{"title":"\"My mind goes dead … I cannot speak\": an expression of DPD.","authors":"D Goeta, M Mula, M Mayhew, N A Poole","doi":"10.1080/13546805.2023.2197201","DOIUrl":"https://doi.org/10.1080/13546805.2023.2197201","url":null,"abstract":"<p><strong>Introduction: </strong>Here we present a case of Depersonalisation-Derealisation Disorder which involves an unusual environmental trigger and profile of symptoms in a patient with an underlying left frontal encephalomalacia.</p><p><strong>Methods: </strong>The clinical information has been collected from multiple neurological, psychiatric, neuropsychological examinations and from the patient's medical records.</p><p><strong>Results: </strong>The neuropsychiatric assessment showed depersonalisation, derealisation, de-somatisation and de-affectualisation, along with a good response to SSRI + Lamotrigine; all typical features of DPD. The neuropsychological assessment showed language problems, and other mild cognitive difficulties that may provide a neuropsychological foundation contributing to the DPD episodes.</p><p><strong>Discussion and conclusion: </strong>Given Mr R's underlying neuropsychological deficit, hearing voices without speech-associated gestures might place excessive demands on his ability to process the information, exacerbating his feelings of threat. This sets up the pattern of suppressed insula activation, and possibly the suppression of the auditory cortex leading to the presented unusual DPD symptoms.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"28 3","pages":"196-206"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9558978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tobias Lohaus, Judith Witt, Anne Schürmeyer, Oliver T Wolf, Patrizia Thoma
{"title":"Fatigue and its relation to general cognition, social cognition and social activity in multiple sclerosis and stroke.","authors":"Tobias Lohaus, Judith Witt, Anne Schürmeyer, Oliver T Wolf, Patrizia Thoma","doi":"10.1080/13546805.2023.2178399","DOIUrl":"https://doi.org/10.1080/13546805.2023.2178399","url":null,"abstract":"<p><strong>Introduction: </strong>The relationship between fatigue and (socio-)cognitive deficits in neurological diseases has sparked increasing research interest in the past years. So far, findings are inconsistent. Most studies focused on general cognitive functioning in specific disorders, particularly cancer or multiple sclerosis (MS).</p><p><strong>Methods: </strong>This study aims to examine the relationship between fatigue, social cognition and social activity, also taking into account general cognition, more closely, including a stroke patient group (<i>n </i>= 57), a MS patient group (<i>n </i>= 31) and a healthy control group (<i>n</i> = 20). The participants underwent a comprehensive (socio-)cognitive test battery and completed questionnaires on fatigue and psychopathology which, in addition to fatigue, can also affect (socio-)cognitive performance.</p><p><strong>Results: </strong>In both MS and stroke patients high fatigue scores were observed. Irrespective of aetiology, patients with high and low fatigue did not differ with regard to general cognition and social cognition. However, high fatigue scores were associated with a reduction of social activities in both patient groups. No other significant relationships were observed between fatigue and (socio-)cognitive measures.</p><p><strong>Conclusions: </strong>Future studies ought to further explore the potentially complex nature of fatigue symptoms and their relationship with (socio-)cognitive performance and social activity in neurological populations.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"28 3","pages":"165-180"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9558074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The entangled nature of the brain","authors":"A. Cavanna, G. Purpura, A. Riva, R. Nacinovich","doi":"10.1080/13546805.2023.2197202","DOIUrl":"https://doi.org/10.1080/13546805.2023.2197202","url":null,"abstract":"","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"28 1","pages":"237 - 242"},"PeriodicalIF":1.7,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49056426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Swiss CAT+, a Data-driven Infrastructure for Accelerated Catalysts Discovery and Optimization.","authors":"Paco Laveille, Pascal Miéville, Sourav Chatterjee, Elisa Clerc, Jean-Charles Cousty, Florian De Nanteuil, Erwin Lam, Edy Mariano, Adrian Ramirez, Urielle Randrianarisoa, Keyan Villat, Christophe Copéret, Nicolai Cramer","doi":"10.2533/chimia.2023.154","DOIUrl":"10.2533/chimia.2023.154","url":null,"abstract":"<p><p>The Catalysis Hub - Swiss CAT+ is a new infrastructure project funded by ETH-domain, co-headed by EPFL and ETHZ. It offers the scientific community a unique integrated technology platform combining automated and high-throughput experimentation with advanced computational data analysis to accelerate the discoveries in the field of sustainable catalytic technologies. Divided into two hubs of expertise, homogeneous catalysis at EPFL and heterogeneous catalysis at ETHZ, the platform is open to academic and private research groups. Following a multi-year investment plan, both hubs have acquired and developed several high-end robotic platforms devoted to the synthesis, characterization, and testing of large numbers of molecular and solid catalysts. The hardware is associated with a fully digitalized experimental workflow and a specific data management strategy to support closed-loop experimentation and advanced computational data analysis.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"15 1","pages":"154-158"},"PeriodicalIF":1.2,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81895385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yvonne C M Rensen, Joukje M Oosterman, Paul A T M Eling, Roy P C Kessels
