Ron Walfisch, Dor Kalmanovich, Dor Hadida Barzilai
{"title":"First-episode psychosis and violence in Capgras syndrome: a retrospective case series.","authors":"Ron Walfisch, Dor Kalmanovich, Dor Hadida Barzilai","doi":"10.1080/13546805.2025.2571120","DOIUrl":"https://doi.org/10.1080/13546805.2025.2571120","url":null,"abstract":"<p><strong>Background: </strong>Capgras syndrome (CS) is a rare delusional misidentification syndrome in which individuals believe that another person has been replaced by an impostor.</p><p><strong>Methods: </strong>A retrospective chart review was conducted for all admissions to two male psychiatric inpatient departments in a tertiary hospital in Israel between August 1, 2024, and January 31, 2025. Cases with explicit documentation of CS were included. Demographic and clinical data were extracted and analyzed.</p><p><strong>Results: </strong>Among 308 hospitalised patients, five (1.62%) met criteria for CS, with a mean age of 33.6 years. Three patients (60%) had schizophrenia spectrum disorders, and two (40%) had organic psychosis associated with left frontal brain lesions. Four patients (80%) presented during their first psychiatric admission after committing severe violence against family members perceived as impostors. Treatment response varied: CS resolved in some cases with antipsychotics alone, while others required Clozapine and adjunctive interventions.</p><p><strong>Conclusions: </strong>CS may be underrecognized but carries significant clinical implications, particularly due to its association with violence in first-episode psychosis. Early identification and tailored treatment are critical for risk reduction.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"1-10"},"PeriodicalIF":0.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brooke M Boulais, John-Christopher A Finley, Anna C Cichocki, Christopher Gonzalez, Madison M Dykins, Thomas A Sedgwick, Neil H Pliskin, Kyle J Jennette, Perry Tsai, Nikita Maniar, Jerry A Krishnan, Jason R Soble, Matthew S Phillips
{"title":"Exploring the relationship between subjective cognitive concerns, psychiatric symptom reporting, and objective neurocognitive test performance in a post-SARS-CoV-2 clinical sample.","authors":"Brooke M Boulais, John-Christopher A Finley, Anna C Cichocki, Christopher Gonzalez, Madison M Dykins, Thomas A Sedgwick, Neil H Pliskin, Kyle J Jennette, Perry Tsai, Nikita Maniar, Jerry A Krishnan, Jason R Soble, Matthew S Phillips","doi":"10.1080/13546805.2025.2566649","DOIUrl":"https://doi.org/10.1080/13546805.2025.2566649","url":null,"abstract":"<p><strong>Introduction: </strong>Approximately 6.9% to 8.9% of nongeriatric adults in the United States report persistent symptoms following SARS-CoV-2, one of which being persistent cognitive concerns. Across clinical populations, discrepancies have been identified between subjective cognitive concerns and performance on objective neurocognitive measures, such that subjective cognitive concerns often do not correlate with objective neurocognitive deficits.</p><p><strong>Methods: </strong>The current study investigated the relationship between subjective cognitive concerns and objective neurocognitive test performance in a sample of 54 nongeriatric adults who underwent outpatient neuropsychological evaluation due to SARS-CoV-2 related persistent cognitive concerns. Multiple linear regressions analysed the relationship between reported cognitive concerns and objective neurocognitive test performance, as well as the relationship between depression and anxiety and subjective cognitive concerns.</p><p><strong>Results: </strong>Subjective cognitive concerns did not significantly predict performance on objective neurocognitive test measures. Increased self-reported symptoms of depression and anxiety predicted the presence of subjective cognitive concerns, with depressive symptom endorsement serving as the primary predictor.</p><p><strong>Conclusions: </strong>Results suggest that internalising psychopathology may be an important marker of subjective cognitive concerns in this population. While the origins of internalising symptoms are unclear, the impact of these factors emphasises the need for comprehensive support in addressing long-term effects experienced by individuals following SARS-CoV-2 infection.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"1-14"},"PeriodicalIF":0.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shu-Ho Chen, Ming-Hong Hsieh, Chieh-Liang Huang, Ming-Chou Ho
