以利塞膦酸钠和锌为疫苗佐剂的微纳米颗粒对老年小鼠的免疫增强作用。

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Yue Liu, Man Yang, Meifeng Nie, Shuyu Wu, Rong Su, Dekui Qiu, Shouneng Lu, Hualong Xiong, Jinlei Zhang, Shengxiang Ge, Quan Yuan, Qinjian Zhao, Tianying Zhang, Yingbin Wang, Ningshao Xia
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引用次数: 0

摘要

背景:老年人对传染病的易感性增加,疫苗反应减弱。疫苗佐剂提供了一种解决方案。尽管铝佐剂的历史悠久,但其在诱导强细胞免疫和保护免疫功能低下个体方面的局限性限制了其应用。在我们之前开发的锌盐颗粒基利塞膦酸盐(Zn-RS)的基础上,我们系统地研究了Zn-RS对老年小鼠的免疫增强作用,并在本研究中深入探讨了这些观察结果的潜在机制。结果:与使用铝佐剂的配方相比,锌rs与水痘-带状疱疹病毒糖蛋白E (gE)或SARS-CoV-2单价STFK蛋白(STFK)联合可显著提高IgG和中和滴度,并具有较好的长期体液免疫。此外,Zn-RS诱导大量树突状细胞(dc)、抗原呈递细胞(APCs)、滤泡辅助性T细胞(TFH)、Th1/Th2/Th9/Th17型免疫细胞、生发中心B细胞(GCBs)和浆细胞。结论:这些发现支持Zn-RS作为一种有希望的老年人群佐剂候选,值得进一步探索其机制和潜在的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunological enhancement of micro-nanoparticle formulated with risedronate and zinc as vaccine adjuvant in aged mice.

Background: Elderly individuals face heightened susceptibility to infectious diseases and diminished vaccine responses. Vaccine adjuvants offer a solution. Despite aluminum adjuvant's long history, its limitations in inducing strong cellular immunity and protecting immunocompromised individuals restrict its application. Building upon our previous development of zinc salt particle-based risedronate (Zn-RS), we systematically investigated the immunoenhancing effects of Zn-RS in aged mice and thoroughly explored the underlying mechanisms responsible for these observations in this study.

Results: Compared to formulations using aluminum adjuvant, Zn-RS combined with either varicella-zoster virus glycoprotein E (gE) or SARS-CoV-2 monovalent STFK protein (STFK) elicited significantly higher IgG and neutralization titers, as well as superior long-term humoral immunity. Moreover, Zn-RS induced greater quantities of dendritic cells (DCs), antigen-presenting cells (APCs), follicular helper T (TFH) cells, Th1/Th2/Th9/Th17 type immune cells, germinal center B cells (GCBs) and plasma cells.

Conclusions: These findings support Zn-RS as a promising adjuvant candidate for elderly populations, warranting further exploration of its mechanisms and potential applications.

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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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