First-episode psychosis and violence in Capgras syndrome: a retrospective case series.

IF 0.9 4区 医学 Q3 PSYCHIATRY
Ron Walfisch, Dor Kalmanovich, Dor Hadida Barzilai
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引用次数: 0

Abstract

Background: Capgras syndrome (CS) is a rare delusional misidentification syndrome in which individuals believe that another person has been replaced by an impostor.

Methods: A retrospective chart review was conducted for all admissions to two male psychiatric inpatient departments in a tertiary hospital in Israel between August 1, 2024, and January 31, 2025. Cases with explicit documentation of CS were included. Demographic and clinical data were extracted and analyzed.

Results: Among 308 hospitalised patients, five (1.62%) met criteria for CS, with a mean age of 33.6 years. Three patients (60%) had schizophrenia spectrum disorders, and two (40%) had organic psychosis associated with left frontal brain lesions. Four patients (80%) presented during their first psychiatric admission after committing severe violence against family members perceived as impostors. Treatment response varied: CS resolved in some cases with antipsychotics alone, while others required Clozapine and adjunctive interventions.

Conclusions: CS may be underrecognized but carries significant clinical implications, particularly due to its association with violence in first-episode psychosis. Early identification and tailored treatment are critical for risk reduction.

Capgras综合征的首发精神病和暴力:回顾性病例系列。
背景:Capgras综合征(CS)是一种罕见的妄想性误认综合征,患者认为另一个人被冒名顶替者所取代。方法:对以色列某三级医院2024年8月1日至2025年1月31日住院的2个男性精神科患者进行回顾性分析。有明确文献记载的CS病例被纳入研究。提取并分析人口学和临床资料。结果:308例住院患者中,5例(1.62%)符合CS标准,平均年龄33.6岁。3名患者(60%)患有精神分裂症谱系障碍,2名患者(40%)患有与左额叶脑病变相关的器质性精神病。4名患者(80%)在对被视为冒名顶替者的家庭成员实施严重暴力后首次入院。治疗效果各不相同:某些病例仅使用抗精神病药物即可解决CS,而其他病例则需要氯氮平和辅助干预。结论:CS可能未被充分认识,但具有重要的临床意义,特别是由于其与首发精神病中的暴力行为有关。早期发现和有针对性的治疗对于降低风险至关重要。
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来源期刊
CiteScore
3.20
自引率
11.80%
发文量
18
审稿时长
>12 weeks
期刊介绍: Cognitive Neuropsychiatry (CNP) publishes high quality empirical and theoretical papers in the multi-disciplinary field of cognitive neuropsychiatry. Specifically the journal promotes the study of cognitive processes underlying psychological and behavioural abnormalities, including psychotic symptoms, with and without organic brain disease. Since 1996, CNP has published original papers, short reports, case studies and theoretical and empirical reviews in fields of clinical and cognitive neuropsychiatry, which have a bearing on the understanding of normal cognitive processes. Relevant research from cognitive neuroscience, cognitive neuropsychology and clinical populations will also be considered. There are no page charges and we are able to offer free color printing where color is necessary.
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