{"title":"Methamphetamine abstainer's \"cool\" and \"hot\" prepotent response inhibition.","authors":"Shu-Ho Chen, Ming-Hong Hsieh, Chieh-Liang Huang, Ming-Chou Ho","doi":"10.1080/13546805.2025.2534543","DOIUrl":"https://doi.org/10.1080/13546805.2025.2534543","url":null,"abstract":"<p><strong>Introduction: </strong>Methamphetamine (MA) abuse remains a critical issue in Taiwan, with impaired inhibitory control contributing to relapse. However, limited research has examined deficits in prepotent response inhibition across both \"cool\" (neutral) and \"hot\" (drug-related) contexts in MA abstainers. This study aimed to investigate these aspects of inhibitory control using a modified antisaccade task.</p><p><strong>Methods: </strong>Twenty-four male MA abstainers and twenty-four healthy controls (HC) completed counterbalanced \"cool\" and \"hot\" antisaccade tasks. The \"hot\" condition used MA-related images as distractor backgrounds, while the \"cool\" condition featured visually similar neutral images. Prepotent response inhibition was assessed across conditions, and correlations with addiction severity, treatment duration, use history, and days of abstinence were analyzed.</p><p><strong>Results: </strong>No significant interaction between group and condition or main effects of group and condition were found. However, in abstainers, prepotent response inhibition in both conditions positively correlated with days of abstinence but not with addiction severity, treatment duration, or use history.</p><p><strong>Conclusions: </strong>Findings suggest that prepotent response inhibition is more closely linked to recent abstinence duration than long-term addiction severity or treatment history. Future interventions should target inhibitory control in MA abstainers to reduce relapse risk and improve long-term recovery outcomes.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"1-13"},"PeriodicalIF":0.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeuropsychiatryPub Date : 2025-05-01Epub Date: 2025-09-09DOI: 10.1080/13546805.2025.2551512
Hana H Kutlikova, Natália Čavojská, Vladimír Ivančík, Alexandra Straková, Jakub Januška, Ján Pečeňák, Anton Heretik, Michal Hajdúk
{"title":"Visual processing of social and non-social stimuli in schizophrenia: investigation of the links to positive and negative symptoms.","authors":"Hana H Kutlikova, Natália Čavojská, Vladimír Ivančík, Alexandra Straková, Jakub Januška, Ján Pečeňák, Anton Heretik, Michal Hajdúk","doi":"10.1080/13546805.2025.2551512","DOIUrl":"10.1080/13546805.2025.2551512","url":null,"abstract":"<p><strong>Introduction: </strong>Schizophrenia (SCZ) spectrum is characterised by aberrant processing of social cues. However, little is known about the specific stages of visual attention and their connection to subclinical and clinical symptoms in psychosis. This study aimed to investigate the visual processing of social and non-social parts of naturalistic scenes, and its link to positive and negative symptoms.</p><p><strong>Methods: </strong>Employing eye-tracking and a free-viewing paradigm, we tested 27 individuals with SCZ and 28 matched controls and compared them on measures capturing both attention orientation (first fixation latency, velocity of entry saccade) and attention maintenance (duration of duration, number of saccades).</p><p><strong>Results: </strong>We did not find significant differences in attentional processing between schizophrenia and the control group. However, we observed that the severity of positive symptoms was associated with a delayed attention orientation toward the social aspects of the scenes, whereas negative symptoms were correlated with delayed attention orientation toward non-social contexts.</p><p><strong>Conclusion: </strong>Our results reveal distinct relationship profiles between positive and negative symptoms in schizophrenia and early stages of visual attention to social vs. non-social stimuli.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"211-222"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeuropsychiatryPub Date : 2025-05-01Epub Date: 2025-05-16DOI: 10.1080/13546805.2025.2504604
Valery Krupnik
{"title":"Decision-making balance in suicide: an active inference account.","authors":"Valery Krupnik","doi":"10.1080/13546805.2025.2504604","DOIUrl":"10.1080/13546805.2025.2504604","url":null,"abstract":"<p><p><b>Introduction:</b> Suicide is a behaviour whose motivation is challenging to explain as it can neither be rewarded nor punished since the agent no longer exists. The conventional explanation is that suicide is motivated as an escape from unresolvable psychological pain. However, despite suicide's high availability, its rates are very low (about 0.014% in the US). This speaks to high ambivalence as an essential feature of the suicidal mind.<b>Method:</b> To explicate the ambivalence of the suicidal mind, suicide has recently been framed within the active inference framework (AIF). AIF appears to be appropriate for conceptualising suicide because it is a theory of choice behaviour under uncertainty that, in suicide, cannot be resolved or, validated by experience. Moreover, AIF is based on the free-energy principle, which is proposed as a principle underwriting the very existence of sentient systems.<b>Results:</b> In this paper, we frame suicidal decision-making as the balance between the expected free energy of survival vs. suicide action policies. Based on this frame, we develop intuitions about the dynamics of suicidal decision-making. These intuitions are then proposed as guides for future research into suicidal decisions as well as suicide prevention.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"149-170"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeuropsychiatryPub Date : 2025-05-01Epub Date: 2025-05-14DOI: 10.1080/13546805.2025.2505691
Mohamad El Haj, Frank Questel, Ahmed A Moustafa
