheral inflammation, accompanied by early diagnosis, could significantly reduce the risk of developing AD. Furthermore, we highlight key immune signaling pathways involved in both central and peripheral immune responses, such as the NLRP3 inflammasome and TREM2, which represent promising therapeutic targets for modulating inflammation while preserving protective immune functions. Strategies aimed at reducing systemic inflammation, identifying early biomarkers, and intervening before significant neurodegeneration occurs may provide novel approaches to delay or prevent AD onset. In conclusion, this review underscores the crucial role of systemic inflammation in AD pathogenesis and progression. By targeting peripheral immune dysfunction, we may advance our understanding of AD mechanisms and develop more effective therapeutic interventions to mitigate disease risk and progression.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"33"},"PeriodicalIF":5.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ageing and dysregulated lung immune responses in fatal COVID-19. 致死性COVID-19患者的衰老和肺免疫反应失调
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-07-17 DOI: 10.1186/s12979-025-00525-9
Natália de Souza Xavier Costa, Jôse Mara de Brito, Carla Froio, Gabriel Ribeiro Júnior, Ana Carolina Alves Lamounier, Leila Antonangelo, Caroline Silvério Faria, Juliana Tiyaki Ito, Fernanda Degobbi Tenorio Quirino Dos Santos Lopes, Renata Aparecida de Almeida Monteiro, Amaro Nunes Duarte-Neto, Paulo Hilário Nascimento Saldiva, Luiz Fernando Ferraz da Silva, Marisa Dolhnikoff, Thais Mauad
{"title":"Ageing and dysregulated lung immune responses in fatal COVID-19.","authors":"Natália de Souza Xavier Costa, Jôse Mara de Brito, Carla Froio, Gabriel Ribeiro Júnior, Ana Carolina Alves Lamounier, Leila Antonangelo, Caroline Silvério Faria, Juliana Tiyaki Ito, Fernanda Degobbi Tenorio Quirino Dos Santos Lopes, Renata Aparecida de Almeida Monteiro, Amaro Nunes Duarte-Neto, Paulo Hilário Nascimento Saldiva, Luiz Fernando Ferraz da Silva, Marisa Dolhnikoff, Thais Mauad","doi":"10.1186/s12979-025-00525-9","DOIUrl":"10.1186/s12979-025-00525-9","url":null,"abstract":"<p><p>Elderly individuals were disproportionally affected during the COVID-19 pandemic, and more than 80% of the global COVID-19-related deaths between 2020 and 2021 occurred among people aged 60 years or older. Several cellular modifications in aged cells may lead to systemic inflammation and fibrotic responses. Age or exogenous insults induce cellular senescence, further increasing the release of pro-inflammatory mediators, leading to the condition known as inflammaging, that can contribute to disease severity. Older individuals presented signs of systemic hyperinflammation in severe COVID-19, but few studies analyzed the influence of age on lung tissue responses in cases of severe COVID-19. We hypothesized that age related alterations regarding innate/acquired immunity and cellular senescence in lung tissue of individuals without lung diseases could predispose to viral infection. We also aimed to identify how the aged lung responded to severe COVID-19 infection. We studied lung tissues from 19 individuals that died from non-pulmonary causes and 28 adult individuals who died from COVID-19 between March and May of 2020, divided according to their age (> or < 60 years). Tissue sections were stained, via immunohistochemistry, and 19 markers among immune cells, COVID-19 receptors, cytokines and senescence were analyzed in the lung parenchyma of both groups. In the COVID-19 group, the Luminex multiplex assay technique was used to detect a panel of 25 cytokines/chemokines. In control lungs, aged individuals had a lower TLR7 expression, without differences in other markers. Older patients had a shorter time between onset of symptoms and death, with a significant negative correlation with age. Unlike the adult younger group, older COVID - 19 patients presented significant differences in relation to their age matched controls in the expression of CD8 + T cells, IFN-α2, TLR7, pSTAT-3, p21 and p53. They also presented higher protein expression that IFN-α2 and TGF-beta than the adult COVID-19 group, with a trend to decreased CD20 + cell density in the lungs. Taken together, our data show age adversely affects the lung expression of key proteins related to COVID-19 susceptibility and severity, by perpetuating inflammation and increasing pro-fibrotic responses.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"32"},"PeriodicalIF":5.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling. 芪复饮通过CCR3信号抑制小胶质细胞衰老,抗ccl11诱导的认知功能障碍。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-07-17 DOI: 10.1186/s12979-025-00528-6
