Immunity & Ageing最新文献

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The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity. 美国老年人的免疫系统老化和全因死亡率:性别和种族/民族的差异。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-06-21 DOI: 10.1186/s12979-025-00521-z
Kate A Duchowny, Yuan S Zhang, Rebecca C Stebbins, Xin Ma, Jaydon Jun Yu Chin, Virginia W Chang, Allison E Aiello, Grace A Noppert
{"title":"The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity.","authors":"Kate A Duchowny, Yuan S Zhang, Rebecca C Stebbins, Xin Ma, Jaydon Jun Yu Chin, Virginia W Chang, Allison E Aiello, Grace A Noppert","doi":"10.1186/s12979-025-00521-z","DOIUrl":"10.1186/s12979-025-00521-z","url":null,"abstract":"<p><strong>Background: </strong>As individuals age, the immune system undergoes complex changes, including an increase in the number of CD8 T cells relative to CD4 T cells, a decline in naïve cell production (including T and B cells), and an accumulation of terminally differentiated cells with diminished functionality. These age-related immune alterations collectively contribute to immunosenescence, a phenotype associated with aging-related declines and diseases such as dementia, Alzheimer's disease, osteoporosis, and diabetes. Premature mortality at older ages often results from cumulative health deterioration initiated by physiological dysregulation over the life course. Mortality risk, therefore, provides a meaningful measure of the long-term impact of physiological changes, including those related to the immune system. Examining the link between mortality risk and immune aging in older adults could illuminate the underlying pathology of aging-related health decline. This study uses data from the Health and Retirement Study (HRS), a national, population-based sample of middle-aged and older Americans, to explore the relationship between specific immune aging ratios and six-year mortality, stratified by race/ethnicity and sex.</p><p><strong>Results: </strong>Using a sample of 8,259 individuals from the HRS, we found that overall, the presence, magnitude, and direction of the association differed by the specific immune ratio measure, sex, and race/ethnicity. We found particularly robust associations among Hispanic and non-Hispanic Black females. Among Hispanic females, for example, a one-unit increase in the log CD4 EMRA: Naïve ratio was associated with a nearly 50% increase in mortality for Hispanic females and a 25% increase in mortality for non-Hispanic Black females which was robust to adjustment for additional covariates. While we found little evidence of an association between immune function and mortality among non-Hispanic White and Hispanic males, we found associations in the opposite direction as what we would expect among non-Hispanic Black males. For example, a one-unit increase in the CD4, EMRA: Naïve ratio was associated with a 15% decrease in mortality among non-Hispanic Black males.</p><p><strong>Conclusions: </strong>Our findings demonstrate that associations between immune aging and mortality are not uniform but instead vary in magnitude and direction across sex and racial/ethnic subgroups. The strongest and most consistent associations were observed among Hispanic and non-Hispanic Black females-groups experiencing multiple forms of marginalization-suggesting that these populations may face heightened vulnerability to the downstream consequences of immune aging. However, the absence or reversal of expected associations in some subgroups-particularly non-Hispanic Black males-underscores the complexity of immune aging processes and their interaction with social and biological contexts. These results highlight the importance of di","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"25"},"PeriodicalIF":5.2,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of serum total light chain kappa and lambda levels with all-cause mortality in Chinese centenarians. 中国百岁老人血清总轻链kappa和lambda水平与全因死亡率的关系。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-06-19 DOI: 10.1186/s12979-025-00520-0