{"title":"\"Cinderella was attacked by the big bad wolf, but the police saved her\": intrusions and confabulations on story recall in Korsakoff's syndrome and alcohol-related cognitive impairments.","authors":"Yvonne C M Rensen, Joukje M Oosterman, Paul A T M Eling, Roy P C Kessels","doi":"10.1080/13546805.2022.2153658","DOIUrl":"https://doi.org/10.1080/13546805.2022.2153658","url":null,"abstract":"<p><strong>Background: </strong>The relation between confabulations and intrusions in patients with Korsakoff's syndrome (KS) and patients with alcohol-related cognitive impairments (ARCI) remains under debate. This study examines (1) differences in the production of confabulations and intrusions between patients with KS and ARCI, (2) whether an altered fairy tale induces more intrusions, and (3) whether different types of intrusions were significantly related to confabulations.</p><p><strong>Methods: </strong>Twenty-three patients with KS and twenty-two patients with ARCI recalled three different types of stories: a novel story, a fairy tale, and a modified fairy tale. Different types of intrusions were correlated with confabulation measures.</p><p><strong>Results: </strong>Patients with KS produced more intrusions in the modified fairy tale condition than patients with ARCI, but these were unrelated to confabulations. Only unrelated intrusions were related to provoked confabulations.</p><p><strong>Conclusions: </strong>The results of this study indicate that researchers and clinicians must be aware that in general<i>,</i> intrusions on memory tests should not be interpreted as confabulations. Especially spontaneous confabulations appear to be something completely different from intrusions on any type of story recall. When measuring confabulations it is crucial to use validated instruments.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"28 2","pages":"85-101"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9913327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
India Kelsall-Foreman, Romola S Bucks, Michael Weinborn, Johanna C Badcock
{"title":"Loneliness and objective social isolation are differentially associated with anomalous perceptions in community-dwelling older adults.","authors":"India Kelsall-Foreman, Romola S Bucks, Michael Weinborn, Johanna C Badcock","doi":"10.1080/13546805.2023.2174841","DOIUrl":"https://doi.org/10.1080/13546805.2023.2174841","url":null,"abstract":"<p><strong>Introduction: </strong>Anomalous perceptions are characterised by the subjective experience of a range of distorted and/or hallucinatory percepts. Whilst considerable attention has been paid to the neurocognitive processes contributing to anomalous perceptions amongst older adults, less is known about the social factors (e.g. social isolation, loneliness). Furthermore, it is unknown whether loneliness and social isolation are associated with different types of anomalous perceptions, including anomalous body-centred self-experiences and anomalous external experiences.</p><p><strong>Methods: </strong>This study examined the cross-sectional relationships between loneliness, objective social isolation, and anomalous perceptions in a sample of community-dwelling older adults (<i>N </i>= 242, <i>M</i><sub>age </sub>= 71.87 ± 7.73, range = 52-91, 67.8% female) using structural equation modelling.</p><p><strong>Results: </strong>Higher levels of loneliness were associated with more anomalous body-centred self-experiences and anomalous external experiences. Those reporting more loneliness also reported higher levels of anxiety and depression; however, the relationship between loneliness and anomalous perceptions was not mediated by these factors. Social disconnection from a religious group was associated with more anomalous external experiences and being married/living with a partner was associated with more anomalous body-centred self-experiences.</p><p><strong>Conclusions: </strong>These findings suggest that loneliness and social isolation have differential associations with anomalous perceptions in older adults and provide additional evidence that attending to loneliness in older adults is important.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"28 2","pages":"130-146"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9913854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Ten dollars today or 50 dollars after one month?\" Temporal discounting in Korsakoff syndrome.","authors":"Mohamad El Haj, Ahmed A Moustafa","doi":"10.1080/13546805.2023.2173059","DOIUrl":"https://doi.org/10.1080/13546805.2023.2173059","url":null,"abstract":"<p><strong>Objective: </strong>Little research has investigated decision making in patients with Korsakoff syndrome (KS). Specifically, to our knowledge, there is a lack of research investigating whether patients with KS may tend to prefer immediate over future rewards (i.e., temporal discounting). Further, we investigated the relationship between temporal discounting and inhibition.</p><p><strong>Methods: </strong>We, for the first time, invited patients with KS and control participants to perform a temporal discounting task, in which they answered questions probing preferences between an immediate, but smaller amount of money, and a delayed, but larger amount of money (e.g., \"would you prefer 10 dollars today or 50 dollars after one month?\"). Furthermore, inhibition was measured using the Stroop Colour Word Test.</p><p><strong>Results: </strong>Analysis demonstrated higher temporal discounting in patients with KS than in control participants. Temporal discounting in both populations was significantly correlated with inhibition.</p><p><strong>Conclusions: </strong>Patients with KS may have difficulties to suppress the temptation of smaller, but immediate, rewards.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"28 2","pages":"116-129"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9556726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Fernanda Cuéllar-García, Isabel Dager-Berecochea, Ana Patricia Villegas-Iparrea, Zuemmy Molina-Escalante, Luis Villalobos-Gallegos, Aldebarán Toledo-Fernández