Sheng Tian, Tianyuan Ye, Chao Tian, Yipeng Zhang, He Li, Hui Shen, Youhua Xu, Xiaorui Cheng
{"title":"Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling.","authors":"Sheng Tian, Tianyuan Ye, Chao Tian, Yipeng Zhang, He Li, Hui Shen, Youhua Xu, Xiaorui Cheng","doi":"10.1186/s12979-025-00528-6","DOIUrl":"10.1186/s12979-025-00528-6","url":null,"abstract":"<p><strong>Background: </strong>The chemokine CCL11 is negatively correlated with cognitive function and is able to cause dysfunctions of synaptic plasticity. This research investigate whether CCL11 induce microglia senescence to damage synaptic plasticity and the protective role of Qifuyin.</p><p><strong>Method: </strong>This study involved the intraperitoneal injection of CCL11 in C57BL/6 mice to create an ageing mouse model. Behavioral tests were conducted to evaluate the changes in cognitive function after Qifuyin treatment. LTP and Golgi staining were used to evaluate synaptic structure and function. Cellular senescence was assessed using SA-β-Gal staining, co-localization of p21 or p16 with Iba-1 was identified using multiplex immunofluorescence, and senescence-associated secretory phenotype (SASP) was evaluated via the Luminex. CCR3 knockout/overexpression HMC3 cells were treated with five brain-entering components of Qifuyin to observe protective effects of Qifuyin.</p><p><strong>Results: </strong>Here we found that Qifuyin improved the ability of object recognition and memory, spatial learning and memory and conditional fear memory in CCL11-induced cognitive dysfunction of C57BL/6 mice. Qifuyin can improve synaptic plasticity, increase the expression of GAP-43, PSD-95 and SYN in the hippocampus of CCL11-induced mice. Cellular senescence of microglia and the amounts of SASP in the hippocampus were also reduced after Qifuyin treatment. Through the study of HMC3 cells with CCR3 gene knockout/overexpression, it was found that the brain components of Qifuyin could unlock the cell cycle arrest induced by CCL11/CCR3 pathway, reduce the proportion of G0 and G1 cells, reduce the expressions of p16, p21 and SASP, and enhance the synaptic connection of HT-22 cells damaged by HMC3 cells.</p><p><strong>Conclusion: </strong>This study discovered that CCL11 precipitates microglia senescence in brain, resulting in synaptic structural damage and impaired neuronal functional plasticity, hence causing disruptions in learning and memory functions. Qifuyin can mitigate microglial senescence, safeguard synaptic plasticity, and enhance cognitive function.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"31"},"PeriodicalIF":5.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential. p38丝裂原活化蛋白激酶驱动CD4+ T淋巴细胞衰老并增加其病理潜能。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-07-15 DOI: 10.1186/s12979-025-00526-8
Luis González-Osuna, Sandra Yasuyo Fukada, María Paz Hernández-Cáceres, Patricia Luz-Crawford, Cristian Cortez, Carolina Rojas, Paola Carvajal, Alfredo Sierra-Cristancho, Rolando Vernal
{"title":"p38 mitogen-activated protein kinase drives senescence in CD4<sup>+</sup> T lymphocytes and increases their pathological potential.","authors":"Luis González-Osuna, Sandra Yasuyo Fukada, María Paz Hernández-Cáceres, Patricia Luz-Crawford, Cristian Cortez, Carolina Rojas, Paola Carvajal, Alfredo Sierra-Cristancho, Rolando Vernal","doi":"10.1186/s12979-025-00526-8","DOIUrl":"10.1186/s12979-025-00526-8","url":null,"abstract":"<p><strong>Background: </strong>In several diseases, senescent T lymphocytes increase in number and release a senescence-associated secretory phenotype (SASP) with inflammatory and osteoclastogenic potential, favoring inflammation and bone loss. It is well known that the activation of p38 mitogen-activated protein kinase (p38 MAPK) orchestrates senescence in CD8<sup>+</sup> T lymphocytes. However, p38 MAPK contribution to CD4<sup>+</sup> T lymphocyte senescence remains less comprehensively characterized and warrants further investigation. This study investigates the contribution of p38 MAPK to senescence in CD4<sup>+</sup> T lymphocytes, focusing on mitochondrial dysfunction and SASP production to elucidate their pathological potential.