Yuting Duan, Zhe Li, Weiguang Zhang, Yue Niu, Bin Wang, Zhe Feng, Ding Sun, Hao Li, Zehao Zhang, Zeyu Qu, Qiushi Wang, Xinye Jin, Jie Zhang, Miao Liu, Hongyan Hu, Yali Zhao, Yao He, Guangyan Cai, Song Hu, Xiangmei Chen, Yizhi Chen
{"title":"Associations of serum total light chain kappa and lambda levels with all-cause mortality in Chinese centenarians.","authors":"Yuting Duan, Zhe Li, Weiguang Zhang, Yue Niu, Bin Wang, Zhe Feng, Ding Sun, Hao Li, Zehao Zhang, Zeyu Qu, Qiushi Wang, Xinye Jin, Jie Zhang, Miao Liu, Hongyan Hu, Yali Zhao, Yao He, Guangyan Cai, Song Hu, Xiangmei Chen, Yizhi Chen","doi":"10.1186/s12979-025-00520-0","DOIUrl":"10.1186/s12979-025-00520-0","url":null,"abstract":"<p><p>The purpose of this study was to determine the relationship between the serum levels of kappa (κ) and lambda (λ) total light chain (TLC), the κ/λ ratio, and the combined serum TLCκ and TLCλ (ΣTLC) levels in Chinese centenarians and all-cause mortality. The association between serum TLC and all-cause mortality was investigated using restricted cubic spline (RCS) analysis, Cox proportional hazards models, and Kaplan‒Meier curves. The study included 906 centenarians (18.8% male), 838 (92.5%) of whom died during a median follow-up of 30 months. The proportions of centenarians with abnormal TLCκ and TLCλ levels were 68.1% and 49.0%, respectively. RCS analysis indicated that the levels of TLCκ, TLCλ, and ΣTLC were associated with all-cause mortality (P < 0.05), whereas the κ/λ ratio was not (P > 0.05). Cox proportional hazards analysis demonstrated that the highest quartiles of TLCκ, TLCλ, and ΣTLC were associated with an increased risk of death, with hazard ratios of 1.434 (95% confidence interval [CI], 1.061-1.939; P = 0.019), 1.351 (95% CI, 1.013-1.802; P = 0.041), and 1.891 (95% CI, 1.347-2.654; P < 0.001), respectively. Kaplan-Meier analysis illustrated that centenarians with higher levels of TLCκ, TLCλ, and ΣTLC had significantly shorter median survival times (26 months versus 35 months, P < 0.001; 26 months versus 32 months, P = 0.003; and 26 months versus 36 months, P < 0.001, respectively). Our findings suggest that serum levels of TLCκ, TLCλ, and ΣTLC are significantly associated with all-cause mortality in centenarians. Trial registration Not applicable.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"24"},"PeriodicalIF":5.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequency of synaptic antigen-specific CD4+ T cells in dementia is age-dependent but not correlated with cognitive impairment. 痴呆患者突触抗原特异性CD4+ T细胞的频率与年龄相关,但与认知障碍无关。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-06-19 DOI: 10.1186/s12979-025-00516-w
Julius Hoffmann, Marie-Luise Machule, Jakob Kreye, Laura Stöffler, Péter Körtvelyessy, Maria Buthut, Rosa Rößling, Petra Bacher, Alexander Scheffold, Harald Prüss
{"title":"Frequency of synaptic antigen-specific CD4<sup>+</sup> T cells in dementia is age-dependent but not correlated with cognitive impairment.","authors":"Julius Hoffmann, Marie-Luise Machule, Jakob Kreye, Laura Stöffler, Péter Körtvelyessy, Maria Buthut, Rosa Rößling, Petra Bacher, Alexander Scheffold, Harald Prüss","doi":"10.1186/s12979-025-00516-w","DOIUrl":"10.1186/s12979-025-00516-w","url":null,"abstract":"<p><p>Neurodegenerative dementias including Alzheimer disease severely impair cognitive and social abilities and are a major cause of mortality with no causal treatment yet. Autoimmune mechanisms have been increasingly considered to contribute to disease progression, e.g. by enhancing protein misfolding or pro-inflammatory immune responses. Understanding this contribution may lead to novel treatment options beyond removing neurodegeneration-associated proteins. We hypothesized that CD4<sup>+</sup> T<sub>H</sub> cells against synaptic proteins may play a role in dementia, given the profound changes of synaptic proteins in the disease. We investigated T<sub>H</sub> cell frequencies and phenotypes after antigen-reactive T cell enrichment (ARTE) using three important synaptic antigens known to play a role in cognitive function, N-Methyl-D-Aspartate receptor (NMDAR), Leucine-rich, glioma inactivated 1 (LGI1) and metabotropic glutamate receptor 5 (mGluR5). Our data revealed that synaptic autoantigen-specific