{"title":"My life story: self-defining memories in Korsakoff syndrome.","authors":"Mohamad El Haj, Frank Questel, Ahmed A Moustafa","doi":"10.1080/13546805.2025.2505691","DOIUrl":"10.1080/13546805.2025.2505691","url":null,"abstract":"<p><strong>Background: </strong>Self-defining memories are emotionally intense memories that help people define who they are. While such memories play a central role in self-concept and emotional well-being, little is known about how they are affected in Korsakoff's syndrome (KS).</p><p><strong>Methods: </strong>We invited patients with KS and healthy control participants to retrieve self-defining memories, which were then analysed for specificity (specific vs. general events), emotional valence (positive vs. negative) and integration of meaning (whether the memory was connected to a broader understanding of the self or life experience).</p><p><strong>Results: </strong>The analysis demonstrated no significant differences between patients with KS and controls in terms of specificity. However, compared with control participants, patients with KS produced more negative and non-integrated self-defining memories. Within-groups comparisons demonstrated more specific than general self-defining memories in patients with KS and control participants. These memories were mainly negative in patients with KS and positive in control participants, non-integrated in patients with KS but integrated in control participants.</p><p><strong>Conclusions: </strong>These findings demonstrate no difficulties in patients with KS to retrieve specific self-defining memories; however, these memories seem to be mainly related to negative events and enduring concerns or unresolved conflicts.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"171-185"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeuropsychiatryPub Date : 2025-05-01Epub Date: 2025-07-27DOI: 10.1080/13546805.2025.2529791
Charley Hillier, Nathan Weber, Ryan P Balzan
{"title":"Overconfidence or resolution in psychosis: a Bayesian reanalysis.","authors":"Charley Hillier, Nathan Weber, Ryan P Balzan","doi":"10.1080/13546805.2025.2529791","DOIUrl":"10.1080/13546805.2025.2529791","url":null,"abstract":"<p><strong>Introduction: </strong>People with psychosis place greater confidence in errors and less confidence in accurate judgements relative to controls. This overconfidence in errors bias is theorised to contribute to the formation and maintenance of delusions. However, no research has examined whether people with psychosis have an impaired ability to judge whether they are confident or not, known as resolution. This study aimed to establish whether psychosis populations show a resolution deficit.</p><p><strong>Method: </strong>We used hierarchical Bayesian modelling and Type 2 Signal Detection Theory to explore whether participants with schizophrenia (<i>n</i> = 25) had poorer resolution and higher overconfidence than high delusion-prone (<i>n</i> = 25) and low delusion-prone participants (<i>n</i> = 25) when making confidence judgements. A discrimination index and over/underconfidence statistic examined resolution and overconfidence, respectively.</p><p><strong>Results: </strong>While all participants showed a low discrimination index, schizophrenia participants had a meaningfully lower discrimination index than low delusion-prone participants, indicating poorer resolution. All groups were overconfident, with schizophrenia participants showing the greatest level of overconfidence.</p><p><strong>Conclusions: </strong>Results suggest schizophrenia patients show impairments in using confidence judgements to discriminate between correct and incorrect judgements. Resolution deficits in psychosis could have theoretical and clinical implications for our approach towards delusions.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"186-198"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeuropsychiatryPub Date : 2025-05-01Epub Date: 2025-08-04DOI: 10.1080/13546805.2025.2539159
Aarush Mehta, Amir H Nikzad, Yan Cong, Sunghye Cho, Sameer Pradhan, Sunny X Tang
{"title":"Sentiment in speech is associated with symptom severity in psychosis.","authors":"Aarush Mehta, Amir H Nikzad, Yan Cong, Sunghye Cho, Sameer Pradhan, Sunny X Tang","doi":"10.1080/13546805.2025.2539159","DOIUrl":"10.1080/13546805.2025.2539159","url":null,"abstract":"<p><strong>Background: </strong>Sentiment in the speech of people with schizophrenia spectrum disorder (SSD) may reflect psychosis severity. Previous research examines speech from semi-structured interviews or self-narrative prompts, where differences in measured sentiment may be driven by differences in life experiences. We measured sentiment in speech evoked from standardised stimuli among participants with a psychotic disorder.</p><p><strong>Methods: </strong>Two cohorts (<i>N</i> = 97) participated in this study. Symptom domains were assessed using the Brief Psychiatric Rating Scale and were represented as <i>Anxious Depression</i>, <i>Hostile Suspiciousness</i>, <i>Thought Disturbance</i>, and <i>Withdrawal Retardation</i>. Participant speech during picture description tasks was quantified for sentiments: <i>Valence</i>, <i>Arousal</i>, <i>Dominance</i>, <i>Happiness</i>, <i>Sadness</i>, <i>Anger</i>, <i>Fear</i>, <i>Disgust</i>, and <i>Surprise</i>. Correlations between clinical and sentiment measures were conducted separately for the two cohorts and two timepoints in Cohort 1. Within-participant longitudinal relationships were examined with linear mixed models.