</p><p><strong>Results: </strong>Splenic CD4<sup>+</sup> T lymphocytes isolated from wild-type C57BL/6 mice were subjected to subcytotoxic oxidative stress by H<sub>2</sub>O<sub>2</sub> exposure to generate stress-induced premature senescence. H<sub>2</sub>O<sub>2</sub>-exposed CD4<sup>+</sup> T lymphocytes exhibited hallmark features of senescence, including increased cell size, reduced cell proliferation, and upregulation of the cell cycle regulators p16<sup>Ink4a</sup> and p21<sup>Cip1</sup>. Additionally, these cells displayed defective mitophagy, accumulation of dysfunctional mitochondria, and a SASP enriched in Th17-associated cytokines. In senescence-induced CD4<sup>+</sup> T lymphocytes, an increase in the expression of phospho-p38 MAPK was also detected. The senescence changes were reversed when p38 MAPK was blocked using the specific inhibitor BIRB-796. In particular, neutralizing p38 MAPK reduced mitochondrial dysfunction and Th17-type SASP production, demonstrating its critical role in driving these senescent traits in CD4<sup>+</sup> T lymphocytes. These findings ratify the involvement of p38 MAPK as a central regulator of CD4<sup>+</sup> T lymphocyte senescence, particularly concerning the accumulation of dysfunctional mitochondria and pro-inflammatory SASP production.</p><p><strong>Conclusions: </strong>This study provides critical insights into immune aging mechanisms in CD4<sup>+</sup> T lymphocytes and underscores the therapeutic potential of targeting p38 MAPK to mitigate senescence-driven inflammatory diseases.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"30"},"PeriodicalIF":5.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs). 衰老调节血源性髓源性抑制细胞(MDSCs)的免疫抑制、极化和代谢功能。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-07-08 DOI: 10.1186/s12979-025-00524-w
Emma Keltsch, Jennifer Greiner, Lena Wahl, Ingrid Knape, Daniel Tews, Michael Denkinger, Klaus-Michael Debatin, Gudrun Strauss
{"title":"Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs).","authors":"Emma Keltsch, Jennifer Greiner, Lena Wahl, Ingrid Knape, Daniel Tews, Michael Denkinger, Klaus-Michael Debatin, Gudrun Strauss","doi":"10.1186/s12979-025-00524-w","DOIUrl":"10.1186/s12979-025-00524-w","url":null,"abstract":"<p><strong>Background: </strong>Immunosenescence describes the gradual remodeling of immune responses, leading to disturbed immune homeostasis and increased susceptibility of older adults for infections, neoplasia and autoimmunity. Decline in cellular immunity is associated with intrinsic changes in the T cell compartment, but can be further pushed by age-related changes in cells regulating T cell immunity. Myeloid-derived suppressor cells (MDSCs) are potent inhibitors of T cell activation and function, whose induction requires chronic inflammation. Since aging is associated with low grade inflammation (inflammaging) and increased myelopoiesis, age-induced changes in MDSC induction and function in relation to T cell immunity were analyzed.</p><p><strong>Results: </strong>MDSC numbers and functions were compared between \"healthy\" young and old adults, who were negatively diagnosed for severe acute and chronic diseases known to induce MDSC accumulation. MDSCs were either isolated from peripheral blood or generated in vitro from blood-derived CD14 cells. Aging was associated with significantly increased MDSC numbers in the monocytic- (M-) and polymorphonuclear (PMN-) MDSC subpopulations. MDSCs could be induced more efficiently from CD14 cells of old donors and these MDSCs inhibited CD3/28-induced T cell proliferation significantly better than MDSCs induced from young donors. Serum factors of old donors supported MDSC induction comparable to serum factors from young donors, but increased immunosuppressive activity of MDSCs was only achieved by serum from old donors. Elevated immunosuppressive activity of MDSCs from old donors was associated with major metabolic changes and increased intracellular levels of neutral and oxidized lipids known to promote immunosuppressive functions. Independent of age, MDSC-mediated suppression of T cell proliferation required direct MDSC- T cell contact. Besides their increased ability to inhibit activation-induced T cell proliferation, MDSCs from old donors strongly shift the immune response towards Th2 immunity and might thereby further contribute to impaired cell-mediated immunity during aging.