T<sub>H</sub> cells occurred in all cohorts and were similarly frequent in patients with dementia and sex- and age-matched controls. However, they were significantly reduced compared to young healthy subjects, indicating strong age-related effects ('immune senescence'). Compared to the ubiquitously available Candida albicans antigen, synaptic autoantigen-specific T<sub>H</sub> cell responses were strongly driven by IFNγ-producing T cells, expression of which markedly decreased with age. Patients with dementia had significantly less IL-17-producing synaptic autoantigen-specific T<sub>H</sub> cells than aged healthy controls. This first direct ex vivo quantitative and qualitative analysis of circulating T cells autoreactive to three synaptic autoantigens in dementia shows no correlation with cognitive impairment. It suggests that synaptic autoantigen-specific T<sub>H</sub> cells decline with age and are not a major driver of dementia development.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"23"},"PeriodicalIF":5.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-associated changes in the lymphoid tissues of Boa constrictor. 巨蟒淋巴组织的年龄相关变化。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-06-19 DOI: 10.1186/s12979-025-00519-7
Eva Dervas, Udo Hetzel, Anja Kipar
{"title":"Age-associated changes in the lymphoid tissues of Boa constrictor.","authors":"Eva Dervas, Udo Hetzel, Anja Kipar","doi":"10.1186/s12979-025-00519-7","DOIUrl":"10.1186/s12979-025-00519-7","url":null,"abstract":"<p><p>Aging is a complex and multifaceted biological process that results in the gradual decline of physiological functions over time. It is associated with reduced performance across multiple systems, affecting metabolic, reproductive, musculoskeletal, and immune functions. While immune aging has been extensively studied in endothermic animals, and in particular mammals such as laboratory rodents, comparatively little is known about how aging manifests in ectothermic vertebrates like reptiles. This study explored the lymphoid tissue (spleen and thymus) of Boa constrictor, a boid snake indigenous to South and Central America and Mexico, but widely kept in captivity all over the world, for potential age-related changes. We observed a significant decrease in cellularity in the spleen, coupled with an increase in organ size correlated with age. In both spleen and thymus the connective tissue of capsule and trabeculae increased significantly with age, indicative of progressive fibrosis. In addition, several changes were observed with increasing frequency in older animals, epithelial hyperplasia in the thymic medulla as well stromal fibrosis and an increasing infiltration by so-called granular cells in both organs. Granular cells likely represent a leukocyte subtype; their presence indicates a progressive chronic low-grade inflammatory state in the lymphoid organs, a feature known as inflammaging in other animal classes. They may also play a role in the progressive fibrosis of the connective tissue. The results firstly describe morphological evidence of aging in B. constrictor and indicate similarities in the aging across animal classes.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"22"},"PeriodicalIF":5.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diverging effects of tumor necrosis factor inhibitors and conventional synthetic disease-modifying antirheumatic drugs on immunosenescence and inflammageing in rheumatoid arthritis: a cross-sectional analysis. 肿瘤坏死因子抑制剂和常规合成疾病改善抗风湿药物对类风湿关节炎免疫衰老和炎症的分化作用:一项横断面分析
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-05-22 DOI: 10.1186/s12979-025-00508-w
Tobias Schwarz, Giovanni Almanzar, Sebastian Völkl, Martin Feuchtenberger, Johannes Leierer, Christian Schmidt, Frank Deininger, Hans-Peter Tony, Marc Schmalzing, Martina Prelog