{"title":"Big Five personality factors predict self-rated cognitive reserve: a two-wave online study in a Mexican sample.","authors":"María Fernanda Cuéllar-García, Isabel Dager-Berecochea, Ana Patricia Villegas-Iparrea, Zuemmy Molina-Escalante, Luis Villalobos-Gallegos, Aldebarán Toledo-Fernández","doi":"10.1080/13546805.2023.2168530","DOIUrl":"https://doi.org/10.1080/13546805.2023.2168530","url":null,"abstract":"<p><p><i>Introduction:</i> One of the main contributors to cognitive reserve (CR) is the involvement in cognitively stimulating activities (CSAs), including education, work, leisure, social and physical activities. Personality traits are plausible determinants of CR, influencing the tendency to engage in CSAs. The goal of this study was to evaluate the association between personality and CR, operationalised as self-rated involvement in CSAs, in a sample of individuals aged 18-50 or more. <i>Method:</i> We collected two-wave non-probabilistic online data throughout Mexico. The instruments were the Big Five Inventory-2 for the baseline, its extra-short form for the follow-up and the Self-Rating of Cognitive Reserve (SRCR). Confirmatory factor analyses (CFAs) were performed to test the unifactorial structure of the SRCR, and multiple regressions were conducted with personality factors as predictors of CR. <i>Results:</i> For the baseline, 2025 participants were recruited, and 610 for the follow-up, most of them female and aged 18-40. CFAs showed excellent goodness-of-fit, and the regression analyses proved Negative Emotionality and Extraversion to be the main predictors of CR. <i>Conclusions:</i> Our study highlights the need to identify personality profiles at high risk of underdevelopment of CR in ages where it is still feasible to promote engagement in CSAs.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"28 2","pages":"102-115"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9558059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephanie S J Morris, Joseph S Raiker, Aaron T Mattfeld, Whitney D Fosco
{"title":"The impact of ADHD symptom severity on reinforcement and punishment learning among adults.","authors":"Stephanie S J Morris, Joseph S Raiker, Aaron T Mattfeld, Whitney D Fosco","doi":"10.1080/13546805.2023.2178398","DOIUrl":"https://doi.org/10.1080/13546805.2023.2178398","url":null,"abstract":"<p><p><b>Introduction:</b> Aberrations in feedback learning are hypothesised to contribute to the behavioural disruptions and impairment of attention-deficit/hyperactivity disorder (ADHD). However, few studies have evaluated the relation of reward/punishment feedback and ADHD symptom severity on learning. The current study evaluates the differential effects of reward and punishment feedback on learning among adults with elevated ADHD. <b>Methods:</b> One hundred five participants self-reported their level of current ADHD symptoms and completed an innovative instrumental learning task. <b>Results:</b> Consistent with predictions, participants with low self-reported ADHD symptom severity benefitted equally from reward and punishment feedback during the learning task, whereas participants with high self-reported symptom severity performed better (indexed by accuracy on learning task) from reward than punishment feedback trials. <b>Conclusions:</b> Overall, adults with high self-reported symptom severity of ADHD learned more from reward-based feedback, which provides critical implications for motivational theories about ADHD, as well as for treatment protocols. Future work should examine the translatability of results within a treatment setting.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"28 2","pages":"147-161"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9558077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luciane Kaiser Pinotti, Anderson da Silva Castro, Gabriel Henrique de Oliveira Garcia, Pedro Henrique Pereira Alvim, Thiago Henrique Roza, Fabiana Antunes Andrade, Pedro André Kowacs, Raffael Massuda
{"title":"Executive functions in migraine patients: a systematic review with meta-analysis.","authors":"Luciane Kaiser Pinotti, Anderson da Silva Castro, Gabriel Henrique de Oliveira Garcia, Pedro Henrique Pereira Alvim, Thiago Henrique Roza, Fabiana Antunes Andrade, Pedro André Kowacs, Raffael Massuda","doi":"10.1080/13546805.2022.2149390","DOIUrl":"https://doi.org/10.1080/13546805.2022.2149390","url":null,"abstract":"<p><p><i>Introduction:</i> Migraine, a common neurological disease, is known to impact the quality of life of individuals with this condition.<i>Methods:</i> We performed a systematic review with meta-analysis to investigate the abnormalities associated with executive functions of migraineurs as compared with healthy controls. In addition, we investigated the differences between patients with and without aura.<i>Results:</i> A total of 25 studies were included in the systematic review and 19 in the meta-analysis. Meta-analysis was conducted using random effects models, with the unit of analysis as the standardised mean difference (calculated as Hedges'g). Patients with migraine had worse performance in the trail making test A (g = 0.40; 95% confidence interval [CI] 0.05-0.74; <i>p</i> = 0.0271) and B (g = 0.40; 95% CI 0.16-0.64; <i>p</i> = 0.0026), and digit span backward test (g = -0.20; 95% CI - 0.31, - 0.09; <i>p</i> = 0.0105). Subgroup analysis revealed no difference between migraine with and without aura.<i>Conclusion:</i> These results suggest that migraine patients may present worse performance for specific executive functional domains, including attention, working memory, and mental flexibility.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":"28 1","pages":"52-66"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}