</p><p><strong>Conclusions: </strong>These results indicate that immunosenescence of innate immunity comprises accumulation and functional changes in the MDSC compartment, which directly impacts T cell functions and contribute to age-associated impaired T cell immunity. Targeting MDSCs during aging might help to maintain functional T cell responses and increase the chance of healthy aging.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"29"},"PeriodicalIF":5.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol. 用天然化合物靶向衰老途径:姜黄素、表没食子儿茶素没食子酸酯、百里醌和白藜芦醇的综述。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-07-03 DOI: 10.1186/s12979-025-00522-y
Mohamed Ahmed
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引用次数: 0
Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells. 年轻和年老造血干细胞壁龛对骨髓来源的树突状细胞的不同影响。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-07-03 DOI: 10.1186/s12979-025-00517-9
Patrik Milić, Mojca Justin Kjuder, Katerina Jazbec Gradišar, Urban Švajger, Primož Rožman
{"title":"Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells.","authors":"Patrik Milić, Mojca Justin Kjuder, Katerina Jazbec Gradišar, Urban Švajger, Primož Rožman","doi":"10.1186/s12979-025-00517-9","DOIUrl":"10.1186/s12979-025-00517-9","url":null,"abstract":"<p><strong>Background: </strong>Aging is linked to various dysfunctions of the immune system, including the decline of its primary developmental source: the hematopoietic stem cell (HSC) niche. This decline leads to chronic inflammation, increased vulnerability to infections, cancer, autoimmune diseases, and reduced vaccine efficacy. As individuals age, the HSC niche undergoes significant changes, including greater adipocyte accumulation and alterations in the molecular microenvironment, which may influence the development and function of immune cells. Among these cells, the impact of the aging HSC niche on dendritic cell (DC) function is less understood. Heterochronic autologous HSC transplantation is a promising intervention to prevent age-related disorders, contributing to the extension of healthspan and longevity, however, several murine experiments failed to produce the expected results, which led us to presume that the problem lies within the old HSC niche. Therefore, we created in vitro models of young and old HSC niches and examined how these microenvironments affect the differentiation and maturation and functionality of BM-derived DCs (BMDCs).</p><p><strong>Results: </strong>An analysis of the conditioned media from young and aged HSC niches revealed that the environment of aged niches exhibited an increased presence of adiponectin. This media was subsequently utilized in BMDC differentiation and maturation protocols, with their effects closely monitored. Our results indicate that the old HSC niche microenvironment promotes premature BMDC activation, characterized by elevated MHC class II expression and enhanced allostimulatory capacity of BMDCs at their immature stage. Additionally, LPS stimulation of BMDCs, used to induce DC maturation, significantly increased CD86 expression on BMDCs from the aged niche. However, these cells did not show superior allostimulatory capacity compared to their counterparts from the young niche environment. By analyzing the BMDC cytokine profile, we observed that when cultured in aged niche-conditioned media, the BMDCs secreted significantly higher levels of IL-6, indicating a heightened proinflammatory activation state.</p><p><strong>Conclusions: </strong>Collectively, our findings suggest that aging-related changes within the HSC niche can considerably alter DC functionality by disrupting their normal development from BM precursors. These results emphasize the significance of this phenomenon and its implications for immunosenescence.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"26"},"PeriodicalIF":5.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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