{"title":"Diverging effects of tumor necrosis factor inhibitors and conventional synthetic disease-modifying antirheumatic drugs on immunosenescence and inflammageing in rheumatoid arthritis: a cross-sectional analysis.","authors":"Tobias Schwarz, Giovanni Almanzar, Sebastian Völkl, Martin Feuchtenberger, Johannes Leierer, Christian Schmidt, Frank Deininger, Hans-Peter Tony, Marc Schmalzing, Martina Prelog","doi":"10.1186/s12979-025-00508-w","DOIUrl":"10.1186/s12979-025-00508-w","url":null,"abstract":"<p><strong>Background: </strong>Immunosenescence is characterized by a decline in naive T cells, a reduced T cell receptor repertoire, and the accumulation of terminally-differentiated and unspecifically-activated proinflammatory cells, a process called inflammageing. Premature immunosenescence is thought to be pathogenetically relevant in rheumatoid arthritis (RA), either by posing a risk factor for its development, or by advancing the rheumatic disease as a result of excess antigenic and inflammatory stimulation. We investigated parameters of immunosenescence in RA patients treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) only compared to patients treated additionally or exclusively with a tumor necrosis factor inhibitor (TNFi) and age-matched healthy controls to investigate the effect of RA treatment on age-associated T cell phenotypes and functions.</p><p><strong>Results: </strong>The csDMARD-only treated patients, compared to the TNFi-treated patients and healthy controls, displayed an enhanced age-dependent decline in CD31<sup>+</sup> recent thymic emigrants (RTE) and Interleukin-7 (IL-7)-receptor α-chain (CD127)-expressing CD4<sup>+</sup> T cells participating in IL-7-associated homeostatic proliferation, a diminished proliferation of RTE and CD127<sup>+</sup> T cells, as well as reduced T cell receptor excision circle (TREC) counts. However, whereas the RA patients exhibited reduced proportions of unspecifically activated IFNγ- and IL-17-producing T cells, TNFi initiation induced an increase in these proinflammatory cells.</p><p><strong>Conclusions: </strong>Whereas a TNFi treatment seems to counteract the non-inflammatory aspects of immunosenescence, it induces increasing proportions of terminally-differentiated, cytokine-producing effector memory T cells, requiring awareness as possibly contributing to secondary autoimmune phenomena in RA.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"21"},"PeriodicalIF":5.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut-vitamin D interplay: key to mitigating immunosenescence and promoting healthy ageing. 肠道与维生素D的相互作用:缓解免疫衰老和促进健康衰老的关键。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-05-19 DOI: 10.1186/s12979-025-00514-y
Hammad Ullah
{"title":"Gut-vitamin D interplay: key to mitigating immunosenescence and promoting healthy ageing.","authors":"Hammad Ullah","doi":"10.1186/s12979-025-00514-y","DOIUrl":"10.1186/s12979-025-00514-y","url":null,"abstract":"<p><strong>Background: </strong>Immunosenescence is the loss and change of immunological organs, as well as innate and adaptive immune dysfunction with ageing, which can lead to increased sensitivity to infections, age-related diseases, and cancer. Emerging evidence highlights the role of gut-vitamin D axis in the regulation of immune ageing, influencing chronic inflammation and systemic health. This review aims to explore the interplay between the gut microbiota and vitamin D in mitigating immunosenescence and preventing against chronic inflammation and age-related diseases.</p><p><strong>Main text: </strong>Gut microbiota dysbiosis and vitamin D insufficiency accelerate immunosenescence and risk of chronic diseases. Literature data reveal that vitamin D modulates gut microbiota diversity and composition, enhances immune resilience, and reduce systemic inflammation. Conversely, gut microbiota influences vitamin D metabolism to promote the synthesis of active vitamin D metabolites with implications for immune health.</p><p><strong>Conclusions: </strong>These findings underscore the potential of targeting gut-vitamin D axis to modulate immune responses, delay the immune ageing, and mitigate age-related diseases. Further research is needed to integrate vitamin D supplementation and microbiome modulation into strategies aimed at promoting healthy ageing.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"20"},"PeriodicalIF":5.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zinc deficiency as possible link between immunosenescence and age-related diseases. 锌缺乏可能与免疫衰老和年龄相关疾病有关。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-05-19 DOI: 10.1186/s12979-025-00511-1