</p><p><strong>Results: </strong>Several replicable relationships between sentiment and symptom severity were found: two replicable findings among Cohorts 1 and 2 and three replicable findings across Cohort 1 timepoints. Five findings were also generalised to within-participant longitudinal relationships.</p><p><strong>Conclusions: </strong>Sentiment measures were related to the four symptom domains in the context of standardised stimuli, suggesting a disruption in emotion processing among people with a psychotic disorder.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"199-210"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeuropsychiatryPub Date : 2025-03-01Epub Date: 2025-02-19DOI: 10.1080/13546805.2025.2464728
Jenna N Pablo, Jorja Shires, Wendy A Torrens, Lena L Kemmelmeier, Sarah M Haigh, Marian E Berryhill
{"title":"Identifying overlapping and distinctive traits of autism and schizophrenia using machine learning classification.","authors":"Jenna N Pablo, Jorja Shires, Wendy A Torrens, Lena L Kemmelmeier, Sarah M Haigh, Marian E Berryhill","doi":"10.1080/13546805.2025.2464728","DOIUrl":"10.1080/13546805.2025.2464728","url":null,"abstract":"<p><strong>Introduction: </strong>Autism spectrum disorder (ASD) and schizophrenia spectrum disorder (SSD) share some symptoms. We conducted machine learning classification to determine if common screeners used for research in non-clinical and subclinical populations, the Autism-Spectrum Quotient (AQ) and Schizotypal Personality Questionnaire - Brief Revised (SPQ-BR), could identify <i>non-overlapping</i> symptoms.</p><p><strong>Methods: </strong>1,397 undergraduates completed the SPQ-BR and AQ. Random forest classification modelled whether SPQ-BR item scores predicted AQ scores and factors, and vice versa. The models first used all item scores and then the least/most important features.</p><p><strong>Results: </strong>Robust trait overlap allows for the prediction of AQ from SPQ-BR and vice versa. Results showed that AQ <i>item scores</i> predicted 2 of 3 SPQ-BR factors (disorganised, interpersonal), and SPQ-BR <i>item scores</i> successfully predicted 2 of 5 AQ factors (communication, social skills). Importantly, classification model <u>failures</u> showed that AQ <i>item scores</i> could not predict the SPQ-BR <i>cognitive-perceptual</i> factor, and the SPQ-BR <i>item scores</i> could not predict 3 AQ factors (imagination, attention to detail, attention switching).</p><p><strong>Conclusions: </strong>Overall, the SPQ-BR and AQ measure overlapping symptoms that can be isolated to some factors. Importantly, where we observe model failures, we capture distinctive factors. We provide guidance for leveraging existing screeners to avert misdiagnosis and advancing specific/selective biomarker identification.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"69-91"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeuropsychiatryPub Date : 2025-03-01Epub Date: 2025-05-04DOI: 10.1080/13546805.2025.2490793
Gertrude Okello, Norman Poole, Daniel Chung
{"title":"\"String hallucinations\": a case of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) with multimodal visual and somatic disturbances.","authors":"Gertrude Okello, Norman Poole, Daniel Chung","doi":"10.1080/13546805.2025.2490793","DOIUrl":"10.1080/13546805.2025.2490793","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary condition primarily caused by mutations on the NOTCH3 gene, leading to hypoperfusion and ischaemic events, with two-thirds of cases having lacunar infarcts mostly within the basal ganglia, thalamus, and brainstem. Here, we focus on an individual with CADASIL who had a thalamic stroke, which preceded symptoms of visual and somatic disturbances.</p><p><strong>Methods: </strong>A single-case report is used to describe the visual and somatic disturbances experienced by a 52-year-old gentleman following a left-sided thalamic stroke, who is genetically heterozygous for c449A > G p.(Tyr150Cys) mutation in the NOTCH3 gene consistent with CADASIL, as well as their response to various psychotropic medications, through information gathered from the patient's clinical records.</p><p><strong>Results: </strong>After trialling several antidepressants, and a trial of a cholinesterase inhibitor, there was no perceived benefit reported; with only lamotrigine, previously prescribed for thalamic pain, and olanzapine, providing the least amount of distress associated with their symptoms.</p><p><strong>Conclusions: </strong>As the management of CADASIL appears to focus on symptom control, this case highlights the need for further research to elucidate the mechanisms driving such unusual perceptual disturbances to inform potential future treatments.</p>","PeriodicalId":51277,"journal":{"name":"Cognitive Neuropsychiatry","volume":" ","pages":"92-103"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}