单核细胞的免疫年龄预测表明,妊娠期糖尿病加速了子代单核细胞的衰老。

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Yan Zhang, Rui Guo, Min Yin, Mei Shi, Ting Zhong, Shanshan Liu, Xia Li
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引用次数: 0

摘要

背景:最近的研究表明,妊娠期糖尿病(GDM)可加速后代多种细胞类型的细胞衰老,但其对免疫衰老的影响尚不确定。我们之前的研究表明GDM增加了后代单核细胞的炎症因子分泌。本研究在单细胞水平上发现衰老单核细胞的转录组特征,探讨GDM对后代单核细胞衰老进程的影响。方法:分析56名健康个体(0-100岁)的单细胞测序数据,包括自测样本(n = 6)和基因表达综合数据库(GEO, n = 50)的公开数据集,以表征单核细胞衰老。线性混合效应模型用于筛选年龄相关基因。建立了一个随机森林模型来预测单核细胞的免疫年龄,允许对衰老进行定量评估。结果:我们检测到炎性单核细胞表达IL1B和CXCL8的数量随着年龄的增长而增加。在单核细胞中发现了两种与年龄相关的基因表达模式。对患有GDM的母亲的后代单核细胞的分析表明,子宫内暴露于GDM环境可能导致衰老相关基因的表达增加,细胞周期受阻,免疫年龄增加。出生时单核细胞的免疫年龄与孕妇体重增加、高空腹血糖水平和怀孕期间脐带血c肽水平显著相关。结论:妊娠期暴露于GDM会加速后代免疫细胞的衰老。在GDM期间监测母亲的体重和血糖有助于防止对后代免疫系统的负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The immunological age prediction of monocytes indicates that gestational diabetes mellitus accelerates the aging of monocytes in offspring.

Background: Recent studies have suggested that gestational diabetes mellitus (GDM) can accelerate cellular aging in multiple cell types in offspring, but its impact on immune senescence remains uncertain. Our prior study reveals GDM increased the secretion of inflammatory factors by monocytes in offspring. This study discovered the transcriptome characteristics of aging monocytes at the single-cell level and explore the impact of GDM on the progression of monocyte aging in offspring.

Method: Single-cell sequencing data from 56 healthy individuals (aged 0-100 years), comprising self-measured samples (n = 6) and publicly available datasets from the Gene Expression Omnibus (GEO, n = 50), were analyzed to characterize monocyte senescence. Linear mixed-effects modeling was used to screen for age-related genes. A random forest model was created to predict immune age in monocytes, allowing for quantitative assessment of aging.

Results: We detected an increase in the number of inflammatory monocytes expressing IL1B and CXCL8 with age. Two age-related gene expression patterns were identified in monocytes. Analysis of offspring monocytes from mothers with GDM suggested that exposure to a GDM environment in the womb may lead to increased expression of aging-related genes, a hindered cell cycle, and increased immune age. The immune age of monocytes at birth is significantly linked to maternal weight gain, high fasting blood glucose levels, and cord blood C-peptide levels during pregnancy.

Conclusions: Exposure to GDM during pregnancy accelerates aging in offspring immune cells. Monitoring maternal weight and blood sugar during GDM can help prevent negative effects on the offspring immune system.

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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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