Michael Tobias Schulz, Lothar Rink
{"title":"Zinc deficiency as possible link between immunosenescence and age-related diseases.","authors":"Michael Tobias Schulz, Lothar Rink","doi":"10.1186/s12979-025-00511-1","DOIUrl":"10.1186/s12979-025-00511-1","url":null,"abstract":"<p><p>As global life expectancy increases, research reveals a critical challenge in aging: the progressive deterioration of immune function, termed immunosenescence. This age-related immune decline is characterized by a complex dysregulation of immune responses, which leaves older adults increasingly vulnerable to infections, chronic inflammatory states, and various degenerative diseases. Without intervention, immunosenescence significantly contributes to morbidity and mortality among the elderly, intensifying healthcare burdens and diminishing quality of life on both individual and societal levels. This review explores the essential role of zinc, a trace element critical for immune health, in mitigating the impact of immunosenescence and slowing the cascade of immunological dysfunctions associated with aging. By modulating the activity of key immune cells and pathways, zinc supplementation emerges as a promising approach to strengthen immunity, reduce oxidative stress, and counteract \"inflammaging,\" a state of chronic, low-grade inflammation that accelerates tissue damage and drives disease progression. Zinc's involvement in cellular defense and repair mechanisms across the immune system highlights its ability to enhance immune cell functionality, resilience, and adaptability, strengthening the body's resistance to infection and its ability to manage stressors that contribute to diseases of aging. Indeed, zinc has demonstrated potential to improve immune responses, decrease inflammation, and mitigate the risk of age-related conditions including diabetes, depression, cardiovascular disease, and vision loss. Given the prevalent barriers to adequate zinc intake among older adults, including dietary limitations, decreased absorption, and interactions with medications, this review underscores the urgent need to address zinc deficiency in aging populations. Recent findings on zinc's cellular and molecular effects on immune health present zinc supplementation as a practical, accessible intervention for supporting healthier aging and improving quality of life. By integrating zinc into targeted strategies, public health efforts may not only sustain immunity in the elderly but also extend healthy longevity, reduce healthcare costs, and potentially mitigate the incidence and impact of chronic diseases that strain healthcare systems worldwide.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"19"},"PeriodicalIF":5.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immunological age prediction of monocytes indicates that gestational diabetes mellitus accelerates the aging of monocytes in offspring. 单核细胞的免疫年龄预测表明,妊娠期糖尿病加速了子代单核细胞的衰老。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-05-13 DOI: 10.1186/s12979-025-00513-z
Yan Zhang, Rui Guo, Min Yin, Mei Shi, Ting Zhong, Shanshan Liu, Xia Li
{"title":"The immunological age prediction of monocytes indicates that gestational diabetes mellitus accelerates the aging of monocytes in offspring.","authors":"Yan Zhang, Rui Guo, Min Yin, Mei Shi, Ting Zhong, Shanshan Liu, Xia Li","doi":"10.1186/s12979-025-00513-z","DOIUrl":"10.1186/s12979-025-00513-z","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have suggested that gestational diabetes mellitus (GDM) can accelerate cellular aging in multiple cell types in offspring, but its impact on immune senescence remains uncertain. Our prior study reveals GDM increased the secretion of inflammatory factors by monocytes in offspring. This study discovered the transcriptome characteristics of aging monocytes at the single-cell level and explore the impact of GDM on the progression of monocyte aging in offspring.</p><p><strong>Method: </strong>Single-cell sequencing data from 56 healthy individuals (aged 0-100 years), comprising self-measured samples (n = 6) and publicly available datasets from the Gene Expression Omnibus (GEO, n = 50), were analyzed to characterize monocyte senescence. Linear mixed-effects modeling was used to screen for age-related genes. A random forest model was created to predict immune age in monocytes, allowing for quantitative assessment of aging.</p><p><strong>Results: </strong>We detected an increase in the number of inflammatory monocytes expressing IL1B and CXCL8 with age. Two age-related gene expression patterns were identified in monocytes. Analysis of offspring monocytes from mothers with GDM suggested that exposure to a GDM environment in the womb may lead to increased expression of aging-related genes, a hindered cell cycle, and increased immune age. The immune age of monocytes at birth is significantly linked to maternal weight gain, high fasting blood glucose levels, and cord blood C-peptide levels during pregnancy.</p><p><strong>Conclusions: </strong>Exposure to GDM during pregnancy accelerates aging in offspring immune cells. Monitoring maternal weight and blood sugar during GDM can help prevent negative effects on the offspring immune system.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"18"},"PeriodicalIF":5.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunological enhancement of micro-nanoparticle formulated with risedronate and zinc as vaccine adjuvant in aged mice. 以利塞膦酸钠和锌为疫苗佐剂的微纳米颗粒对老年小鼠的免疫增强作用。
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-05-13 DOI: 10.1186/s12979-025-00512-0
Yue Liu, Man Yang, Meifeng Nie, Shuyu Wu, Rong Su, Dekui Qiu, Shouneng Lu, Hualong Xiong, Jinlei Zhang, Shengxiang Ge, Quan Yuan, Qinjian Zhao, Tianying Zhang, Yingbin Wang, Ningshao Xia
{"title":"Immunological enhancement of micro-nanoparticle formulated with risedronate and zinc as vaccine adjuvant in aged mice.","authors":"Yue Liu, Man Yang, Meifeng Nie, Shuyu Wu, Rong Su, Dekui Qiu, Shouneng Lu, Hualong Xiong, Jinlei Zhang, Shengxiang Ge, Quan Yuan, Qinjian Zhao, Tianying Zhang, Yingbin Wang, Ningshao Xia","doi":"10.1186/s12979-025-00512-0","DOIUrl":"10.1186/s12979-025-00512-0","url":null,"abstract":"<p><strong>Background: </strong>Elderly individuals face heightened susceptibility to infectious diseases and diminished vaccine responses. Vaccine adjuvants offer a solution. Despite aluminum adjuvant's long history, its limitations in inducing strong cellular immunity and protecting immunocompromised individuals restrict its application. Building upon our previous development of zinc salt particle-based risedronate (Zn-RS), we systematically investigated the immunoenhancing effects of Zn-RS in aged mice and thoroughly explored the underlying mechanisms responsible for these observations in this study.</p><p><strong>Results: </strong>Compared to formulations using aluminum adjuvant, Zn-RS combined with either varicella-zoster virus glycoprotein E (gE) or SARS-CoV-2 monovalent STFK protein (STFK) elicited significantly higher IgG and neutralization titers, as well as superior long-term humoral immunity. Moreover, Zn-RS induced greater quantities of dendritic cells (DCs), antigen-presenting cells (APCs), follicular helper T (T<sub>FH</sub>) cells, Th1/Th2/Th9/Th17 type immune cells, germinal center B cells (GCBs) and plasma cells.</p><p><strong>Conclusions: </strong>These findings support Zn-RS as a promising adjuvant candidate for elderly populations, warranting further exploration of its mechanisms and potential applications.</p>","PeriodicalId":51289,"journal":{"name":"Immunity & Ageing","volume":"22 1","pages":"17"},"PeriodicalIF":5.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome - results of the PolSenior2 substudy. pentaxin -3和c -反应蛋白血浆水平预测有或无代谢综合征的老年人的生存——PolSenior2亚研究的结果
IF 5.2 2区 医学
Immunity & Ageing Pub Date : 2025-05-08 DOI: 10.1186/s12979-025-00509-9
Aleksander J Owczarek, Anna Ochman, Anna Chudek, Małgorzata Mossakowska, Monika Puzianowska-Kuźnicka, Hanna Kujawska-Danecka, Tomasz Zdrojewski, Andrzej Więcek, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz
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